Poder nobiliario y poder político en la Corte de Enrique IV (1454 - 1474)

Sin resume

Common allelic variants of the vitamin receptor D gene rs7975232 (Apai) do not influence bone mineral density figures in postmenopausal osteoporotic women

Este estudio examina la asociación entre la densidad mineral ósea (DMO) y el polimosfirmo rs7975232 (ApaI) del gen receptor de la vitamina D (VDR). El polimorfismo es detectado mediante un PCR en tiempo real por el método TaqMan. El genotipo rs7975232, se determinó en 274 fracturas osteoporóticas en mujeres españolas posmenopáusicas, con 60.53±8.02 años. Las frecuencias genotípicas observadas estaban de acuerdo con el equilibrio de Hardy-Weinberg (χ2=1.85, p=0.1736). No hubo diferencias significativas en el grupo genotipo rs7975232 de la muestra total de fracturas osteoporóticas por mujeres en edad, años después de la menopausia, la altura, el peso y la DMO en el cuello femoral, trochanter femoral y columna lumbar. Se encontraron diferencias significativas en la edad de la menarca (aa vs Aa; P=0,008) y el IMC (aa vs AA; P=0.029). Concluimos que el gen VDR del polimorfismo rs7975232 no está relacionado con las cifras de la densidad mineral ósea en fracturas osteoporóticas en mujeres españolas.This study examined the association between bone mineral density (BMD) and the rs7975232 (ApaI) poly¬morphism of the vitamin receptor D (VDR) gene. The polymorphism was detected using the real-time PCR TaqMan method. The rs7975232 genotype was determined in 274 postmenopausal osteoporotic Spanish women who were 60.53±8.02 years old. The observed genotype frequencies were in agreement with Hardy-Weinberg equilibrium (χ2=1.85, P=0.1736). There were no significant differences in the rs7975232 genotype groups in our total sample of osteoporotic women regarding age, years since menopause, height, weight, and BMD at femoral neck, femoral trochanter and lumbar spine. Significant differences were found in menarche age (aa vs Aa; P=0.008) and BMI (aa vs AA; P=0.029). We conclude that the VDR gene rs7975232 polymorphism is not related to figures of bone mineral density in postmenopausal osteoporotic Spanish women.peerReviewe

Lack of influence of vitamin D receptor bsmI (rs1544410) polymorphism on the rate of bone loss in a cohort of postmenopausal Spanish women affected by osteoporosis and followed for five years

Se ha realizado un estudio longitudinal para investigar la relación entre un polimorfismo en el gen receptor de la vitamina D (VDR) y los cambios en la densidad mineral ósea (DMO) y ultrasonido cuantitativo de las falanges (QUS) durante un período de cinco años. Los sujetos fueron 456 mujeres posmenopáusicas con osteoporosis en tratamiento, de edades comprendidas entre los 59,95±7,97 años (media ± desviación estándar [SD]) en la línea de base. Se midió la DMO en columna lumbar y la cadera mediante absorciometría de rayos X de doble energía y el QUS fue medido por medio de una velocidad que depende de la amplitud del sonido Ad SoS en las falanges. La información de estilo de vida se obtiene a través de un cuestionario. Las frecuencias de los genotipos BsmI (rs1544410) polimorfismo genético fueron 29,4%, 47,1% y 23,5%para bb, BB y BB, respectivamente. Después de cinco años, la DMO (variación anual en %/año) en el cuello femoral (FN) mostraron una modificación significativa sobre la base de la rs1544410 genotipo (BB vs Bb); hubo una disminución general de la masa ósea (0,70±2,79%/año; P = 0,025). Un análisis de covarianza con ajustes para la edad, peso, altura, porcentaje de cambio de peso por año, previsto la DMO y la ingesta de calcio mostraron que las asociaciones observadas ya no fueron significativas (P = 0,429). No se hallaron asociaciones significativas entre las mediciones QUS y el genotipo rs1544410 después del período de cinco años. Las limitaciones de nuestro estudio incluyen la falta de información sobre el tipo y la duración de la duración del tratamiento de la osteoporosis. Nuestros resultados indican que los polimorfismos rs1544410 no cuentan significativamente por los cambios en la masa ósea en mujeres españolas con osteoporosis en tratamiento.A longitudinal study was conducted to investigate the relation between a polymorphism in the vitamin D receptor (VDR) gene and changes in bone mineral density (BMD) and quantitative ultrasound of the phalanges (QUS) over a five-year period. The subjects were 456 postmenopausal women with steoporosis undergoing treatment, aged 59.95±7.97 years (mean ± standard deviation [SD]) at baseline. BMD was measured at the hips and lumbar spine by dual energy X-ray absorptiometry, and QUS was measured by means of amplitude-dependent speed of sound (Ad SoS) at the phalanges. Lifestyle information was obtained via a questionnaire. The genotype frequencies of the BsmI (rs1544410) gene polymorphism were 29.4%, 47.1%, and 23.5%for bb, Bb, and BB, respectively. After five years, BMD (annual change in %/year) at the femoral neck (FN) showed a significant modification based on the rs1544410 genotype (BB vs Bb); there was an overall decrease in bone mass (-0.70±2.79%/year; P = 0.025). An analysis of covariance with adjustments for age, weight, height, percentage of weight change per year, baseline BMD and calcium intake showed that the observed associations were no longer significant (P = 0.429). No significant associations were found between the QUS measurements and the rs1544410 genotype after the five-year period. Our study limitations includes lack of information about type and length of duration of the osteoporosis treatment. Our results indicate that rs1544410 polymorphisms do not account ignificantly for the changes in bone mass in Spanish women with osteoporosis undergoing treatment.peerReviewe

Lack of association of vitamin D receptor BsmI gene polymorphism with bone mineral density in Spanish postmenopausal women

La osteoporosis es un trastorno poligénico que está determinada por los efectos de varios genes, cada uno con efectos relativamente modestos en la masa ósea. El objetivo de este estudio es determinar si el receptor de la vitamina D, único nucleótido polimorfismo BsmI, está asociado con la densidad mineral ósea (DMO) de mujeres posmenopáusicas españolas. Un total de 210 mujeres posmenopáusicas sanas, mayores de 60 ± 8 años, fueron genotipificadas utilizando ensayos de genotipado SNP TaqMan® lumbar y la DMO femoral; y se determinó por la absorciometría de rayos X de energía dual (DEXA) la cantidad diaria de calcio y vitamina D. No se encontraron diferencias en el cuello femoral, trocánter, triángulo de salas, L2, L3, L4, L2-L4, o entre el cuello femoral y la DMO de cadera total tras el ajuste para posibles factores de confusión (P > 0,05) (edad, IMC, años después de la menopausia y la ingesta diaria de calcio). La BsmI polimorfismo en el gen VDR no se asoció con la DMO en mujeres posmenopáusicas españolas.Osteoporosis is a polygenic disorder that is determined by the effects of several genes, each with relatively modest effects on bone mass. The aim of this study was to determine whether the vitamin D receptor single nucleotide polymorphism BsmI is associated with bone mineral density (BMD) in Spanish postmenopausal women. A total of 210 unrelated healthy postmenopausal women aged 60 ± 8 years were genotyped using TaqManR SNP Genotyping Assays. Lumbar and femoral BMD were determined by dual-energy X-ray absorptiometry (DEXA). Daily calcium and vitamin D intake were determined by a food questionnaire. No differences were found in the femoral neck, trochanter, Ward’s Triangle, L2, L3, L4, L2-L4, or between the femoral neck and total hip BMD after further adjustment for potential confounding factors (P > 0.05) (age, BMI, years since menopause and daily calcium intake). The BsmI polymorphism in the VDR gene was not associated with BMD in Spanish postmenopausal women.peerReviewe

Design of linearly polarized parallel plate slot antennas

The authors propose a design method for calculating the position and length of the slots in a linearly polarized parallel plate slot antenna for 12 GHz. The beam is tilted 5” in order to improve the reflection coefficient and to reduce the grating lobes level. The antenna is filled with a dielectric of low constant, to reduce the total cost of the antenna. The feeding system is a resonant slotted waveguide placed at the bottom of the parallel plate

Devolución de IVA y su impacto social en personas con Discapacidad del Cantón Portoviejo, Año 2021-2022

This research study is carried out with the objective of analyzing the social impact of the return of Value Added Tax (VAT) on people with disabilities in the Portoviejo canton. Therefore, a scientific article is developed framed in a methodology of quantitative approach, descriptive type, with analytical method. Applying documentary review and survey as data collection technique, the latter to a sample of 109 individuals. Among the most important results, it stands out that the people with disabilities who are the subject of the study have a considerably high disability, which ranges between 50% and 75%. These allocate the resources obtained from the benefit of the VAT refund to mostly cover food expenses, it is important to mention that, before implementing this benefit as a right, the population under study could only cover their expenses. and meet their basic needs on some occasions. So, there is a positive social impact that generates the benefit of the VAT refund for people with disabilities in the Portoviejo canton. Therefore, it is recommended to the rest of the people who are among the country's priority groups, to seek the necessary advice to carry out the efficient execution of the request to obtain the benefit.  El presente estudio de investigación se lleva a cabo con el objetivo de analizar el impacto social de la devolución del Impuesto al Valor Agregado (IVA) en las personas con discapacidad del cantón Portoviejo. Se aplicó una metodología de enfoque cuantitativo, de tipo descriptivo, con método analítico; aplicando como técnica de recolección de datos, la revisión documental y la encuesta, esta última a una muestra de 109 beneficiarios. Entre los resultados más importantes se destaca que las personas con discapacidad que son sujeto de estudio, presentan una discapacidad considerablemente elevada, la cual oscila entre el 50% y 75%. Estas destinan los recursos obtenidos por concepto del beneficio de la devolución del IVA, a cubrir en su mayoría gastos de alimentación, siendo trascendente mencionar que, antes de hacer la ejecución de este beneficio como derecho, la población en estudio, solo podían cubrir sus gastos personales y solventar sus necesidades básicas en algunas ocasiones. Existe un impacto social positivo que genera el beneficio de la devolución del IVA en las personas con discapacidad del cantón Portoviejo. &nbsp

Promoting mental fitness in the context of active ageing policies: Comparative analysis of action programme objectives in eight countries.

In the context of an ageing European population there is increasing demand for policies and strategies aimed at maintaining or stimulating the cognitive abilities of older adults. Mental fitness programmes seek to maintain and promote the emotional and psychological wellbeing of older adults, enabling them to meet the demands of everyday life. Although many European countries have implemented programmes and services within a broad framework of active ageing, there are no standardised guidelines regarding how this should be done. In order to learn more about these programmes and services and provide useful information for decision making by policy makers we conducted a comparative study of the initiatives undertaken in eight different countries. Using qualitative content analysis we examined the stated objectives – in terms of attitudes, knowledge and abilities – of 116 programmes and services implemented across these countries. Overall, the results showed that ability objectives are much more common than are those focused on attitudes and knowledge. A more specific network analysis also provided information about how the sub-categories of each of the three kinds of objective are related to one another. The findings have practical implications for future planning of mental fitness programmes

Mating structure of the blue and red shrimp, Aristeus antennatus (Risso, 1816) characterized by relatedness analysis

Understanding life history variation and strategies is crucial for stock assessment and fisheries management due to the direct effects on population dynamics, effective population size, sex-ratios, levels of inbreeding, and relatedness among individuals. Aristeus antennatus (En ─ Blue and red shrimp; Fr ─ Crevette rouge; Sp ─ Gamba rosada) is one of the most exploited demersal resources in the Western Mediterranean Sea. However, information regarding the mating system and mate choice preferences remains largely unknown. Advances in molecular genetic markers and methods of inferring biological relationships among individuals have facilitated new insights into the reproductive dynamics of the species in the wild. Here, we used microsatellite markers to examine the A. antennatus mating system and putative mate choice preferences. Our results provided clear evidence of polyandry and polygyny. Relatedness analyses, together with FST and DAPC values showed females exhibited a mating bias towards unrelated males. Mating males were inferred from spermatophores and suggested males were sympatric with females and were also from other spawning grounds. Our findings provided the first description of the reproductive behavior of blue and red shrimpThis work was supported by a grant from Spanish Ministerio de Economia y Competitividad (CTM2014-54648-C2-2-R) to MIR. LP benefited from predoctoral fellowship from the Universitat de Girona (BR2014)S

Decontamination of dental implant surface in peri-implantitis treatment: a literature review

Etiological treatment of peri-implantitis aims to reduce the bacterial load within the peri-implant pocket and decontaminate the implant surface in order to promote osseointegration. The aim of this literature review was to evaluate the efficacy of different methods of implant surface decontamination. A search was conducted using the PubMed (Medline) database, which identified 36 articles including in vivo and in vitro studies, and reviews of different decontamination systems (chemical, mechanical, laser and photodynamic therapies). There is sufficient consensus that, for the treatment of peri-implant infections, the mechanical removal of biofilm from the implant surface should be supplemented by chemical decontamination with surgical access. However, more long-term research is needed to confirm this and to establish treatment protocols responding to different implant characterics

Cytotoxic effects of curcumin in osteosarcoma cells

Carta al editor de International Journal of Nanomedicine, en la que los autores puntualizan ciertos resultados de investigaciones de R. Chang et al.; y de D. K. Walters et al. en relación a sus aplicaciones para la curación de algunos cánceres y enfermedades óseas metabólicas.Letter to the editor of International Journal of Nanomedicine, in which the authors point out certain results of research by R. Chang et al.; and DK Walters et al. in relation to their applications for the cure of some cancers and metabolic bone diseases