Process of construction of the guiding dimensions for interactive school projects: the basis in the spatial perception of students with visual impairments

O artigo trata da Percepção Espacial, investigada sob a ótica dos projetos escolares focados nos alunos com restrições visuais do Ensino Fundamental, tendo seus estudos iniciados no curso de Mestrado, culminando na conclusão da Tese de Doutoramento de uma das autoras. Demonstra parte do processo de construção do Sistema Norteador de Projetos Interativos, essencialmente, a estruturação das dimensões norteadoras de um dos seus elementos estruturadores basilares, a Percepção Espacial. Focada nos seus propósitos, a pesquisa foi concretizada, sob um processo sistêmico, em três etapas: Conceitualização, Estruturação e Legitimação, orientadas pelo Design de Interação e aplicação de técnicas de pesquisas, tais como, a Análise de Conteúdo e Análise do Conceito. As Dimensões fundamentadas na percepção multissensorial estão alinhadas à proposta dos Projetos Interativos Escolares, os quais possuem como produto, o espaço físico tratado como sistema de artefatos. A pesquisa observa a importância da Interação Espacial em projetos escolares, propondo resultados que favorecem aos leitores interessados no fenômeno tratado. Contempla pesquisadores e profissionais envolvidos no planejamento dos espaços físicos escolares, observando a PE como diretriz de projetos de escolas que buscam beneficiar à Inclusão Escolar, bem como, aqueles que desejem utilizar a orientação teórica e metodológica desta pesquisa para abordar outros contextos.El artículo trata de la percepción espacial, investigada desde la perspectiva de proyectos escolares centrados en estudiantes con restricciones visuales de la escuela primaria. Demuestra parte del construcción del Sistema interactivo de gestión de proyectos, esencialmente la estructuración de las dimensiones guía de uno de sus elementos básicos de estructuración, la Percepción espacial. Centrada en sus propósitos, la investigación se llevó a cabo, bajo un proceso sistémico, en tres etapas: conceptualización, estructuración y legitimación, guiada por el diseño de interacción y la aplicación de técnicas de investigación, como el análisis de contenido y el análisis conceptual. Las dimensiones basadas en la percepción multisensorial están alineadas con la propuesta de Proyectos Escolares Interactivos, que tienen como producto el espacio físico tratado como un sistema de artefactos. La investigación señala la importancia de la interacción espacial en los proyectos escolares, proponiendo resultados que favorezcan a los lectores interesados ​​en el fenómeno abordado. Contempla a investigadores y profesionales involucrados en la planificación de espacios físicos escolares, observando la educación física como una guía de proyectos escolares que buscan beneficiarse de la inclusión escolar, así como a aquellos que desean utilizar la orientación teórica y metodológica de esta investigación para abordar otros contextos.The theme of this article is the Spatial Perception, investigated from the perspective of school projects focused on students with visual impairment of Elementary School, whose studies started in the Mastercourse, culminating in the conclusion of a Doctoral Thesis of one of the authors. The objective is to demonstrate part of the process of construction of the Guide System of Interactive Projects, essentially thestructuring of the guiding dimensions of one of its basic structuring elements, Spatial Perception. Focused on its purposes, the research was carried out, under a systemic process, in three steps: Conceptualization,Structuring and Legitimation, guided by Interaction Design and application of research techniques, such as Content Analysis and Concept Analysis. The Guiding Dimensions, based on multisensory perception are aligned with the proposal of Interactive School Projects, which have as a product, the physical space treated as an Artifact System. The research notes the importance of Spatial Interaction in school projects, proposing results that favor readers interested in the subject and phenomenon addressed. It contemplates the researchers and professionals involved in the planning of school physical spaces, observing the SP as a guideline for school projects that seek to benefit School Inclusion..

Supplier Relationship Management: a review focused on Logistics and Production integration

Integrating information regarding planning, decisions and processes within a focal company and between companies is a primary challenge for many organizations. Both internal (among business functions) and external (between suppliers and customers) integration aim to maximize the value added to customers and to minimize the required efforts involved in integration. However, identifying which activities demand a higher level of integration among business functions and what the possible results are is not always easy to understand, both within the organization and among their relationships. The purpose of this paper is therefore to understand the integration between Logistics and Production in supplier relationship management (SRM) by performing a systematic literature review. A systematic literature review was conducted as a research method of this paper, followed by a critical analysis of the selected works in order to thoroughly identify how these functions participate in the main activities of the SRM process. As a result, it was realized that integrating Logistics and Production may contribute to supplier relationship management by sharing information on strategic supply specifications (time and sequence) and also by improving the flow of information/materials to meet quality, quantity, cost and time requirements for the customer

O ensino de Língua Portuguesa no contexto da cultura digital

Este artigo analisa as práticas educativas utilizadas por professoras de Língua Portuguesa, mais especificamente relacionadas sobre as práticas de multiletramentos, abrangendo a cultura digital nos processos educativos. A metodologia abrangeu revisão bibliográfica de estudos que tratam das perspectivas dos multiletramentos e da cultura digital. Como instrumento de coleta de dados, foram realizados cinco encontros virtuais, com quatro professoras de Língua Portuguesa, que atuam em redes públicas estaduais de ensino no estado de São Paulo, com o objetivo de realizar o processo de escuta de suas narrativas sobre suas experiências com multiletramentos. Os resultados apontaram que a escola, com base nessas escutas de relatos de professores, precisa reavaliar seus processos pedagógicos no ensino de Língua Portuguesa, incluindo suas novas demandas sociais, que interferem nas linguagens e, sobretudo, nas práticas educativas e sociais

Desarrollo de un sitio WEB de apoyo a la evaluacion de proyectos de inversion en frutales.

78 p.Este trabajo presenta el desarrollo de un Sitio Web de Apoyo a la evaluación privada de proyectos, basado en técnicas financieras y económicas de evaluación. El software permite la formulación de un proyecto de inversión, a través de un sistema de interacción Hombre- Máquina que busca satisfacer criterios de arquitectura de información. Las técnicas de evaluación financieras y económicas utilizadas en un proyecto específico son transparentes para el usuario.En este trabajo se aborda el problema de la evaluación de proyectos de fruta y de Viñas, en las cuales se podrán evaluar proyectos de plantación de Manzanas, Peras, Kiwis Frutales y Uva. El software está restringido a la clase de problemas de evaluación de inversiones en ese dominio

Molecular epidemiology of rabies virus isolated of herbivores from Brazilian Amazon

Amostras do vírus da raiva (n = 17) isoladas de bovinos (n = 11), equinos (n = 4) e bubalinos (n = 2) procedentes do Pará (n = 7), Tocantins (n = 6) e Rondônia (n = 4) foram submetidas à técnica de RT-PCR para amplificação parcial dos genes da Nucleoproteína (N) e Glicoproteína (G). As sequências nucleotídicas obtidas foram analisadas pelo método de reconstrução filogenética Neighbor-Joining com o modelo evolutivo Kimura 2-parâmetros. Todas as 17 amostras pertenceram ao cluster A, que se encontrou na linhagem associado com morcego hematófago Desmodus rotundus. A análise filogenética baseada nos genes N e G, sugere a presença de cinco sublinhagens (A1-A5) e sete sublinhagens (A1-A7), respectivamente. Quando se compara ambas as filogenias, as sublinhagens A1 até A3 mostram composição e distribuição geográfica concordante, já a diversidade observada na composição das sublinhagens restantes é atribuída ao uso de sequências de diferentes alinhamentos. A glicoproteína mostrou marcadores moleculares nas sublinhagens A2, A3, A4 e A7, o que fornece elementos para melhor compreensão da epidemiologia molecular da raiva das linhagens circulantes na Amazônia Brasileira.Rabies virus samples (n = 17) isolated from bovines (n = 11), equines (n = 4) and buffalo (n = 2) from Pará State (n = 7), Tocantins (n = 6) and Rondônia (n = 4) were submitted to RT-PCR in order to obtain partial sequences of nucleoprotein (N) and glycoprotein gene (G). Nucleotide sequences were analyzed using Neighbor-Joining model, Kimura 2-parameters evolutionary model. All the 17 samples analyzed were related to cluster A, lineage associated with the hematophagous bat Desmodus rotundus. The phylogenetic analysis based on the N and G genes, suggests the presence of five sub-lineages (A1-A5), while G gene showed seven sub-lineages (A1-A7). In both phylogenies, sublineages A1 to A3 exhibit a similar composition and geographic distribution. Diverse composition of remaining groups of N and G gene is attributable to different sequences used in the alignments for each genomic region. Glycoprotein amino acid sequence showed molecular markers in sub-lineages A2, A3, A4 and A7. This information provides a better comprehension of molecular epidemiology of rabies, starting with the knowledge of viral lineages circulating in the Brazilian Amazon

Molecular epidemiology of rabies virus isolated of herbivores from Brazilian Amazon

Rabies virus samples (n = 17) isolated from bovines (n = 11), equines (n = 4) and buffalo (n = 2) from Pará State (n = 7), Tocantins (n = 6) and Rondônia (n = 4) were submitted to RT-PCR in order to obtain partial sequences of nucleoprotein (N) and glycoprotein gene (G). Nucleotide sequences were analyzed using Neighbor-Joining model, Kimura 2-parameters evolutionary model. All the 17 samples analyzed were related to cluster A, lineage associated with the hematophagous bat Desmodus rotundus. The phylogenetic analysis based on the N and G genes, suggests the presence of five sub-lineages (A1-A5), while G gene showed seven sub-lineages (A1-A7). In both phylogenies, sublineages A1 to A3 exhibit a similar composition and geographic distribution. Diverse composition of remaining groups of N and G gene is attributable to different sequences used in the alignments for each genomic region. Glycoprotein amino acid sequence showed molecular markers in sub-lineages A2, A3, A4 and A7. This information provides a better comprehension of molecular epidemiology of rabies, starting with the knowledge of viral lineages circulating in the Brazilian Amazon

Social inequalities in care for the elderly with diabetes in Brazil

[Abstract] Objective: To measure the prevalence of various care services offered to the elderly with diabetes mellitus in Brazil, and to assess the social inequalities in these services. Methods: This cross-sectional, population-based study was carried out in 2013. The care services offered were evaluated in terms of the following eight indicators: recommendations to lower carbohydrates, to measure blood glucose, and to examine the feet; requests made for blood tests, for glycated hemoglobin tests, and for glycemic curve tests; and whether service users had had their eyes or feet examined in the previous year. We used the slope index of inequality and the concentration index to assess the inequalities among wealth quintiles. Results: A total of 1 685 elderly persons with diabetes were evaluated. Overall, 41.7% of them had had their eyes examined in the preceding year, 35.4% had had their feet examined in the preceding year, and 10.9% had been offered all eight of the care services. The largest absolute differences (in percentage points) between the first (poorest) and fifth (richest) wealth quintiles in terms of the care services that were offered to the users were for: a recommendation to measure blood glucose (25.8), a glycated hemoglobin test request (27.4), a glycemic curve test request (31.9), having the eyes examined in the preceding year (29.3), and having the feet examined in the preceding year (27.0). Conclusion: There were notable inequalities in the prevalences of the care services. In the future, measurement of blood glucose and examination of the feet should be emphasized, especially for elderly persons in a lower socioeconomic level.[Resumen] Objetivo: Medir la prevalencia de los diversos servicios de atención que se ofrecen a las personas mayores con diabetes mellitus en Brasil y evaluar las desigualdades sociales en dichos servicios. Métodos: Este estudio transversal y basado en la población se llevó a cabo en el 2013. Los servicios de atención que se ofrecen se evaluaron en cuanto a los siguientes ocho indicadores: recomendaciones para reducir los carbohidratos, medir la glucemia y revisarse los pies; solicitudes de análisis de sangre, pruebas de glucohemoglobina y pruebas de la curva de glucemia; y si a los usuarios de los servicios les habían examinado los ojos o los pies en el último año. Usamos el índice de pendiente de la desigualdad y el índice de concentración para evaluar las desigualdades entre los quintiles de riqueza. Resultados: Se evaluó en total a 1.685 personas mayores con diabetes. En términos generales, en el último año les habían examinado los ojos a 41,7% de ellos, en el último año les habían examinado los pies a 35,4% y les habían ofrecido los ocho servicios de atención a 10,9%. Las mayores diferencias absolutas en puntos porcentuales entre el primer quintil de riqueza (los más pobres) y el quinto (los más ricos) en cuanto a los servicios de atención ofrecidos a los usuarios se encontraron en la recomendación de medir la glucemia (25,8), la solicitud de pruebas de glucohemoglobina (27,4), la solicitud de pruebas de curvas de glucemia (31,9), el examen de los ojos en el último año (29,3) y el examen de los pies en el último año (27,0). Conclusiones: Hubo notables desigualdades en la prevalencia de los servicios de atención. En el futuro, debe hacerse énfasis en la medición de la glucemia y el examen de los pies, especialmente en las personas mayores de un nivel socioeconómico bajo.[Resumo] Objetivo: Medir a prevalência de vários serviços de atenção oferecidos a idosos portadores de diabetes mellitus no Brasil e avaliar desigualdades sociais nestes serviços. Métodos: Estudo transversal, de caráter populacional, realizado em 2013. Os serviços de atenção oferecidos foram avaliados quanto aos oito indicadores a seguir: recomendação de diminuir o consumo de carboidratos, medir a glicemia e examinar os pés; pedido de exames de sangue, hemoglobina glicada e curva glicêmica; e realização de exame dos olhos ou pés nos usuários do serviço durante o ano anterior. Foram utilizados o índice absoluto de desigualdade e o índice de concentração para avaliar as desigualdades entre quintis de renda. Resultados: Foram avaliados 1.685 idosos com diabetes. Destes, 41,7% haviam sido submetidos a exame dos olhos no ano anterior, 35,4% a exame dos pés, e a 10,9% haviam sido oferecidos todos os oito serviços de atenção. As maiores diferenças absolutas (em pontos percentuais) entre o primeiro (mais pobre) e quinto (mais rico) quintis de renda foram constatadas para os seguintes serviços de atenção: recomendação de medir a glicemia (25,8), pedido de exame de hemoglobina glicada (27,4), pedido de exame de curva glicêmica (31,9), exame de olhos no ano anterior (29,3) e exame dos pés no ano anterior (27,0). Conclusão: Foram constatadas desigualdades notáveis na prevalência dos serviços de atenção. Futuramente, deve-se dar ênfase à medição da glicemia e do exame dos pés, principalmente em idosos de nível socioeconômico mais baixo

Enhanced efficacy of endonuclease inhibitor baloxavir acid against orthobunyaviruses when used in combination with ribavirin

OBJECTIVES: Baloxavir acid is an endonuclease inhibitor approved for use against influenza. We evaluated whether this compound also targets the endonuclease domain of orthobunyaviruses and therefore could potentially be used against orthobunyavirus infections. METHODS: We performed a thermal shift assay and a fluorescence resonance energy transfer (FRET)-based nuclease monitoring assay using the La Crosse virus (LACV) endonuclease and baloxavir acid to prove their interaction and identify an inhibitory effect. Their interaction was further studied in a docking simulation using Glide SP. We show that baloxavir acid inhibits the viral replication of Bunyamwera virus (BUNV)-mCherry in vitro using high-content imaging and virus yield assay. Lastly, we investigated the use of baloxavir acid in combination with ribavirin in vitro by implementing the Zero Interaction Potency response surface model. RESULTS: We show that baloxavir acid augments LACV enzyme's melting temperature with ΔTm 9.5 ± 0.4°C and inhibited substrate cleavage with IC50 0.39 ± 0.03 μM. Moreover, our docking simulation suggests that baloxavir acid is able to establish an efficient binding with the LACV endonuclease. In the cell-based assay, we observed that baloxavir acid and ribavirin inhibited BUNV-mCherry with an EC50 of 0.7 ± 0.2 μM and 26.6 ± 8.9 μM, respectively. When used in combination, we found a maximum synergistic effect of 8.64. CONCLUSIONS: The influenza endonuclease inhibitor baloxavir acid is able to bind to and interfere with the endonuclease domain of orthobunyaviruses and yields a more potent antiviral effect than ribavirin against BUNV-mCherry. The combination of both compounds results in a more potent antiviral effect, suggesting that these molecules could potentially be combined to treat orthobunyavirus-infected patients.status: publishe

Metabolizable energy and oil intake in brown commercial layers

With the objective to establish the best metabolizable energy (ME) intake for layers, and the best dietary vegetable oil addition level to optimize egg production, an experiment was carried out with 432 30-week-old Hisex Brown layers. Birds were distributed into nine treatments with six replicates of eight birds each according to a 3 x 3 factorial arrangement, consisting of three daily metabolizable energy intake (280, 300 or 320 kcal/bird/day) and three oil levels (0.00; 0.75 and 1.50 g/bird/day). Daily feed intake was limited to 115, 110 and 105 g/bird in order to obtain the desired energy and oil intake in each treatment. The following parameters were evaluated: initial weight, final weight, body weight change, egg production, egg mass, feed conversion ratio per dozen eggs and per egg mass and energy conversion. There was no influence of the treatments on egg production (%) or egg mass (g/bird/day). Final weight and body weight change were significantly affected by increasing energy intake. Feed conversion ratio per egg mass, feed conversion ratio per dozen eggs and energy conversion significantly worsened as a function of the increase in daily energy intake. An energy intake of 280 kcal/bird/day with no addition of dietary oil does not affect layer performance