Einstellung, Bedenken und Selbstwirksamkeitserwartung von Lehramtsstudierenden zur schulischen Inklusion

In diesem technischen Bericht werden die Trennschärfe und der Cronbach‘s alpha der Skalen AIS, ITICS, CIES, TEIP und IPRS von zwei Erhebungen an der Technischen Universität Dortmund und der Technischen Universität München dargestellt. Die Reliabilitätsanalysen ergeben zufriedenstellende Werte für die einzelnen Skalen. Zu Beginn des Berichts werden die Stichproben und Datenerhebungen beschrieben. Anschließend folgen die technischen Daten der Skalen und die deutsche Fassung der Items sowie die englischen Originalversionen. Nach der Analyse der Skalen folgt der Originalfragebogen, der zur Datenerfassung an der TU Dortmund verwendet wurde

Achievement and Integration of Students with Special Needs (SEN) in the Fifth Grade

In Styria 77.3% of all students with special needs are educated in integrated classrooms. Currently, it is not known much either about the school performance nor the active class participation of these students. This study examined 230 fifth grade students – 43 with and 187 students without special educational needs (SEN). Moreover, it is important to acknowledge that the available data for this study represents the first wave of larger longitudinal study. The school performance of the students with SEN ranged one standard deviation below the level of the students without SEN. All students felt emotionally well integrated in the school settings, but the differences in the degree of social integration were evident. In fact, the students with SEN mentioned that they got along well with their classmates less frequently than the students without SEN

Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro

Purpose: The biologic relevance of human connective tissue growth factor (hCTGF) for primary human tenon fibroblasts (HTFs) was investigated by RNA expression profiling using affymetrix (TM) oligonucleotide array technology to identify genes that are regulated by hCTGF. Methods: Recombinant hCTGF was expressed in HEK293T cells and purified by affinity and gel chromatography. Specificity and biologic activity of hCTGF was confirmed by biosensor interaction analysis and proliferation assays. For RNA expression profiling HTFs were stimulated with hCTGF for 48h and analyzed using affymetrix (TM) oligonucleotide array technology. Results were validated by real time RT-PCR. Results: hCTGF induces various groups of genes responsible for a wound healing and inflammatory response in HTFs. A new subset of CTGF inducible inflammatory genes was discovered (e.g., chemokine [C-X-C motif] ligand 1 [CXCL1], chemokine [C-X-C motif] ligand 6 [CXCL6], interleukin 6 [IL6], and interleukin 8 [IL8]). We also identified genes that can transmit the known biologic functions initiated by CTGF such as proliferation and extracellular matrix remodelling. Of special interest is a group of genes, e.g., osteoglycin (OGN) and osteomodulin (OMD), which are known to play a key role in osteoblast biology. Conclusions: This study specifies the important role of hCTGF for primary tenon fibroblast function. The RNA expression profile yields new insights into the relevance of hCTGF in influencing biologic processes like wound healing, inflammation, proliferation, and extracellular matrix remodelling in vitro via transcriptional regulation of specific genes. The results suggest that CTGF potentially acts as a modulating factor in inflammatory and wound healing response in fibroblasts of the human eye

Comparing wavelengths simulated by the coastal wave model CWAM and TerraSAR-X satellite data

The accuracy of the high resolution coastal wave forecast model CWAM is validated on the basis of sea state information from satellite images of TerraSAR-X (TS-X). Employing 2-dimensional Fast Fourier Transformation, image spectra are derived from TS-X and locally varying patterns of the peak wavelengths are provided. Subsequently, wavelength comparisons are performed between a typical set of TS-X scenes acquired in December 2013 over the German Bight and the model hindcasts. This results mostly in reasonable agreement. Potential wave modelling errors are discussed as well

Physical Disability, Stigma, and Physical Activity in Children - A Replica Study

Introduction: Stereotypes can be reduced through positive descriptions. A stigma that able-bodied adults have towards children with physical disability can be reduced when the child is portrayed as being active. The study found out that a sporty active child, who uses a wheelchair, is perceived as more competent than the sporty active able-bodied child. Objective: This study is a replica study to support the hypotheses and to examine the stereotypes of able-bodied adults towards children with and without (physical) disabilities. Methods: This study presents two experimental replica studies using a 2 (physical activity) x 2 (sporty activities). The dependent variables were the perception of competencies and warmth according to Stereotype Content Model (SCM). Study 1 is an online experiment with 355 students of the Open University of Hagen. Study 2 surveys 1176 participants (from Munich and Graz) with a paper-pencil-questionnaire. Results: The significant interaction effect was not supported by our studies. The sporty able-bodied child was rated higher in competences than the sporty child, who use a wheelchair. Sporting activity only reduces the stigma towards children with a physical disability slightly. Conclusion: The stigma towards children with physical disability can be reduced when the child is portrayed as being active, but the effect was not strong enough to chance the original classification by the SCM

Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes

Resveratrol is reported to possess chemotherapeutic properties in several cancers. In this study, we wanted to investigate the molecular mechanisms of resveratrol-induced cell cycle arrest and apoptosis as well as the impact of resveratrol on NAMPT and SIRT1 protein function and asked whether there are differences in hepatocarcinoma cells (HepG2, Hep3B cells) and non-cancerous primary human hepatocytes. We found a lower basal NAMPT mRNA and protein expression in hepatocarcinoma cells compared to primary hepatocytes. In contrast, SIRT1 was significantly higher expressed in hepatocarcinoma cells than in primary hepatocytes. Resveratrol induced cell cycle arrest in the S- and G2/M- phase and apoptosis was mediated by activation of p53 and caspase-3 in HepG2 cells. In contrast to primary hepatocytes, resveratrol treated HepG2 cells showed a reduction of NAMPT enzymatic activity and increased p53 acetylation (K382). Resveratrol induced NAMPT release from HepG2 cells which was associated with increased NAMPT mRNA expression. This effect was absent in primary hepatocytes where resveratrol was shown to function as NAMPT and SIRT1 activator. SIRT1 inhibition by EX527 resembled resveratrol effects on HepG2 cells. Furthermore, a SIRT1 overexpression significantly decreased both p53 hyperacetylation and resveratrol-induced NAMPT release as well as S-phase arrest in HepG2 cells. We could show that NAMPT and SIRT1 are differentially regulated by resveratrol in hepatocarcinoma cells and primary hepatocytes and that resveratrol did not act as a SIRT1 activator in hepatocarcinoma cells

Linking Self-Rated Social Inclusion to Social Behaviour. An Emperical Study of Students with and without Special Education in Secondary Schools

Successful inclusive education creates a learning environment that supports not only the cognitive abilities of all children but also their social and emotional development. The present study focuses on the development of social participation of students with and without special education needs (SEN). A longitudinal study with two measurement times was conducted. The first measurement (T1) took place at the end of fifth grade, the second (T2) one year later. The sample consisted of 35 SEN students and108 non-SEN students from mainstream classes in Graz, Austria. For assessing the self-perception of social inclusion, items from the ‘dimensions of integration’ questionnaire (FDI 4–6) were used. Social participation does not seem to be a very stable phenomenon; its retest reliability was only .47 for SEN students and .54 for non-SEN students. Results indicate that children with SEN experienced less social participation than children without SEN at T1 and T2. To identify the predictors for social participation, a multiple regression analysis was conducted. Next to social participation at T1, indirect aggressive behaviour (self-assessed) also appears to predict social participation at T2