Propiedades psicométricas del instrumento para la evaluación del Bullying (INSEBULL) en adolescentes de la Provincia de Huamanga 2020

La presente información tuvo como objetivo principal determinar las propiedades psicométricas del Instrumento para la Evaluación del Bullying (Insebull) en adolescentes de la ciudad de Huamanga, 2020. La metodología utilizada fue de tipo tecnológico por ello se orientará a los logros psicométricos y de diseño no experimental. La muestra seleccionada fue de 376 adolescentes, pertenecientes a una institución educativa de Ayacucho, a través de un tipo de muestreo estratificado. El instrumento utilizado fue El Instrumento para la Evaluación del Bullying (INSEBULL), que contiene 35 ítems y 8 dimensiones, estas son: Intimidación, Victimización, Red social, Solución Moral, Falta de integración social, Constatación del maltrato, Identificación participantes acoso escolar, Vulnerabilidad escolar ante el abuso

An Efficient Machine Learning Method to Identify Genetic Drivers of Avian Influenza Virus Adaptation to Humans

In this work we developed a method, based on a logistic regression model, to identify mutations subject to directional selection. We tested the model analyzing thousands of AIV (H5N1, H7N9) sequences from public datasets, to predict mutations facilitating the process of adaptation in host-switching. Additionally, the effect of predicted mutations in the viral fitness and viral infectivity of influenza mutant viruses was performed to validate the bioinformatics tools. We found mutations significantly associated with the emergence into humans in all AIV segments, being 238 and 62 mutations detected in H5N1 and H7N9, respectively. Most of them were located in the polymerase complex (PA, PB1 and PB2 genes). Interestingly, up to 18% of these mutations are known to be involved in AIV adaptive processes through host-switching. Related those influenza mutant viruses we reverted the candidate mutation driving human adaptation to avian state. Using reverse genetics, we introduced the mutations into human IAV (H3N2) backbone for each specific segment. We studied the infectivity of mutant viruses in ovo and in vitro at different times post infection compared to the wild-type virus. The results obtained in ovo showed that the most significant differences were observed in those viruses carrying the mutations in the PA, PB2, NP and PB1 segments. Regarding the in vitro study, we highlight that in the DF-1 cell line most of the mutant viruses reached higher titers at some point during the viral growth compared to the wild-type, enhancing viral growth in those mutant viruses with the mutations introduced in the viral polymerase and in the viral nucleoprotein. Consequently, the generated pipeline exhibits fastness and robustness in discerning manifestations of directional selection. Its application in AIV contexts suggests widespread adaptative trends in host-switching, thus exerting potential influence on all regions of the genome.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

First spectral emissivity study of a solar selective coating in the 150 to 600 C temperature range

A complete experimental study of temperature dependence of the total spectral emissivity has been performed, for the first time, for absorber reflector selective coatings used in concentrated solar power (CSP) systems for energy harvesting. The coating consist of double cermet layers of silicon oxide with different amounts of molybdenum over a silver infrared mirror layer. The experimental measurements were carried out by a high accurate radiometer (HAIRL) with controlled atmosphere in the mid-infrared and for temperatures between 150 and 600 C. The spectral emissivity is nearly constant in this temperature range. Therefore, the temperature dependence of the total emissivity is given by Planck function. These results were compared with those obtained with the usual calculus using room temperature reflectance spectrum. Finally, the performance of the coating was analyzed by comparison of coated respect to non-coated stainless steel.Comment: 6 pages, 10 figure

Impacts of a hydroinfiltrator rainwater harvesting system on soil moisture regime and groundwater distribution for olive groves in semi-arid Mediterranean regions

Dry periods in semi-arid regions constitute one of the greatest hazardous features that agriculture faces. This study investigates the effects of using a new device called ‘Hydroinfiltrator Rainwater Harvesting System (HRHS) on the water balance of soils. It was designed for arid and semi-arid zones affected by long periods of drought punctuated by heavy rainstorms. The new hydroinfiltrator consists of a net-like shell filled mainly with biochar. It is cylindrical in shape, is placed vertically and is half-buried in the soil around the crop tree to facilitate the infiltration of rainwater, irrigation or runoff water deep into the soil. The experimental plot is located in Baena (Córdoba, southern Spain) in an olive grove where the hydroinfiltrator was installed in 90 olive trees while 10 were left as a control group. In the xeric climate (bordering on arid), typical of the region, soils without a hydroinfiltrator have had a low infiltration rate, which reduces the effectiveness of precipitation and significantly increases the risk of water erosion. The effects of infiltration assisted by the device were analysed by simulating a torrential rain in which 600 L of water were passed through the hydroinfiltrator on an olive tree which had been installed 3 years previously. Geophysical methods (electrical resistivity tomography, ERT), direct analyses of soil samples, both in situ and in the laboratory, and theoretical flow models indicated a very significant increase in soil moisture (which nearly tripled in respect to the control group) because water was absorbed into the soil quickly, preventing runoff and water erosion. The soil moisture at 20 cm depth was 2.97 times higher with the HRHS than in the control plots. In addition, olive production increased by 211% and was higher in fat yield by 177%. Moreover, the resistivity profiles, taken by ERT showed that the water that entered the soil accumulated in the root zone of the olive tree, encouraged by the preferential pathways created by the roots and away from the surface, which prevented rapid evaporation during the high temperatures of spring and summer. Here we show for the first time that the use of the hydroinfiltrator rainwater harvesting system represents a significant improvement in the use of scarce water resources caused by climate change, providing agronomic and environmental benefits for rainfed, Mediterranean agricultural systems

Comorbidities in patients with Primary Sjögren's Syndrome and Systemic Lupus Erythematosus: A comparative registries-based study

OBJECTIVE: To compare the prevalence of the main comorbidities in 2 large cohorts of patients with primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), with a focus on cardiovascular (CV) diseases. METHODS: This was a cross-sectional multicenter study where the prevalence of more relevant comorbidities in 2 cohorts was compared. Patients under followup from SJOGRENSER (Spanish Rheumatology Society Registry of Primary SS) and RELESSER (Spanish Rheumatology Society Registry of SLE), and who fulfilled the 2002 American-European Consensus Group and 1997 American College of Rheumatology classification criteria, respectively, were included. A binomial logistic regression analysis was carried out to explore potential differences, making general adjustments for age, sex, and disease duration and specific adjustments for each variable, including CV risk factors and treatments, when appropriate. RESULTS: A total of 437 primary SS patients (95% female) and 2,926 SLE patients (89% female) were included. The mean age was 58.6 years (interquartile range [IQR] 50.0-69.9 years) for primary SS patients and 45.1 years (IQR 36.4-56.3 years) for SLE patients (P?<?0.001), and disease duration was 10.4 years (IQR 6.0-16.7 years) and 13.0 years (IQR 7.45-19.76 years), respectively (P?<?0.001). Smoking, dyslipidemia, and arterial hypertension were associated less frequently with primary SS (odds ratio [OR] 0.36 [95% confidence interval (95% CI) 0.28-0.48], 0.74 [95% CI 0.58-0.94], and 0.50 [95% CI 0.38-0.66], respectively) as were life-threatening CV events (i.e., stroke or myocardial infarction; OR 0.57 [95% CI 0.35-0.92]). Conversely, lymphoma was associated more frequently with primary SS (OR 4.41 [95% CI 1.35-14.43]). The prevalence of severe infection was lower in primary SS than in SLE (10.1% versus 16.9%; OR 0.54 [95% CI 0.39-0.76]; P?<?0.001). CONCLUSION: Primary SS patients have a consistently less serious CV comorbidity burden and a lower prevalence of severe infection than those with SLE. In contrast, their risk of lymphoma is greater

CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease

Huntington’s disease (HD) is a hereditary neurodegenerative disorder of the basal ganglia for which disease-modifying treatments are not yet available. Although gene-silencing therapies are currently being tested, further molecular mechanisms must be explored to identify druggable targets for HD. Cytoplasmic polyadenylation element binding proteins 1 to 4 (CPEB1 to CPEB4) are RNA binding proteins that repress or activate translation of CPE-containing transcripts by shortening or elongating their poly(A) tail. Here, we found increased CPEB1 and decreased CPEB4 protein in the striatum of patients and mouse models with HD. This correlated with a reprogramming of polyadenylation in 17.3% of the transcriptome, markedly affecting neurodegeneration-associated genes including PSEN1, MAPT, SNCA, LRRK2, PINK1, DJ1, SOD1, TARDBP, FUS, and HTT and suggesting a new molecular mechanism in neurodegenerative disease etiology. We found decreased protein content of top deadenylated transcripts, including striatal atrophy–linked genes not previously related to HD, such as KTN1 and the easily druggable SLC19A3 (the ThTr2 thiamine transporter). Mutations in SLC19A3 cause biotin-thiamine–responsive basal ganglia disease (BTBGD), a striatal disorder that can be treated with a combination of biotin and thiamine. Similar to patients with BTBGD, patients with HD demonstrated decreased thiamine in the cerebrospinal fluid. Furthermore, patients and mice with HD showed decreased striatal concentrations of thiamine pyrophosphate (TPP), the metabolically active form of thiamine. High-dose biotin and thiamine treatment prevented TPP deficiency in HD mice and attenuated the radiological, neuropathological, and motor HD-like phenotypes, revealing an easily implementable therapy that might benefit patients with HD

Effect of the Infiltrator Device on soil moisture in olive orchards of semi‐arid Mediterranean regions

En las regiones semiáridas, los períodos de sequía representan uno de los mayores desafíos para la agricultura. El Hidroinfiltrador o Dispositivo Infiltrador (DI) (Patente Española No. ES 2793448 A1) ayuda a reestablecer el equilibrio hídrico de los suelos. El DI tiene forma cilíndrica que permite su colocación vertical, enterrado parcialmente en el suelo alrededor de los árboles de cultivo, facilitando así la infiltración profunda de agua de lluvia, riego o escorrentía. Es especialmente útil en zonas áridas y semiáridas afectadas por largos períodos de sequía y fuertes tormentas. En una finca experimental de olivar ubicada en Baena (Córdoba), se instalaron 90 DI en olivos, dejando 10 árboles como control (sin DI). Los suelos de esta finca presentan una baja tasa de infiltración, lo cual reduce la eficacia de la precipitación y aumenta significativamente el riesgo de erosión hídrica. Para analizar los efectos del DI, se simuló una lluvia torrencial en la que se pasaron 600 litros de agua a través del DI instalado en un olivo 3 años antes del experimento. Mediante el método geofísico de Tomografía Eléctrica de Resistividad (ERT en sus siglas en inglés) y análisis directos de muestras de suelo tanto in situ como en laboratorio, se observó un considerable aumento de la humedad del suelo donde había DI. En comparación con los olivos control (sin DI), la humedad casi se triplicó gracias a la rápida penetración del agua en el suelo, evitando así la escorrentía y la erosión hídrica. Además, se registró un incremento del 211% en la producción de aceitunas y un aumento del 177% en el rendimiento graso. Los perfiles ERT mostraron que el agua que penetra en el suelo se acumula en la zona de raíces del olivo, alejada de la superficie, favorecida su distribución por las rutas preferentes creadas por las raíces. Esto evita una evaporación rápida durante las altas temperaturas de primavera y verano. En este estudio, se muestra cómo el uso del sistema de recolección de agua de lluvia con DI representa una mejora significativa en la gestión de los escasos recursos hídricos provocados por el cambio climático. Además, proporciona beneficios agronómicos y ambientales para los sistemas agrícolas mediterráneos de secano

Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis

Objective To assess organ damage, with emphasis on the cardiovascular system, over the different stages of the disease in a large SLE cohort.Methods Multicentre, longitudinal study of a cohort of 4219 patients with SLE enrolled in the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). We longitudinally analysed SDI (globally and for each domain) over time only in the 1274 patients whose dates of damage events had been recorded.Results During the first year after diagnosis of SLE, 20% of the 1274 patients presented with new damage manifestations. At years 2 and 3, new damage was recorded in 11% and 9% of patients. The annual percentage of patients with new damage after year 5 decreased to 5%. In the first year with the disease, most damage was accumulated in the musculoskeletal, neuropsychiatric and renal systems; in later stages, most damage was in the musculoskeletal, ocular and cardiovascular systems. Considering 'cerebrovascular accident' and 'claudication for 6 months' as cardiovascular items, the cardiovascular system was the second most affected system during the early stages of SLE, with 19% of the patients who presented with damage affected at first year after diagnosis. During the late stages, 20-25% of the patients presenting with new damage did so in this modified cardiovascular domain of the SDI.Conclusions New damage occurs mainly during the first year following diagnosis of SLE. Cardiovascular damage is relevant in both the early and the late stages of the disease. Strategies to prevent cardiovascular damage should be implemented early after diagnosis of SLE

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Voluntariado en Acción Catálogo de iniciativas de voluntariado Centros de Educación para el Desarrollo.

Este catálogo compila todas las iniciativas de voluntariado que enmarcan y orientan las acciones de más de dos mil voluntarios anuales que aportan con su tiempo y conocimiento al fortalecimiento de las comunidades, sus organizaciones sociales y comunitarias que trabajan decididamente para construir una mejor sociedad. Durante los últimos tres años hemos apostado por el fortalecimiento de esta estrategia generando nuevas modalidades, diversos escenarios para el desarrollo del voluntariado, capacitando a los 19 líderes y los voluntarios en las sedes, siempre bajo la profunda convicción de que el mundo se puede cambiar cuando mucha gente pequeña, en lugares pequeños, haciendo cosas pequeñas, logran tocar la vida de las personas que más lo necesitan