Joaquín Rieta y el teatro de la Banda Primitiva de Llíria

Joaquín Rieta Síster (Valencia, 1897-1982) es uno de los principales exponentes de la arquitectura valenciana de las décadas centrales del siglo XX. Su reconocimiento se circunscribe principalmente a las obras racionalistas de la década de 1930. Menos conocida es, sin embargo, su “otra” arquitectura, la construida después de la Guerra Civil, ignorada con frecuencia desde la óptica de una historiografía excluyente que ha puesto el valor en la modernidad. Dentro de este contexto podemos situar el teatro de la Banda Primitiva de Llíria (1950-1951). El presente estudio comienza encuadrando la figura del arquitecto y académico, seguida de una breve recensión de la sociedad comitente, la prestigiosa banda bicentenaria valenciana. A continuación, el discurso se centra en el análisis arquitectónico de los dos proyectos del teatro, y de su habilidosa reconducción de la mano de Rieta, para finalmente poner en valor su realidad física como bien patrimonial plenamente activo. Al interés arquitectónico y social se suma el hecho de ser el único de los teatros construidos por Rieta que se conserva en buen estado y con escasas alteraciones

PSA Response to Lenalidomide Therapy in a Pre-Treated Patient with Metastatic Prostate Cancer Refractory to Hormones and Chemotherapy: A Case Report

Hormone-resistant prostate cancer (HRPC) occurs when prostate cancer is no longer responsive to hormone therapy. Treatment options are limited, and there is a clear necessity for therapies that improve outcome. Preclinical and clinical evidence supports the role of the immunomodulatory agent lenalidomide in HRPC. In this paper, we report that lenalidomide showed antitumoral activity in a patient with HRPC and bone metastases pre-treated with chemotherapy, decreased the PSA level and improved the patient's health status for the first 5 months. It is important to emphasize that it was not associated with hematologic toxicity

Durable complete remission of a brainstem glioma treated with a combination of bevacizumab and cetuximab

Treatment of a relapsed glioma is a clinical challenge nowadays. New active treatments are required to treat these difficult diseases. Here we present a durable complete remission of a relapsed glioblastoma that has achieved a complete radiologic response with the combination of cetuximab and bevacizumab, in a third-line setting, that has offered a progression-free survival of 20 months. We consider here both potential mechanisms for the explanation of this result. First, the potential target of the cancer stem cells (CSCs) with these two antibodies, and second, the potential recruitment of the immune system to directly pursue the CSCs

CMAG: a mission to study and monitor the inner corona magnetic field

Measuring magnetic fields in the inner corona, the interface between the solar chromosphere and outer corona, is of paramount importance if we aim to understand the energetic transformations taking place there, and because it is at the origin of processes that lead to coronal heating, solar wind acceleration, and of most of the phenomena relevant to space weather. However, these measurements are more difficult than mere imaging because polarimetry requires differential photometry. The coronal magnetograph mission (CMAG) has been designed to map the vector magnetic field, line-of-sight velocities, and plane-of-the-sky velocities of the inner corona with unprecedented spatial and temporal resolutions from space. This will be achieved through full vector spectropolarimetric observations using a coronal magnetograph as the sole instrument on board a spacecraft, combined with an external occulter installed on another spacecraft. The two spacecraft will maintain a formation flight distance of 430 m for coronagraphic observations, which requires a 2.5 m occulter disk radius. The mission will be preferentially located at the Lagrangian L5 point, offering a significant advantage for solar physics and space weather research. Existing ground-based instruments face limitations such as atmospheric turbulence, solar scattered light, and long integration times when performing coronal magnetic field measurements. CMAG overcomes these limitations by performing spectropolarimetric measurements from space with an external occulter and high-image stability maintained over time. It achieves the necessary sensitivity and offers a spatial resolution of 2.5″ and a temporal resolution of approximately one minute, in its nominal mode, covering the range from 1.02 solar radii to 2.5 radii. CMAG relies on proven European technologies and can be adapted to enhance any other solar mission, offering potential significant advancements in coronal physics and space weather modeling and monitoring

The on-ground data reduction and calibration pipeline for SO/PHI-HRT

The ESA/NASA Solar Orbiter space mission has been successfully launched in February 2020. Onboard is the Polarimetric and Helioseismic Imager (SO/PHI), which has two telescopes, a High Resolution Telescope (HRT) and the Full Disc Telescope (FDT). The instrument is designed to infer the photospheric magnetic field and line-of-sight velocity through differential imaging of the polarised light emitted by the Sun. It calculates the full Stokes vector at 6 wavelength positions at the Fe I 617.3 nm absorption line. Due to telemetry constraints, the instrument nominally processes these Stokes profiles onboard, however when telemetry is available, the raw images are downlinked and reduced on ground. Here the architecture of the on-ground pipeline for HRT is presented, which also offers additional corrections not currently available on board the instrument. The pipeline can reduce raw images to the full Stokes vector with a polarimetric sensitivity of 10−3⋅Ic or better.Sección Deptal. de Óptica (Óptica)Fac. de Óptica y OptometríaTRUEBMWi - Bundesministerium für Wirtschaft und Energie (Alemania)MPG - Max-Planck-Gesellschaft (Alemania)Ministerio de Ciencia e Innovación de España - MCIUInstituto de Astrofísica de Andalucía - CSIC (España)CNES - Centre National d'études spatiales (Francia)Fondos FEDERAgencia Estatal de Investigación - AEI (ESpaña)pu