333 research outputs found
Loci for primary ciliary dyskinesia map to chromosome 16p12.1-12.2 and 15q13.1-15.1 in Faroe Islands and Israeli Druze genetic isolates
Quantum to Classical Transition in a Single-Ion Laser
Stimulated emission of photons from a large number of atoms into the mode of
a strong light field is the principle mechanism for lasing in "classical"
lasers. The onset of lasing is marked by a threshold which can be characterised
by a sharp increase in photon flux as a function of external pumping strength.
The same is not necessarily true for the fundamental building block of a laser:
a single trapped atom interacting with a single optical radiation mode. It has
been shown that such a "quantum" laser can exhibit thresholdless lasing in the
regime of strong coupling between atom and radiation field. However, although
theoretically predicted, a threshold at the single-atom level could not be
experimentally observed so far. Here, we demonstrate and characterise a
single-atom laser with and without threshold behaviour by changing the strength
of atom-light field coupling. We observe the establishment of a laser threshold
through the accumulation of photons in the optical mode even for a mean photon
number substantially lower than for the classical case. Furthermore,
self-quenching occurs for very strong external pumping and constitutes an
intrinsic limitation of single-atom lasers. Moreover, we find that the
statistical properties of the emitted light can be adjusted for weak external
pumping, from the quantum to the classical domain. Our observations mark an
important step towards fundamental understanding of laser operation in the
few-atom limit including systems based on semiconductor quantum dots or
molecules.Comment: 19 pages, 4 figures, 10 pages supplement, accepted by Nature Physic
Statistical challenges in the development and evaluation of marker-based clinical tests
Exciting new technologies for assessing markers in human specimens are now available to evaluate unprecedented types and numbers of variations in DNA, RNA, proteins, or biological structures such as chromosomes. These markers, whether viewed individually, or collectively as a 'signature', have the potential to be useful for disease risk assessment, screening, early detection, prognosis, therapy selection, and monitoring for therapy effectiveness or disease recurrence. Successful translation from basic research findings to clinically useful test requires basic, translational, and regulatory sciences and a collaborative effort among individuals with varied types of expertise including laboratory scientists, technology developers, clinicians, statisticians, and bioinformaticians. The focus of this commentary is the many statistical challenges in translational marker research, specifically in the development and validation of marker-based tests that have clinical utility for therapeutic decision-making
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Divided attention selectively impairs memory for self-relevant information
Information that is relevant to oneself tends to be remembered more than information that relates to other people, but the role of attention in eliciting this "self-reference effect" is unclear. In the present study, we assessed the importance of attention in self-referential encoding using an ownership paradigm, which required participants to encode items under conditions of imagined ownership by themselves or by another person. Previous work has established that this paradigm elicits a robust self-reference effect, with more "self-owned" items being remembered than "other-owned" items. Access to attentional resources was manipulated using divided-attention tasks at encoding. A significant self-reference effect emerged under full-attention conditions and was related to an increase in episodic recollection for self-owned items, but dividing attention eliminated this memory advantage. These findings are discussed in relation to the nature of self-referential cognition and the importance of attentional resources at encoding in the manifestation of the self-reference effect in memory
Effect of biased noise fluctuations on the output radiation of coherent beat laser
Effect of biased noise fluctuations on the degree of squeezing as well as the
intensity of a radiation generated by a one-photon coherent beat laser is
presented. It turns out that the radiation exhibits squeezing inside and
outside the cavity under certain conditions. The degree of squeezing is
enhanced by the biased noise input significantly in both regions. Despite the
presence of the biased environment modes outside the cavity, the degree of
squeezing outside the cavity can be greater than or equal to or even less than
the cavity radiation depending on the initial preparation of the atomic
superposition and amplitude of the external driving radiation. But the
intensity of the radiation is found to be lesser outside the cavity regardless
of these parameters.Comment: 18 pages, 7 figure
Wolbachia in the flesh: symbiont intensities in germ-line and somatic tissues challenge the conventional view of Wolbachia transmission routes
Symbionts can substantially affect the evolution and ecology of their hosts. The investigation of the tissue-specific distribution of symbionts (tissue tropism) can provide important insight into host-symbiont interactions. Among other things, it can help to discern the importance of specific transmission routes and potential phenotypic effects. The intracellular bacterial symbiont Wolbachia has been described as the greatest ever panzootic, due to the wide array of arthropods that it infects. Being primarily vertically transmitted, it is expected that the transmission of Wolbachia would be enhanced by focusing infection in the reproductive tissues. In social insect hosts, this tropism would logically extend to reproductive rather than sterile castes, since the latter constitute a dead-end for vertically transmission. Here, we show that Wolbachia are not focused on reproductive tissues of eusocial insects, and that non-reproductive tissues of queens and workers of the ant Acromyrmex echinatior, harbour substantial infections. In particular, the comparatively high intensities of Wolbachia in the haemolymph, fat body, and faeces, suggest potential for horizontal transmission via parasitoids and the faecal-oral route, or a role for Wolbachia modulating the immune response of this host. It may be that somatic tissues and castes are not the evolutionary dead-end for Wolbachia that is commonly thought
A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer’s disease using an indwelling CSF catheter
Stochastic population growth in spatially heterogeneous environments
Classical ecological theory predicts that environmental stochasticity
increases extinction risk by reducing the average per-capita growth rate of
populations. To understand the interactive effects of environmental
stochasticity, spatial heterogeneity, and dispersal on population growth, we
study the following model for population abundances in patches: the
conditional law of given is such that when is small the
conditional mean of is approximately , where and are the abundance and per
capita growth rate in the -th patch respectivly, and is the
dispersal rate from the -th to the -th patch, and the conditional
covariance of and is approximately . We show for such a spatially extended population that if
is the total population abundance, then ,
the vector of patch proportions, converges in law to a random vector
as , and the stochastic growth rate equals the space-time average per-capita growth rate
\sum_i\mu_i\E[Y_\infty^i] experienced by the population minus half of the
space-time average temporal variation \E[\sum_{i,j}\sigma_{ij}Y_\infty^i
Y_\infty^j] experienced by the population. We derive analytic results for the
law of , find which choice of the dispersal mechanism produces an
optimal stochastic growth rate for a freely dispersing population, and
investigate the effect on the stochastic growth rate of constraints on
dispersal rates. Our results provide fundamental insights into "ideal free"
movement in the face of uncertainty, the persistence of coupled sink
populations, the evolution of dispersal rates, and the single large or several
small (SLOSS) debate in conservation biology.Comment: 47 pages, 4 figure
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