An Air-Filter Sensor for Home-Used Air Conditioners

This paper presents a successful senior project of instrumentation developed in a Mechanical Engineering Technology senior capstone course. Students were encouraged to approach the problem of designing an air-filter sensor and to propose an optimum and practical solution for the problem. Work includes conceptual design and analysis, implementation, tests and modifications. When an air filter is used in a home air conditioner, inhabitants often forget when to replace it until the cooling or heating capacity is obviously reduced. If the filter remains in service, the efficiency of the cooling/heating system will continue decreasing while the electricity bill will significantly increase. In some worst cases, the air quality will also be affected. This paper presents an idea of designing and fabricating an air-filter sensor to alleviate this problem. The sensor will send a warning signal when the filter collects a specific amount of dust in the air filter. It can be easily installed and only consumes a negligible amount of electricity. A photo sensor with an infrared LED emitter and receiver is used in this design. As the infrared LED can transmit through most of the home-used air filter to its receiver, a signal will be sent out when a specified amount of dust is collected in the filter and the light is blocked from the emitter to the receiver. The emitter and receiver are mounted on a simple fixture and can be easily fitted on an air filter. In addition, cost analysis of using the sensor show that it can save a significant amount on an electricity bill, when filters are replaced properly

NFAT promotes carcinoma invasive migration through glypican-6

Invasive migration of carcinoma cells is a prerequisite for the metastatic dissemination of solid tumours. Numerous mechanisms control the ability of cancer cells to acquire a motile and invasive phenotype, and subsequently degrade and invade the basement membrane. Several genes that are up-regulated in breast carcinoma are responsible for mediating the metastatic cascade. Recent studies have revealed that the NFAT (nuclear factor of activated T-cells) is a transcription factor that is highly expressed in aggressive breast cancer cells and tissues, and mediates invasion through transcriptional induction of pro-invasion and migration genes. In the present paper we demonstrate that NFAT promotes breast carcinoma invasion through induction of GPC (glypican) 6, a cell-surface glycoprotein. NFAT transcriptionally regulates GPC6 induction in breast cancer cells and binds to three regulatory elements in the GPC6 proximal promoter. Expression of GPC6 in response to NFAT signalling promotes invasive migration, whereas GPC6 silencing with shRNA (small-hairpin RNA) potently blocks this phenotype. The mechanism by which GPC6 promotes invasive migration involves inhibition of canonical β-catenin and Wnt signalling, and up-regulation of non-canonical Wnt5A signalling leading to the activation of JNK (c-Jun N-terminal kinase) and p38 MAPK (mitogen-activated protein kinase). Thus GPC6 is a novel NFAT target gene in breast cancer cells that promotes invasive migration through Wnt5A signalling

Limitations of Absolute Current Densities Derived from the Semel & Skumanich Method

Semel and Skumanich proposed a method to obtain the absolute electric current density, |Jz|, without disambiguation of 180 degree in the transverse field directions. The advantage of the method is that the uncertainty in the determination of the ambiguity in the magnetic azimuth is removed. Here, we investigate the limits of the calculation when applied to a numerical MHD model. We found that the combination of changes in the magnetic azimuth with vanishing horizontal field component leads to errors, where electric current densities are often strong. Where errors occur, the calculation gives |Jz| too small by factors typically 1.2 ~ 2.0.Comment: 10 pages, 4 figures. To appear on Science in China Series G: Physics, Mechanics & Astronomy, October 200

An algorithm for detecting <i>Trichodesmium</i> surface blooms in the South Western Tropical Pacific

<i>Trichodesmium</i>, a major colonial cyanobacterial nitrogen fixer, forms large blooms in NO₃-depleted tropical oceans and enhances CO₂ sequestration by the ocean due to its ability to fix dissolved dinitrogen. Thus, its importance in C and N cycles requires better estimates of its distribution at basin to global scales. However, existing algorithms to detect them from satellite have not yet been successful in the South Western Tropical Pacific (SP). Here, a novel algorithm (TRICHOdesmium SATellite) based on radiance anomaly spectra (RAS) observed in SeaWiFS imagery, is used to detect <i>Trichodesmium</i> during the austral summertime in the SP (5° S–25° S 160° E–170° W). Selected pixels are characterized by a restricted range of parameters quantifying RAS spectra (e.g. slope, intercept, curvature). The fraction of valid (non-cloudy) pixels identified as <i>Trichodesmium</i> surface blooms in the region is low (between 0.01 and 0.2 %), but is about 100 times higher than deduced from previous algorithms. At daily scales in the SP, this fraction represents a total ocean surface area varying from 16 to 48 km² in Winter and from 200 to 1000 km² in Summer (and at monthly scale, from 500 to 1000 km² in Winter and from 3100 to 10 890 km² in Summer with a maximum of 26 432 km² in January 1999). The daily distribution of <i>Trichodesmium</i> surface accumulations in the SP detected by TRICHOSAT is presented for the period 1998–2010 which demonstrates that the number of selected pixels peaks in November–February each year, consistent with field observations. This approach was validated with in situ observations of <i>Trichodesmium</i> surface accumulations in the Melanesian archipelago around New Caledonia, Vanuatu and Fiji Islands for the same period

A Large Retinal Capillary Hemangioma in the Anterior Retina Treated with Photodynamic Therapy

www.karger.com/cop This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License (www.karger.com/OA-license), applicable to the online version of the article only. Distribution for non-commercial purposes only

Design and Analysis of an Air Filter Sensor for a Residential Heating and Cooling System

This is a design project of an air-filter sensor to be used in home heating and cooling system. The project includes conceptual design, analysis, implementation, tests and modifications. First, the air quality and power consumption between a clean air filter and a dirty air filter is studied. Then, a photo sensor circuit with an ultra high brightness LED emitter and a phototransistor receiver is used to detect dust particles. A red warning LED lights up when a specified amount of dust is collected on the filter and blocks the light beam between the emitter and the receiver. The emitter and receiver are mounted on a simple fixture and can be easily fitted on any air filter. In addition, the cost analysis shows that this design can significantly reduce the electricity bill if the filters are properly replaced

Molecular Dynamics Simulation Study of Nonconcatenated Ring Polymers in a Melt: I. Statics

Molecular dynamics simulations were conducted to investigate the structural properties of melts of nonconcatenated ring polymers and compared to melts of linear polymers. The longest rings were composed of N=1600 monomers per chain which corresponds to roughly 57 entanglement lengths for comparable linear polymers. For the rings, the radius of gyration squared was found to scale as N to the 4/5 power for an intermediate regime and N to the 2/3 power for the larger rings indicating an overall conformation of a crumpled globule. However, almost all beads of the rings are "surface beads" interacting with beads of other rings, a result also in agreement with a primitive path analysis performed in the following paper (DOI: 10.1063/1.3587138). Details of the internal conformational properties of the ring and linear polymers as well as their packing are analyzed and compared to current theoretical models.Comment: 15 pages, 14 figure

Diffusion in a multi-component Lattice Boltzmann Equation model

Diffusion phenomena in a multiple component lattice Boltzmann Equation (LBE) model are discussed in detail. The mass fluxes associated with different mechanical driving forces are obtained using a Chapman-Enskog analysis. This model is found to have correct diffusion behavior and the multiple diffusion coefficients are obtained analytically. The analytical results are further confirmed by numerical simulations in a few solvable limiting cases. The LBE model is established as a useful computational tool for the simulation of mass transfer in fluid systems with external forces.Comment: To appear in Aug 1 issue of PR