Scattered light mapping of protoplanetary disks

High-contrast scattered light observations have revealed the surface morphology of several dozens of protoplanetary disks at optical and near-infrared wavelengths. Inclined disks offer the opportunity to measure part of the phase function of the dust grains that reside in the disk surface which is essential for our understanding of protoplanetary dust properties and the early stages of planet formation. We aim to construct a method which takes into account how the flaring shape of the scattering surface of an (optically thick) protoplanetary disk projects onto the image plane of the observer. This allows us to map physical quantities (scattering radius and scattering angle) onto scattered light images and retrieve stellar irradiation corrected (r^2-scaled) images and dust phase functions. We apply the method on archival polarized intensity images of the protoplanetary disk around HD 100546 that were obtained with VLT/SPHERE in R'-band and VLT/NACO in H- and Ks-band. The brightest side of the r^2-scaled R'-band polarized intensity image of HD 100546 changes from the far to the near side of the disk when a flaring instead of a geometrically flat disk surface is used for the r^2-scaling. The decrease in polarized surface brightness in the scattering angle range of ~40-70 deg is likely a result of the dust phase function and degree of polarization which peak in different scattering angle regimes. The derived phase functions show part of a forward scattering peak which indicates that large, aggregate dust grains dominate the scattering opacity in the disk surface. Projection effects of a protoplanetary disk surface need to be taken into account to correctly interpret scattered light images. Applying the correct scaling for the correction of stellar irradiation is crucial for the interpretation of the images and the derivation of the dust properties in the disk surface layer.Comment: Accepted for publication in A&A, 6 pages, 3 figure

Constraining the mass of the planet(s) sculpting a disk cavity. The intriguing case of 2MASS J16042165-2130284

The large cavities observed in the dust and gas distributions of transition disks may be explained by planet-disk interactions. At ~145 pc, 2MASS J16042165-2130284 (J1604) is a 5-12 Myr old transitional disk with different gap sizes in the mm- and $\mu$m-sized dust distributions (outer edges at ~79 and at ~63 au, respectively). Its $^{12}$CO emission shows a ~30 au cavity. This radial structure suggests that giant planets are sculpting this disk. We aim to constrain the masses and locations of plausible giant planets around J1604. We observed J1604 with the Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) at the Very Large Telescope (VLT), in IRDIFS\_EXT, pupil-stabilized mode, obtaining YJH- band images with the integral field spectrograph (IFS) and K1K2-band images with the Infra-Red Dual-beam Imager and Spectrograph (IRDIS). The dataset was processed exploiting the angular differential imaging (ADI) technique with high-contrast algorithms. Our observations reach a contrast of $\Delta K, YH$ ~12 mag from 0.15" to 0.80" (~22 to 115 au), but no planet candidate is detected. The disk is directly imaged in scattered light at all bands from Y to K, and it shows a red color. This indicates that the dust particles in the disk surface are mainly $\gtrsim0.3\,\mu$m-sized grains. We confirm the sharp dip/decrement in scattered light in agreement with polarized light observations. Comparing our images with a radiative transfer model we argue that the southern side of the disk is most likely the nearest. This work represents the deepest search yet for companions around J1604. We reach a mass sensitivity of $\gtrsim 2-3M_{Jup}$ from ~22 to ~115 au according to a hot start scenario. We propose that a brown dwarf orbiting inside of ~15 au and additional Jovian planets at larger radii could account for the observed properties of J1604 while explaining our lack of detection.Comment: 10 pages, 7 Figures. Accepted for publication in A&A . Abridged abstrac

The Best Field Trip Ever: An Artistic and Scientific Analysis of the Value of Field Trips to an Environmental Center

The Center for the Urban River at Beczak is a 3900-square-foot environmental education and research facility located on 2 acres of Hudson riverfront park in downtown Yonkers. It is operated by Sarah Lawrence College in cooperation with the Beczak Environmental Education Center. The objective of this study was to measure the effects of a field trip to CURB on students’ environmental empathy, environmental engagement, cultural awareness, and interest in CURB. This was achieved with qualitative and quantitative measures, including a multi-case study (Bogdan & Biklen, 1998) and a quantitative survey. The qualitative multi-case study, in the field of participatory action research (Denzin & Lincoln, 2000), included note-taking and observation of students attending CURB programs

Weekly epirubicin plus lonidamine in advanced breast carcinoma

: Lonidamine has been demonstrated to potentiate the cytotoxic activity of several antineoplastic drugs, for example anthracyclines. Moreover, epirubicin is considered one of the most active drugs in advanced breast cancer, although optimal dose and schedule remains to be defined. In the present study we have treated 51 patients with advanced breast cancer with a combination of lonidamine (450 mg/day orally from day 1 throughout treatment) and epirubicin (25 mg/m2 i.v.) administered according to a weekly schedule for 24 weeks. Objective responses were observed in 29 out of 51 patients (57%; CR 16%, PR 41%). Liver metastases responded in eight out of 12 evaluable patients (67%). Average response duration was 12.4 months and median overall survival was 23 months (range 1-90+). Toxicity was negligible. The combination of weekly epirubicin and lonidamine is feasible and active in advanced breast cancer patients

Organic molecules in the protoplanetary disk of DG Tau revealed by ALMA

Planets form in protoplanetary disks and inherit their chemical compositions. It is thus crucial to map the distribution and investigate the formation of simple organics, such as formaldehyde and methanol, in protoplanetary disks. We analyze ALMA observations of the nearby disk-jet system around the T Tauri star DG Tau in the o-H$_2$CO $3_{1,2}-2_{1,1}$ and CH$_3$OH $3_{-2,2}-4_{-1,4}$ E, $5_{0,5}-4_{0,4}$ A transitions at an unprecedented resolution of $\sim0.15"$, i.e., $\sim18$ au at a distance of 121 pc. The H$_2$CO emission originates from a rotating ring extending from $\sim40$ au with a peak at $\sim62$ au, i.e., at the edge of the 1.3mm dust continuum. CH$_3$OH emission is not detected down to an r.m.s. of 3 mJy/beam in the 0.162 km/s channel. Assuming an ortho-to-para ratio of 1.8-2.8 the ring- and disk-height-averaged H$_2$CO column density is $\sim0.3-4\times10^{14}$ cm$^{-2}$, while that of CH$_3$OH is $<0.04-0.7\times10^{14}$ cm$^{-2}$. In the inner $40$ au no o-H$_2$CO emission is detected with an upper limit on its beam-averaged column density of $\sim0.5-6\times10^{13}$ cm$^{-2}$. The H$_2$CO ring in the disk of DG Tau is located beyond the CO iceline (R$_{\rm CO}\sim30$ au). This suggests that the H$_2$CO abundance is enhanced in the outer disk due to formation on grain surfaces by the hydrogenation of CO ice. The emission peak at the edge of the mm dust continuum may be due to enhanced desorption of H$_2$CO in the gas phase caused by increased UV penetration and/or temperature inversion. The CH$_3$OH/H$_2$CO abundance ratio is $<1$, in agreement with disk chemistry models. The inner edge of the H$_2$CO ring coincides with the radius where the polarization of the dust continuum changes orientation, hinting at a tight link between the H$_2$CO chemistry and the dust properties in the outer disk and at the possible presence of substructures in the dust distribution.Comment: 8 pages, 6 figures, accepted for publication on A&A Letter

Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy.

Tumor cell tolerance to nutrient deprivation can be an important factor for tumor progression, and may depend on deregulation of both oncogenes and oncosuppressor proteins. Homeodomain-interacting protein kinase 2 (HIPK2) is an oncosuppressor that, following its activation by several cellular stress, induces cancer cell death via p53-dependent or -independent pathways. Here, we used genetically matched human RKO colon cancer cells harboring wt-HIPK2 (HIPK2(+/+)) or stable HIPK2 siRNA interference (siHIPK2) to investigate in vitro whether HIPK2 influenced cell death in glucose restriction. We found that glucose starvation induced cell death, mainly due to c-Jun NH2-terminal kinase activation, in HIPK2(+/+)cells compared with siHIPK2 cells that did not die. (1)H-nuclear magnetic resonance quantitative metabolic analyses showed a marked glycolytic activation in siHIPK2 cells. However, treatment with glycolysis inhibitor 2-deoxy-D-glucose induced cell death only in HIPK2(+/+) cells but not in siHIPK2 cells. Similarly, siGlut-1 interference did not re-establish siHIPK2 cell death under glucose restriction, whereas marked cell death was reached only after zinc supplementation, a condition known to reactivate misfolded p53 and inhibit the pseudohypoxic phenotype in this setting. Further siHIPK2 cell death was reached with zinc in combination with autophagy inhibitor. We propose that the metabolic changes acquired by cells after HIPK2 silencing may contribute to induce resistance to cell death in glucose restriction condition, and therefore be directly relevant for tumor progression. Moreover, elimination of such a tolerance might serve as a new strategy for cancer therapy

P62/sqstm1/keap1/nrf2 axis reduces cancer cells death-sensitivity in response to zn(Ii)–curcumin complex

The hyperactivation of nuclear factor erythroid 2 p45-related factor 2 (NRF2), frequently found in many tumor types, can be responsible for cancer resistance to therapies and poor patient prognosis. Curcumin has been shown to activate NRF2 that has cytotprotective or protumorigenic roles according to tumor stage. The present study aimed at investigating whether the zinc–curcumin Zn(II)–curc compound, which we previously showed to display anticancer effects through multiple mechanisms, could induce NRF2 activation and to explore the underlying molecular mechanisms. Biochemical studies showed that Zn(II)–curc treatment increased the NRF2 protein levels along with its targets, heme oxygenase-1 (HO-1) and p62/SQSTM1, while markedly reduced the levels of Keap1 (Kelch-like ECH-associated protein 1), the NRF2 inhibitor, in the cancer cell lines analyzed. The silencing of either NRF2 or p62/SQSTM1 with specific siRNA demonstrated the crosstalk between the two molecules and that the knockdown of either molecule increased the cancer cell sensitivity to Zn(II)–curc-induced cell death. This suggests that the crosstalk between p62/SQSTM1 and NRF2 could be therapeutically exploited to increase cancer patient response to therapies

DZ Cha: a bona fide photoevaporating disc

DZ Cha is a weak-lined T Tauri star (WTTS) surrounded by a bright protoplanetary disc with evidence of inner disc clearing. Its narrow \Ha line and infrared spectral energy distribution suggest that DZ Cha may be a photoevaporating disc. We aim to analyse the DZ Cha star + disc system to identify the mechanism driving the evolution of this object. We have analysed three epochs of high resolution optical spectroscopy, photometry from the UV up to the sub-mm regime, infrared spectroscopy, and J-band imaging polarimetry observations of DZ Cha. Combining our analysis with previous studies we find no signatures of accretion in the \Ha line profile in nine epochs covering a time baseline of $\sim20$ years. The optical spectra are dominated by chromospheric emission lines, but they also show emission from the forbidden lines [SII] 4068 and [OI] 6300$\,\AA$ that indicate a disc outflow. The polarized images reveal a dust depleted cavity of $\sim7$ au in radius and two spiral-like features, and we derive a disc dust mass limit of M_\mathrm{dust} 80 \MJup) companions are detected down to 0\farcs07 ($\sim 8$ au, projected). The negligible accretion rate, small cavity, and forbidden line emission strongly suggests that DZ Cha is currently at the initial stages of disc clearing by photoevaporation. At this point the inner disc has drained and the inner wall of the truncated outer disc is directly exposed to the stellar radiation. We argue that other mechanisms like planet formation or binarity cannot explain the observed properties of DZ Cha. The scarcity of objects like this one is in line with the dispersal timescale ($\lesssim 10^5$ yr) predicted by this theory. DZ Cha is therefore an ideal target to study the initial stages of photoevaporation.Comment: A&A in press, language corrections include