Trust Management: A Cooperative Approach Using Game Theory

Trust, defined as the willingness to accept risk and vulnerability based upon positive expectations of the intentions or behaviours of another. The qualities or behaviours of one person that create good expectations in another are referred to as trustworthiness. Because of its perceived link to cooperative behaviour, many social scientists regard trust as the backbone of effective social structures. With the advancement in technology, through these online social media people can explore various products, services and facilities. Through these networks the end users want to communicate are usually physically unknown with each other, the evaluation of their trustworthiness is mandatory. Mathematical methods and computational procedures do not easily define trust. Psychological and sociological factors can influence trust. End users are vulnerable to a variety of risks. The need to define trust is expanding as businesses try to establish effective marketing strategies through their social media activities, and as a result, they must obtain consumer trust. Game theory is a theoretical framework for analysing strategic interactions between two or more individuals, in the terminology of game theory, called players. Thus, a conceptual framework for trust evaluation can be designed using a game theory approach that can indicate the conditions under which trustworthy behaviour can be determined

Financial Management Strategies for Sustainable Farming Practices

This paper delves into the multifaceted realm of sustainable farming, offering a holistic view of its definition, significance, and the manifold benefits it brings to the agricultural landscape. Sustainable farming represents a paradigm shift in agriculture, emphasizing environmental responsibility, societal well-being, and economic viability. The benefits it offers span across the realms of environmental conservation, social equity, and financial sustainability, making it a compelling and pressing approach for modern farmers. The financial fundamentals of sustainable farming are explored, covering crucial aspects such as budgeting, cash flow management, and the integration of sustainable technologies. Sound financial management is pivotal for ensuring that eco-friendly practices align with economic stability and long-term prosperity. Risk management is another cornerstone, with a focus on identifying and mitigating potential threats, as well as the role of insurance and hedging in safeguarding farming operations. Access to capital is addressed from both traditional and alternative sources, highlighting the significance of financial support for the adoption of sustainable practices. Record-keeping and financial analysis are essential tools for farmers, facilitating informed decision-making, performance tracking, and the adaptability of strategies to achieve maximum sustainability benefits. Study underscores the pivotal role of government support, encapsulating policies, incentives, and tax benefits designed to encourage sustainable farming practices and compliance with regulatory standards. By adhering to these guidelines, farmers not only contribute to environmental conservation but also secure their economic future

Utility of Serum Neopterin and Serum IL-2 Receptor Levels to Predict Absolute CD4 T Lymphocyte Count in HIV Infected Cases

A prospective study was carried out to evaluate the efficacy of serum neopterin and soluble IL-2 receptor (sIL-2R) concentrations in comparison to CD4 count to study the progression of HIV disease and monitor response to ART in HIV cases. One hundred newly diagnosed HIV seropositive subjects were recruited. CD4 counts were determined by FACS system. Serum neopterin and sIL-2R levels were measured using enzyme immunoassay. In our study, levels of neopterin and sIL-2R were significantly higher in subjects with CD4 <200 cells/μL (with S. neopterin levels of >25.1 nmol/L and sIL-2R levels of >47.1 pM as cutoff values for CD4 <200 cells/μL) compared to those in subjects with CD4 >200 cells/μL at baseline which indicate that these markers can be utilized for initiation of ART in HIV cases. The levels of these markers decreased significantly after initiation of ART. In patients with CD4 >200 cells/μL, these markers are helpful in predicting disease progression

MYC amplification in subtypes of breast cancers in African American women

BACKGROUND: MYC overexpression is associated with poor prognosis in breast tumors (BCa). The objective of this study was to determine the prevalence of MYC amplification and associated markers in BCa tumors from African American (AA) women and determine the associations between MYC amplification and clinico-pathological characteristics. METHODS: We analyzed 70 cases of well characterized archival breast ductal carcinoma specimens from AA women for MYC oncogene amplification. Utilizing immune histochemical analysis estrogen receptor (ER), progesterone receptor (PR), and (HER2/neu), were assessed. Cases were Luminal A (ER or PR+, Ki-67 \u3c 14%), Luminal B (ER or PR+, Ki-67 = \u3e 14% or ER or PR+ HER2+), HER2 (ER-, PR-, HER2+), and Triple Negative (ER-, PR-, HER2-) with basal-like phenotype. The relationship between MYC amplification and prognostic clinico-pathological characteristics was determined using chi square and logistic regression modeling. RESULTS: Sixty-five (97%) of the tumors showed MYC gene amplification (MYC: CEP8 \u3e 1). Statistically significant associations were found between MYC amplification and HER2-amplified BCa, and Luminal B subtypes of BCa (p \u3c 0.0001), stage (p \u3c 0.001), metastasis (p \u3c 0.001), and positive lymph node status (p = 0.039). MYC amplification was associated with HER2 status (p = 0.01) and tumor size (p = 0.01). High MYC amplification was seen in grade III carcinomas (MYC: CEP8 = 2.42), pre-menopausal women (MYC: CEP8 = 2.49), PR-negative status (MYC: CEP8 = 2.42), and ER-positive status (MYC: CEP8 = 2.4). CONCLUSIONS: HER2 positive BCas in AA women are likely to exhibit MYC amplification. High amplification ratios suggest that MYC drives HER2 amplification, especially in HER2 positive, Luminal B, and subtypes of BCa

Stakeholder perspectives on the effectiveness of governance in red panda conservation programmes in Nepal: a comparative analysis

This paper investigates the views of multi-stakeholders on the governance quality of existing forest management strategies for red panda (Ailurus fulgens) protection in Nepal, focusing on forest governance in general, red panda conservation programmes and natural habitat protection in particular. The study deployed two surveys in August and September 2020. The first survey was conducted online for the stakeholders with internet access; for those without, it was conducted over the phone. While the results reveal almost similar perspectives among the stakeholders regarding the effectiveness of the red panda management approaches, they differ significantly between the online survey and telephonic survey, in terms of the relative scores given to these initiatives. In depth, follow-up interviews revealed that marginalised groups had little access to income generation from conservation activities and few capacity-building opportunities. These findings indicate that while management strategies for red panda conservation were generally considered effective by online survey participants which are generally more privileged, this is less effective for marginalised people. Local people, who are typically resource-poor and reliant on the forest, continue to endure inequitable resource distribution and benefit sharing. Consequently, greater attention should be paid to balancing the conservation needs and basic needs of forest-dependent communities through capacity building, income generation and alternative sources of livelihood

Putative amniotic fluid stem (AFS) cells express transcription factor Oct-4 in goat (Capra aegagrus hircus)

Abstract The current study was carried out to isolate, culture, characteriz

Compendium of Climate-smart Agriculture Technologies and Practices

Nepal is a vulnerable country to the impacts of climate change. The adverse effects of climate change have decreased agricultural production and productivity. Therefore, technologies and strategies to develop resilience agriculture and increased agriculture productivity are urgently needed to create climate-smart technologies and help the existing technologies to adapt to climate change. This compendium presents climate-smart agriculture (CSA) technologies and interventions for enhancing food security with adaptation and mitigation as co-benefits. CSA involves smart farming practices and strategies that help develop resilience agriculture, increase crop and livestock productivity, reduce greenhouse gas emissions, and enhance food security goals. This compendium has been developed for extension workers to support up-scaling climate-smart technologies and build climate resilience villages that enhance food, nutrition, and income, mainly for marginal communities striving in marginal areas

Cross-sectional study evaluating the impact of SARS-CoV-2 variants on Long COVID outcomes in UK hospital survivors

OBJECTIVES: COVID-19 studies report on hospital admission outcomes across SARS-CoV-2 waves of infection but knowledge of the impact of SARS-CoV-2 variants on the development of Long COVID in hospital survivors is limited. We sought to investigate Long COVID outcomes, aiming to compare outcomes in adult hospitalised survivors with known variants of concern during our first and second UK COVID-19 waves, prior to widespread vaccination. DESIGN: Prospective observational cross-sectional study. SETTING: Secondary care tertiary hospital in the UK. PARTICIPANTS: This study investigated Long COVID in 673 adults with laboratory-positive SARS-CoV-2 infection or clinically suspected COVID-19, 6 weeks after hospital discharge. We compared adults with wave 1 (wildtype variant, admitted from February to April 2020) and wave 2 patients (confirmed Alpha variant on viral sequencing (B.1.1.7), admitted from December 2020 to February 2021). OUTCOME MEASURES: Associations of Long COVID presence (one or more of 14 symptoms) and total number of Long COVID symptoms with SARS-CoV-2 variant were analysed using multiple logistic and Poisson regression, respectively. RESULTS: 322/400 (wave 1) and 248/273 (wave 2) patients completed follow-up. Predictors of increased total number of Long COVID symptoms included: pre-existing lung disease (adjusted count ratio (aCR)=1.26, 95% CI 1.07, 1.48) and more COVID-19 admission symptoms (aCR=1.07, 95% CI 1.02, 1.12). Weaker associations included increased length of inpatient stay (aCR=1.02, 95% CI 1.00, 1.03) and later review after discharge (aCR=1.00, 95% CI 1.00, 1.01). SARS-CoV-2 variant was not associated with Long COVID presence (OR=0.99, 95% CI 0.24, 4.20) or total number of symptoms (aCR=1.09, 95% CI 0.82, 1.44). CONCLUSIONS: Patients with chronic lung disease or greater COVID-19 admission symptoms have higher Long COVID risk. SARS-CoV-2 variant was not predictive of Long COVID though in wave 2 we identified fewer admission symptoms, improved clinical trajectory and outcomes. Addressing modifiable factors such as length of stay and timepoint of clinical review following discharge may enable clinicians to move from Long COVID risk stratification towards improving its outcome