Academic climate and psychopathological symptomatology in Spanish medical students

© The Authors 2023. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Accepted version of a Published Work that appeared in final form in BMC Medical Education. To access the final edited and published work see https://doi.org/10.1186/s12909-023-04811-2Medical Education studies suggest that medical students experience depression, anxiety and psychopathological symptomatology in a proportion higher than in the rest of the population. In the present study, we aimed to conduct a nationwide analysis to describe student’s perceptions of Educational Climate in Spanish medical schools, and its relationship with psychopathological symptomatology.MethodsThe study was carried out in 2022 in all 44 medical schools in Spain, and analyses the academic climate, and psychopathological symptomatology among medical students (n = 4374). To measure these variables, we used the Dundee Ready Education Environment Measure (DREEM) for academic climate, and the SA-45 (Symptom Assessment-45 Questionnaire was used to assess psychopathological symptomatology.ResultsThe mean DREEM global score was low, 95.8 (SD 22.6). Worse perception of the academic climate has been found in females (t -2.21, p 0.027), in students of the clinical academic years (t 16.9, p < 0.001), and public medical schools ( t 15.6, p < 0.001).The SA45 general index score was high (p90) in 25.6% of participants. In respect of gender, female students presented higher levels of SA45 general index score, depression, interpersonal sensitivity, somatization, anxiety, obsession-compulsion, and phobic anxiety symptoms.Higher DREEM global and subscale scores corresponded to a higher SA-45 global index score and higher SA-45 subscale scores.ConclusionsOur study suggests a correlation between a poor perception of academic climate, increased depression, anxiety, and other psychopathological symptoms, with a pattern that varies between different faculties. The perception of academic climate varied between medical schools, as did the psychopathological symptoms scores. Our finding suggests the prevalence of these variables in medical students is, at least in part, attributable to factors directly related to the learning atmosphere

La ética y la sostenibilidad en comparación con un sistema de gestión de la calidad

El objetivo de este artículo es mostrar la funcionalidad, la sostenibilidad así como el sentido común y ética en comparación de la implantación de un sitema de gestión de la calidad dentro de la organización sea pública y/o privada. Mediante las definiciones de los términos de ética y sostenibilidad pretendemos aclarar el término así como también poder detectar los lazos de unión entre un sistema de gestión de la calidad y los términos sostenibilidad y ética. Un sistema de gestión de la calidad es un sitema vivo, que nos ofrece la sitemática para poder realizar un análisis y una descripción de todos los procesos que se realizan en la institución y/o empresa, así como una posterior sistematización y mejora de los mismos durante el paso del tiempo. Esta mejora de los procesos da lugar a un producto mejorado, dentro del término producto también se engloba la propiedad intelectual, así como lo establece un marco de trabajo con lo que se mejora el ambiente laboral. El sistema de gestión de la calidad nos confina en un marco de trabajo con unos objetivos definidos y cambiantes en el tiempo, así como un planteamiento de buenas intenciones, la política de calidad, que ofrece al empleado el rumbo marcado por la alta dirección, de la emprea y/o insticución. En la actualidad para mejorar la eficiencia en cualquier empresa y/o entidad pública es imprescindible seguir criterios marcados por los diferentes sistemas de gestión de calidad (ISO, OSHAS, AUDIT, etc.) para el cumplimiento acerca de una temática.Postprint (published version

Assessment of biowaste composting process for industrial support tool development through macro data approach

This study aims to assess composting efficiency and quality of compost through the study of the parameters of the Catalan Waste Agency (ARC) data-base by developing indicators useful for industrial sector. The study includes 17 composting plants for an 8-years period (2010–2017), the quantities of materials treated and generated in these plants: biowaste, yard trimmings, refuse and compost, as well as chemical characterization of compost: moisture, total organic matter, organic nitrogen, pH, electrical conductivity, self-heating test, pollutants and ammonium. Plant were sorted into 4 size classes depending on size capacity and into 4 technologies employed during thermophilic phasePostprint (updated version

Precise enhancement quantification in post-operative MRI as an indicator of residual tumor impact is associated with survival in patients with glioblastoma

Matemàtiques i informàtica; Neurologia; OncologiaMatemáticas e informática; Neurología; OncologíaMathematics and computing; Neurology; OncologyGlioblastoma is the most common primary brain tumor. Standard therapy consists of maximum safe resection combined with adjuvant radiochemotherapy followed by chemotherapy with temozolomide, however prognosis is extremely poor. Assessment of the residual tumor after surgery and patient stratification into prognostic groups (i.e., by tumor volume) is currently hindered by the subjective evaluation of residual enhancement in medical images (magnetic resonance imaging [MRI]). Furthermore, objective evidence defining the optimal time to acquire the images is lacking. We analyzed 144 patients with glioblastoma, objectively quantified the enhancing residual tumor through computational image analysis and assessed the correlation with survival. Pathological enhancement thickness on post-surgical MRI correlated with survival (hazard ratio: 1.98, p < 0.001). The prognostic value of several imaging and clinical variables was analyzed individually and combined (radiomics AUC 0.71, p = 0.07; combined AUC 0.72, p < 0.001). Residual enhancement thickness and radiomics complemented clinical data for prognosis stratification in patients with glioblastoma. Significant results were only obtained for scans performed between 24 and 72 h after surgery, raising the possibility of confounding non-tumor enhancement in very early post-surgery MRI. Regarding the extent of resection, and in agreement with recent studies, the association between the measured tumor remnant and survival supports maximal safe resection whenever possible.This work was supported by the Fundacio La Caixa. R.P.L is supported by a Prostate Cancer Foundation Young Investigator Award, CRIS Foundation Talent Award (TALENT-05), Fero Foundation, and the Spanish Ministry of Health FIS Program (Instituto de Salud Carlos III-Investigación en Salud PI18/01395). Mr Guillermo Villacampa Javierre kindly provided statistical advice for this manuscript

The impact of improper materials in biowaste on the quality of compost

Separate collection of biodegradable waste provides a better-quality raw material for the production of fertilisers than material obtained from the mechanical separation of municipal solid waste. Source-collected biowaste can be used for the production of compost, and its quality will depend on factors ranging from the presence of improper materials—inter alia, glass, and plastic—to the duration of the treatment process. This project was commissioned by the Catalan Waste Agency (ARC), and was developed by ENT Environment & Management and by the Barcelona School of Agricultural Engineering (ESAB) of the Universitat Politecnica de Catalunya (UPC). The authors would like to thank Noemí Iglesias Farran and Meri Pous Alo of the ARC for their support in the development of this project, and Raimon Rafols Florenciano for his support in the revision of this paper. This paper contributes to the project DECISIVE (DECentralIzed management Scheme for Innovative Valorization of urban biowastE), which received funding from the European Commission under EU’s Horizon 2020 researchand-innovation program (grant agreement number 68922).Postprint (updated version

Characterization of methicillin-resistant Staphylococcus aureus strains colonizing the nostrils of Spanish children

Objective: To characterize the Staphylococcus aureus strains colonizing healthy Spanish children. Methods: Between March and July 2018, 1876 Spanish children younger than 14 years attending primary healthcare centers were recruited from rural and urban areas. Staphylococcus aureus colonization of the anterior nostrils was analyzed. MecA and mecC genes, antibiotic susceptibility, and genotyping according to the spa were determined in all strains, and the following toxins were examined: Panton-Valentine leucocidin (pvl), toxic shock syndrome toxin (tst), and exfoliative toxins (eta, etb, etd). Multilocus sequence typing (MLST) and staphylococcal cassette chromosome (SCCmec) typing were performed on methicillin-resistant Staphylococcus aureus (MRSA) strains, as well as pulsed-field gel electrophoresis (PFGE). Results: 619 strains were isolated in 1876 children (33%), and 92% of them were sent for characterization to the Spanish National Centre of Microbiology (n = 572). Twenty (3.5%) of these strains were mecA-positive. Several spa types were detected among MRSA, being t002 the most frequently observed (30%), associating with SCCmec IVc. Among MSSA, 33% were positive for tst, while only 0.73% were positive for pvl. The 20 MRSA strains were negative for pvl, and 6 (30%) harbored the tst gene. Conclusions: methicillin-resistant Staphylococcus aureus nasal colonization in Spanish children is rare, with t002 being the most observed spa type, associated with SCCmec IVc. None of the MRSA strains produced pvl, but up to 30% of S. aureus strains were positive for tst.Sociedad Española Infectologia Pediatrica, Grant/Award Number: José María Corretger. Grant 2018; Spanish Association of Paediatric Primary Care, Grant/Award Number: Grant 2018; European Society for Paediatric Infectious Diseases, Grant/Award Number: Small Grant Award 2018; Instituto de Salud Carlos III, Grant/Award Number: PI18CIII/00372S

High spatial heterogeneity and low connectivity of bacterial communities along a Mediterranean subterranean estuary

Unidad de excelencia María de Maeztu CEX2019-000940-MSubterranean estuaries are biogeochemically active coastal sites resulting from the underground mixing of fresh aquifer groundwater and seawater. In these systems, microbial activity can largely transform the chemical elements that may reach the sea through submarine groundwater discharge (SGD), but little is known about the microorganisms thriving in these land-sea transition zones. We present the first spatially-resolved characterization of the bacterial assemblages along a coastal aquifer in the NW Mediterranean, considering the entire subsurface salinity gradient. Combining bulk heterotrophic activity measurements, flow cytometry, microscopy and 16S rRNA gene sequencing we find large variations in prokaryotic abundances, cell size, activity and diversity at both the horizontal and vertical scales that reflect the pronounced physicochemical gradients. The parts of the transect most influenced by freshwater were characterized by smaller cells and lower prokaryotic abundances and heterotrophic production, but some activity hotspots were found at deep low-oxygen saline groundwater sites enriched in nitrite and ammonium. Diverse, heterogeneous and highly endemic communities dominated by Proteobacteria, Patescibacteria, Desulfobacterota and Bacteroidota were observed throughout the aquifer, pointing to clearly differentiated prokaryotic niches across these transition zones and little microbial connectivity between groundwater and Mediterranean seawater habitats. Finally, experimental manipulations unveiled large increases in community heterotrophic activity driven by fast growth of some rare and site-specific groundwater Proteobacteria. Our results indicate that prokaryotic communities within subterranean estuaries are highly heterogeneous in terms of biomass, activity and diversity, suggesting that their role in transforming nutrients will also vary spatially within these terrestrial-marine transition zones

Staphylococcus aureus Nasal Colonization in Spanish Children. The COSACO Nationwide Surveillance Study

Objective: To assess the prevalence and risk factors for S. aureus and methicillin-resistant S. aureus (MRSA) nasal colonization in Spanish children. Methods: Cross-sectional study of patients <14 years from primary care centers all over Spain. Clinical data and nasal aspirates were collected from March to July 2018. Results: A total of 1876 patients were enrolled. Prevalence of S. aureus and MRSA colonization were 33% (95% CI 30.9-35.1) and 1.44% (95% CI 0.9-2), respectively. Thirty-three percent of the children (633/1876) presented chronic conditions, mainly atopic dermatitis, asthma and/or allergy (524/633). Factors associated with S. aureus colonization were age ≥5 years (OR 1.10, 95% CI 1.07-1.12), male sex (OR 1.43, 95% CI 1.17-1.76), urban setting (OR 1.46, 95% CI 1.08-1.97) and the presence of asthma, atopic dermatitis or allergies (OR 1.25; 95% CI: 1.093-1.43). Rural residence was the only factor associated with MRSA colonization (OR 3.62, 95% CI 1.57-8.36). MRSA was more frequently resistant than methicillin-susceptible S. aureus to ciprofloxacin [41.2% vs 2.6%; p<0.0001], clindamycin [26% vs 16.9%; p=0.39], and mupirocin [14.3% vs 6.7%; p=0.18]. None of the MRSA strains was resistant to tetracycline, fosfomycin, vancomycin or daptomycin. Conclusions: The main risk factors for S. aureus colonization in Spanish children are being above five years of age, male gender, atopic dermatitis, asthma or allergy, and residence in urban areas. MRSA colonization is low, but higher than in other European countries and is associated with rural settings.This study has been supported by The Spanish Ministry of Science and Innovation – Instituto de Salud Carlos III, and Fondos FEDER of the EU, Grant Nº PI18CIII/00372 [Fondo de Investigaciones Sanitarias-Spanish Health Research Fund (ISCIII)]; Grant Award “Jose María Corretger” from the Spanish Society for Pediatric Infectious Diseases; Grant Research Award from the Spanish Association of Pediatric Primary Care; and a Small Grant Award from the European Society for Pediatric Infectious Diseases.S

New Biochemical Insights into the Mechanisms of Pulmonary Arterial Hypertension in Humans

Diagnosis of pulmonary arterial hypertension (PAH) is difficult due to the lack of specific clinical symptoms and biomarkers, especially at early stages. We compared plasma metabolic fingerprints of PAH patients (n = 20) with matched healthy volunteers (n = 20) using, for the first time, untargeted multiplatform metabolomics approach consisting of high-performance liquid and gas chromatography coupled with mass spectrometry. Multivariate statistical analyses were performed to select metabolites that contribute most to groups' classification (21 from liquid in both ionization modes and 9 from gas chromatography-mass spectrometry). We found metabolites related to energy imbalance, such as glycolysis-derived metabolites, as well as metabolites involved in fatty acid, lipid and amino acid metabolism. We observed statistically significant changes in threitol and aminomalonic acid in PAH patients, which could provide new biochemical insights into the pathogenesis of the disease. The results were externally validated on independent case and control cohorts, confirming up to 16 metabolites as statistically significant in the validation study. Multiplatform metabolomics, followed by multivariate chemometric data analysis has a huge potential for explaining pathogenesis of PAH and for searching potential and new more specific and less invasive markers of the disease.This research was supported by the Polish National Science Center (2014/13/N/NZ7/04231), the Spanish Ministry of Economy and Competitiveness (MINECO) (SAF2014-58920R), by the Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III and co-funding by Fondo Europeo de Desarrollo Regional (FEDER) (PI14-01427), and by the quality-promoting subsidy from the Ministry of Science and Higher Education of Poland, Leading National Research Centre (KNOW programme 2012-2017). The CNIC is supported by the Spanish Ministry of Economy and Competitiveness and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.S

Previous fire occurrence, but not fire recurrence, modulates the effect of charcoal and ash on soil C and N dynamics in Pinus pinaster Aiton forests

Understanding the effects of fire history on soil processes is key to characterise their resistance and resilience under future fire events. Wildfires produce pyrogenic carbonaceous material (PCM) that is incorporated into the soil, playing a critical role in the global carbon (C) cycle, but its interactions with soil processes are poorly un derstood. We evaluated if the previous occurrence of wildfires modulates the dynamic of soil C and nitrogen (N) and microbial community by soil ester linked fatty acids, after a new simulated low-medium intensity fire. Soils with a different fire history (none, one, two or three fires) were heat-shocked and amended with charcoal and/or ash derived from Pinus pinaster. Soil C and N mineralization rates were measured under controlled condi tions, with burned soils showing lower values than unburned (without fire for more than sixty years). In general, no effects of fire recurrence were observed for any of the studied variables. Microbial biomass was lower in burned, with a clear dominance of Gram-positive bacteria in these soils. PCM amendments increased cumulative carbon dioxide (CO2) production only in previously burned soils, especially when ash was added. This contrasted response to PCM between burned and unburned soils in CO2 production could be related to the effect of the previous wildfire history on soil microorganisms. In burned soils some microorganisms might have been adapted to the resulting conditions after a new fire event. Burned soils showed a significant positive priming effect after PCM amendment, mainly ash, probably due to an increased pH and phosphorous availability. Our results reveal the role of different PCMs as drivers of C and N mineralization processes in burned soils when a new fire occurs. This is relevant for improving models that evaluate the net impact of fire in C cycling and to reduce uncertainties under future changing fire regimes scenarios