Primary hyperparathyroidism

Primary hyperparathyroidism is an endocrine disorder that results in overproduction of parathyroid hormone by overactivated parathyroid gland leading to a significant rise in blood serum calcium. It results in hypercalcaemia, which has a significant impact mainly on the kidneys and bones and results in a variety of signs and symptoms. Primary hyperparathyroidism should be treated because, if left without any therapy, it can lead even to death. Surgery is considered as the best and only successful therapy, with very low risk of recurrence and relatively low complication rate. The aim of this review is to present clinical basis, aetiology, diagnostic possibilities, and treatment opportunities

Compressed Membership for NFA (DFA) with Compressed Labels is in NP (P)

In this paper, a compressed membership problem for finite automata, both deterministic and non-deterministic, with compressed transition labels is studied. The compression is represented by straight-line programs (SLPs), i.e. context-free grammars generating exactly one string. A novel technique of dealing with SLPs is introduced: the SLPs are recompressed, so that substrings of the input text are encoded in SLPs labelling the transitions of the NFA (DFA) in the same way, as in the SLP representing the input text. To this end, the SLPs are locally decompressed and then recompressed in a uniform way. Furthermore, such recompression induces only small changes in the automaton, in particular, the size of the automaton remains polynomial. Using this technique it is shown that the compressed membership for NFA with compressed labels is in NP, thus confirming the conjecture of Plandowski and Rytter and extending the partial result of Lohrey and Mathissen; as it is already known, that this problem is NP-hard, we settle its exact computational complexity. Moreover, the same technique applied to the compressed membership for DFA with compressed labels yields that this problem is in P; for this problem, only trivial upper-bound PSPACE was known

On Maximal Unbordered Factors

Given a string $S$ of length $n$, its maximal unbordered factor is the longest factor which does not have a border. In this work we investigate the relationship between $n$ and the length of the maximal unbordered factor of $S$. We prove that for the alphabet of size $\sigma \ge 5$ the expected length of the maximal unbordered factor of a string of length~$n$ is at least $0.99 n$ (for sufficiently large values of $n$). As an application of this result, we propose a new algorithm for computing the maximal unbordered factor of a string.Comment: Accepted to the 26th Annual Symposium on Combinatorial Pattern Matching (CPM 2015

Queries on LZ-Bounded Encodings

We describe a data structure that stores a string $S$ in space similar to that of its Lempel-Ziv encoding and efficiently supports access, rank and select queries. These queries are fundamental for implementing succinct and compressed data structures, such as compressed trees and graphs. We show that our data structure can be built in a scalable manner and is both small and fast in practice compared to other data structures supporting such queries

Synchronization Problems in Automata without Non-trivial Cycles

We study the computational complexity of various problems related to synchronization of weakly acyclic automata, a subclass of widely studied aperiodic automata. We provide upper and lower bounds on the length of a shortest word synchronizing a weakly acyclic automaton or, more generally, a subset of its states, and show that the problem of approximating this length is hard. We investigate the complexity of finding a synchronizing set of states of maximum size. We also show inapproximability of the problem of computing the rank of a subset of states in a binary weakly acyclic automaton and prove that several problems related to recognizing a synchronizing subset of states in such automata are NP-complete.Comment: Extended and corrected version, including arXiv:1608.00889. Conference version was published at CIAA 2017, LNCS vol. 10329, pages 188-200, 201

Detecting One-variable Patterns

Given a pattern $p = s_1x_1s_2x_2\cdots s_{r-1}x_{r-1}s_r$ such that $x_1,x_2,\ldots,x_{r-1}\in\{x,\overset{{}_{\leftarrow}}{x}\}$, where $x$ is a variable and $\overset{{}_{\leftarrow}}{x}$ its reversal, and $s_1,s_2,\ldots,s_r$ are strings that contain no variables, we describe an algorithm that constructs in $O(rn)$ time a compact representation of all $P$ instances of $p$ in an input string of length $n$ over a polynomially bounded integer alphabet, so that one can report those instances in $O(P)$ time.Comment: 16 pages (+13 pages of Appendix), 4 figures, accepted to SPIRE 201

Block trees

Let string S[1..n] be parsed into z phrases by the Lempel-Ziv algorithm. The corresponding compression algorithm encodes S in O(z) space, but it does not support random access to S. We introduce a data structure, the block tree, that represents S in O(z log(n/z)) space and extracts any symbol of S in time O(log(n/z)), among other space-time tradeoffs. The structure also supports other queries that are useful for building compressed data structures on top of S. Further, block trees can be built in linear time and in a scalable manner. Our experiments show that block trees offer relevant space-time tradeoffs compared to other compressed string representations for highly repetitive strings. (C) 2020 Elsevier Inc. All rights reserved.Peer reviewe

Forward Analysis and Model Checking for Trace Bounded WSTS

We investigate a subclass of well-structured transition systems (WSTS), the bounded---in the sense of Ginsburg and Spanier (Trans. AMS 1964)---complete deterministic ones, which we claim provide an adequate basis for the study of forward analyses as developed by Finkel and Goubault-Larrecq (Logic. Meth. Comput. Sci. 2012). Indeed, we prove that, unlike other conditions considered previously for the termination of forward analysis, boundedness is decidable. Boundedness turns out to be a valuable restriction for WSTS verification, as we show that it further allows to decide all $\omega$-regular properties on the set of infinite traces of the system