Lista de Peces de la provincia de San Luis

Fil: Nadalin, Diego Oscar. División Zoología Vertebrados. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Garelis, Patricia A.. Facultad de Química. Bioquímica y Farmacia. Universidad Nacional de San Luis. San Luis; ArgentinaFil: Fernández, Luis A.. Fundación Miguel Lillo.Tucumán; ArgentinaFil: Bustamente, Gustavo J.. Facultad de Química. Bioquímica y Farmacia. Universidad Nacional de San Luis. San Luis; ArgentinaFil: López, Hugo Luis. División Zoología Vertebrados. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; Argentin

SLC19A1 transports immunoreactive cyclic dinucleotides.

The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway3. The binding of DNA to cGAS activates its enzymatic activity, leading to the synthesis of a second messenger, cyclic guanosine monophosphate-adenosine monophosphate (2'3'-cGAMP)4-7. This cyclic dinucleotide (CDN) activates STING8, which in turn activates the transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), promoting the transcription of genes encoding type I interferons and other cytokines and mediators that stimulate a broader immune response. Exogenous 2'3'-cGAMP produced by malignant cells9 and other CDNs, including those produced by bacteria10-12 and synthetic CDNs used in cancer immunotherapy13,14, must traverse the cell membrane to activate STING in target cells. How these charged CDNs pass through the lipid bilayer is unknown. Here we used a genome-wide CRISPR-interference screen to identify the reduced folate carrier SLC19A1, a folate-organic phosphate antiporter, as the major transporter of CDNs. Depleting SLC19A1 in human cells inhibits CDN uptake and functional responses, and overexpressing SLC19A1 increases both uptake and functional responses. In human cell lines and primary cells ex vivo, CDN uptake is inhibited by folates as well as two medications approved for treatment of inflammatory diseases, sulfasalazine and the antifolate methotrexate. The identification of SLC19A1 as the major transporter of CDNs into cells has implications for the immunotherapeutic treatment of cancer13, host responsiveness to CDN-producing pathogenic microorganisms11 and-potentially-for some inflammatory diseases

Intense synchrotron radiation from a magnetically compressed relativistic electron layer

Using a simple model of a relativistic electron layer rotating in an axial magnetic field, energy gain by an increasing magnetic field and energy loss by synchrotron radiation were considered. For a typical example, initial conditions were approximately 8 MeV electron in approximately 14 kG magnetic field, at a layer radius of approximately 20 mm, and final conditions were approximately 4 MG magnetic field approximately 100 MeV electron layer energy at a layer radius of approximately 1.0 mm. In the final state, the intense 1-10 keV synchrotron radiation imposes an electron energy loss time constant of approximately 100 nanoseconds. In order to achieve these conditions in practice, the magnetic field must be compressed by an imploding conducting liner; preferably two flying rings in order to allow the synchrotron radiation to escape through the midplane. The synchrotron radiation loss rate imposes a lower limit to the liner implosion velocity required to achieve a given final electron energy (approximately 1 cm/$mu$sec in the above example). In addition, if the electron ring can be made sufficiently strong (field reversed), the synchrotron radiation would be a unique source of high intensity soft x-radiation. (auth

Revaluación de la herpetofauna en la peculiar biodiversidad de la provincia de San Luis (Argentina)

Se presenta una actualizada discusión de los anfibios y reptiles de la provincia de San Luis (Argentina). Composición y características de la herpetofauna en la biodiversidad puntana permiten evidenciar su significado ecológico y biogeográfico comparadas con elementos similares de la biodiversidad de la contigua provincia de Mendoza. Relaciones pretéritas con comunidades Chaqueñas o Serranas Cordobesas se señalan y documentan para numerosas especies puntanas de saurios y ofidios.An up-dated valuation of the amphibians and reptiles from biodiversity of the San Luis province (Argentina) is presented and discussed. An ecological and systematic comparison with the herpetofauna of the western bordering Mendoza province is carried out. The interesting relationships between several species of lacertilians and snakes from biocenotic communities of San Luis and similar tropico-subtropical communities from Chacoan belt and the neighboring Córdoba Sierras are reported and emphasized.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Revaluación de la herpetofauna en la peculiar biodiversidad de la provincia de San Luis (Argentina)

Se presenta una actualizada discusión de los anfibios y reptiles de la provincia de San Luis (Argentina). Composición y características de la herpetofauna en la biodiversidad puntana permiten evidenciar su significado ecológico y biogeográfico comparadas con elementos similares de la biodiversidad de la contigua provincia de Mendoza. Relaciones pretéritas con comunidades Chaqueñas o Serranas Cordobesas se señalan y documentan para numerosas especies puntanas de saurios y ofidios.An up-dated valuation of the amphibians and reptiles from biodiversity of the San Luis province (Argentina) is presented and discussed. An ecological and systematic comparison with the herpetofauna of the western bordering Mendoza province is carried out. The interesting relationships between several species of lacertilians and snakes from biocenotic communities of San Luis and similar tropico-subtropical communities from Chacoan belt and the neighboring Córdoba Sierras are reported and emphasized.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Revaluación de la herpetofauna en la peculiar biodiversidad de la provincia de San Luis (Argentina)

Se presenta una actualizada discusión de los anfibios y reptiles de la provincia de San Luis (Argentina). Composición y características de la herpetofauna en la biodiversidad puntana permiten evidenciar su significado ecológico y biogeográfico comparadas con elementos similares de la biodiversidad de la contigua provincia de Mendoza. Relaciones pretéritas con comunidades Chaqueñas o Serranas Cordobesas se señalan y documentan para numerosas especies puntanas de saurios y ofidios.An up-dated valuation of the amphibians and reptiles from biodiversity of the San Luis province (Argentina) is presented and discussed. An ecological and systematic comparison with the herpetofauna of the western bordering Mendoza province is carried out. The interesting relationships between several species of lacertilians and snakes from biocenotic communities of San Luis and similar tropico-subtropical communities from Chacoan belt and the neighboring Córdoba Sierras are reported and emphasized.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Concentrations of Homovanillic Acid and 5-Hydroxyindoleacetic Acid in Cerebrospinal Fluid from Human Infants in the Perinatal Period

To assess maturation of central serotonin and catecholamine pathways at birth, we measured lumbar CSF homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), stable acid metabolites of dopamine and serotonin, using HPLC with electrochemical detection. CSFs from 57 neonates (38 premature and 19 at term) and 13 infants 1–6 months old were studied. HVA levels increased with maturity (p < 0.05; ANOVA), whereas, 5-HIAA levels were similar in all these subjects. HVA/5-HIAA ratios increased markedly from 1 ± 0.12 in the most premature neonates to 1.98 ± 0.17 in the older infants (p < 0.01; t test). There were no sex differences for these values.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66233/1/j.1471-4159.1984.tb06109.x.pd

APDA Bulletin 131

Report issued by the APDA over fuel enrichment processes at the Enrico Fermi Atomic Power Plant. As stated in the introduction, "the results that directly apply to the determination of the enrichment will be given" (p. 6). This report includes tables, and illustrations

SODIUM-AIR ACCIDENT STUDY FOR A SODIUM COOLED REACTOR. Technical Memorandum No. 20

The design requirements of a containnment building for a sodium-cooled reactor have been investigated from the point of view of a hypothetical sodium - air reaction. In particular, this study was directed toward the containment building of the Enrico Fermi Atomic Power Plant. The hypothetical accident assumes a major leak in the sodium system with a concurrent or earlier failure of the ventilation and cooling systems which allows air to enter the areas around the sodium system which are normally maintained in an atmosphere inert insofar as sodium burning is concerned. The resulting sodium pool, equivalent in burning surface to the fraction of the cross sectional area of the containment buildings which is flooded, burns at a rate depending upon oxygen concentration and gas temperature in the containment building. A series of experiments were carried out to determine this burning rate and its mechanism. The resulting gas temperature and pressure due to the sodium-air incident were determined by solving a system of equations based on time dependent heat balances on the containment building and its contents. The assumed incident gives a maximum gas pressure of about 26 psig and a corresponding gas temperature of 1115 F. This pressure is well below the design pressure of 32 psig for the containment vessel. In addition to the study of the sodium-air reaction in the assumed incident, the theoretical maximum pressure and temperature for the constant volume adiabatic sodium-air reaction is also discussed. (auth