Probing the pc- and kpc-scale environment of the powerful radio galaxy Hercules A

We present the kpc-scale behaviour of the powerful extragalactic radio source Hercules A and the behaviour of the intracluster gas in which the radio source is situated. We have found that Hercules A exhibits a strong Laing-Garrington effect. The X-ray observations have revealed an extended X-ray emission elongated along the radio galaxy axis. The estimated temperature of the cluster is kT = 2.45 keV and the central electron density is no~7.8 x 10^(-3) cm^(-3) which reveals a hot, dense environment in which Hercules A is situated. From the combined study of the radio and X-ray data we have estimated a central value of 3<Bo (muG)<9. We also present the most recent results from the analysis of the radio data on the pc-scale structure of the radio galaxy, observed at 18 cm by the EVN-MERLIN array. A faint but compact radio source, coincident with the optical centre of Hercules A was detected by the EVN at 18 mas resolution. The total flux density of the EVN core is 14.6 mJy. Its angular size is 18 x 7 mas with a position angle of ~139 degrees. There is also evidence for extended emission in the NW-SE direction, most probably from the eastern pc-scale jet. If this is true then there is a misalignment between the direction of the pc-eastern and the aligned kpc-scale jets of ~35 degrees.Comment: 7 pages, 2 figures, Submitted to PAS

Reactive infiltration of hydrous melt above the mantle transition zone

[1] Seismic studies repeatedly image a low-velocity layer overlying the mantle transition zone in tectonic settings ranging from subduction zones to continental cratons. This layer has been hypothesized to result from the presence of a dense partial melt formed by dehydration melting as relatively wet transition zone material is advected by convection currents into the low-water-solubility upper mantle. Here we examine this hypothesis by considering the dynamic infiltration of a low-viscosity reactive hydrous melt into a high-viscosity ambient solid. The thickness of the melt layer is strongly controlled by return flow induced in the surrounding viscous solid, and in steady state a dynamic equilibrium is achieved where the melt lens is restrained from collapse by the exterior mantle. Melt layers with thicknesses in excess of 10 km develop for a wide range of mantle parameters and develop on timescales equivalent to the lifespan of an ocean basin. Citation: Leahy, G. M., and D. Bercovici (2010), Reactive infiltration of hydrous melt above the mantle transition zone

Underplating of the Hawaiian Swell : evidence from teleseismic receiver functions

Author Posting. © The Authors, 2010. This article is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in Geophysical Journal International 183 (2010): 313-329, doi:10.1111/j.1365-246X.2010.04720.x.The Hawaiian Islands are the canonical example of an age-progressive island chain, formed by volcanism long thought to be fed from a hotspot source that is more or less fixed in the mantle. Geophysical data, however, have so far yielded contradictory evidence on subsurface structure. The substantial bathymetric swell is supportive of an anomalously hot upper mantle, yet seafloor heat flow in the region does not appear to be enhanced. The accumulation of magma beneath pre-existing crust (magmatic underplating) has been suggested to add chemical buoyancy to the swell, but to date the presence of underplating has been constrained only by local active-source experiments. In this study, teleseismic receiver functions derived from seismic events recorded during the PLUME project were analysed to obtain a regional map of crustal structure for the Hawaiian Swell. This method yields results that compare favourably with those from previous studies, but permits a much broader view than possible with active-source seismic experiments. Our results indicate that the crustal structure of the Hawaiian Islands is quite complicated and does not conform to the standard model of sills fed from a central source. We find that a shallow P-to-s conversion, previously hypothesized to result from the volcano-sediment interface, corresponds more closely to the boundary between subaerial and subaqueous extrusive material. Correlation between uplifted bathymetry at ocean-bottom-seismometer locations and presence of underplating suggests that much of the Hawaiian Swell is underplated, whereas a lack of underplating beneath the moat surrounding the island of Hawaii suggests that underplated crust outward of the moat has been fed from below by dykes through the lithosphere rather than by sills spreading from the island centre. Local differences in underplating may reflect focusing of magma-filled dykes in response to stress from volcanic loading. Finally, widespread underplating adds chemical buoyancy to the swell, reducing the amplitude of a mantle thermal anomaly needed to match bathymetry and supporting observations of normal heat flow.We are grateful to the Ocean Sciences Division of the U.S. National Science Foundation for their support of this project under grants OCE-0002470, OCE-0002552 and OCE-0002819

HER2 therapy. HER2 (ERBB2): functional diversity from structurally conserved building blocks

EGFR-type receptor tyrosine kinases achieve a broad spectrum of cellular responses by utilizing a set of structurally conserved building blocks. Based on available crystal structures and biochemical information, significant new insights have emerged into modes of receptor control, its deregulation in cancer, and the nuances that differentiate the four human receptors. This review gives an overview of current models of the control of receptor activity with a special emphasis on HER2 and HER3

The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand

The human ErbB family of receptor tyrosine kinases comprises the epidermal growth factor receptor (EGFR/ErbB1/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). ErbBs play fundamental roles in cell growth and differentiation events in embryonic and adult tissues, and inappropriate ErbB activity has been implicated in several human cancers. We report here the 2.4 Å crystal structure of the extracellular region of human ErbB4 in the absence of ligand and show that it adopts a tethered conformation similar to inactive forms of ErbB1 and ErbB3. This structure completes the gallery of unliganded ErbB receptors and demonstrates that all human ligand-binding ErbBs adopt the autoinhibited conformation. We also show that the binding of neuregulin-1β to ErbB4 and ErbB3 and the binding of betacellulin to both ErbB4 and ErbB1 does not decrease at low pH, unlike the binding of epidermal growth factor and transforming growth factor-α to ErbB1. These results indicate an important role for ligand in determining pH-dependent binding and may explain different responses observed when the same ErbB receptor is stimulated by different ligands