Six-fermion production and Higgs boson physics at future e+e−e^+ e^- colliders

The six-fermion production processes $e^+e^-\to q\bar q l^+ l^-\nu\bar\nu$, with all the lepton flavours and $q=u,d,c,s$, relevant to the study of the intermediate-mass Higgs boson at future $e^+e^-$ linear colliders, are analysed. A Monte Carlo program, taking into account the whole set of tree-level scattering amplitudes and the relevant radiative effects, is developed to provide integrated cross sections and generation of unweighted events. The complete calculation is compared with the available results of real Higgs production, and the opportunities of precision studies with event generation are discussed, demonstrating the relevance of a full six-fermion calculation. Numerical results for integrated cross sections with various kinematical cuts and including radiative effects are given and commented. In the analysis of event samples, several distributions are studied and found to be sensitive to the presence and to the properties of the Higgs boson.Comment: LaTeX, 27 pages, 13 figures included. Minor changes, final version to appear in Eur. Phys. J.

The anomaly-free quantization of two-dimensional relativistic string. I

An anomaly-free quantum theory of a relativistic string is constructed in two-dimensional space-time. The states of the string are found to be similar to the states of a massless chiral quantum particle. This result is obtained by generalizing the concept of an ``operator'' in quantum field theory.Comment: LaTeX, 19 pages, no figure

At risk policy and early intervention programmes for underperforming students: Ensuring success?

Purpose - The purpose of this paper is to examine a University's at risk program and ask is the intervention strategy working? The program seeks to assist at risk students who may be experiencing difficulties transitioning, for example from school into university. The program also seeks to identify problems and suggest remediation strategies before attrition

Input-output modeling of the economic impact of a farming innovation organisation on a regional economy - a top-down versus hybrid approach

This thesis involves construction of input-output models measuring the economic impact of a farming innovation organisation (The Birchip Cropping Group) on the Victorian regional economy of Buloke Shire. The input-output modeling undertaken is of two forms; the first being a simple naïve top-down model, and the second a more sophisticated hybrid model. The naïve top-down model is based on input-output coefficients drawn from the Australian national input-output tables, and is regarded as naïve because these input-output coefficients are not adjusted to take account of local economic factors. The hybrid model uses the same national input-output coefficients as a base, and then modifies these coefficients to better reflect industrial conditions in the Shire using a location quotients-adjustment technique, as well as using original survey data collected from entities operating in B uloke Shire. One of the aims of the thesis is to determine whether the simpler naïve top-down approach produces results consistent with the theoretically more accurate hybrid methodology, and thus whether the naïve top-down approach represents a reliable method of conducting regional economic impact analysis. That is, can such studies be undertaken accurately using a naïve top down approach, or is it necessary to adopt the more resource intensive methodology of a hybrid model. The results of the analysis suggest construction of a hybrid model is advisable, as generally the naïve top-down approach produces over-estimates of the economic effects of the Birchip Cropping Group. That is, it appears the economic impact multipliers estimated with the naïve top-down model are too large, suggesting the time and effort involved in constructing the hybrid model was worthwhile. Using the hybrid model, the conclusion is that the Birchip Cropping Group has a significant affect on the regional economy of Buloke Shire, with the economic impact being estimated at close to $600,000 in additional output,$61,000 in additional income, and 3.5 additional jobs per year

Hybrid Refining Approach of PrOnto Ontology

This paper presents a refinement of PrOnto ontology using a validation test based on legal experts’ annotation of privacy policies combined with an Open Knowledge Extraction (OKE) algorithm. To ensure robustness of the results while preserving an interdisciplinary approach, the integration of legal and technical knowledge has been carried out as follows. The set of privacy policies was first analysed by the legal experts to discover legal concepts and map the text into PrOnto. The mapping was then provided to computer scientists to perform the OKE analysis. Results were validated by the legal experts, who provided feedbacks and refinements (i.e. new classes and modules) of the ontology according to MeLOn methodology. Three iterations were performed on a set of (development) policies, and a final test using a new set of privacy policies. The results are 75,43% of detection of concepts in the policy texts and an increase of roughly 33% in the accuracy gain on the test set, using the new refined version of PrOnto enriched with SKOS-XL lexicon terms and definitions

Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in MGUS and MM. In an age where the therapy of neoplastic monoclonal gammopathies largely relies on drugs capable of acting on the immune system (immunomodulants, immunological checkpoint inhibitors, CAR-T), detailed knowledge of the the differences existing in benign and neoplastic forms of gammopathy is the main foundation for the adequate and optimal use of new drugs

Experiments on real-life emotions challenge Ekman's model

Ekman's emotions (1992) are defined as universal basic emotions. Over the years, alternative models have emerged (e.g. Greene and Haidt 2002; Barrett 2017) describing emotions as social and linguistic constructions. The variety of models existing today raises the question of whether the abstraction provided by such models is sufficient as a descriptive/predictive tool for representing real-life emotional situations. Our study presents a social inquiry to test whether traditional models are sufficient to capture the complexity of daily life emotions, reported in a textual context. The intent of the study is to establish the human-subject agreement rate in an annotated corpus based on Ekman's theory (Entity-Level Tweets Emotional Analysis) and the human-subject agreement rate when using Ekman's emotions to annotate sentences that don't respect the Ekman's model (The Dictionary of Obscure Sorrows). Furthermore, we investigated how much alexithymia can influence the human ability to detect and categorise emotions. On a total sample of 114 subjects, our results show low within subjects agreement rates for both datasets, particularly for subjects with low levels of alexithymia; low levels of agreement with the original annotations; frequent use of emotions based on Ekman model, particularly negative one, in people with high levels of alexithymia

Interactions Between Spermine-Derivatized Tentacle Porphyrins And The Human Telomeric DNA G-Quadruplex

G-rich DNA sequences have the potential to fold into non-canonical G-Quadruplex (GQ) structures implicated in aging and human diseases, notably cancers. Because stabilization of GQs at telomeres and oncogene promoters may prevent cancer, there is an interest in developing small molecules that selectively target GQs. Herein, we investigate the interactions of meso-tetrakis-(4-carboxysperminephenyl)porphyrin (TCPPSpm4) and its Zn(II) derivative (ZnTCPPSpm4) with human telomeric DNA (Tel22) via UV-Vis, circular dichroism (CD), and fluorescence spectroscopies, resonance light scattering (RLS), and fluorescence resonance energy transfer (FRET) assays. UV-Vis titrations reveal binding constants of 4.7 × 10⁶ and 1.4 × 10⁷ M⁻¹ and binding stoichiometry of 2–4:1 and 10–12:1 for TCPPSpm4 and ZnTCPPSpm4, respectively. High stoichiometry is supported by the Job plot data, CD titrations, and RLS data. FRET melting indicates that TCPPSpm4 stabilizes Tel22 by 36 ± 2 °C at 7.5 eq., and that ZnTCPPSpm4 stabilizes Tel22 by 33 ± 2 °C at ~20 eq.; at least 8 eq. of ZnTCPPSpm4 are required to achieve significant stabilization of Tel22, in agreement with its high binding stoichiometry. FRET competition studies show that both porphyrins are mildly selective for human telomeric GQ vs duplex DNA. Spectroscopic studies, combined, point to end-stacking and porphyrin self-association as major binding modes. This work advances our understanding of ligand interactions with GQ DNA