IDEA Reinvisioned Charge

This documents details the purpose, accountabilities, and timeline for IDEA 2.0, a group of university library staff who focus on active interrogation of existing policies and practices. The group works to ensure that the library’s policies and practices do not reinforce existing inequitable power structures with an early focus on white supremacy culture, but not to the exclusion of other inequities such as patriarchy, ableism, and others. IDEA 2.0 acts as a guiding body to establish best practices and mechanisms of accountability

Simulação Termo-hidráulica de um Conjunto Combustível do Reator Nuclear AP1000

One of the challenges of future nuclear power is the development of safer and more efficient nuclear reactor designs. The AP1000 reactor based on the PWR concept of generation III + has several advantages, which can be summarized as: a modular construction, which facilitates its manufacture in series reducing the total construction time, simplification of the different systems, reduction of the initial capital investment and improvement of safety through the implementation of passive emergency systems. Being a novel design it is important to study the thermohydraulic behavior of the core applying the most modern tools. To determine the thermohydraulic behavior of a typical AP1000 fuel assembly, a computational model based on CFD was developed. A coupled neutronic-thermohydraulic calculation was performed, allowing to obtain the axial power distribution in the typical fuel assembly. The geometric model built used the certified dimensions for this type of installation that appear in the corresponding manuals. The thermohydraulic study used the CFD-based program ANSYS-CFX, considering an eighth of the fuel assembly. The neutronic calculation was performed with the program MCNPX version 2.6e. The work shows the results that illustrate the behavior of the temperature and the heat transfer in different zones of the fuel assembly. The results obtained agree with the data reported in the literature, which allowed the verification of the consistency of the developed model.Um dos desafios da futura energia nuclear é o desenvolvimento de projetos de reatores nucleares mais seguros e eficientes. O reator AP1000 baseado no conceito PWR de geração III + possui várias vantagens, que podem ser resumidas como: uma construção modular, que facilita sua fabricação em série reduzindo o tempo total de construção, simplificação dos diferentes sistemas, redução do investimento de capital inicial e melhoria da segurança através da implementação de sistemas passivos de emergência. Por ser um projeto inovador, é importante estudar o comportamento termo-hidráulico do núcleo aplicando as ferramentas mais modernas. Para determinar o comportamento termo-hidráulico de um conjunto típico de combustível do núcleo do reator AP 1000, foi desenvolvido um modelo computacional baseado em CFD. Foi realizado um cálculo nêutron-termo-hidráulico acoplado que permitiu obter a distribuição da potência axial no conjunto típico de combustível. O modelo geométrico construído utiliza as dimensões certificadas para este tipo de instalação que constam dos respectivos manuais. O estudo termo-hidráulico realizado utilizou o programa ANSYS-CFX baseado em CFD, e considerou um oitavo da montagem do combustível. O cálculo de nêutrons foi realizado com o programa MCNPX versão 2.6e. O trabalho mostra os resultados que ilustram o comportamento da temperatura e da transferência de calor nas diferentes zonas do conjunto combustível. Os resultados obtidos estão de acordo com os dados relatados na literatura, o que permitiu a verificação da consistência do modelo proposto

University Libraries Faculty Assembly Covid-19 Impact Statement

This University Libraries Faculty Assembly Covid-19 Impact Statement serves as documentation of changes that occurred across University Libraries and caused disparate, inequitable, impact to faculty throughout the pandemic, beginning in March 2020 and spanning into 2021. The document is necessarily limited in scope to assist faculty candidates in the tenure-track process and mitigate potential traumas as a result of the pandemic’s impact on that process. The structure of the tenure-track process is imperfect in nature, and this statement takes a trauma-informed, person-first, approach to investigating how to best support candidates in making their case for contract renewal, tenure, and/or promotion

The coordination chemistry of the neutral tris-2-pyridyl silicon ligand [PhSi(6-Me-2-py)3]

Producción CientíficaDifficulties in the preparation of neutral ligands of the type [RSi(2-py)3] (where 2-py is an unfunctionalised 2-pyridyl ring unit) have thwarted efforts to expand the coordination chemistry of ligands of this type. However, simply switching the pyridyl substituents to 6-methyl-pyridyl groups (6-Me-2-py) in the current paper has allowed smooth, high-yielding access to the [PhSi(6-Me-2-py)3] ligand (1), and the first exploration of its coordination chemistry with transition metals. The synthesis, single-crystal X-ray structures and solution dynamics of the new complexes [{PhSi(6-Me-2-py)3}CuCH3CN][PF6], [{PhSi(6-Me-2-py)3}CuCH3CN][CuCl2], [{PhSi(6-Me-2-py)3}FeCl2], [{PhSi(6-Me-2-py)3}Mo(CO)3] and [{PhSi(6-Me-2-py)3}CoCl2] are reported. The paramagnetic Fe2+ and Co2+ complexes show strongly shifted NMR resonances for the coordinated pyridyl units due to large Fermi-contact shifts. However, magnetic anisotropy also leads to considerable pseudo-contact shifts so that both contributions have to be included in the paramagnetic NMR analysis.The Leverhulme Trust (Grant for DSW and RG-R, postdoctoral funding for ALC, RGP-2017-146Ministerio de Economía, Industria y Competitividad - Agencia Estatal de Investigación (AEI)European Social Fund (ESF)Ramón y Cajal contract (RG-R, RYC-2015–19035

Evaluation of the New Lateral Flow Card MDmulticard® Basic Extended Phenotype in Routine Clinical Practice

Background: Transfusion emergencies and critical situations require specifically designed devices to simplify and optimize the standard procedures. In addition, matching antigens over and above ABO-Rh-K would be beneficial. Methods: Routine blood samples were collected in four immunohematology centers and tested with the new MDmulticard Basic Extended Phenotype for the simultaneous detection of the Duffy, Kidd, and Ss antigens, according to the principle of the lateral flow. Results were compared with those obtained using routine serology methods. Discrepancies were analyzed by molecular techniques/genotyping. Results: 310 samples were tested (167 donors; 75 patients; 28 subjects with positive direct antiglobulin test (DAT); 15 newborns; 25 previously transfused patients). The 285 samples with non-mixed-field reaction yielded 1,710 antigen results with 8 discrepancies (0.47%) six of which in DAT-positive subjects: three false-positive (Fy(a)) for MDmulticard, and two false-positive (Fy(a)) plus three false-negative (Fy(b)) for the reference methods (MDmulticard PPA for donors/patients/newborns: 99.82%; negative percent agreement: 100%; sensitivity: 100%; specificity: 99.39%, positive predictive value: 99.75%; negative predictive value: 100%). The MDmulticard detected mixed-field in 15 antigen reactions from 13 transfused patients, undetected by the comparative method, with the opposite result in 8 antigens (5 patients). Conclusion: The MDmulticard Basic Extended Phenotype met the criteria prescribed for the testing of donor, patient, DAT-positive, and newborn samples in transfusion laboratory routine

An experimental and theoretical study of the coordination and donor properties of tris-2-pyridyl-phosphine ligands

Producción CientíficaThe coordination characteristics and donor/acceptor properties of a series of 2-pyridyl substituted phosphine ligands have been investigated using structural, spectroscopic and DFT calculational studies. A range of different coordination modes are observed in Mo and W carbonyl complexes of tris-2-pyridyl-phosphine ligands of the type P(2-py’) (2-py’ = substituted or unsubstituted 2-pyridyl group), including an unprecedented example exhibiting N,N′,μ2-π coordination. DFT calculations were used to assess the relative donor/acceptor properties of a range of related 2-pyridyl-phosphine ligands with respect to PPh3 and PtBu3.Ministerio de Ciencia, Innovación y Universidades (PGC2018-096880-A-I00. AEI / FEDER, UE

Deprotonation, insertion and isomerisation in the post-functionalisation of tris-pyridyl aluminates

Producción CientíficaPost-functionalisation of the aluminate anion [EtAl(6-R-2-py)3]− (6-R-2-py = 6-R-2-pyridyl, R = Me or Br) can be accomplished via nucleophilic addition of the pyridyl groups to the electrophilic C[double bond, length as m-dash]O group of aldehydes (RCH[double bond, length as m-dash]O) or by deprotonation of carboxylic acids (RCO2H). NMR spectroscopic and crystallographic studies show how 6-Me-2-py groups can detect chirality and reveal a new aspect of isomerism.Ministerio de Economía, Industria y Competitividad - Agencia Estatal de Investigación - Fondo Social Europeo (Ramon y Cajal contract RG-R, RYC-2015-19035)

A Tris(3‐pyridyl)stannane as a Building Block for Heterobimetallic Coordination Polymers and Supramolecular Cages

Producción CientíficaThe systematic assembly of supramolecular arrangements is a persistent challenge in modern coordination chemistry, especially where further aspects of complexity are concerned, as in the case of large molecular mixed‐metal arrangements. One targeted approach to such heterometallic complexes is to engineer metal‐based donor ligands of the correct geometry to build 3D arrangements upon coordination to other metals. This simple idea has, however, only rarely been applied to main group metal‐based ligand systems. Here, we show that the new, bench‐stable tris(3‐pyridyl)stannane ligand PhSn(3‐Py)3 (3‐Py=3‐pyridyl) provides simple access to a range of heterometallic SnIV/transition metal complexes, and that the presence of weakly coordinating counter anions can be used to build discrete molecular arrangements involving anion encapsulation. This work therefore provides a building strategy in this area, which parallels that of supramolecular transition metal chemistry.Ministerio de Economía, Industria y Competitividad - Agencia Estatal de Investigación - Fondo Social Europeo (Ramon y Cajal contract RG‐R, RYC‐2015‐19035)Ministerio de Ciencia, Innovación y Universidades - Agencia Estatal de Investigación - FEDER - Unión Europea (project PGC2018‐096880‐A‐I00)

Immune Response in Gingival Disease: Role of Macrophage Migration Inhibitory Factor

The term periodontal disease encompasses a wide variety of chronic inflammatory conditions of the periodontium, including gingivitis and periodontitis. The gingival disease is an infectious process, which occurs due to the progression of untreated gingivitis. It is characterized by a destructive inflammatory process that affects the supporting tissues of the teeth, which causes the loss of the dental organs. As a result of inflammation, a wide range of cytokines and inflammatory mediators together contribute to tissue degradation and bone resorption. However, some molecules that have not been studied in the inflammatory process of this disease, such as the macrophage migration inhibitory factor (MIF) which is considered an important cytokine of the innate immune system; it is expressed constitutively in immune and nonimmune cells, and it is released immediately against bacterial stimuli, hypoxia, and proliferative signals. MIF has been described in some chronic degenerative, inflammatory, and autoimmune diseases. Previous studies have described that in murine models of periodontitis, MIF promotes the activation and differentiation of osteoclasts that could position this cytokine in the immunopathogenesis of gingival disease in humans