Cerámica y climatización saludable: paneles cerámicos radiantes en edificios. Condiciones de confort y demanda energética frente a sistemas convectivos

Porcelain stoneware is a widely used building material. In recent years, its range of uses has expanded to encompass a new spectrum of innovative and inventive applications in architecture. In this research, we analysed the patented Thermal Ceramic Panel. This consists of a thin porcelain stoneware panel that incorporates a capillary system of polypropylene tubes measuring 3.5 mm in diameter embedded in a conductive ceramic interface. The system works with hot or cold water, producing healthy heating and cooling by means of radiant surfaces. Following an initial prototype test in which panels were placed on the walls of an office, we conducted simulations at the University of Alicante Museum using wall, ceiling and baffle panels, having previously monitored the state of the building. Thermal behaviour parameters were analysed and compared with those of other standard finishing materials, obtaining results for thermal comfort and energy savings in comparison with all-air systems.El gres porcelánico es un material ampliamente utilizado en edificación. En los últimos años su uso ha experimentado un nuevo espectro de líneas de innovación e invención en sus aplicaciones en la arquitectura. En esta investigación de analiza la patente Panel de Acondicionamiento Térmico Cerámico, consistente en piezas de gres porcelánico de bajo espesor, que contienen tramas capilares a base de tubos de polipropileno de 3,5 mm de diámetro, e interfaz de pasta conductora. Estos sistemas trabajan con agua fría o caliente produciendo una climatización saludable por superficies radiantes. Tras una primera experiencia de prototipado y colocación de paneles en pared en un despacho de oficina, se han realizado simulaciones en el Museo de la Universidad de Alicante, colocando los paneles en pared, techo o tipo bafle, previa monitorización del estado actual del edificio. Se han analizado los parámetros de comportamiento térmico y se han comparado con otros materiales de acabado habituales. Se han obtenido resultados de confort térmico y ahorros energéticos de forma comparativa frente a sistemas todo-aire

Visual Impact of Large and Giant Congenital Naevi: Comparison of Surgical Scars with Naevi Before Surgery

Surgical attempts to remove large/giant congenital melanocytic naevi (LGCMN) are supported mainly by the theoretical improvement in patients’ self-image; however such surgery can result in unaesthetic scarring. We hypothesize that difference in appearance itself has an impact, and hence surgery cannot negate this impact. The aim of this cross-sectional study was to explore how LGCMN and scarring are perceived by non-affected people. We surveyed the visual impact on 1,015 health and non-health professionals working in a university hospital. Participants were assigned to 1 of 3 surveys, which, based on photographs of children: (i) assessed the visual impact of LGCMN; (ii) the visual impact of scarring; (iii) compared the impact of LGCMN and scarring. Feelings and perceptions evoked by images of children, either with LGCMN or with scarring, were remarkably similar. However, when the images of the same child (with LGCMN or scarring) were shown together, respondents showed significantly increased preference for scarring

COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry

BACKGROUND: Cancer patients are at higher risk of COVID-19 complications and mortality than the rest of the population. Breast cancer patients seem to have better prognosis when infected by SARS-CoV-2 than other cancer patients. METHODS: We report a subanalysis of the OnCovid study providing more detailed information in the breast cancer population. RESULTS: We included 495 breast cancer patients with a SARS-CoV-2 infection. Mean age was 62.6 years; 31.5% presented more than one comorbidity. The most frequent breast cancer subtype was luminal-like (n = 245, 49.5%) and 177 (35.8%) had metastatic disease. A total of 332 (67.1%) patients were receiving active treatment, with radical intent in 232 (47.6%) of them. Hospitalization rate was 58.2% and all-cause mortality rate was 20.3%. One hundred twenty-nine (26.1%) patients developed one COVID-19 complication, being acute respiratory failure the most common (n = 74, 15.0%). In the multivariable analysis, age older than 70 years, presence of COVID-19 complications, and metastatic disease were factors correlated with worse outcomes, while ongoing anticancer therapy at time of COVID-19 diagnosis appeared to be a protective factor. No particular oncological treatment was related to higher risk of complications. In the context of SARS-CoV-2 infection, 73 (18.3%) patients had some kind of modification on their oncologic treatment. At the first oncological reassessment (median time: 46.9 days ± 36.7), 255 (51.6%) patients reported to be fully recovered from the infection. There were 39 patients (7.9%) with long-term SARS-CoV-2-related complications. CONCLUSION: In the context of COVID-19, our data confirm that breast cancer patients appear to have lower complications and mortality rate than expected in other cancer populations. Most breast cancer patients can be safely treated for their neoplasm during SARS-CoV-2 pandemic. Oncological treatment has no impact on the risk of SARS-CoV-2 complications, and, especially in the curative setting, the treatment should be modified as little as possible

The effect of diet and sociopolitical change on physiological stress and behavior in late Roman‐Early Byzantine (300–700 AD) and Islamic (902–1,235 AD) populations from Ibiza, Spain

Objectives This study evaluated chronological changes in physiological stress and levels of habitual loading of Ibizan populations from the Late Roman-Early Byzantine to the Islamic period (300-1235 AD) using measures of body size and bone cross-sectional properties. It also explored the effect of diet, modeled using stable isotopes, on physiological stress levels and behavior. Materials and Methods American Journal of Physical Anthropology, Volume 172, Issue 2, June 2020 pp. 189-213 DOI:10.1002/ajpa.24062 Published by Wiley. This is the Author Accepted Manuscript issued with: Creative Commons Attribution Non-Commercial License (CC:BY:NC 4.0). The final published version (version of record) is available online at DOI:10.1002/ajpa.24062. Please refer to any applicable publisher terms of use. 2 The sample comprised individuals from three archaeological populations: Urban Late Roman- Early Byzantine (LREB) (300-700 AD), Medieval Urban Islamic (902-1235 AD), and Rural Islamic. Bone lengths, femoral head dimensions, and diaphyseal products and circumferences were compared to assess differences in body size and habitual loading in 222 adult individuals. Ordinary least squares regression evaluated the correlations between these measures and carbon (δ13C) and nitrogen (δ15N) stable isotope ratios in 115 individuals for whom both isotope values and osteological measures are available. Results The Rural Islamic group had shorter stature and reduced lower limb cross-sectional properties compared to the two urban groups. In both LREB and Islamic groups, body mass and femur length was positively correlated with δ13C values, and δ15N shows a positive correlation with left humerus shape in the LREB Urban sample. Conclusions The low stature and cross-sectional properties of the Rural Islamic group are most likely an indicator of greater physiological stress, potentially due to poorer diet. Positive correlations between measures of body size and δ13C values further suggest that greater access to C4 resources improved diet quality. Alternatively, this relationship could indicate greater body size among migrants from areas where individuals consumed more C4 resources

A model-based approach for integrating third party systems with web applications

Abstract. New Web applications are rapidly moving from stand-alone systems to distributed applications that need to interoperate with third party systems, such as external Web services or legacy applications. In most cases, this integration is not properly addressed by current Web Engineering proposals, that either achieve it only at one single level (user interface, process, code or data), or assume the existence of a central conceptual model, something which is not always true in a service-oriented scenario. This paper presents a model-based framework that provides concepts and mechanisms for facilitating the high-level integration of Web applications with third party systems, allowing the manipulation of the external entities of such systems as native elements of our models.

Combinación de distintos dispositivos de Terapia V.A.C.® para el cierre de defectos abdominales complejos

La terapia de presión negativa Vacuum-Assisted Closure o V.A.C.® (KCI Clinic Spain SL) ha resultado ser de gran utilidad en la curación de heridas complejas de la pared abdominal, desde la fase aguda con abdomen abierto o grandes desbridamientos, hasta las fases de granulación y cobertura final del defecto, gracias a los distintos tipos de apósitos que pueden aplicarse sucesivamente, incluso ante una posible exposición intestinal con drenaje purulento hasta la granulación del defecto, y que empleados conjuntamente con matrices dérmicas y/o injertos cutáneos. Aceleran el cierre definitivo del defecto de forma poco lesiva y confortable para el paciente. Presentamos 3 casos de heridas complejas de pared abdominal en los que logramos la cicatrización de los defectos combinando técnicas quirúrgicas más tradicionales con los distintos apósitos de terapia V.A.C.® (ABTheraTM, V.A.C. GranuFoamTM, V.A.C. GranuFoam Silver® y V.A.C.® WhiteFoam dressing)

Cytosolic peroxiredoxin Tsa1 modulates acetic acid production in winemaking conditions

Resumen del trabajo presentado a la 8th Conference on Physiology of Yeasts and Filamentous Fungi (PYFF8), celebrada en Cork (Ireland) del 5 al 8 de junio de 2023.Saccharomyces cerevisiae role in wine production has different phases that are under stress conditions and are subject to improvement: biomass propagation, biomass dehydration and grape juice fermentation. Oxidative stress is produced by Reactive Oxygen Species (ROS) that can damage macromolecules if not removed. H2O2 is a ROS produced by mitochondria and Tsa1 is a cytosolic peroxiredoxin responsible to remove it. In addition, Tsa1 is involved in many processes as redox sensor and we have proved that it has an impact in the industrial use of S. cerevisiae. Recently we have shown that Tsa1 has a role in pH homeostasis through regulation of acetic acid production. This regulation during winemaking is important for the quality of the wine: high level of acetic acid worsen wine. The role of Tsa1 on acetic acid productions is dependent on the metabolic status of the cell. At first day in synthetic grape juice fermentation, TSA1 deletion causes a drop in acetic acid production. This difference is lost at later stages and at the very end the mutant accumulates more acetic acid. This correlates with a lower activity of the cytosolic aldehyde dehydrogenase Ald6, and not mitochondrial Ald4, in the tsa1 strain early in fermentation. In laboratory media the production of acetic and pyruvic acid is also decreased in the mutant strain, but in this case that also happens at longer times, when the culture reaches a postdiauxic status. In plates assays with pH probe bromocresol purple, a delay in the acid burst is also seen in the TSA1 deletion mutant, reinforcing the role of this peroxiredoxin in pH control. Combined deletions of TSA1 and the main aldehyde dehydrogenase confirm the role of this peroxiredoxin on pH regulation at different points of cell growth cycle.Funded by AEI, PID2021-122370OB-I00. CP funded by Maria Zambrano modality (ZA21-068).Peer reviewe