Enhancing M Currents: A Way Out for Neuropathic Pain?

Almost three decades ago, the M current was identified and characterized in frog sympathetic neurons (Brown and Adams, 1980). The years following this discovery have seen a huge progress in the understanding of the function and the pharmacology of this current as well as on the structure of the underlying ion channels. Therapies for a number of syndromes involving abnormal levels of excitability in neurons are benefiting from research on M currents. At present, the potential of M current openers as analgesics for neuropathic pain is under discussion. Here we offer a critical view of existing data on the involvement of M currents in pain processing. We believe that enhancement of M currents at the site of injury may become a powerful strategy to alleviate pain in some peripheral neuropathies

A simple current control strategy for a four-leg indirect matrix converter

In this paper the experimental validation of a predictive current control strategy for a four-leg indirect matrix converter is presented. The four-leg indirect matrix converter can supply energy to an unbalanced three-phase load whilst providing a path for the zero sequence load. The predictive current control technique is based on the optimal selection among the valid switching states of the converter by evaluating a cost function, resulting in a simple approach without the necessity for modulators. Furthermore, zero dc-link current commutation is achieved by synchronizing the state changes in the input stage with the application of a zero voltage space vector in the inverter stage. Simulation results are presented and the strategy is experimentally validated using a laboratory prototype

Cloud media video encoding:review and challenges

In recent years, Internet traffic patterns have been changing. Most of the traffic demand by end users is multimedia, in particular, video streaming accounts for over 53%. This demand has led to improved network infrastructures and computing architectures to meet the challenges of delivering these multimedia services while maintaining an adequate quality of experience. Focusing on the preparation and adequacy of multimedia content for broadcasting, Cloud and Edge Computing infrastructures have been and will be crucial to offer high and ultra-high definition multimedia content in live, real-time, or video-on-demand scenarios. For these reasons, this review paper presents a detailed study of research papers related to encoding and transcoding techniques in cloud computing environments. It begins by discussing the evolution of streaming and the importance of the encoding process, with a focus on the latest streaming methods and codecs. Then, it examines the role of cloud systems in multimedia environments and provides details on the cloud infrastructure for media scenarios. After doing a systematic literature review, we have been able to find 49 valid papers that meet the requirements specified in the research questions. Each paper has been analyzed and classified according to several criteria, besides to inspect their relevance. To conclude this review, we have identified and elaborated on several challenges and open research issues associated with the development of video codecs optimized for diverse factors within both cloud and edge architectures. Additionally, we have discussed emerging challenges in designing new cloud/edge architectures aimed at more efficient delivery of media traffic. This involves investigating ways to improve the overall performance, reliability, and resource utilization of architectures that support the transmission of multimedia content over both cloud and edge computing environments ensuring a good quality of experience for the final user

Patent foramen ovale, deep venous thrombosis and stroke; a paradoxical embolism in an 80-year-old male

Background: A patent foramen ovale (PFO) is a congenital cardiac malformation describing a shunt in between the atrial walls. The overall incidence of a PFO is around 27.3% with a progressive decrease to 25.4% in the 4th and 8th decades. Once it has been established that a patient with an ischemic stroke/transient ischemic attack (TIA) has a PFO and other sources of the stroke have been ruled out, it is imperative to consider deep vein thrombosis (DVT) as the source of a paradoxical embolus. Case Presentation: 80-year-old gentleman with a history of right internal carotid occlusion of 80-90% status post right internal carotid endarterectomy. Presented to the emergency department (ED) for sudden left-sided weakness, left facial droop, slurred speech, and dizziness. Upon initial evaluation he was asymptomatic; NIH stroke score 1. Magnetic resonance imaging of the brain showed important watershed infarcts. Cerebral angiogram found 50% concentric stenosis of the right middle cerebral artery (MCA) with minimal lineal filling defect in the stenotic segment. The filling defect cleared after injection of intra-arterial integrillin. Post procedure, patient was started on heparin drip. Cardiology was consulted for suspected paroxysmal atrial fibrillation and a transesophageal echocardiogram (TEE). Two days after the post cerebral angiogram, the patient began to complain of severe right leg pain. He was noted to be tachycardic and hypoxemic. The venous doppler of the leg revealed a DVT and subsequent CT chest angiography revealed bilateral pulmonary embolism (PE). TEE results showed a positive agitative saline test with defect in the intra-atrial wall. The patient was on heparin drip and transitioned after 7 days to oral anticoagulation. Loop recorder was installed with possible PFO correction by cardiology in the outpatient. Patients\u27 symptoms improved and he was discharged to inpatient rehab. Conclusion: Although rare a paradoxical embolus should be considered in patients presenting with a stroke/TIA, PFO, and an unidentified source of embolus. Although this patient did have 50% occlusion of the R MCA, we cannot fully exclude a PFO-related stroke. The discovery of a DVT, and bilateral PEs supports the high suspicion for PFO-related stroke in the form of paradoxical embolus

PROCESOS DE DEFORESTACIÓN Y REDUCCIÓN DE DENSIDAD DEL ARBOLADO DEL PARQUE NACIONAL NEVADO DE TOLUCA

Históricamente las áreas naturales de alta montaña en México han sufrido de presión a sus recursos naturales provocados por diversos factores como la extracción de recursos maderables y las plagas y enfermedades. Los intentos de zonificación resultan muy generalistas y se hace imposible hacer una evaluación de las transiciones menores de 10 años, debido a que los procesos necesarios para su evaluación suponen una elevada inversión en tiempo para tener un producto detallado y funcional. Para el Parque Nacional Nevado de Toluca se elaboró un mapa de ocupación del suelo para 2009 con una imagen SPOT basado en la categorización Cetenal de uso de suelo y vegetación escala 1:50 000 para 1972 y se contrastó con la más reciente actualización para el año 2000 como referencia. Se realizó una sobreposición de los mapas de ocupación del suelo para los años 2000 y 2009 para hacer la interpretación interactiva por sectores de las transiciones en el periodo de estudio. Así se obtuvieron las áreas en donde se ha verificado deterioro en terrenos forestales. Las áreas con mayor dinámica negativa son los bosques de pino, por efectos de deforestación y de pérdida de densidad del arbolado. Se calculó una tasa general de 35 ha año-1, contra solo 3 ha año-1 de bosques recuperados. Se concluye que el área natural protegida está sujeta a intensos procesos de tala selectiva de manera ilegal o por saneamiento

Predictive current control with instantaneous reactive power minimization for a four-leg indirect matrix converter

This paper presents the experimental valida¬tion of a predictive current control strategy with minimiza¬tion of the instantaneous reactive input power for a Four-Leg Indirect Matrix Converter (4Leg-IMC). The topology includes an input matrix converter stage, which provides the dc voltage for a four-leg voltage source converter (VSC) output stage. The VSC’s fourth leg provides a path for the zero sequence load current. The control technique is based on a finite control set model predictive control (FCS-MPC) strategy, whereby the switching states for the input and out¬put converters are selected by evaluating a predictive cost function. This results in a simpler approach than that seen in other well-known modulation methods, such as three-dimensional space vector modulation (3D-SVM). Positive dc voltage, (a requirement for the safe operation of the IMC) and minimization of the instantaneous input reactive power are obtained, while maintaining good tracking of the load reference currents. Furthermore, soft switching is achieved by synchronizing the state changes in the input stage with the application of zero voltage space vectors in the inverter stage. The control strategy is experimentally verified using a laboratory prototype

Heat and Cooling Demand and Market Perspective

In order to fully understand the national potentials for cogeneration, it is essential to identify the existing and prospective demand of heat and cooling by sector. A study will be performed on a MS level to describe the demand of heat and cooling by different sectors (i.e. industrial, residential), demand types (different temperatures) and supply technologies. This work aims to analyze the current situation and future trends of heat and cooling demand in the EU, as well as, the use and availability of industrial. Within each sector the demand will be presented for different segments. The focus is to map the demand of heat and cooling on temperature intervals possible to be supplied by district heating, district cooling or CHP. In order to capture the characteristics of heat, heat is split into different types; space heating, warm water, cooking, and industrial heat. For cooling, space cooling is the main type applicable to district cooling.JRC.F.6-Energy systems evaluatio

HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin

<p>Abstract</p> <p>Background</p> <p>Chromatin binding plays a central role in the molecular mechanism of LEDGF/p75 in HIV-1 DNA integration. Conflicting results have been reported in regards to the relevance of the LEDGF/p75 chromatin binding element PWWP domain in its HIV-1 cofactor activity.</p> <p>Results</p> <p>Here we present evidence that re-expression of a LEDGF/p75 mutant lacking the PWWP domain (ΔPWWP) rescued HIV-1 infection in cells verified to express background levels of endogenous LEDGF/p75 that do not support efficient HIV-1 infection. The HIV-1 cofactor activity of LEDGF/p75 ΔPWWP was similar to that of LEDGF/p75 wild type (WT). A possible molecular explanation for the nonessential role of PWWP domain in the HIV-1 cofactor activity of LEDGF/p75 comes from the fact that coexpression of HIV-1 integrase significantly restored the impaired chromatin binding activity of LEDGF/p75 ΔPWWP. However, integrase failed to promote chromatin binding of a non-chromatin bound LEDGF/p75 mutant that lacks both the PWWP domain and the AT hook motifs (ΔPWWP/AT) and that exhibits negligible HIV-1 cofactor activity. The effect of integrase on the chromatin binding of LEDGF/p75 requires the direct interaction of these two proteins. An HIV-1 integrase mutant, unable to interact with LEDGF/p75, failed to enhance chromatin binding, whereas integrase wild type did not increase the chromatin binding strength of a LEDGF/p75 mutant lacking the integrase binding domain (ΔIBD).</p> <p>Conclusions</p> <p>Our data reveal that the PWWP domain of LEDGF/p75 is not essential for its HIV-1 cofactor activity, possibly due to an integrase-mediated increase of the chromatin binding strength of this LEDGF/p75 mutant.</p

Óptimos técnicos para la producción de leche y carne en el sistema bovino de doble propósito del trópico mexicano

Se presenta información útil y relevante en términos de economía y producción como herramienta para la toma de desicionesEl objetivo de este estudio fue estimar y analizar los resultados obtenidos de una función de producción de leche y carne en unidades de producción del sistema de doble propósito (DP). Los datos se obtuvieron a través de encuestas mensuales, donde se registró información de producción de leche, carne, ingresos y egresos económicos, durante 12 meses. Las funciones se estimaron por el método indirecto de regresión lineal con datos transformados para una función Cobb-Douglas. La función para leche mostró que los insumos alimento y vacas explican el 91 % de la producción, con coeficientes de elasticidad de 0.34 y 0.5, productos marginales de 0.75 y 892.2 con valores de $4.03 y$4,800.2 respectivamente. Los insumos utilizados para la producción de leche se encuentran en la etapa II de producción con rendimientos marginales decrecientes, mientras que para la producción de carne los insumos alimento y vacas explican el 72 % de la producción, con coeficientes de elasticidades de producción de -0.20 y 1.11 respectivamente; el alimento se ubicó en la etapa III de producción con rendimientos marginales negativos, y el insumo vacas se encontró en la etapa I con rendimientos marginales crecientes. La suma de los coeficientes de ambas funciones que fueron 0.92 y 0.91 por ser menores a uno, tienen rendimientos decrecientes a escala. El nivel óptimo técnico de producción fue de 488.97 L diarios y 10 becerros al año. Los insumos para producción de leche se están utilizando de forma racional, pero se debe evaluar la cantidad de alimento utilizada para producción de carne, ya que refleja que es sobre utilizado

Cooling Performance of Fresh and Aged Automatic Transmission Fluids for Hybrid Electric Vehicles

The cooling performance of automatic transmission fluids (ATFs) plays an important role in hybrid electrical vehicles, in which the electric motor (EM) is placed inside the transmission housing due to their mission of cooling the EM. The cooling performance of the ATFs depends on their thermophysical properties, but these properties change with the oxidation of the ATFs. This work studies the influence of the oxidation of three ATFs (A, B, C) on their thermophysical properties, as well as on some figures-of-merit (FOMs) which are relevant for evaluating the cooling performance. The results indicated that the influence of the molecular structure on thermal conductivity and heat capacity is stronger than on density and viscosity, whereas the molecular structure hardly affects the FOMs of the fresh ATFs; ATFs B and C, formulated with base oils from API Group III, indicated better cooling performance than ATF A which was formulated with base oils from API Group I; the sensitivity to temperature of the variation with oxidation of the studied properties, including the FOMs, was almost null, except for ATF A; therefore, FOMs should be used to compare the cooling performance of ATFs for electric drivetrains instead of a single property, such as thermal conductivity