A comparison between the Randot animals and the Randot forms in a screening setting

A comparison of the the Randot animals (non random dot stereotest, NRDS) and the Randot forms (random dot stereotest, RDS) was accomplished using 255 first grade children at a Pacific University elementary school screening. The purpose was to determine which of the two stereotests was clinically more sensitive for detecting vision problems in grade school children as indicated by failing any portion of the screening. The findings indicate that children with significant refractive errors (hyperopia, astigmatism and/or anisometropia) or any type of binocular anomaly do worse on the RDS than on the NRDS. Based on these results, a random dot stereotest would be a valuable test to include in a grade school screening programs, since it provides a substantial amount of information with relatively little effort and time

Electronic structure, imaging contrast and chemical reactivity of graphene moir\'e on metals

Realization of graphene moir\'e superstructures on the surface of 4d and 5d transition metals offers templates with periodically modulated electron density, which is responsible for a number of fascinating effects, including the formation of quantum dots and the site selective adsorption of organic molecules or metal clusters on graphene. Here, applying the combination of scanning probe microscopy/spectroscopy and the density functional theory calculations, we gain a profound insight into the electronic and topographic contributions to the imaging contrast of the epitaxial graphene/Ir(111) system. We show directly that in STM imaging the electronic contribution is prevailing compared to the topographic one. In the force microscopy and spectroscopy experiments we observe a variation of the interaction strength between the tip and high-symmetry places within the graphene moir\'e supercell, which determine the adsorption cites for molecules or metal clusters on graphene/Ir(111).Comment: submitted on Sep, 6th 201

Clinical comparison of flat versus alignment fitting philosophies

A clinical study of twenty-three subjects was conducted to compare corneal changes and patient responses observed with flat versus alignment fitting philosophies. Corneal changes were assessed by comparison of initial and endpoint data gathered on refractive status, corneal curvature, and corneal staining. The subjective response to lens comfort was also monitored. Corneas fitted with lenses on alignment showed statistically less change in corneal astigmatism, visual acuity, and staining than lenses fitted flat

An Artificially Lattice Mismatched Graphene/Metal Interface: Graphene/Ni/Ir(111)

We report the structural and electronic properties of an artificial graphene/Ni(111) system obtained by the intercalation of a monoatomic layer of Ni in graphene/Ir(111). Upon intercalation, Ni grows epitaxially on Ir(111), resulting in a lattice mismatched graphene/Ni system. By performing Scanning Tunneling Microscopy (STM) measurements and Density Functional Theory (DFT) calculations, we show that the intercalated Ni layer leads to a pronounced buckling of the graphene film. At the same time an enhanced interaction is measured by Angle-Resolved Photo-Emission Spectroscopy (ARPES), showing a clear transition from a nearly-undisturbed to a strongly-hybridized graphene $\pi$-band. A comparison of the intercalation-like graphene system with flat graphene on bulk Ni(111), and mildly corrugated graphene on Ir(111), allows to disentangle the two key properties which lead to the observed increased interaction, namely lattice matching and electronic interaction. Although the latter determines the strength of the hybridization, we find an important influence of the local carbon configuration resulting from the lattice mismatch.Comment: 9 pages, 3 figures, Accepted for publication in Phys. Rev.

Effects of topical clonidine versus brimonidine on choroidal blood flow and intraocular pressure during squatting

PURPOSE. Clonidine and brimonidine, two ␣-2 agonists, have been shown to reduce intraocular pressure (IOP) in patients with glaucoma. Little is known, however, about the exact role of ␣ receptors in the control of ocular blood flow in the posterior pole of the eye. Hence, the study was conducted to investigate the effects of topical clonidine versus topical brimonidine on choroidal blood flow and intraocular pressure during squatting. METHODS. This was a randomized, double-masked, controlled, two-way crossover study. Twelve healthy male nonsmoking volunteers, aged between 19 and 35 years were included in the study. Two drops of clonidine or brimonidine were administered in the subjects' study eyes. Continuous measurement using the compact laser Doppler flowmeter was performed during a 6-minute squatting period, to assess choroidal blood flow regulation during an increase in ocular perfusion pressure. RESULTS. Both substances induced a pronounced but comparable (P ϭ 0.8) decrease in IOP. Squatting increased mean arterial pressure (MAP) and ocular perfusion pressure (P Ͻ 0.01). This increase was comparable between the clonidine and the brimonidine study day (P ϭ 0.88). Squatting induced an increase in choroidal blood flow that was less pronounced than the increase in ocular perfusion pressure. Compared with baseline the ␣-2 agonists decreased choroidal blood flow during squatting (P ϭ 0.0026) to a comparable degree (P ϭ 0.86). Vascular resistance increased at baseline and during squatting after administration of the ␣-2 agonists (P Ͻ 0.01) in both groups to a comparable degree (P ϭ 0.56). CONCLUSIONS. Topical ␣-2 agonists may induce changes in choroidal blood flow, even after a single administration. Long-term studies are needed to study potential effects of brimonidine and clonidine in the clinical setting. (Invest Ophthalmol Vis Sci. 2007;48:4220 -4225

Exploring consensus on preventive measures and identification of patients at risk of age-related macular degeneration using the delphi process

Background: Early identification of AMD can lead to prompt and more effective treatment, better outcomes, and better final visual acuity; several risk scores have been devised to determine the individual level of risk for developing AMD. Herein, the Delphi method was used to provide recommendations for daily practice regarding preventive measures and follow-up required for subjects at low, moderate, and high risk of AMD evaluated with the Simplified Test AMD Risk-assessment Scale (STARS® ) questionnaire. Methods: A steering committee of three experts drafted and refined 25 statements on the approach to be recommended in different clinical situations [general recommendations (n = 2), use of evaluation tools (n = 4), general lifestyle advice (n = 3), and AREDS-based nutritional supplementation (n = 5)] with the help of a group of international experts, all co-authors of this paper. Thirty retinal specialists from Europe and the US were chosen based on relevant publications, clinical expertise, and experience in AMD, who then provided their level of agreement with the statements. Statements for which consensus was not reached were modified and voted upon again. Results: In the first round of voting, consensus was reached for 24 statements. After modification, consensus was then reached for the remaining statement. Conclusion: An interprofessional guideline to support preventive measures in patients at risk of AMD based on STARS® scoring has been developed to aid clinicians in daily practice, which will help to optimize preventive care of patients at risk of AMD

Effects of Pentoxifylline and Alprostadil on Ocular Hemodynamics in Healthy Humans

PURPOSE. Alprostadil, a prostaglandin (PG)E 1 analogue and pentoxifylline, an alkylxanthine derivate, have been shown to exert vasodilatory effects in several vascular beds. The purpose of the present study was to investigate the effect of PGE 1 and pentoxifylline on the ocular circulation. METHODS. A placebo-controlled, double-masked, three-way, crossover study was performed in 15 healthy male subjects. Subjects received pentoxifylline (300 mg), PGE 1 (alprostadil 60 g), or placebo intravenously over 2 hours on three trial days. Choroidal red blood cell flow was assessed with laser Doppler flowmetry and pulsatile choroidal blood flow with laser interferometric measurement of fundus pulsation amplitude (FPA). Retinal blood cell flow was calculated based on the measurements of maximum erythrocyte velocity in a retinal vein assessed with bidirectional laser Doppler velocimetry, and diameter measurements of retinal vessels were obtained with a retinal vessel analyzer. RESULTS. Pentoxifylline increased FPA by 15.4% Ϯ 1.1% (P Ͻ 0.001 versus placebo and baseline). Alprostadil tended to increase FPA, but this effect did not reach the level of significance (P ϭ 0.07 versus placebo). Choroidal blood flow as measured with laser Doppler flowmetry tended to increase during pentoxifylline and PGE 1 infusion by 8.9% Ϯ 2.9% (P ϭ 0.062) and 4.5% Ϯ 6.2% (P ϭ 0.29), respectively, but none of these effects was significant. The drugs under study had no effect on mean red blood cell velocity in retinal veins, on retinal vessel diameters, intraocular pressure, blood pressure, or pulse rate. CONCLUSIONS. PGE 1 did not alter the parameters of retinal or choroidal circulation in healthy subjects. Pentoxifylline increased FPA, but did not change choroidal blood flow as measured with laser Doppler flowmetry and did not affect retinal blood flow parameters. Accordingly, neither pentoxifylline nor PGE 1 appears to be suitable to improve ocular blood flow in healthy subjects. Whether long-term treatment with alprostadil would improve choroidal blood flow in patients with vascular disease remains to be established. (Invest Ophthalmol Vis Sci

Flicker Light–Induced Retinal Vasodilation in Diabetes and Diabetic Retinopathy

10.2337/dc09-0075Diabetes Care32112075-2080DICA