7 research outputs found
Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease
- Author
- Agard C
- Alegre Sancho J
- Allanore Y
- Alves J
- Alves M
- Aringer M
- Azuma A
- Balbir-Gurman A
- Bascom R
- Becvar R
- Behera D
- Bergna M
- Bernardes M
- Bewig B
- Blaas S
- Bondue B
- Bourdin A
- Carreira Delgado P
- Casado G
- Castellv\ued Barranco I
- Ch'ng SS
- Cheah C
- Cifri\ue1n Mart\uednez J
- Clerisme-Beaty E
- Cordeiro A
- Costa J
- Cottin V
- Crestani B
- Criner G
- Csuka ME
- Cutolo M
- Dankiewicz-Fares I
- de Vries-Bouwstra JK
- Dematte D'Amico J
- Denton CP
- Diot E
- Distler J
- Distler O
- Dominique S
- Ehrchen J
- Ekwall AH
- Ettinger N
- Ewert R
- Fischer A
- Fischer A
- Freire Dapena MC
- Funakubo Y
- Gabrielli A
- Gahlemann M
- Gayathri Devi HJ
- Gerbino A
- Gerke A
- Girard M
- Gl\ue4ser S
- Glassberg M
- Glazer C
- Golden J
- Gripaldo R
- Guill\ue9n Del Castillo A
- Gupta N
- Hachulla E
- Hamblin M
- Henes J
- Henry M
- Herrick A
- Highland K
- Highland KB
- Ho L
- Hoffmann-Vold AM
- Houssiau F
- Huang C
- Huggins JT
- Hummers L
- Hunzelmann N
- Iaccarino L
- Inoue Y
- Jiang Z
- Johnson S
- Jones L
- Jouneau S
- K\uf6nig R
- K\uf6tter I
- Kadel J
- Kahaleh M
- Kan S
- Kawaguchi Y
- Kawakami A
- Kawamura T
- Kawedia M
- Keystone E
- Khalidi N
- Khanna D
- Kilpel\ue4inen M
- Kim H
- Kondoh Y
- Kramer M
- Kreuter M
- Kumar D
- Kumar U
- Kuwana M
- Kuwana M
- L\uf3pez-Longo FJ
- Lancaster LH
- Leroy S
- Levesque M
- Li J
- Litinsky I
- Liu Y
- Loeffler-Ragg J
- Lokhande R
- Losonczy G
- Luckhardt T
- M\ufcller R
- Madhok R
- Madsen H
- Mahakkanukrauh A
- Maher TM
- Maher TM
- Malpani A
- Mannucci Walter P
- Maturana Rozas R
- Maurer B
- Mayes M
- Mayes MD
- Mendoza Ballesteros F
- Mihai CM
- Mohabir P
- Mohan M
- Mooney J
- Morrissey B
- Moua T
- Myll\ue4rniemi M
- Nalawade A
- Nanki T
- Nantiruj K
- Neves S
- Nishioka Y
- Nozawa K
- Nunes H
- O'Reilly K
- Oguragawa T
- Okamoto M
- Olesiejuk R
- Olschewski H
- Ovalles JG
- Padilla M
- Parakh U
- Patel N
- Perez R
- Pesci A
- Prasse A
- Prevot G
- Proudman S
- Pulka G
- Raghu G
- Raja Mohamed RB
- Riccieri V
- Rivera Gallego A
- Rom\ue1n Ivorra JA
- Roman J
- Rosner I
- Rossman M
- Russell T
- S\uf8ndergaard K
- Saketkoo L
- Salvador MJ
- Sano H
- Sasai R
- Sasaki N
- Sauter W
- Scholand MB
- Schulze-Koops H
- Seip M
- Selman M
- Sfikakis P
- Shah A
- Shlobin O
- Shobha V
- Silva Orellana A
- Simmssetts R
- Siripaitoon B
- Smith V
- Spiera R
- Steen V
- Stevens W
- Stowasser S
- Suda T
- Swarnakar R
- Szepietowski J
- Takahashi H
- Takeuchi T
- Tanaka S
- Tetzlaff K
- Thakkar V
- Thangakunam B
- Troy L
- Udwadia Z
- van den Toorn L
- Veeraraghavan S
- Vettori S
- Vlachoyiannopoulos P
- Vonken M
- Voskuyl AE
- Wallaert B
- Weigt S.
- Wemeau L
- West A
- Wuyts W
- Xiao W
- Xu J
- Yamasaki Y
- Zeng X
- Zheng Y
- Zou H
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND: Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis and a leading cause of systemic sclerosis-related death. Nintedanib, a tyrosine kinase inhibitor, has been shown to have antifibrotic and antiinflammatory effects in preclinical models of systemic sclerosis and ILD. METHODS: We conducted a randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of nintedanib in patients with ILD associated with systemic sclerosis. Patients who had systemic sclerosis with an onset of the first non-Raynaud's symptom within the past 7 years and a high-resolution computed tomographic scan that showed fibrosis affecting at least 10% of the lungs were randomly assigned, in a 1:1 ratio, to receive 150 mg of nintedanib, administered orally twice daily, or placebo. The primary end point was the annual rate of decline in forced vital capacity (FVC), assessed over a 52-week period. Key secondary end points were absolute changes from baseline in the modified Rodnan skin score and in the total score on the St. George's Respiratory Questionnaire (SGRQ) at week 52. RESULTS: A total of 576 patients received at least one dose of nintedanib or placebo; 51.9% had diffuse cutaneous systemic sclerosis, and 48.4% were receiving mycophenolate at baseline. In the primary end-point analysis, the adjusted annual rate of change in FVC was 1252.4 ml per year in the nintedanib group and 1293.3 ml per year in the placebo group (difference, 41.0 ml per year; 95% confidence interval [CI], 2.9 to 79.0; P=0.04). Sensitivity analyses based on multiple imputation for missing data yielded P values for the primary end point ranging from 0.06 to 0.10. The change from baseline in the modified Rodnan skin score and the total score on the SGRQ at week 52 did not differ significantly between the trial groups, with differences of 120.21 (95% CI, 120.94 to 0.53; P=0.58) and 1.69 (95% CI, 120.73 to 4.12 [not adjusted for multiple comparisons]), respectively. Diarrhea, the most common adverse event, was reported in 75.7% of the patients in the nintedanib group and in 31.6% of those in the placebo group. CONCLUSIONS: Among patients with ILD associated with systemic sclerosis, the annual rate of decline in FVC was lower with nintedanib than with placebo; no clinical benefit of nintedanib was observed for other manifestations of systemic sclerosis. The adverse-event profile of nintedanib observed in this trial was similar to that observed in patients with idiopathic pulmonary fibrosis; gastrointestinal adverse events, including diarrhea, were more common with nintedanib than with placebo
Isoniazid associated psychosis: case series from a tertiary care centre
- Publication venue
- 'Diva Enterprises Private Limited'
- Publication date
- 01/07/2018
- Field of study
Isoniazid (INH) is a commonly used first line antitubercular drug. INH associated psychosis is a rare psychiatric manifestation. We report two cases of pulmonary tuberculosis, where the patients developed psychosis after being given a therapeutic dose of INH. In vulnerable patients, INH may cause change in concentration of neurotransmitters by inhibition of monoamine oxidase (MAO) and deficiency of pyridoxine. This might precipitate psychosis. Our observation also supports the hypothesis that INH associated psychotic disorders might have a pathophysiological substrate in common with some schizophrenia patients, who show remarkable response to low doses of atypical antipsychotic agents and pyridoxine supplementation
Pulmonary alveolar microlithiasis
- Author
- Publication venue
- Medknow Publications
- Publication date
- 01/01/2011
- Field of study
Pulmonary alveolar microlithiasis is a rare disease of unknown cause. We report a case in a young boy who presented with history of failure to thrive and chest X-ray finding suggestive of miliary mottling. Open lung biopsy revealed pulmonary alveolar microlithiasis
Hypersensitivity pneumonitis: Clinical manifestations – Prospective data from the interstitial lung disease-India registry
- Author
- Alhamad
- AlokeG Ghoshal
- Arpita Jindal
- BharatB Sharma
- BridgetF Collins
- DayaK Mangal
- Deepak Talwar
- Dhooria
- Fernández
- Ganesh Raghu
- Hanak
- Hanak
- HJ Gayathri Devi
- JaiK Samaria
- Jitesh Ahuja
- Johannson
- JyotsanaM Joshi
- Karakatsani
- Khushboo Pilania
- Kreuter
- Kundu
- Lacasse
- Lawrence Ho
- LĂłpez-Campos
- Molyneaux
- Morell
- Morell
- Morisset
- Musellim
- NirmalK Jain
- Nishtha Singh
- Parthasarthi Bhattacharya
- Parvaiz Koul
- Raghu
- Raghu
- Raja Dhar
- Rajesh Swarnakar
- Ravindran Chetambath
- Richerson
- Ryerson
- Salisbury
- Sandeep Katiyar
- Sen
- Sheetu Singh
- Singh
- Singh
- Subhash
- SubodhK Katiyar
- Sudhakar Pipavath
- Sudhir Chaudhari
- Surya Kant
- Tejraj Singh
- Thomeer
- Travis
- Vasakova
- Virendra Singh
- Walsh
- Publication venue
- 'Medknow'
- Publication date
- 01/01/2019
- Field of study
Bis(3,5-diiodo-2,4,6-trihydroxyphenyl)squaraine photodynamic therapy disrupts redox homeostasis and induce mitochondria-mediated apoptosis in human breast cancer cells
- Author
- A Glasauer
- A Stanley
- A Vantieghem
- AA Rosenkranz
- AP Thomas
- BTS Da Wei Huang
- CT Karadedou
- D Gayathri Devi
- D Ramaiah
- D Ramaiah
- D Ramaiah
- DR Youlden
- E Buytaert
- E Puig-Vilanova
- F-M Wang
- FJ Oliver
- G Anether
- G Bellomo
- GT Charras
- H Nakamura
- HJ Park
- I Gage
- J Frank
- J Moan
- JR Kirshner
- K Kannan
- K Wang
- M Coleman
- M Desouza
- M González-Bártulos
- M Soumya
- MC DeRosa
- MR Bubb
- N Shishkova
- PH Elkhuizen
- R Schmidt
- RR Avirah
- RR Avirah
- RR Avirah
- SC Karunakaran
- SF Altschul
- SM Laster
- T Kawabe
- T Takemura
- T-S Chang
- V Rapozzi
- VS Jisha
- VS Jisha
- W Cui
- W Ding
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cytotoxic effects of Mn(III) N
- Author
- Aird KM
- Artak Tovmasyan
- Batinic-Haberle I
- Batinic-Haberle I
- Batinic-Haberle I
- Batinic-Haberle I
- Batinic-Haberle I
- Batinić-Haberle I
- Batinić-Haberle I
- Beck R
- Beck R
- Bielski BHJ
- Bottino R
- Brown NS
- Buetter GR
- Buettner GR
- Buettner GR
- Cabelli DE
- Casey Dedeugd
- Chen Q
- Chen Q
- Chen Q
- Cullen JJ
- Diane Fels
- Dorai T
- Engelmann FM
- Espey MG
- Ferrer-Sueta G
- Ferrer-Sueta G
- Forman HJ
- Fridovich I
- Garcia J
- Gayathri R. Devi
- Gutteridge JM
- Halliwell B
- Halliwell B.
- Hempel N
- Hempel N
- Hussain SP
- Ines Batinic-Haberle
- Ivan Kos
- Ivan Spasojevic
- Jaramillo MC
- Jaramillo MC
- Jaramillo MC
- Jennifer L. Allensworth
- Kam W. Leong
- Katherine M. Aird
- Keir ST
- Kim A
- Kobayashi N
- Kos I
- Kos I
- Levine M
- Levine M
- Liao D
- Lu X
- Mark W. Dewhirst
- Miller DM
- Miller DM
- Moeller BJ
- Nadezhdin AD
- Nam W
- Nishikimi M
- Noble JE
- Okado-Matsumoto A
- Oliver KM
- Pollard JM
- Rabbani ZN
- Ranzato E
- Reuter S
- Sandstrom PA
- Semchyshyn H
- Sheng H
- Sheng H
- Spasojevic I
- Spasojevic I
- Spasojevic I
- Spasojevic I
- Spasojevic I
- Stoll B
- Sun Y
- Tareen B
- Tew KD
- Tian J
- Tovmasyan A
- Tse H
- Tzur A
- Verrax J
- Verrax J
- Verrax J
- Williams NH
- Won Park
- Woodward WA
- Xiaodong Ye
- Ye X
- Yerlikaya A
- Yu L
- Zhao Y
- Zhou Y
- Zocchi E
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
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- S. L. Gaff in and S. Watanabe J
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- Y. Miyake T. Abe, and T. Yamano, in International Symposium on Oxidases and Related Redox Systems
- YA Sharonov
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- YA Sharonov
- YE Erokhin
- YJ Kang
- YK Turakulov
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- Z Bradic
- Z Gasyna
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1984
- Field of study