Pinel-Hauterive – Hauterive

Identifiant de l'opération archéologique : 025435 Date de l'opération : 2008 (SU) Dans le cadre de l’agrandissement de l’usine de traitement des eaux du Lot, il a été mis au jour un certain nombre de structures romaines, dont un four ayant produit des pièces liées à la construction romaine. Le site se trouve sur la berge alluvionnaire récente dominant la rive droite du Lot en pied de falaise. Il y a une vingtaine d’années, lors de travaux d’agrandissement précédents, le site avait livré l’ext..

Multiframe Scene Flow with Piecewise Rigid Motion

We introduce a novel multiframe scene flow approach that jointly optimizes the consistency of the patch appearances and their local rigid motions from RGB-D image sequences. In contrast to the competing methods, we take advantage of an oversegmentation of the reference frame and robust optimization techniques. We formulate scene flow recovery as a global non-linear least squares problem which is iteratively solved by a damped Gauss-Newton approach. As a result, we obtain a qualitatively new level of accuracy in RGB-D based scene flow estimation which can potentially run in real-time. Our method can handle challenging cases with rigid, piecewise rigid, articulated and moderate non-rigid motion, and does not rely on prior knowledge about the types of motions and deformations. Extensive experiments on synthetic and real data show that our method outperforms state-of-the-art.Comment: International Conference on 3D Vision (3DV), Qingdao, China, October 201

Débat sur les perspectives économiques à court terme du 20 avril 2017

Le document sur nos prévisions préparé en vue de ce débat est de nature différente de celui des précédentes prévisions en raison des prochaines élections. La conjoncture dans les mois à venir dépendra du résultat des élections et des décisions du prochain gouvernement. Des prévisions plus précises pour la France seront donc développées en juillet, après les élections, à l'aide des premières mesures prises par le candidat vainqueur. (Premier paragraphe

Contact-based navigation for an autonomous flying robot

Autonomous navigation in obstacle-dense indoor environments is very challenging for flying robots due to the high risk of collisions, which may lead to mechanical damage of the platform and eventual failure of the mission. While conventional approaches in autonomous navigation favor obstacle avoidance strategies, recent work showed that collision-robust flying robots could hit obstacles without breaking and even self-recover after a crash to the ground. This approach is particularly interesting for autonomous navigation in complex environments where collisions are unavoidable, or for reducing the sensing and control complexity involved in obstacle avoidance. This paper aims at showing that collision-robust platforms can go a step further and exploit contacts with the environment to achieve useful navigation tasks based on the sense of touch. This approach is typically useful when weight restrictions prevent the use of heavier sensors, or as a low-level detection mechanism supplementing other sensing modalities. In this paper, a solution based on force and inertial sensors used to detect obstacles all around the robot is presented. Eight miniature force sensors, weighting 0.9g each, are integrated in the structure of a collision-robust flying platform without affecting its robustness. A proof-of-concept experiment demonstrates the use of contact sensing for exploring autonomously a room in 3D, showing significant advantages compared to a previous strategy. To our knowledge this is the first fully autonomous flying robot using touch sensors as only exteroceptive sensors

euHCVdb: the European hepatitis C virus database

The hepatitis C virus (HCV) genome shows remarkable sequence variability, leading to the classification of at least six major genotypes, numerous subtypes and a myriad of quasispecies within a given host. A database allowing researchers to investigate the genetic and structural variability of all available HCV sequences is an essential tool for studies on the molecular virology and pathogenesis of hepatitis C as well as drug design and vaccine development. We describe here the European Hepatitis C Virus Database (euHCVdb, ), a collection of computer-annotated sequences based on reference genomes. The annotations include genome mapping of sequences, use of recommended nomenclature, subtyping as well as three-dimensional (3D) molecular models of proteins. A WWW interface has been developed to facilitate database searches and the export of data for sequence and structure analyses. As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses

Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke

BACKGROUND Trials of patent foramen ovale (PFO) closure to prevent recurrent stroke have been inconclusive. We investigated whether patients with cryptogenic stroke and echocardiographic features representing risk of stroke would benefit from PFO closure or anticoagulation, as compared with antiplatelet therapy. METHODS In a multicenter, randomized, open-label trial, we assigned, in a 1:1:1 ratio, patients 16 to 60 years of age who had had a recent stroke attributed to PFO, with an associated atrial septal aneurysm or large interatrial shunt, to transcatheter PFO closure plus long-term antiplatelet therapy (PFO closure group), antiplatelet therapy alone (antiplatelet-only group), or oral anticoagulation (anticoagulation group) (randomization group 1). Patients with contraindications to anticoagulants or to PFO closure were randomly assigned to the alternative noncontraindicated treatment or to antiplatelet therapy (randomization groups 2 and 3). The primary outcome was occurrence of stroke. The comparison of PFO closure plus antiplatelet therapy with antiplatelet therapy alone was performed with combined data from randomization groups 1 and 2, and the comparison of oral anticoagulation with antiplatelet therapy alone was performed with combined data from randomization groups 1 and 3. RESULTS A total of 663 patients underwent randomization and were followed for a mean (+/- SD) of 5.3 +/- 2.0 years. In the analysis of randomization groups 1 and 2, no stroke occurred among the 238 patients in the PFO closure group, whereas stroke occurred in 14 of the 235 patients in the antiplatelet-only group (hazard ratio, 0.03; 95% confidence interval, 0 to 0.26; P<0.001). Procedural complications from PFO closure occurred in 14 patients (5.9%). The rate of atrial fibrillation was higher in the PFO closure group than in the antiplatelet-only group (4.6% vs. 0.9%, P = 0.02). The number of serious adverse events did not differ significantly between the treatment groups (P = 0.56). In the analysis of randomization groups 1 and 3, stroke occurred in 3 of 187 patients assigned to oral anticoagulants and in 7 of 174 patients assigned to antiplatelet therapy alone. CONCLUSIONS Among patients who had had a recent cryptogenic stroke attributed to PFO with an associated atrial septal aneurysm or large interatrial shunt, the rate of stroke recurrence was lower among those assigned to PFO closure combined with antiplatelet therapy than among those assigned to antiplatelet therapy alone. PFO closure was associated with an increased risk of atrial fibrillation

Molecular and phenotypic profiling from base to the crown in maritime pine wood-forming tissue

Research• Environmental, developmental and genetic factors affect variation in wood properties at the chemical, anatomical and physical levels. Here, the phenotypic variation observed along the tree stem was explored and the hypothesis tested that this variation could be the result of the differential expression of genes/proteins during wood formation. • Differentiating xylem samples of maritime pine (Pinus pinaster) were collected from the top (crown wood, CW) to the bottom (base wood, BW) of adult trees. These samples were characterized by Fourier transform infrared spectroscopy (FTIR) and analytical pyrolysis. Two main groups of samples, corresponding to CW and BW, could be distinguished from cell wall chemical composition. • A genomic approach, combining large-scale production of expressed sequence tags (ESTs), gene expression profiling and quantitative proteomics analysis, allowed identification of 262 unigenes (out of 3512) and 231 proteins (out of 1372 spots) that were differentially expressed along the stem. • A good relationship was found between functional categories from transcriptomic and proteomic data. A good fit between the molecular mechanisms involved in CW–BW formation and these two types of wood phenotypic differences was also observed. This work provides a list of candidate genes for wood properties that will be tested in forward genetic

COPD – eine unterschätzte Erkrankung

COPD - An Underestimated Disease Abstract: Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition with a complex clinical picture. The diagnosis is not easy to make because COPD can develop insidiously and remain unnoticed for a long time. Therefore, general practitioners play a central role in the early detection of the disease. Suspected COPD can be confirmed by special examinations in collaboration with pulmonologists. The new GOLD guideline defines three COPD risk groups (A-B-E) which should guide the personalized treatment concept. A short- or long-acting bronchodilator (SAMA/SABA or LAMA/LABA) is recommended for group A, and a dual long-acting bronchodilator therapy (LABA+LAMA) is recommended for group B and E. In case of blood eosinophilia (≥300 cells/µl) and/or recent hospitalization for COPD exacerbation, triple therapy (LABA+LAMA+ICS) is recommended. General practitioners are important in implementing non-pharmacological measures (smoking cessation, regular exercise, vaccinations, patient selfmanagement education). However, this also underlines the high demands of the implementation of the GOLD guideline in daily practice.COPD ist eine heterogene Erkrankung mit komplexem Krankheitsbild. Die Diagnose ist nicht einfach zu stellen, denn COPD kann sich schleichend entwickeln und lange unbemerkt bleiben. Hausärztinnen und -ärzten kommt daher für die Früherkennung eine zentrale Rolle zu. Der COPD-Verdacht kann in Zusammenarbeit mit Pneumologen durch spezielle Untersuchungen abgesichert werden als Voraussetzung für das medikamentöse Therapiekonzept. Die neue GOLD-Guideline definiert drei COPD-Risikogruppen (A-B-E). Für Gruppe A wird ein kurz- oder langwirksamer Bronchodilatator (SAMA/SABA bzw. LAMA/LABA) empfohlen. Für Gruppe B und E wird eine Kombinationstherapie LABA+LAMA empfohlen. Bei Bluteosinophilie (≥ 300 Zellen/μl) und/oder kürzlicher Hospitalisierung aufgrund einer COPD-Exazerbation wird eine Dreifachtherapie (LABA+LAMA+ICS) empfohlen. Hausärztinnen und -ärzte sind wichtig bei der Umsetzung therapiebegleitender Massnahmen (Coaching von Patientinnen und Patienten, Impfungen, Rauchstopp, regelmässige Bewegung). Dies unterstreicht aber auch die hohen Anforderungen der Umsetzung der GOLD-Guideline in den Praxisalltag

A map and a database for flint-bearing formations in Southern France: A tool for Petroarchaeology

Une carte des principales formations à silex du sud de la France est en cours de réalisation. Elle propose, à tous les préhistoriens, une base nécessaire au développement d’études interrégionales sur la circulation des silex. Elle est le fruit d’une collaboration entre des acteurs impliqués dans la problématique de caractérisation de la provenance des silex. Elle regroupe les résultats de leurs prospections systématiques ou ciblées dans six régions (Aquitaine, Auvergne, Languedoc-Roussillon, Midi-Pyrénées, Provence-Alpes-Côte-d’Azur, Rhône-Alpes). Elle intègre, en plus, le dépouillement d’un grand nombre de documents : i) les principaux articles et thèses traitant des formations à silex du sud de la France ; ii) plus de 200 fiches issues de la base de données du sous-sol BSS du BRGM, qui permettent de visualiser des logs ou des documents scannés ; iii) 529 cartes géologiques à 1/50 000 et leurs notices. La carte est organisée en trois couches de données superposables : une carte des affleurements ou gîtes primaires, une carte des altérites et des formations superficielles remaniées et une carte des formations alluviales. La carte existera dans deux versions numériques aisément actualisables : une version dans un format PDF et une version sous la forme d’un SIG. C’est l’ensemble de la formation contenant le ou les même(s) type(s) de silex qui est prise en compte, le terme de formation désignant un terrain possédant des caractères communs et qui constitue un ensemble cartographiable. Chacune des formations recensées fait l’objet d’une notice simplifiée qui décrit l’encaissant et - le ou les - type(s) de silex présent(s). Ces notices descriptives et explicatives contiennent des photos à toutes les échelles (de la formation à l’échelle microscopique). Des références bibliographiques géologiques et archéologiques complèteront chaque notice. La version définitive de ces notices constituera un atlas. Les archéologues et géologues disposeront ainsi de fiches descriptives pour chaque type de silex et son encaissant. Elles serviront aux diagnoses analytiques (structures, textures et compositions minéralogiques).A map of the main flint bearing formations in the South of France is under construction. It will provide an essential basis to develop interregional studies about flint procurements and travels. It results from collaboration between actors involved in topic flint sourcing. It includes results of their systematic surveys and studies in six regions (Aquitaine, Auvergne, Languedoc-Roussillon, Midi-Pyrenees, Provence-Alpes - Côte d’Azur, Rhône-Alpes). Moreover, it includes a large number of associated data : i) The main papers and those dealing with flint bearing formations of southern France, ii) more than 200 records from the under-soil database BSS BRGM, which give access to logs or scanned documents iii) 529 geological maps at 1/50 000 and their leaflets. The map is organized in three superimposed layers : a map of outcrops or primary deposits, a map of surficial weathered formation and a revised map of alluvial formations. The map is available in two versions which are easily updatable : a PDF version and an interactive GIS version. In this document, every formation containing the same type (s) (s) of flint is taken into account and forms a mappable entity. Every listed formation is linked to a text which describes the parent rock and/or the type(s) of flint(s). These records contain descriptive and explanatory pictures at different scale (naked eye to microscopic scale). Geological and archaeological references complement every record. The final version will constitute an atlas. Archaeologists and geologists will find description sheets of every type of flint and bearing rock. They will help for analytical diagnoses (structure, texture and mineralogical composition)