176 research outputs found

    Presentación. Literatura y cine o “el Cine Soñado”

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    Fotogenia literaria en Carreteras secundarias, de Ignacio Martínez de Pisón: un viaje de ida y vuelta

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    The cinema, his synthetic character, and the dialogue that it establishes from the origin with other arts as literature, has not stopped offering a wide space of synergies for the adaptation practice and for the study of confluence areas between image and word. New generations of writers and directors propiciate across their work an opening that, beside integrating the expressive resources of the literature and the screen, consider the text as a productive and plural activity, capable of being spread in a stereophony that postpones its meaning in every process of reading, making it coincide with a practice of writing and creation. Ignacio Martinez de Pisón's literature contains sugerent keys to advance in the dialogue between literature and cinema in current Spanish narrative.El cine, su carácter sintético, y el diálogo que desde el origen establece con otras artes como la literatura, no han dejado de ofrecer un espacio amplio de sinergias para la práctica adaptativa y para la reflexión acerca de los ámbitos de confluencia entre la imagen y la palabra. Las generaciones de escritores y de directores más jóvenes propician a través de su obra una apertura que, además de integrar los recursos expresivos de la literatura y la pantalla, considera al texto como una actividad productiva y plural capaz de diseminarse en una estereofonía que aplaza su significado en cada proceso de lectura haciéndolo coincidir con una práctica de escritura y de creación. La literatura de Martínez de Pisón contiene claves sugerentes para desentrañar este diálogo entre literatura y cine en la narrativa española actual

    Electrochemical sensing platform with gold nanoparticles capped by PDDA for benzyl alcohol determination

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    An electrochemical sensor has been developed, by modifying screen-printed carbon devices (SPCE) with photochemically synthesized gold nanoparticles (AuNP), to determine benzyl alcohol, a preservative widely used in the cosmetic industry. To obtain the AuNP with the best properties for electrochemical sensing applications, the photochemical synthesis was optimized using chemometric tools. A response surface methodology based on central composite design was used to optimize the synthesis conditions, as irradiation time, and the concentrations of metal precursor and the capping/reducing agent (poly(diallyldimethylammonium) chloride, PDDA). The anodic current of benzyl alcohol on SPCE modified with the AuNP was used as response of the system. The best electrochemical responses were obtained using the AuNP generated by irradiating for 18 min a 7.20 × 10−4 mol L−1 AuCl4−-1.7% PDDA solution. The AuNP were characterized by transmission electron microscopy, cyclic voltammetry and dynamic light scattering. The nanocomposite-based sensor formed by the optimal AuNP (AuNP@PDDA/SPCE) was used to determine benzyl alcohol by linear sweep voltammetry in 0.10 mol L−1 KOH. The anodic current at + 0.017 ± 0.003 V (vs. AgCl) was used as analytical signal. Detection limit obtained under these conditions was 2.8 µg mL−1. The AuNP@PDDA/SPCE was applied to determine benzyl alcohol in cosmetic samplesOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Natur

    A MWCNTs-COOH/PSS nanocomposite–modified screen-printed electrode for the determination of synthetic phenolic antioxidants by HPLC with amperometric detection

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    New sensing platforms based on screen-printed carbon electrodes modifed with composites based on polystyrene sulfonate and oxidized multi-walled carbon nanotubes (PSS/MWCNTs-COOH/SPCE) have been used to develop a novel HPLC method with electrochemical detection (ECD) for the determination of the most used synthetic phenolic antioxidants in cosmetics: butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), tert-butylhydroquinone (TBHQ) and propyl gallate (PG). Optimal separation conditions were achieved using methanol: 0.10 mol L−1 acetate solution at pH 6 as mobile phase with a gradient elution program from 60 to 90% of methanol percentage in 15 min. The electrochemical detection was carried out in amperometric mode using the PSS/MWCNTs-COOH/SPCE at+0.80 V vs. Ag. Under these optimal separation and detection conditions, the limits of detection (LOD) were between 0.11 and 0.25 mg L−1. These LOD values were better, especially for BHT, than those previously published in other HPLC methods. Linear ranges from 0.37 mg L−1, 0.83 mg L−1, 0.69 mg L−1 and 0.56 mg L−1 to 10 mg L−1 were obtained for PG, TBHQ, BHA and BHT, respectively. RSD values equal or lower than 5% and 8% were achieved for repeatability and reproducibility, respectively. The HPLC-ECD method was successfully applied to analyze diferent cosmetic samples. Recovery values within 83–109% were obtained in the validation studiesOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Natur

    Estudio de las rocas paleozoicas y los macizos graníticos que afloran en el Parc Natural de l'Alt Pirineu y zonas colindantes mediante datos geológicos, geofísicos y petrofísicos

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    The Parc Natural de l’Alt Pirineu is located between the La Maladeta and Andorra- Mount Louis granites. The characterization of the Parc’s geology at depth can help to know the emplacement mechanism of these granites, their relationships with the plutonic and volcanic rocks outcropping to the North and South of the Parc, respectively, and if all these rocks belong to the same magmatic system. To achieve these objectives, in the frame of the present research project, we have compiled and homogenezed previous gravimetric and magnetic data, and acquired new geophysical data, in particular, gravity data. We have also constructed new geological cross-sections oriented NE-SW from previous and new acquired geological data and characterized the petrophysical properties of the geological units in order to obtain the density and magnetic susceptibility of all different rocks outcropping in the study area. The geological cross-sections together with the petrophysical data will be used in the 2,5 and 3D gravimetric modelling to improve our understanding of the subsurface geology of this part of the Central Pyrenees and of the Parc Natural de l’Alt Pirineu.El Parc Natural de l’Alt Pirineu se encuentra en la zona situada entre el granito de La Maladeta y el granito de Andorra-Mount Louis. Conocer y entender la geología del subsuelo del Parc nos ayudará a saber cómo se produjo el emplazamiento de ambos macizos graníticos, su relación con las rocas plutónicas y volcánicas que afloran en la parte norte y sur del Parc, respectivamente, y si forman parte de un mismo sistema magmático. Para alcanzar estos objetivos, se está realizando una recopilación y homogeneización de datos gravimétricos y magnéticos ya existentes, así como la adquisición de nuevos datos geofísicos, en particular de gravimetría. Además, partiendo de estudios geológicos previos y datos propios, se está llevando a cabo la realización de cortes geológicos de dirección NE-SO y el estudio petrofísico de las unidades geológicas para obtener los valores de densidad y susceptibilidad magnética de todos los tipos de rocas que afloran en el área de estudio. Los cortes geológicos junto con los datos de petrofísica se utilizarán en la modelización gravimétrica 2,5D y 3D para mejorar la interpretación de la geología del subsuelo en este sector de II Jornades de Recerca del Parc Natural de l‘Alt Pirineu 87 los Pirineos Centrales y del Parc Natural de l’Alt Pirineu.Este trabajo se está llevando a cabo en el marco de los subproyectos CGL2017-84901-C2-1 y CGL2017-84901-C2-2-P del Ministerio de Ciencia, Innovación y Universidades. Los desarrollos metodológicos en exploración con técnicas geofísicas se encuentran alineados con el proyecto europeo 3DGeoEU- GeoERA (ERANET Cofund action 731166 [H2020], Project code GeoE.171.005). Los autores agradecen al Parc Natural de l’Alt Pirineu las facilidades prestadas y la organización de las jornadas de investigación para mostrar los trabajos realizados

    CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

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    Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research
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