The Desired Effect : Pontiac\u27s Rebellion and the Native American Struggle to Survive in Britain\u27s North American Conquest

Ravaged by war and in debt after its victory in the French and Indian War, Britain was not only recuperating, but rejoicing over the signing of the Treaty of Paris in 1763. This treaty officially ended the fighting and gave Britain all of the land east of the Mississippi River, formerly owned by the French. The ink on the treaty was barely dry when a new insurgence arose in British occupied North America. Native Americans, dissatisfied after the war with their position as conquered people and not as allies, rebelled collectively against British colonists and forts along the frontier. Before the war had started, the French had traded and lived among the Native Americans, but perhaps most importantly, they had given them presents to show respect and diplomacy. The Native Americans had grown accustomed to this act of friendliness and when Britain, in debt after the war, wanted to considerably reduce the number of gifts given, there were severe consequences. In 1763, the Native Americans led an insurgence, commonly called Pontiac’s Rebellion because of Pontiac, the Ottawa leader. This insurgence would culminate in the first extensive multi-tribal resistance to European colonization in America. In response to Britain’s new policies, the Native Americans took ten of their forts, which led not only to excess in conflict, but to the British exposing smallpox blankets onto the Native Americans

Revealing Casual Pathways to Sustainable Water Service Delivering Using fsQCA

This study aimed to build on theory and practice regarding the combinations of conditions that influence water service sustainability when external partners are involved. The study investigates 26 well projects that have been implemented in developing countries with the assistance of Engineers Without Borders-USA (EWB-USA). Using past literature on sustainable water service delivery in developing communities, emergent coding techniques with project documents, and surveys with EWB-USA team members, this study identifies a set of project conditions to conduct fuzzy-set Qualitative Comparative Analysis (fsQCA). Findings show that the presence of a water committee cannot alone account for project sustainability. Additional conditions, such as technology and construction processes, project governance, and community engagement practices must also be considered for project sustainability. The relationship between construction quality and financial sustainability is also discussed. Overall, the findings from this research contribute to sector theory and reveal distinct pathways towards sustainable water services. These findings informed recommendations for EWB-USA well project implementation and management, and demonstrate the utility of fsQCA as a tool to navigate the complexities of water service delivery by external partners and improve understanding to increase water service sustainability

Teologia egiziana nel PMG IV: un commento storico-religioso

Il grande Papiro Magico di Parigi (PGM IV) mostra una forte convergenza di tecnica rituale (mageutiké techne) e di discorso teologico (logos tes theologias). Ne risulta una "nuova teologia" in cui le tradizioni religiose dei vari popoli del Mediterraneo convergono e si fondono in una vasta prospettiva cosmosofica dalle forti connotazioni solari. In particolare è presente un ricco patrimonio mitologico egiziano che conferma l'importanza della tradizione rituale e teologica egiziana nella formazione di quell'originale "amalgama" culturale costituito dalla magia tardo-antica. Si conferma in pari tempo il rilievo del tutto centrale della vicenda drammatica di Osiride, con le connesse figure di Iside, Horus, Anubis, Thot e Seth, quale modello di riferimento nelle formule e nelle azioni rituali utilizzate dall'operatore magico al fine di ottenere i risultati previsti, con speciale attenzione alla sfera oracolare e a quella della magia erotica.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Activity of eribulin mesylate in brain metastasis from breast cancer. a stone in a pond?

Background: Brain metastases develop in approximately 10-25% of patients with metastatic breast cancer (MBC) and are associated with a very poor prognosis. Case Report: We report the case of a 40-year-old woman with MBC and associated lung, bone, liver, and brain metastases, who experienced a time to progression of several months with eribulin after whole-brain radiotherapy (WBRT), 2 lines of chemotherapy, and 1 line of hormonal therapy, maintaining a good toxicity profile. Discussion: Eribulin, in association with local treatment such as WBRT, can be well tolerated and effective in achieving a long progression-free survival and a good control of brain metastases in patients with MBC who have received multiple lines of treatment. The vascular remodeling properties of eribulin, combined with brain radiotherapy, might facilitate the passage of eribulin across the blood brain barrier, improving brain response. Conclusion: Our anecdotal experience suggests that eribulin may have a potentially beneficial effect on brain metastases while maintaining a good systemic control of the disease in patients with MBC

Impressive long-term response with pertuzumab and trastuzumab in HER2-positive breast cancer with brain metastasis

This is a case report of a 40-year-old woman who, after conservative breast cancer treatment, developed a HER2 positive solitary brain metastasis in the left temporal lobe, without extracranial disease. She underwent surgery resection followed by stereotactic radiotherapy and, because of early brain progression, she was submitted to the first line therapy with pertuzumab, trastuzumab and weekly paclitaxel. After six months of treatment, a brain magnetic resonance imaging revealed a complete disappearance of brain recurrence, which persisted for more than 24 months

GERDA: a Germanium Detector Array to Search for Neutrinoless Double Beta Decay

The GERDA, a new experiment to search for the double beta decay of 76 Ge, is being installed at Laboratori Nazionali del Gran Sasso. The potentialities of this experiment as well as the status of the project are reviewed.JRC.D.4-Isotope measurement

Project Intermediation: The Critical Role of Negotiating Socio-Technical Regimes and Technological Niches to Achieve Climate Change Policies

This paper uses the socio-technical transitions model to understand the characteristics of the evolving, interdisciplinary, and externalized context of climate change. Specifically, we (1) identify the elements of the multi-level perspective that exist under new climate change policies and trends and (2) conceptualized how this multi-level perspective will result in emerging project practices. Together, these two areas of insights help us create a preliminary framework to better understand and identify specific contextual characteristics that might influence the use and adoption of project practices. This conceptual framework leads us to a key insight: the role of projects in a socio-technical transitions context. Unlike projects that are delivered within a closedsystem environment, these projects are supported and affected by established institutional and policy measures. The preliminary conceptual framework emphasizes project intermediaries and how they choose project practices that translate policies into climate change outcomes. From this framework, we lay forth propositions that will inform and be tested in subsequent empirical case studies, where we plan to further explore project intermediation, focusing on the empirical setting of climate change infrastructure

Liquid film spray deposition of transparent conducting oxide coatings

A room temperature spraying technique was developed for the deposition of transparent conducting sol-gel ATO (antimony doped tin oxide, SnO2:Sb) coatings, based on an 0.2 M solution of SnCl2 in 1-propanol with 5 mol.% SbCl3 and a mixture of 2-isopropoxyethanol and 2-butoxyethanol as additives with a low evaporation rate. The selection of solvents and the adjustment of the evaporation rate are crucial to obtain uniform films and to avoid film defects like wetting problems or an orange peel effect. The ATO coatings were spray deposited manually on complex shaped substrates as well as on large area flat substrates with a size up to 21 x 30 cm2 by means of an industrial flat spray coater. The resulting ATO coatings are characterised by a thickness of up to 120 nm, a resistivity of approximately 2 x 10-2 Ω cm and a transmission T>85% in the visible, which is similar to the properties obtained for dip coated films