1,803 research outputs found
Finding and Mitigating Geographic Vulnerabilities in Mission Critical Multi-Layer Networks
Title from PDF of title page, viewed on June 20, 2016Dissertation advisor: Cory BeardVitaIncludes bibliographical references (pages 232-257)Thesis(Ph.D.)--School of Computing and Engineering. University of Missouri--Kansas City, 2016In Air Traffic Control (ATC), communications outages may lead to immediate loss
of communications or radar contact with aircraft. In the short term, there may be safety
related issues as important services including power systems, ATC, or communications
for first responders during a disaster may be out of service. Significant financial damage
from airline delays and cancellations may occur in the long term. This highlights the
different types of impact that may occur after a disaster or other geographic event. The
question is How do we evaluate and improve the ability of a mission-critical network to
perform its mission during geographically correlated failures?
To answer this question, we consider several large and small networks, including
a multi-layer ATC Service Oriented Architecture (SOA) network known as SWIM. This
research presents a number of tools to analyze and mitigate both long and short term geographic vulnerabilities in mission critical networks. To provide context for the tools, a
disaster planning approach is presented that focuses on Resiliency Evaluation, Provisioning Demands, Topology Design, and Mitigation of Vulnerabilities.
In the Resilience Evaluation, we propose a novel metric known as the Network
Impact Resilience (NIR) metric and a reduced state based algorithm to compute the NIR
known as the Self-Pruning Network State Generation (SP-NSG) algorithm. These tools
not only evaluate the resiliency of a network with a variety of possible network tests, but
they also identify geographic vulnerabilities.
Related to the Demand Provisioning and Mitigation of Vulnerabilities, we present
methods that focus on provisioning in preparation for rerouting of demands immediately following an event based on Service Level Agreements (SLA) and fast rerouting
of demands around geographic vulnerabilities using Multi-Topology Routing (MTR). The
Topology Design area focuses on adding nodes to improve topologies to be more resistant
to geographic vulnerabilities.
Additionally, a set of network performance tools are proposed for use with mission
critical networks that can model at least up to 2nd order network delay statistics. The first
is an extension of the Queueing Network Analyzer (QNA) to model multi-layer networks
(and specifically SOA networks). The second is a network decomposition tool based
on Linear Algebraic Queueing Theory (LAQT). This is one of the first extensive uses
of LAQT for network modeling. Benefits, results, and limitations of both methods are
described.Introduction -- SWIM Network - Air traffic Control example -- Performance analysis of mission critical multi-layer networks -- Evaluation of geographically correlated failures in multi-layer networks -- Provisioning and restoral of mission critical services for disaster resilience -- Topology improvements to avoid high impact geographic events -- Routing of mission critical services during disasters -- Conclusions and future research -- Appendix A. Pub/Sub simulation model description -- Appendix B. ME Random Number Generatio
Nebraska Intellectual Freedom Manual
Much has changed in libraries and society since the publication of the 2004 revision of the Nebraska Library Association Intellectual Freedom Manual. The consensus of the current members of the Nebraska Library Association round table on Intellectual Freedom (NLA IF) was not to just revise the former manual, but to create an entirely new edition. In doing so, the authors have addressed a number of new issues. The intention was to keep it relatively brief but still useful. Readers should be able to read sections independent of one another for quick reference on topics of interest. For readers of the electronic version, there are many hyperlinks included.
Though this is a new edition, the introduction to the 2004 revision still applies: As librarians, we are all concerned with the concept of intellectual freedom. It is our professional obligation to provide varied forms of information that meet the varied interests and needs of our community members. It is also our professional obligation to oppose the efforts of those who would attempt to monitor, challenge, change, or remove the materials of choice in our society. This handbook provides access to relevant resources for all librarians who may face a censorship challenge. Included are interpretations from the Library Bill of Rights, policies and procedures, examples of useful forms, and a list of library related organizations that may be contacted for further information.
For additional information, readers are encouraged to consult the latest edition of the American Library Association (ALA) Intellectual Freedom Manual, as well as manuals from other U.S. states\u27 library organizations. A companion to the ALA manual is available online at http://www.ifmanual.org/ . For current information about intellectual freedom issues in Nebraska, visit the NLA IF website.https://digitalcommons.unl.edu/zeabook/1044/thumbnail.jp
Nebraska Intellectual Freedom Manual
Much has changed in libraries and society since the publication of the 2004 revision of the Nebraska Library Association Intellectual Freedom Manual. The consensus of the current members of the Nebraska Library Association round table on Intellectual Freedom (NLA IF) was not to just revise the former manual, but to create an entirely new edition. In doing so, the authors have addressed a number of new issues. The intention was to keep it relatively brief but still useful. Readers should be able to read sections independent of one another for quick reference on topics of interest. For readers of the electronic version, there are many hyperlinks included.
Though this is a new edition, the introduction to the 2004 revision still applies: As librarians, we are all concerned with the concept of intellectual freedom. It is our professional obligation to provide varied forms of information that meet the varied interests and needs of our community members. It is also our professional obligation to oppose the efforts of those who would attempt to monitor, challenge, change, or remove the materials of choice in our society. This handbook provides access to relevant resources for all librarians who may face a censorship challenge. Included are interpretations from the Library Bill of Rights, policies and procedures, examples of useful forms, and a list of library related organizations that may be contacted for further information.
For additional information, readers are encouraged to consult the latest edition of the American Library Association (ALA) Intellectual Freedom Manual, as well as manuals from other U.S. states\u27 library organizations. A companion to the ALA manual is available online at http://www.ifmanual.org/ . For current information about intellectual freedom issues in Nebraska, visit the NLA IF website.https://digitalcommons.unl.edu/zeabook/1044/thumbnail.jp
Forecasting Random Walks under Drift Instability
This paper considers forecast averaging when the same model is used but estimation is carried out over different estimation windows. It develops theoretical results for random walks when their drift and/or volatility are subject to one or more structural breaks. It is shown that compared to using forecasts based on a single estimation window, averaging over estimation windows leads to a lower bias and to a lower root mean square forecast error for all but the smallest of breaks. Similar results are also obtained when observations are exponentially down-weighted, although in this case the performance of forecasts based on exponential down-weighting critically depends on the choice of the weighting coefficient. The forecasting techniques are applied to monthly inflation series of 21 OECD countries and it is found that average forecasting methods in general perform better than using forecasts based on a single estimation window
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing
molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images
Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images
of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL
maps are derived through computational staining using a convolutional neural network trained to
classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and
correlation with overall survival. TIL map structural patterns were grouped using standard
histopathological parameters. These patterns are enriched in particular T cell subpopulations
derived from molecular measures. TIL densities and spatial structure were differentially enriched
among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial
infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic
patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for
the TCGA image archives with insights into the tumor-immune microenvironment
US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report
This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in
Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference
Dark sectors 2016 Workshop: community report
This report, based on the Dark Sectors workshop at SLAC in April 2016,
summarizes the scientific importance of searches for dark sector dark matter
and forces at masses beneath the weak-scale, the status of this broad
international field, the important milestones motivating future exploration,
and promising experimental opportunities to reach these milestones over the
next 5-10 years
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