Ess target performance for different beam pulses

Last trends in the design of linear accelerators for high power spallation sources point to the use of ion beams of larger energies and shorter pulse lengths in order to enhance the reliability of the system. In this sense the recommendations for ESS are to increase the energy of the proton beam from 1.3GeV to 2-2.5GeV and to reduce the length of the beam pulse from 2ms to 1-1.5ms, keeping the source average power at 5MW. Different values for the repetition rate are also being discussed (16 2/3, 20, 25 Hz). ESS Bilbao is analyzing the impact of these modifications on the design of the target system. In this paper the effects of the different beam energies on the target disc thermohydraulics and the neutron performance of the source are discussed. Initial calculations were performed for a rotating target with ESS 2002 parameters. During the development of the work –that are being performed in collaboration with SNS– the decision was made to use the SNS-STS Target-Moderator-Reflector Assembly (TMRA) –slightly modified to accommodate the target design being studied for ESS– which presents a state of the art design with a cylindrical liquid para-hydrogen moderator in wing configuration aimed to enhance cold neutron productio

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis

Computing a T-transitive opening of a proximity

A fast method to compute a T-indistinguishability from a reflexive and symmetric fuzzy relation is given for any left-continuous t-norm, taking O(n(3)) time complexity, where n is the number of elements in the universe. It is proved that the computed fuzzy relation is a T-transitive opening when T is the minimum t-norm or a strictly growing t-norm. As far as we know, this is the first known algorithm that computes T-transitive openings preserving the reflexive and symmetric properties

Nuevo híbrido del género Centaurea L. (Compositae) sección Seridia (Juss.) Czerep.

[EN] A new hybrid of the Centaurea L. genus (Compositae) is described: Centaurea x subdecurrens nothosubsp. oblanceolata (C. aspera subsp. stenophylla x C. seridis. subsp. cruenta). It is only found at the contact areas between the parental species, and is therefore a very rare taxon. Key words: Centaurea, hybrid, taxonomy.[ES] Se describe un nuevo híbrido del género Centaurea L. (Compositae): Centaurea x subdecurrens nothosubsp. oblanceolata (C. aspera subsp. stenophylla x C. seridis subsp. cruenta). Su área de distribución es muy reducida y se circunscribe únicamente a las zonas de contacto entre ambos parentales. Palabras clave: Centaurea, híbrido, taxonomía.Merle Farinós, HB.; Garmendia Salvador, A.; Ferriol Molina, M. (2010). Nuevo híbrido del género Centaurea L. (Compositae) sección Seridia (Juss.) Czerep. Flora Montibérica. 44:66-71. http://hdl.handle.net/10251/89689S66714

Classifying Fuzzy Measures

Suppor

Restoring seagrass meadows in Basque estuaries: nature-based solution for successful management

Seagrass meadows provide a wide variety of ecosystem goods and services (biodiversity maintenance, carbon sequestration, sediment oxygenation and enrichment, filtering, coastal protection, and nursery area for other species). For this reason, they are areas of high economic development while historically highly impacted by human activity. Therefore, there is a growing need for the restoration and conservation of these habitat engineers as a nature-based solution for climate change mitigation and biodiversity conservation. The Basque Country region (northern Spain) has experienced a decline in seagrass meadows driven by increases in nutrient concentrations and decreases in water clarity. In this region, only 3 out of its 12 estuaries currently host natural intertidal populations of the protected species Zostera noltei. However, there is written evidence of the previous presence of this species in other estuaries within the region. Despite significant improvement in water quality has been observed in most Basque estuaries, these plants show a low capacity for a successful natural recolonization, requiring human restoration planning and implementation. To ensure a successful seagrass restoration a plan is needed which encompasses four phases: feasibility and pre-project planning, project design, pre-restoration tasks, and restoration/monitoring. This work focuses on the first and second phases, which include the selection of the most suitable reception sites and restoration trials. Therefore, a restoration and monitoring plan is proposed for a Basque estuary which includes further involvement of local stakeholders (users, managers) to increase the probability of success

Are hepatocellular carcinoma surveillance programs effective at improving the therapeutic options?: ¿mejoran las opciones terapéuticas de estos pacientes? Eficacia de los programas de cribado de hepatocarcinoma

Aim: to evaluate whether the current surveillance programs (ultrasonography and alpha-fetoprotein testing every six months) are successful in detecting patients in the early stages. Material and methods: the health records of all patients diagnosed with hepatocellular carcinoma in Donostia Hospital between 2003 and 2005 were reviewed retrospectively. Eighty-five patients (11 women and 74 men) were included in the study and demographic data, risk factors and clinical data were obtained. Patients were split into two groups according to whether or not they had been included in a surveillance program. Results: seventy per cent of patients of the surveillance group is diagnosed in early stage opposite to 26.7% of patients in no surveillance group (p < 0.05). Thirteen patients cannot receive curative treatment in spite of the diagnosis in early stage (9 in the surveillance group and 4 in the no surveillance group. The global sensibility of the surveillance program in our series is 95%. Conclusions: current hepatocellular carcinoma surveillance programs, which comprise six-monthly ultrasonography and alpha-fetoprotein tests, are highly sensitive and effective. These programs result in the detection of hepatocellular carcinoma in its early-stages, when potentially curative treatment may be offered.<br>Objetivo: determinar si la utilización en nuestro medio del programa de cribado de HCC establecido -alfa-fetoproteína (AFP) y ecografia semestral- en pacientes con hepatopatía crónica permite detectar pacientes en estadios precoces de la enfermedad. Material y métodos: Diseño experimental: estudio retrospectivo. Criterios diagnósticos de HCC: 2 o más técnicas de imagen con lesión hipervascular mayor de 2 cm o 1 técnica de imagen con lesión hipervascular mayor de 2 cm asociado a AFP mayor de 400 ng/ml. Pacientes: 85 pacientes diagnosticados de HCC en el Hospital Donostia entre los años 2003 y 2005. Datos analizados: información demográfica (sexo, edad), factores de riesgo (alcohol, virus de hepatitis, hemocromatosis, otras enfermedades asociadas), e información clínica (etiología de la hepatopatía, estadio de Child-Pugh, determinación de AFP, hallazgos radiológicos, criterios de resecabilidad, tratamiento recibido, evolución). Se divide la muestra en dos grupos según hubieran seguido o no un programa de cribado. Resultados: el 70% de los pacientes del grupo de cribado se diagnostican en estadio precoz frente al 26,7% del grupo de no cribado (p < 0,05). Trece pacientes no pueden recibir tratamiento curativo a pesar del diagnóstico en fase precoz (9 en el grupo de cribado y 4 en el de no cribado). La sensibilidad global del cribado en nuestra serie es del 95%. Conclusiones: en nuestro medio, el programa de cribado de hepatocarcinoma es eficaz en términos de aplicación de tratamientos curativos

Are hepatocellular carcinoma surveillance programs effective at improving the therapeutic options?: ¿mejoran las opciones terapéuticas de estos pacientes?

Aim: to evaluate whether the current surveillance programs (ultrasonography and alpha-fetoprotein testing every six months) are successful in detecting patients in the early stages. Material and methods: the health records of all patients diagnosed with hepatocellular carcinoma in Donostia Hospital between 2003 and 2005 were reviewed retrospectively. Eighty-five patients (11 women and 74 men) were included in the study and demographic data, risk factors and clinical data were obtained. Patients were split into two groups according to whether or not they had been included in a surveillance program. Results: seventy per cent of patients of the surveillance group is diagnosed in early stage opposite to 26.7% of patients in no surveillance group (p < 0.05). Thirteen patients cannot receive curative treatment in spite of the diagnosis in early stage (9 in the surveillance group and 4 in the no surveillance group. The global sensibility of the surveillance program in our series is 95%. Conclusions: current hepatocellular carcinoma surveillance programs, which comprise six-monthly ultrasonography and alpha-fetoprotein tests, are highly sensitive and effective. These programs result in the detection of hepatocellular carcinoma in its early-stages, when potentially curative treatment may be offered