1,371 research outputs found
Organic molecules in the protoplanetary disk of DG Tau revealed by ALMA
Planets form in protoplanetary disks and inherit their chemical compositions.
It is thus crucial to map the distribution and investigate the formation of
simple organics, such as formaldehyde and methanol, in protoplanetary disks. We
analyze ALMA observations of the nearby disk-jet system around the T Tauri star
DG Tau in the o-HCO and CHOH E,
A transitions at an unprecedented resolution of ,
i.e., au at a distance of 121 pc. The HCO emission originates from
a rotating ring extending from au with a peak at au, i.e., at
the edge of the 1.3mm dust continuum. CHOH emission is not detected down to
an r.m.s. of 3 mJy/beam in the 0.162 km/s channel. Assuming an ortho-to-para
ratio of 1.8-2.8 the ring- and disk-height-averaged HCO column density is
cm, while that of CHOH is
cm. In the inner au no o-HCO emission
is detected with an upper limit on its beam-averaged column density of
cm. The HCO ring in the disk of DG Tau is
located beyond the CO iceline (R au). This suggests that the
HCO abundance is enhanced in the outer disk due to formation on grain
surfaces by the hydrogenation of CO ice. The emission peak at the edge of the
mm dust continuum may be due to enhanced desorption of HCO in the gas phase
caused by increased UV penetration and/or temperature inversion. The
CHOH/HCO abundance ratio is , in agreement with disk chemistry
models. The inner edge of the HCO ring coincides with the radius where the
polarization of the dust continuum changes orientation, hinting at a tight link
between the HCO chemistry and the dust properties in the outer disk and at
the possible presence of substructures in the dust distribution.Comment: 8 pages, 6 figures, accepted for publication on A&A Letter
Constraining the mass of the planet(s) sculpting a disk cavity. The intriguing case of 2MASS J16042165-2130284
The large cavities observed in the dust and gas distributions of transition
disks may be explained by planet-disk interactions. At ~145 pc, 2MASS
J16042165-2130284 (J1604) is a 5-12 Myr old transitional disk with different
gap sizes in the mm- and m-sized dust distributions (outer edges at ~79
and at ~63 au, respectively). Its CO emission shows a ~30 au cavity.
This radial structure suggests that giant planets are sculpting this disk. We
aim to constrain the masses and locations of plausible giant planets around
J1604. We observed J1604 with the Spectro-Polarimetric High-contrast Exoplanet
REsearch (SPHERE) at the Very Large Telescope (VLT), in IRDIFS\_EXT,
pupil-stabilized mode, obtaining YJH- band images with the integral field
spectrograph (IFS) and K1K2-band images with the Infra-Red Dual-beam Imager and
Spectrograph (IRDIS). The dataset was processed exploiting the angular
differential imaging (ADI) technique with high-contrast algorithms. Our
observations reach a contrast of ~12 mag from 0.15" to 0.80"
(~22 to 115 au), but no planet candidate is detected. The disk is directly
imaged in scattered light at all bands from Y to K, and it shows a red color.
This indicates that the dust particles in the disk surface are mainly
m-sized grains. We confirm the sharp dip/decrement in
scattered light in agreement with polarized light observations. Comparing our
images with a radiative transfer model we argue that the southern side of the
disk is most likely the nearest. This work represents the deepest search yet
for companions around J1604. We reach a mass sensitivity of from ~22 to ~115 au according to a hot start scenario. We propose
that a brown dwarf orbiting inside of ~15 au and additional Jovian planets at
larger radii could account for the observed properties of J1604 while
explaining our lack of detection.Comment: 10 pages, 7 Figures. Accepted for publication in A&A . Abridged
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Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy.
Tumor cell tolerance to nutrient deprivation can be an important factor for tumor progression, and may depend on deregulation of both oncogenes and oncosuppressor proteins. Homeodomain-interacting protein kinase 2 (HIPK2) is an oncosuppressor that, following its activation by several cellular stress, induces cancer cell death via p53-dependent or -independent pathways. Here, we used genetically matched human RKO colon cancer cells harboring wt-HIPK2 (HIPK2(+/+)) or stable HIPK2 siRNA interference (siHIPK2) to investigate in vitro whether HIPK2 influenced cell death in glucose restriction. We found that glucose starvation induced cell death, mainly due to c-Jun NH2-terminal kinase activation, in HIPK2(+/+)cells compared with siHIPK2 cells that did not die. (1)H-nuclear magnetic resonance quantitative metabolic analyses showed a marked glycolytic activation in siHIPK2 cells. However, treatment with glycolysis inhibitor 2-deoxy-D-glucose induced cell death only in HIPK2(+/+) cells but not in siHIPK2 cells. Similarly, siGlut-1 interference did not re-establish siHIPK2 cell death under glucose restriction, whereas marked cell death was reached only after zinc supplementation, a condition known to reactivate misfolded p53 and inhibit the pseudohypoxic phenotype in this setting. Further siHIPK2 cell death was reached with zinc in combination with autophagy inhibitor. We propose that the metabolic changes acquired by cells after HIPK2 silencing may contribute to induce resistance to cell death in glucose restriction condition, and therefore be directly relevant for tumor progression. Moreover, elimination of such a tolerance might serve as a new strategy for cancer therapy
THE PAST AND THE FUTURE OF DIRECT SEARCH OF GW FROM PULSARS IN THE ERA OF GW ANTENNAS
In this paper we will give an overview of the past and present status of Gravitational Wave (GW) research associated with pulsars, taking into account the target sensitivity achieved from interferometric laser GW antennas such as Tama, Geo, Ligo and Virgo. We will see that the upper limits obtained with searches for periodic GW begin to be astrophysically interesting by imposing non-trivial constraints on the structure and evolution of the neutron stars. We will give prospects for the future detection of pulsar GW signals, with Advanced Ligo and Advanced Virgo and future enhanced detectors, e.g. the Einstein Telescope
THE PAST AND THE FUTURE OF DIRECT SEARCH OF GW FROM PULSARS IN THE ERA OF GW ANTENNAS
In this paper we will give an overview of the past and present status of Gravitational Wave (GW) research associated with pulsars, taking into account the target sensitivity achieved from interferometric laser GW antennas such as Tama, Geo, Ligo and Virgo. We will see that the upper limits obtained with searches for periodic GW begin to be astrophysically interesting by imposing non-trivial constraints on the structure and evolution of the neutron stars. We will give prospects for the future detection of pulsar GW signals, with Advanced Ligo and Advanced Virgo and future enhanced detectors, e.g. the Einstein Telescope
Weekly epirubicin plus lonidamine in advanced breast carcinoma
: Lonidamine has been demonstrated to potentiate the cytotoxic activity of several antineoplastic drugs, for example anthracyclines. Moreover, epirubicin is considered one of the most active drugs in advanced breast cancer, although optimal dose and schedule remains to be defined. In the present study we have treated 51 patients with advanced breast cancer with a combination of lonidamine (450 mg/day orally from day 1 throughout treatment) and epirubicin (25 mg/m2 i.v.) administered according to a weekly schedule for 24 weeks. Objective responses were observed in 29 out of 51 patients (57%; CR 16%, PR 41%). Liver metastases responded in eight out of 12 evaluable patients (67%). Average response duration was 12.4 months and median overall survival was 23 months (range 1-90+). Toxicity was negligible. The combination of weekly epirubicin and lonidamine is feasible and active in advanced breast cancer patients
P62/sqstm1/keap1/nrf2 axis reduces cancer cells death-sensitivity in response to zn(Ii)–curcumin complex
The hyperactivation of nuclear factor erythroid 2 p45-related factor 2 (NRF2), frequently found in many tumor types, can be responsible for cancer resistance to therapies and poor patient prognosis. Curcumin has been shown to activate NRF2 that has cytotprotective or protumorigenic roles according to tumor stage. The present study aimed at investigating whether the zinc–curcumin Zn(II)–curc compound, which we previously showed to display anticancer effects through multiple mechanisms, could induce NRF2 activation and to explore the underlying molecular mechanisms. Biochemical studies showed that Zn(II)–curc treatment increased the NRF2 protein levels along with its targets, heme oxygenase-1 (HO-1) and p62/SQSTM1, while markedly reduced the levels of Keap1 (Kelch-like ECH-associated protein 1), the NRF2 inhibitor, in the cancer cell lines analyzed. The silencing of either NRF2 or p62/SQSTM1 with specific siRNA demonstrated the crosstalk between the two molecules and that the knockdown of either molecule increased the cancer cell sensitivity to Zn(II)–curc-induced cell death. This suggests that the crosstalk between p62/SQSTM1 and NRF2 could be therapeutically exploited to increase cancer patient response to therapies
DZ Cha: a bona fide photoevaporating disc
DZ Cha is a weak-lined T Tauri star (WTTS) surrounded by a bright
protoplanetary disc with evidence of inner disc clearing. Its narrow \Ha line
and infrared spectral energy distribution suggest that DZ Cha may be a
photoevaporating disc. We aim to analyse the DZ Cha star + disc system to
identify the mechanism driving the evolution of this object. We have analysed
three epochs of high resolution optical spectroscopy, photometry from the UV up
to the sub-mm regime, infrared spectroscopy, and J-band imaging polarimetry
observations of DZ Cha. Combining our analysis with previous studies we find no
signatures of accretion in the \Ha line profile in nine epochs covering a
time baseline of years. The optical spectra are dominated by
chromospheric emission lines, but they also show emission from the forbidden
lines [SII] 4068 and [OI] 6300 that indicate a disc outflow. The
polarized images reveal a dust depleted cavity of au in radius and two
spiral-like features, and we derive a disc dust mass limit of
M_\mathrm{dust}
80 \MJup) companions are detected down to 0\farcs07 ( au,
projected). The negligible accretion rate, small cavity, and forbidden line
emission strongly suggests that DZ Cha is currently at the initial stages of
disc clearing by photoevaporation. At this point the inner disc has drained and
the inner wall of the truncated outer disc is directly exposed to the stellar
radiation. We argue that other mechanisms like planet formation or binarity
cannot explain the observed properties of DZ Cha. The scarcity of objects like
this one is in line with the dispersal timescale ( yr) predicted
by this theory. DZ Cha is therefore an ideal target to study the initial stages
of photoevaporation.Comment: A&A in press, language corrections include
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