Exposition professionnelle maternelle aux solvants organiques et malformations congenitales

The aim of this project was to study the relation between maternal occupational exposure to solvents and congenital malformations.This project used data from the PELAGIE study. This is a mother child cohort which had included 3 421 women from the general population at the beginning of their pregnancy in Britany. Occupational exposure to solvents was assessed by different methods (self-report, job exposure matrix, and urinary determination of glycol ethers and chlorinated solvents metabolites).We have shown an association between solvent exposure using indirect method of assessment and congenital malformations. Using a randomized sample of 451 women, we have studied the occupational and non occupational determinants of urinary detection of glycol ethers and chlorinated solvents metabolites. Finally, we have studied in a nested case-control study, the relation between urinary solvent metabolites and congenital malformations.L’objectif général de ce travail était d’étudier la relation entre exposition professionnelle maternelle aux solvants organiques et malformations congénitales.Ce projet s’est appuyé sur les données de la cohorte PELAGIE. Il s’agit d’une cohorte mère enfant avec inclusion de 3 421 femmes en début de grossesse en population générale en Bretagne. L’exposition aux solvants était définie par différentes méthodes (expositions déclarées, matrices emplois-expositions, dosages urinaires de métabolites de solvants chlorés et d’éthers de glycol).Nous avons mis en évidence une relation entre l’exposition aux solvants mesurée par des méthodes indirectes et les malformations congénitales. Puis, pour un échantillon aléatoire de451 femmes, nous avons étudié les déterminants de la détection urinaire des métabolites de solvants. Enfin, dans le cadre d’une étude cas-témoins dans la cohorte, la relation entre métabolites urinaires de solvants et malformations congénitales a été étudiée

Syndrome du canal carpien : impact de la co-exposition à des agents neurotoxiques et à des contraintes biomécaniques

Le syndrome du canal carpien est l’une des principales causes de maladie professionnelle. Dans un grand nombre de situations de travail, les travailleurs sont confrontés à des expositions multiples, mais peu de données sont disponibles sur les co-expositions des travailleurs à des agents chimiques neurotoxiques et à des contraintes biomécaniques

Urinary Biomarkers of Prenatal Atrazine Exposure and Adverse Birth Outcomes in the PELAGIE Birth Cohort

Background: Despite evidence of atrazine toxicity in developing organisms from experimental studies, few studies—and fewer epidemiologic investigations—have examined the potential effects of prenatal exposure

Screening for Chronic Obstructive Pulmonary Disease in Smoking Cessation ‎Clinic in France

Background: The purpose of this study was to detect chronic obstructive pulmonary disease (COPD) among smokers seeking treatment for the first time in a smoking cessation clinic and to assess the predictors of positive screening. Methods: This study was based on a multicenter survey with questionnaires (Richmond, Fagerstrom, clinical signs) and spirometry miniaturized. Data were analyzed with SAS® by Pearson chi-square test, the test of analysis of variance, Spearman correlation coefficient, and multivariate logistic regression step down. Findings: 1918 patients were assessed for eligibility and only 1737 were included. The report forced expiratory volume in 1 second (FEV1/FEV6) was < 0.8 for 33.2% of smokers and < 0.7 for 7.5% of them. People with likely COPD had more dyspnea (P < 0.010) and chronic bronchitis (CB) (P < 0.010). In multivariate analysis, CB, duration of smoking history since longer than 30 years, and dyspnea significantly increased the risk of being detected as COPD. The odds ratios of the above factors were 2.9, 4.1, and 4.5, respectively. Conclusion: 7.5% of smokers were likely COPD. Patient’s risk factors, such as the presence of CB, smoking addiction for longer than 30 years, or dyspnea, were predictive of a positive screening for COPD

: Gender differences in STEMI

International audienceBACKGROUND: Gender differences in presentation, management and outcome in patients with ST-segment elevation myocardial infarction (STEMI) have been reported. AIM: To determine whether female gender is associated with higher inhospital mortality. METHODS: Data from ORBI, a regional STEMI registry of 5 years' standing, were analysed. The main data on presentation, management, inhospital outcome and prescription at discharge were compared between genders. Various adjusted hazard ratios were then calculated for inhospital mortality (women versus men). RESULTS: The analysis included 5000 patients (mean age 62.6±13 years), with 1174 women (23.5%). Women were on average 8 years older than men, with more frequent co-morbidities. Median ischaemia time was 215 minutes (26 minutes longer in women; P<0.05). Reperfusion strategies in women less frequently involved fibrinolysis, coronary angiography, radial access and thrombo-aspiration. Female gender, especially in patients aged<60 years, was associated with poorer inhospital prognosis (including higher inhospital mortality: 9% vs. 4% in men; P<0.0001), and underutilization of recommended treatments at discharge. Moreover, excess female inhospital mortality was independent of presentation, revascularization time and reperfusion strategy (hazard ratio for women 1.33, 95% confidence interval 1.01-1.76; P=0.04). CONCLUSIONS: One in four patients admitted for STEMI was female, with significant differences in presentation. Female gender was associated with less-optimal treatment, both in the acute-phase and at discharge. Efforts should be made to reduce these differences, especially as female gender was independently associated with an elevated risk of inhospital mortality

Maternal Occupational Exposure to Organic Solvents and Congenital Malformations

L’objectif général de ce travail était d’étudier la relation entre exposition professionnelle maternelle aux solvants organiques et malformations congénitales.Ce projet s’est appuyé sur les données de la cohorte PELAGIE. Il s’agit d’une cohorte mère enfant avec inclusion de 3 421 femmes en début de grossesse en population générale en Bretagne. L’exposition aux solvants était définie par différentes méthodes (expositions déclarées, matrices emplois-expositions, dosages urinaires de métabolites de solvants chlorés et d’éthers de glycol).Nous avons mis en évidence une relation entre l’exposition aux solvants mesurée par des méthodes indirectes et les malformations congénitales. Puis, pour un échantillon aléatoire de451 femmes, nous avons étudié les déterminants de la détection urinaire des métabolites de solvants. Enfin, dans le cadre d’une étude cas-témoins dans la cohorte, la relation entre métabolites urinaires de solvants et malformations congénitales a été étudiée.The aim of this project was to study the relation between maternal occupational exposure to solvents and congenital malformations.This project used data from the PELAGIE study. This is a mother child cohort which had included 3 421 women from the general population at the beginning of their pregnancy in Britany. Occupational exposure to solvents was assessed by different methods (self-report, job exposure matrix, and urinary determination of glycol ethers and chlorinated solvents metabolites).We have shown an association between solvent exposure using indirect method of assessment and congenital malformations. Using a randomized sample of 451 women, we have studied the occupational and non occupational determinants of urinary detection of glycol ethers and chlorinated solvents metabolites. Finally, we have studied in a nested case-control study, the relation between urinary solvent metabolites and congenital malformations

Comments Regarding Masroor et al: Perceptions and Barriers to Universal Gloving for Infection Prevention

International audienceLetter to the Edito

Maternal smoking during pregnancy, semen characteristics and reproductive hormone levels in men consulting for couple infertility

International audienc

Reply II. Cord blood androgen measurements: the importance of assay validation

International audienceReply: We thank Keelan and colleagues for their letter questioning the accuracy of testosterone measurement in cord blood obtained by immunoassay methods..