148 research outputs found
Quantum non-Markovian behavior at the chaos border
In this work we study the non-Markovian behaviour of a qubit coupled to an
environment in which the corresponding classical dynamics change from
integrable to chaotic. We show that in the transition region, where the
dynamics has both regular islands and chaotic areas, the average non-Markovian
behaviour is enhanced to values even larger than in the regular regime. This
effect can be related to the non-Markovian behaviour as a function of the the
initial state of the environment, where maxima are attained at the regions
dividing separate areas in classical phase space, particularly at the borders
between chaotic and regular regions. Moreover, we show that the fluctuations of
the fidelity of the environment -- which determine the non-Markovianity measure
-- give a precise image of the classical phase portrait.Comment: 23 pages, 9 figures (JPA style). Closest to published versio
Hydrogen sulphide as a guard cell network regulator
Hydrogen sulphide (H2S) is an endogenously produced gasotransmitter that has rapidly emerged as an active signalling component of several plant processes, stomatal movement regulation among them. The guard cells (GCs), pairs of cells that neighbour the stomatal pores, transduce endogenous and environmental signals, through signalling network, to control stomatal pore size. In this complex network, which has become a model system for plant signalling, few highly connected components form a core that links most of the pathways. The evidence summarized in this insight, on the interplay between H2S and different key components of the GC networks, points towards H2S as a regulator of the GC core signalling pathway.Fil: Pantaleno, Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Scuffi, Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Garcia-Mata, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentin
Coprophagia in a patient with borderline personality disorder
Background and Objectives: Human coprophagia is a rare phenomenon
with severe medical and social consequences. So far, coprophagia has mainly been associated
with severe mental retardation, schizophrenia, dementia, and depression. We report a case
of coprophagia in a 30-year-old woman with Borderline Personality Disorder (DSM-IV).
This case report illustrates the severity of symptoms and maladaptive social consequences of
severe personality disorders, comparable to those of patients with schizophrenia. Pharmacological
interventions and, particularly intensive psychotherapy might be effective for patients
diagnosed with borderline personality disorder displaying severe behavior disorders.
The treatment of choice for coprophagia is aversive behavioral interventionThis study was funded in part by the National Alliance for Research on Schizophrenia
and Affective Disorders (NARSAD), Fondo de Investigación Sanitaria (FIS) [grant number
PI060092]; Fondo de Investigación Sanitaria FIS [grant number RD06/0011/0016]; ETES
[grant number PI07/90207]; the Conchita Rabago Foundation, the Harriet and Esteban
Vicente Foundation, the Spanish Ministry of Health, Instituto de Salud Carlos III, CIBERSAM (Intramural Project, P91B; Rio Hortega CM08/00170 –Dr. Hilario Blasco-Fontecilla), the Alicia Koplowitz foundation, and the National Institutes of Health, USA [grant number K24MH072712
Further Studies on the Physical and Biogeochemical Causes for Large Interannual Changes in the Patagonian Shelf Spring-Summer Phytoplankton Bloom Biomass
A very strong and persistent phytoplankton bloom was observed by ocean color satellites during September - December 2003 along the northern Patagonian shelf. The 2003 bloom had the highest extent and chlorophyll a (Chl-a) concentrations of the entire Sea-viewing Wide Field-of-view Sensor (SeaWiFS) period (1997 to present). SeaWiFS-derived Chl-a exceeded 20 mg/cu m in November at the bloom center. The bloom was most extensive in December when it spanned more than 300 km across the shelf and nearly 900 km north-south (35degS to 43degS). The northward reach and the deep penetration on the shelf of the 2003 bloom were quite anomalous when compared with other years, which showed the bloom more confined to the Patagonian shelf break (PSB). The PSB bloom is a conspicuous austral spring-summer feature detected by ocean color satellites and its timing can be explained using the Sverdrup critical depth theory. Based on high-resolution numerical simulations, in situ and remote sensing data, we provide some suggestions for the probable mechanisms responsible for that large interannual change of biomass as seen by ocean color satellites. Potential sources of macro and micro (e.g., Fe) nutrients that sustain the high phytoplankton productivity of the Patagonian shelf waters are identified, and the most likely physical processes that maintain the nutrient balance in the region are discussed
EL PROBLEMA DE TRANSPORTE POR EL CRITERIO DEL COSTO: SOLUCIÓN A TRAVÉS DE MATHCAD / TRANSPORTATION PROBLEM BY THE CRITERIA OF COST: SOLUTION THROUGH MATHCAD
Los métodos de Programación Lineal encuentran cada vez mayor atención en la economía, la tecnología, el ámbito militar y en otras aplicaciones. El crecimiento exponencial de las computadoras ha permitido un amplio desarrollo de esta especialidad matemática, dando solución a problemas que eran imposibles de resolver en décadas pasadas. Entre las aplicaciones de la Programación Lineal se destaca el denominado Problema de Transporte, que constituye el tema del presente artículo, mostrando destacados avances tecnológicos. Su objetivo radica en el diseño de un modelo matemático (basado en la programación lineal) el cual permite la distribución de un determinado producto (en nuestro caso arena para construcción) de forma óptima y con el mínimo costo
Exogenous Nitro-Oleic Acid Treatment Inhibits Primary Root Growth by Reducing the Mitosis in the Meristem in Arabidopsis thaliana
Nitric oxide (NO) is a second messenger that regulates a broad range of physiological processes in plants. NO-derived molecules called reactive nitrogen species (RNS) can react with unsaturated fatty acids generating nitrated fatty acids (NO2-FA). NO2-FA work as signaling molecules in mammals where production and targets have been described under different stress conditions. Recently, NO2-FAs were detected in plants, however their role(s) on plant physiological processes is still poorly known. Although in this work NO2-OA has not been detected in any Arabidopsis seedling tissue, here we show that exogenous application of nitro-oleic acid (NO2-OA) inhibits Arabidopsis primary root growth; this inhibition is not likely due to nitric oxide (NO) production or impaired auxin or cytokinin root responses. Deep analyses showed that roots incubated with NO2-OA had a lower cell number in the division area. Although this NO2-FA did not affect the hormonal signaling mechanisms maintaining the stem cell niche, plants incubated with NO2-OA showed a reduction of cell division in the meristematic area. Therefore, this work shows that the exogenous application of NO2-OA inhibits mitotic processes subsequently reducing primary root growth.Fil: Di Fino, Luciano Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Cerrudo, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Salvatore, Sonia Rosana. Univeristy of Pittsburgh. School of Medicine; Estados UnidosFil: Schopfer, Francisco Jose. University of Pittsburgh at Johnstown; Estados UnidosFil: Garcia-Mata, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Laxalt, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentin
Spatiotemporal variability of dissolved inorganic macronutrients along the northern Antarctic Peninsula (1996–2019)
The northern Antarctic Peninsula is a key region of the Southern Ocean due to its complex ocean dynamics, distinct water mass sources, and the climate-driven changes taking place in the region. Despite the importance of macronutrients in supporting strong biological carbon uptake and storage, little is known about their spatiotemporal variability along the northern Antarctic Peninsula. Hence, we explored for the first time a 24-year time series (1996–2019) in this region to understand the processes involved in the spatial and interannual variability of macronutrients. We found high macronutrient concentrations, even in surface waters and during strong phytoplankton blooms. Minimum concentrations of dissolved inorganic nitrogen (DIN; 16 μmol kg−1), phosphate (0.7 μmol kg−1), and silicic acid (40 μmol kg−1) in surface waters are higher than those recorded in surrounding regions. The main source of macronutrients is the intrusions of Circumpolar Deep Water and its modified variety, while local sources (organic matter remineralization, water mass mixing, and mesoscale structures) can enhance their spatiotemporal variability. However, we identified a depletion in silicic acid due to the influence of Dense Shelf Water from the Weddell Sea. Macronutrient concentrations show substantial interannual variability driven by the balance between the intrusions of modified Circumpolar Deep Water and advection of Dense Shelf Water, which is largely modulated by the Southern Annular Mode (SAM) and to some extent by El Niño-Southern Oscillation (ENSO). These findings are critical to improving our understanding of the natural variability of this Southern Ocean ecosystem and how it is responding to climate changes
A novel hydrographic gridded data set for the northern Antarctic Peninsula
The northern Antarctic Peninsula (NAP) is a highly dynamic transitional zone between the subpolarpolar and oceanic-coastal environments, and it is located in an area affected by intense climate change, including intensification and spatial shifts of the westerlies as well as atmospheric and oceanic warming. In the NAP area, the water masses originate mainly from the Bellingshausen and Weddell seas, which create a marked regional dichotomy thermohaline characteristic. Although the NAP area has relatively easy access when compared to other Southern Ocean environments, our understanding of the water masses distribution and the dynamical processes affecting the variability of the region is still limited. That limitation is closely linked to the sparse data coverage, as is commonly the case in most Southern Ocean environments. This work provides a novel seasonal three-dimensional high-resolution hydrographic gridded data set for the NAP (version 1), namely the NAPv1.0. Hydrographic measurements from 1990 to 2019 comprising data collected by conductivity, temperature, depth (CTD) casts; sensors from the Marine Mammals Exploring the Oceans Pole to Pole (MEOP) consortium; and Argo floats have been optimally interpolated to produce maps of in situ temperature, practical salinity, and dissolved oxygen at 10 km spatial resolution and 90 depth levels. The water masses and oceanographic features in this regional gridded product are more accurate than other climatologies and state estimate products currently available. The data sets are available in netCDF format at https://doi.org/10.5281/zenodo.4420006 (Dotto et al., 2021). The novel and comprehensive data sets presented here for the NAPv1.0 product are a valuable tool to be used in studies addressing climatological changes in the unique NAP region since they provide accurate initial conditions for ocean models and improve the end of the 20th-And early 21st-century ocean mean-state representation for that area
P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer
The GTPase Rac1 is a well-established master regulator of cell motility and invasiveness contributing to cancer metastasis. Dysregulation of the Rac1 signaling pathway, resulting in elevated motile and invasive potential, has been reported in multiple cancers. However, there are limited studies on the regulation of Rac1 in prostate cancer. Here, we demonstrate that aggressive androgen-independent prostate cancer cells display marked hyperactivation of Rac1.
This hyperactivation is independent of P-Rex1 activity or its direct activators, the PI3K product PIP3 and Gβγ subunits. Furthermore, we demonstrate that the motility and invasiveness of PC3 prostate cancer cells is independent of P-Rex1, supporting the analysis of publicly available datasets indicating no correlation between high P-Rex1 expression and cancer progression in patients. Rac1 hyperactivation was not related to the presence of activating Rac1 mutations and was insensitive to overexpression of a Rac-GAP or the silencing of specific Rac-GEFs expressed in prostate cancer cells. Interestingly, active Rac1 levels in these cells were markedly reduced by elevations in intracellular calcium or by serum stimulation, suggesting the presence of an alternative means of Rac1 regulation in prostate cancer that does not involve previously established paradigms.Centro de Investigaciones Inmunológicas Básicas y Aplicada
Hydrogen sulfide increases production of NADPH oxidase-dependent hydrogen peroxide and phospholipase D-derived phosphatidic acid in guard cell signaling
Hydrogen sulfide (H2S) is an important gaseous signaling molecule in plants that participates in stress responses and development. L-Cys desulfhydrase 1, one of the enzymatic sources of H2S in plants, participates in abscisic acid-induced stomatal closure. We combined pharmacological and genetic approaches to elucidate the involvement of H2S in stomatal closure and the interplay between H2S and other second messengers of the guard cell signaling network, such as hydrogen peroxide (H2O2) and phospholipase D (PLD)-derived phosphatidic acid in Arabidopsis (Arabidopsis thaliana). Both NADPH oxidase isoforms, respiratory burst oxidase homolog (RBOH)D and RBOHF, were required for H2S-induced stomatal closure. In vivo imaging using the cytosolic ratiometric fluorescent biosensor roGFP2-Orp1 revealed that H2S stimulates H2O2 production in Arabidopsis guard cells. Additionally, we observed an interplay between H2S and PLD activity in the regulation of reactive oxygen species production and stomatal movement. The PLDα1 and PLDδ isoforms were required for H2S-induced stomatal closure, and most of the H2S-dependent H2O2 production required the activity of PLDα1. Finally, we showed that H2S induced increases in the PLDδ-derived phosphatidic acid levels in guard cells. Our results revealed the involvement of H2S in the signaling network that controls stomatal closure, and suggest that H2S regulates NADPH oxidase and PLD activity in guard cells.Fil: Scuffi, Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina. Universidad Nacional de Mar del Plata; ArgentinaFil: Nietzel, Thomas. Westfalische Wilhelms Universitat; Alemania. Universitat Bonn; AlemaniaFil: Di Fino, Luciano Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina. Universidad Nacional de Mar del Plata; ArgentinaFil: Meyer, Andreas J.. Universitat Bonn; AlemaniaFil: Lamattina, Lorenzo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina. Universidad Nacional de Mar del Plata; ArgentinaFil: Schwarzlände, Markus. Westfalische Wilhelms Universitat; Alemania. Universitat Bonn; AlemaniaFil: Laxalt, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina. Universidad Nacional de Mar del Plata; ArgentinaFil: Garcia-Mata, Carlos. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentin
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