Leges Romanae on‐line: diseño colaborativo y multidisciplinar de recursos educativos en abierto

Fac. de DerechoFALSEsubmitte

Roma en Red: docencia transversal entre 3 disciplinas y aprendizaje colaborativo para la creación y difusión on-line de contenidos didácticos comunes

Depto. de Derecho Romano e Historia del DerechoFac. de DerechoFALSEsubmitte

Hispania Virtual: las leyes municipales romanas vistas desde tres disciplinas UCM

Depto. de Derecho Romano e Historia del DerechoFac. de DerechoFALSEsubmitte

Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities

Background Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark of biological aging, has been associated with worse COVID-19 outcomes. We sought to determine TL in patients with severe COVID-19 requiring hospitalization to analyze whether clinical outcomes and post-COVID-19 manifestations are associated with shorter TL. Results We analyzed 251 patients with PCR-confirmed COVID-19, hospitalized in the first months of the pandemics. We determined TL in PBL at admission by quantitative-PCR (qPCR) analysis in patients. A healthy cohort from the same area with a similar age range (n = 169) was used to calculate TL Z-scores. After hospital discharge, 144 COVID-19 survivors were followed-up for persistent COVID-19 manifestations. A second TL determination was performed in a smaller group of 63 patients 1 year later and compared with baseline TL. Hospitalized COVID-19 patients had a decreased baseline age-adjusted TL Z-score compared to the reference group. No differences in Z-scores were observed in patients with different COVID-19 outcomes, classified as WHO ordinal scores. In 144 patients, followed for a median of 8 months, post-COVID manifestations were not associated to differences in TL. Persistence of lung radiographic abnormalities was associated with shorter baseline TL. In patients with a second TL determination, further telomere shortening (TS) was observed in 35% and telomere lengthening in 49%. Patients with further TS had suffered a more severe disease. Conclusion Shorter TL is associated with COVID-19 hospitalization but not with hospital clinical outcomes nor with persistent post-COVID-19 manifestations. Delayed resolution of radiographic lung abnormalities was also associated with shorter TL.This work was supported by a research grant from FOREUM Foundation for Research in Rheumatology. Authors also received financial support from Fondo de Investigación Sanitaria, Instituto de Salud Carlos III (PI19/01129, COV20/00181, and RICOR RD21/0002) co-financed by the European Regional Development Fund (FEDER). MR.Peer reviewe

Roma antigua digital: Tres Facultades UCM en la colonia romana de Urso

Depto. de Derecho Romano e Historia del DerechoFac. de DerechoFALSEsubmitte

Servicio de Atención Psicológica en el Hospital Marina Baixa (SAPMB) durante la Pandemia Covid-19

El presente trabajo pretende mostrar la puesta en marcha del Servicio de Atención Psicológica en el Hospital Marina Baixa durante la pandemia COVID-19 (Villajoyosa, Alicante), así como detallar la intervención realizada con diferentes tipos de afectados. El servicio se crea fundamentado en el papel clave de la prevención primaria, resaltando el cuidado emocional de las personas y ofreciendo intervención en crisis. Se propusieron objetivos como prestar apoyo psicológico al personal interviniente en primera línea, a personas ingresadas afectadas por el virus y a sus familiares. Con el personal sanitario se llevaron a cabo intervenciones grupales de regulación emocional basadas en Mindfulness e intervenciones telefónicas/presenciales con aquellos que lo requirieron. Respecto a los pacientes, la intervención consistió en asistencia psicológica de manera presencial y telefónica a pacientes positivos ingresados y los familiares de éstos. Se registraron el número de usuarios atendidos en las diferentes formas de intervención, que se tuvo que ir adaptando a las necesidades detectadas en la población atendida y a la evolución de la pandemia. Los resultados muestran como, mediante la creación de este servicio, se cumplieron los objetivos marcadosThis paper develops the start-up of the Psychological Care Service at the Marina Baixa Hospital during the COVID-19 pandemic (Villajoyosa, Alicante, Spain), as well as detailing intervention carried out with different types of affected people. The implementation of the service is based on the key role of primary prevention, highlighting the emotional care of people, and offering intervention in crisis. Objectives were proposed such as providing psychological support to first-line personnel, as well as hospitalized persons affected by the virus and their families. Emotional regulation interventions based on Mindfulness and telephone or face to face intervention were carried out with healthcare personnel, as well as telephone and face to face intervention, in some cases that required it, of patient admitted to both ward and intensive care unit. Number of users served in different intervention formats was recorded, which had to be adapted to needs detected in population served and to pandemic evolution. Results show that by creating this service objectives set were met

Formación de los tutores de las prácticas externas como herramienta eficaz en la mejora del aprendizaje del estudiante y su inserción laboral

El objetivo del proyecto es mejorar la calidad de la tutorización de las prácticas externas y fomentar las buenas prácticas que garanticen el proceso de enseñanza-aprendizaje. Están implicados tutores académicos, externos, instituciones y estudiante

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]