Los yesos del Mioceno superior de Campo Coy (Cordillera Bética oriental, España)

The Campo Coy basin contains an important evaporite succession, up to 350 meters thick of gypsum, including two gypsum units: lower and upper gypsum units. These are characterized by fine-grain laminated and selenitic primary gypsums and by nodular-laminated and meganodular secondary gypsums. The geochemical study based on sulfate isotope compositions (δ34S and δ18O) and strontium isotope ratios (87Sr/86Sr) point to the chemical recycling of Triassic marine evaporites. Isotope compositions (δ18O and δD) of the hydration water of gypsum point to continental waters for primary gypsum precipitation. These results are consistent with a shallow lacustrine environment for the Campo Coy gypsum deposit.La cuenca de Campo Coy registra una sucesión evaporítica de más de 350 metros de potencia de yeso, dividida en dos unidades de yesos: unidad inferior y unidad superior. Estas unidades están formadas por litofacies de yeso primario laminado y yeso selenítico junto con litofacies de yeso secundario laminado-nodular y meganodular. El estudio geoquímico de la composición isotópica del sulfato (δ34S y δ18O) y de la relación isotópica del estroncio (87Sr/86Sr) muestra valores indicativos del reciclaje de evaporitas marinas triásicas. Los valores isotópicos del agua de hidratación del yeso (δ18O y δD) indican aguas de origen continental para el yeso primario. Estos resultados reflejan un ambiente lacustre somero durante la formación del depósito evaporítico de Campo Coy.This study was supported by the projects CGL-2013-42689 and CGL2016-79458 of the Spanish Government

Adsorption of gallic acid, propyl gallate and polyphenols from Bryophyllum extracts on activated carbon

The adsorption of gallic acid (GA) and propyl gallate (PG) on activated carbon (AC) was studied as a function of the AC mass and temperature. Clean first order behavior was obtained for at least three half-lives and the equilibrium was reached after ∼4 h contact time. An increase in the temperature (T = 20–40 °C) increases their adsorption rate constant values (k1) by 2.5 fold but has a negligible effect on the amount of antioxidant adsorbed per mass of AC at equilibrium. We also analyzed the adsorption process of polyphenols from Bryophyllum extracts and ca 100% of the total amount of the polyphenols in the extract were adsorbed when using 7 mg of AC. Results can be explained on the basis of the Freundlich isotherm but do not fit the Langmuir model. Results suggest that the combination of emerging in vitro plant culture technologies with adsorption on activated carbon can be successfully employed to remove important amounts of bioactive compounds from plant extracts by employing effective, sustainable and environmental friendly proceduresXunta de Galicia | Ref. ED431D 2017/18Xunta de Galicia | Ref. ED431E 2018/07Ministerio de Educación, Cultura y Deporte | Ref. FPU15/04849Xunta de Galicia | Ref. POS-B/2016/01

Composición isotópica del sulfato de las evaporitas Messinienses de la cuenca del Piamonte (Italia)

The Piedmont basin (NW Italy) records a Messinian Salinity Crisis (MSC) succession including a selenite gypsum deposit assigned to the Primary Lower Gypsum (PLG, MSC stage 1). Strontium isotope ratios are in the range of the PLG deposits of the Mediterranean area. Sulfate isotope compositions of vertically oriented selenite gypsum beds, in the lower part of the succession, are similar to those reported in other PLG deposits. However, flattened branching selenite cones in the upper part show higher isotope compositions, mainly in δ34S values, suggesting intense BSR conditions, stronger than reported in other PLG deposits. We interpret this chemical shift during deposition of the upper part of the PLG as the result of increased marine restriction assisted by the marginal position of this basin in the Adriatic Gulf during the Apennine and Alpine upliftsLa cuenca del Piamonte (NW Italia) contiene una serie Messiniense que incluye una unidad de yeso selenítico atribuida al PLG (MSC estadio 1). La isotopía del estroncio confirma esta asignación. La isotopía del sulfato de los yesos seleníticos de desarrollo vertical de la parte inferior de la serie es comparable a la de otras series PLG del Mediterráneo. Sin embargo, los conos de desarrollo horizontal de la parte superior de la serie muestran composiciones isotópicas mayores, especialmente en δ34S, sugiriendo una intensa actividad bacteriana (BSR) no observada en otros depósitos PLG. Interpretamos esta diferencia como resultado de mayores condiciones de restricción marina de la cuenca del Piamonte debidas a la posición marginal de esta cuenca en el Golfo Adriático durante el levantamiento de los Apeninos y los Alpe

HDOT — An approach towards productive programming of hybrid applications

bulk synchronous parallel (BSP) communication model can hinder performance increases. This is due to the complexity to handle load imbalances, to reduce serialisation imposed by blocking communication patterns, to overlap communication with computation and, finally, to deal with increasing memory overheads. The MPI specification provides advanced features such as non-blocking calls or shared memory to mitigate some of these factors. However, applying these features efficiently usually requires significant changes on the application structure. Task parallel programming models are being developed as a means of mitigating the abovementioned issues but without requiring extensive changes on the application code. In this work, we present a methodology to develop hybrid applications based on tasks called hierarchical domain over-decomposition with tasking (HDOT). This methodology overcomes most of the issues found on MPI-only and traditional hybrid MPI+OpenMP applications. However, by emphasising the reuse of data partition schemes from process-level and applying them to task-level, it enables a natural coexistence between MPI and shared-memory programming models. The proposed methodology shows promising results in terms of programmability and performance measured on a set of applications.This work has been developed with the support of the European Union H2020 program through the INTERTWinE project (agreement number 671602); the Severo Ochoa Program awarded by the Spanish Government (SEV-2015-0493); the Generalitat de Catalunya (contract 2017-SGR-1414); and the Spanish Ministry of Science and Innovation (TIN2015-65316-P, Computaci on de Altas Prestaciones VII). The authors gratefully acknowledge Dr. Arnaud Mura, CNRS researcher at Institut PPRIME in France, for the numerical tool CREAMS. Finally, the manuscript has greatly bene ted from the precise comments of the reviewers.Peer ReviewedPostprint (author's final draft

Neurofuzzy logic predicts a fine-tuning metabolic reprogramming on elicited Bryophyllum PCSCs guided by salicylic acid

Novel approaches to the characterization of medicinal plants as biofactories have lately increased in the field of biotechnology. In this work, a multifaceted approach based on plant tissue culture, metabolomics, and machine learning was applied to decipher and further characterize the biosynthesis of phenolic compounds by eliciting cell suspension cultures from medicinal plants belonging to the Bryophyllum subgenus. The application of untargeted metabolomics provided a total of 460 phenolic compounds. The biosynthesis of 164 of them was significantly modulated by elicitation. The application of neurofuzzy logic as a machine learning tool allowed for deciphering the critical factors involved in the response to elicitation, predicting their influence and interactions on plant cell growth and the biosynthesis of several polyphenols subfamilies. The results indicate that salicylic acid plays a definitive genotype-dependent role in the elicitation of Bryophyllum cell cultures, while methyl jasmonate was revealed as a secondary factor. The knowledge provided by this approach opens a wide perspective on the research of medicinal plants and facilitates their biotechnological exploitation as biofactories in the food, cosmetic and pharmaceutical fields.Xunta de Galicia | Ref. ED431E 2018/07Xunta de Galicia | Ref. ED431D2017/1

Exploring the hydrochemical evolution of brines leading to sylvite precipitation in ancient evaporite basins.

Sylvite is a very common mineral in ancient evaporite deposits. Due to the absence of current deposits, the natural geochemical mechanism/s for synsedimentary sylvite precipitation and accumulation are not well understood. Numerous sylvite deposits or portions of them have been described as a result of diagenesis (i.e. Sergipe subbasin, Brasil). However, a number of deposits have been described as synsdimentary or being formed during primary evaporite deposition. It is the last group of deposits that can be studied to better understand the hydrochemical processes taking place in the brine at the onset of sylvite precipitation. The Salt IV sylvite beds from the Mulhouse potash basin, Alsace (France) have been described as synsedimentary in origin (LOWENSTEIN and SPENCER, 1990; CENDON et al., 2008). While sylvite in itself does not contain fluid inclusions viable for micro analysis, primary textures in neighboring halite are used as a proxy to understand brine evolution. Two halite-sylvite cycles from the B1 and B2 layers of the potash lower seam were selected. These exhibited clear primary halite crystal textures with sylvite adapting to an irregular halite sedimentary surface and finishing with a flat surface. The nine halite samples, selected at centimeter scale, provided close to 100 single fluid inclusion analyses, representing both the transition towards sylvite precipitation and the post sylvite precipitation. The fluid inclusion analyses revealed strong fluctuations in K concentration, well over the analytical error (<10%). These variations, in the same halite crystal, seem aligned in growth bands, with fluid inclusions within a certain growth band showing practically identical K concentrations, while neighboring bands exhibit a different concentration. Overall, the closer we are from a sylvite layer the higher K concentrations are. However, strong fluctuations continue when growth bands are compared. This pattern shows cycles of increasing K concentration along parallel growth bands with sharp falls followed by the initiation of a new increasing trend. The small “growth band” scale of the K concentration variations, suggests very sensitive processes within the brine with potential environmental changes (i.e. seasonal variations, day-night temperature fluctuations cycles) leading towards the final mass precipitation of a sylvite layer

Plant antioxidants in food emulsions

Addition of free radical scavenging antioxidants (AOs) is one of practical strategies controlling the oxidative stability in food emulsions. Attention has been directed toward AOs derived from natural plant extracts with the capacity to improve health and well-being due to lack of consumers’ trust toward synthetic antioxidant in food. Nevertheless, antioxidant efficiency varies widely from one compound to another and the most abundant AOs in our diet are not necessarily those that have the best availability profile at the reaction place with free radicals. In this book chapter, we will provide a state-of-the-art summary of the uses of plant AOs in colloidal systems, ranging from their main structural features to their benefits for the human health and their antioxidant role in controlling the oxidative stress and, particularly, the oxidation of lipid-based food emulsions.Xunta de Galicia | Ref. ED431D-2017/18Ministerio de Educación y Ciencia | Ref. CTQ2006-13969-BQUMinisterio de Educación, Cultura y Deporte | Ref. FPU15/04849Xunta de Galicia | Ref. POS-B/2016/01

Further insights in trichothiodistrophy: a clinical, microscopic, and ultrastructural study of 20 cases and literature review

Background: Trichothiodistrophy (TTD) is a rare autosomal recessive condition that is characterized by a specific congenital hair shaft dysplasia caused by deficiency of sulfur associated with a wide spectrum of multisystem abnormalities. In this article, we study clinical, microscopic, and ultrastructural findings of 20 patients with TTD with the aim to add further insights regarding to this rare condition. Additionally, analyses of our results are compared with those extracted from the literature in order to enhance its comprehensibility. Materials and Methods: Twenty cases of TTD were included: 7 from Mexico and 14 from Spain. Clinical, microscopic, scanning electron microscopy (SEM) studies and X-ray microanalysis (XrMa) were carried out in all of them. Genetic studies were performed in all seven Mexican cases. Patients with xeroderma pigmentosum and xeroderma pigmentosum/TTD-complex were excluded. Results: Cuticular changes and longitudinal crests of the hair shaft were demonstrated. These crests were irregular, disorganized, following the hair longest axis. Hair shaft sulfur deficiency was disposed discontinuously and intermittently rather than uniformly. This severe decrease of sulfur contents was located close to the trichoschisis areas. Only five patients did not show related disturbances. Micro-dolichocephaly was observed in five cases and represented the most frequent facial dysmorphism found. It is also remarkable that all patients with urologic malformations also combined diverse neurologic disorders. Moreover, three Mexican sisters demonstrated the coexistence of scarce pubic vellus hair, developmental delay, onychodystrophy, and maxillar/mandibullar hypoplasia. Conclusions: TTD phenotype has greatly varied from very subtle forms to severe alterations such as neurologic abnormalities, blindness, lamellar ichthyosis and gonadal malformations. Herein, a multisystem study should be performed mandatorily in patients diagnosed with TTD

Further insights in trichothiodistrophy: A clinical, microscopic, and ultrastructural study of 20 cases and literature review

Trichothiodistrophy (TTD) is a rare autosomal recessive condition that is characterized by a specific congenital hair shaft dysplasia caused by deficiency of sulfur associated with a wide spectrum of multisystem abnormalities. In this article, we study clinical, microscopic, and ultrastructural findings of 20 patients with TTD with the aim to add further insights regarding to this rare condition. Additionally, analyses of our results are compared with those extracted from the literature in order to enhance its comprehensibility. Materials and Methods: Twenty cases of TTD were included: 7 from Mexico and 14 from Spain. Clinical, microscopic, scanning electron microscopy (SEM) studies and X-ray microanalysis (XrMa) were carried out in all of them. Genetic studies were performed in all seven Mexican cases. Patients with xeroderma pigmentosum and xeroderma pigmentosum/TTD-complex were excluded. Results: Cuticular changes and longitudinal crests of the hair shaft were demonstrated. These crests were irregular, disorganized, following the hair longest axis. Hair shaft sulfur deficiency was disposed discontinuously and intermittently rather than uniformly. This severe decrease of sulfur contents was located close to the trichoschisis areas. Only five patients did not show related disturbances. Micro-dolichocephaly was observed in five cases and represented the most frequent facial dysmorphism found. It is also remarkable that all patients with urologic malformations also combined diverse neurologic disorders. Moreover, three Mexican sisters demonstrated the coexistence of scarce pubic vellus hair, developmental delay, onychodystrophy, and maxillar/mandibullar hypoplasia. Conclusions: TTD phenotype has greatly varied from very subtle forms to severe alterations such as neurologic abnormalities, blindness, lamellar ichthyosis and gonadal malformations. Herein, a multisystem study should be performed mandatorily in patients diagnosed with TTD