A planar integrated folded reflectarray antenna with circular polarization

This communication presents the complete design of a circularly polarized (CP) folded reflectarray (FRA) antenna with an integrated planar structure for the first time in the open literature. To achieve circularly polarized, a printed meander-line polarizer is designed and integrated with the linearly polarized (LP) FRA. To achieve a low-profile planar structure, an integrated 2×2 planar array is designed as the feed source instead of a horn. Thus, the whole antenna, including the feed source, LPFRA, and meander-line polarizer, can be fully integrated and fabricated using low-cost printed circuit board technology. To validate the concept, a right-handed CPFRA operating in C-band is designed, fabricated, and measured. The broadside axial ratio (AR) of the proposed CPFRA is lower than 1 dB over a bandwidth from 5.22 to 5.46 GHz. In addition, the maximum gain of 22.8 dBic is obtained at 5.38 GHz with the antenna efficiency of 27%. The antenna is promising for applications in satellite communication due to advantages of low profile, easy fabrication, low cost, and high gain

Practical Guide for Building Superconducting Quantum Devices

Quantum computing offers a powerful new paradigm of information processing that has the potential to transform a wide range of industries. In the pursuit of the tantalizing promises of a universal quantum computer, a multitude of new knowledge and expertise has been developed, enabling the construction of novel quantum algorithms as well as increasingly robust quantum hardware. In particular, we have witnessed rapid progress in the circuit quantum electrodynamics (cQED) technology, which has emerged as one of the most promising physical systems that is capable of addressing the key challenges in realizing full-stack quantum computing on a large scale. In this Tutorial, we present some of the most crucial building blocks developed by the cQED community in recent years and a précis of the latest achievements towards robust universal quantum computation. More importantly, we aim to provide a synoptic outline of the core techniques that underlie most cQED experiments and offer a practical guide for a novice experimentalist to design, construct, and characterize their first quantum device

Circularly polarized integrated filtering antenna with polarization reconfigurability

A new design of circularly polarized (CP) integrated filtering antennas with reconfigurable polarization is proposed in this paper. Two phase-reconfigurable coupled λ/2-resonator pairs have been used to feed the antenna and generate the 2nd-order filtering response and the circular polarization simultaneously. By switching the PIN diodes inserted in the feeding network, a phase difference of +90° or - 90° can be realized at the outputs of the feeding network. This renders the antenna’s capability of switching its polarization from right hand circular polarization (RHCP) to left hand circular polarization (LHCP) or vice versa. The use of the coupled-resonator pairs significantly improves the frequency selectivity and out-of-band rejection of the CP antenna. To the best of the authors’ knowledge, this is the first report of a multifunctional antenna which has integrated filtering performance, circular polarization and polarization reconfigurability. To verify the design concept, a reconfigurable CP antenna operating at 2.45 GHz is implemented. The simulated and measured results agree well with each other and show that the antenna has an impedance bandwidth of 4.5 %, an average in-band gain of 6.0 dBic (LHCP)/6.1 dBic (RHCP), out-of-band rejections of greater than 10.8 dB, and 3-dB AR bandwidth of 9.4 %/10.5 %

Definitive endoderm derived from human embryonic stem cells highly express the integrin receptors αV and β5

Human embryonic stem cells (hESCs) can be directed to differentiate into a number of endoderm cell types, however mature functional cells have yet to be produced in vitro. This suggests that there may be important factors that have yet to be described, which may be essential for the proper derivation of these cells. One such factor is the integrin mediated interactions between a cell and the extracellular matrix (ECM). On this basis, the present study investigated the role of the ECM in the directed differentiation of hESCs to definitive endoderm via analysis of integrin gene expression. The results showed that definitive endoderm can be efficiently and effectively derived from hESCs in a feeder free, single defined ECM of laminin. Analysis of integrin expression also showed that definitive endoderm highly express the integrins αV and β5, which have the ability to bind to vitronectin, whilst expression of the pluripotency related laminin binding integrins α3, α6 and β4 were downregulated. This suggested a potential role of vitronectin binding integrins in the development of definitive endoderm. © 2010 Landes Bioscience

Electrotunable liquid sulfur microdroplets.

Manipulating liquids with tunable shape and optical functionalities in real time is important for electroactive flow devices and optoelectronic devices, but remains a great challenge. Here, we demonstrate electrotunable liquid sulfur microdroplets in an electrochemical cell. We observe electrowetting and merging of sulfur droplets under different potentiostatic conditions, and successfully control these processes via selective design of sulfiphilic/sulfiphobic substrates. Moreover, we employ the electrowetting phenomena to create a microlens based on the liquid sulfur microdroplets and tune its characteristics in real time through changing the shape of the liquid microdroplets in a fast, repeatable, and controlled manner. These studies demonstrate a powerful in situ optical battery platform for unraveling the complex reaction mechanism of sulfur chemistries and for exploring the rich material properties of the liquid sulfur, which shed light on the applications of liquid sulfur droplets in devices such as microlenses, and potentially other electrotunable and optoelectronic devices

Monte Carlo integration in Glauber model analysis of reactions of halo nuclei

Reaction and elastic differential cross sections are calculated for light nuclei in the framework of the Glauber theory. The optical phase-shift function is evaluated by Monte Carlo integration. This enables us to use the most accurate wave functions and calculate the phase-shift functions without approximation. Examples of proton nucleus (e.g. p-$^6$He, p-$^6$Li) and nucleus-nucleus (e.g. $^6$He$-^{12}$C) scatterings illustrate the effectiveness of the method. This approach gives us a possibility of a more stringent analysis of the high-energy reactions of halo nuclei.Comment: 20 pages, 8 figure

Tightly Coupled Array Antennas for Ultra-Wideband Wireless Systems

Tightly coupled array (TCA) antenna has become a hot topic of research recently, due to its potential of enabling one single antenna array to operate over an extremely wide frequency range. Such an array antenna is promising for applications in numerous wideband/multi-band and multi-function wireless systems such as wideband high-resolution radars, 5G mobile communications, satellite communications, global navigation satellite systems, sensors, wireless power transmission, internet of things and so on. Many papers on this topic have been published by researchers internationally. This paper provides a detailed review of the recent development on TCA that utilizes the capacitive coupling. The basic principles and the historical evolution of the TCAs are introduced firstly. Then, recent development in the analysis and design of TCAs, such as equivalent circuit analysis, bandwidth limitation analysis, array elements, feed structures, substrates/superstrates loading, etc., are explained and discussed. The performances of the state-of-the-art TCAs are presented and a comparison amongst some TCAs reported recently is summarized and discussed. To illustrate the practical designs of TCA, one case study is provided, and the detailed design procedures of the TCA are explained so as to demonstrate the TCA design methodology. Simulated results including the VSWR at different angles of scanning, patterns and antenna gain are shown and discussed. A conclusion and future work are given in the end

Listening In on the Past: What Can Otolith δ18O Values Really Tell Us about the Environmental History of Fishes?

Oxygen isotope ratios from fish otoliths are used to discriminate marine stocks and reconstruct past climate, assuming that variations in otolith δ18O values closely reflect differences in temperature history of fish when accounting for salinity induced variability in water δ18O. To investigate this, we exploited the environmental and migratory data gathered from a decade using archival tags to study the behaviour of adult plaice (Pleuronectes platessa L.) in the North Sea. Based on the tag-derived monthly distributions of the fish and corresponding temperature and salinity estimates modelled across three consecutive years, we first predicted annual otolith δ18O values for three geographically discrete offshore sub-stocks, using three alternative plausible scenarios for otolith growth. Comparison of predicted vs. measured annual δ18O values demonstrated >96% correct prediction of sub-stock membership, irrespective of the otolith growth scenario. Pronounced inter-stock differences in δ18O values, notably in summer, provide a robust marker for reconstructing broad-scale plaice distribution in the North Sea. However, although largely congruent, measured and predicted annual δ18O values of did not fully match. Small, but consistent, offsets were also observed between individual high-resolution otolith δ18O values measured during tag recording time and corresponding δ18O predictions using concomitant tag-recorded temperatures and location-specific salinity estimates. The nature of the shifts differed among sub-stocks, suggesting specific vital effects linked to variation in physiological response to temperature. Therefore, although otolith δ18O in free-ranging fish largely reflects environmental temperature and salinity, we counsel prudence when interpreting otolith δ18O data for stock discrimination or temperature reconstruction until the mechanisms underpinning otolith δ18O signature acquisition, and associated variation, are clarified

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.

Cross-talk among oncogenic signaling and metabolic pathways may create opportunities for new therapeutic strategies in cancer. Here we show that although acute inhibition of EGFR-driven glucose metabolism induces only minimal cell death, it lowers the apoptotic threshold in a subset of patient-derived glioblastoma (GBM) cells. Mechanistic studies revealed that after attenuated glucose consumption, Bcl-xL blocks cytoplasmic p53 from triggering intrinsic apoptosis. Consequently, targeting of EGFR-driven glucose metabolism in combination with pharmacological stabilization of p53 with the brain-penetrant small molecule idasanutlin resulted in synthetic lethality in orthotopic glioblastoma xenograft models. Notably, neither the degree of EGFR-signaling inhibition nor genetic analysis of EGFR was sufficient to predict sensitivity to this therapeutic combination. However, detection of rapid inhibitory effects on [18F]fluorodeoxyglucose uptake, assessed through noninvasive positron emission tomography, was an effective predictive biomarker of response in vivo. Together, these studies identify a crucial link among oncogene signaling, glucose metabolism, and cytoplasmic p53, which may potentially be exploited for combination therapy in GBM and possibly other malignancies