An entrepreneurial theorising of the recycling industry.

The research interest for this study began with a general observation of the lack of theory-practice integration between the academic context of recycling and entrepreneurship set against the growth in the recycling industry. The research thus began by asking, how well does entrepreneurship explain the recycling industry? This research focuses on the recycling entrepreneurs entrepreneurial experiences and their relationships with their social context. Twenty-five recycling entrepreneurs were interviewed in-depth using unstructured interviews as the primary data collection method. Inductive analysis has been applied to these data on multiple levels. Firstly, a context (structure) level analysis identified a green culture and structure arising from social demands pertaining to environmental concerns and the corresponding political responses that gave rise to socio-cultural and economic implications. Secondly, an entrepreneur (agent) level analysis revealed that the entrepreneurs motivation to start and continue recycling businesses was attached to a particular value perception of the recycling opportunity. This orientation underlies the different forms of opportunity constructions. Analysis at the process level drew upon the interactive processes between the preceding two levels to understand the dynamic relationship between structure and agency. The analysis demonstrated the entrepreneurs role in manifesting entrepreneurial events via value extraction processes realised through embeddedness. This included different ways of adaptation to the green structure, adoption of green values and the forging of ties. In doing so, they imbued the structure with an apparent overarching creation of green values. The novel analytical approach adopted for this study provides avenues of advancement in entrepreneurship research: firstly, in the adoption of value orientation as the unit of analysis; and secondly, in the dynamic nature of the analytical approach which explored the interrelatedness between structure, agent and agency. This analysis has identified a paradox whereby entrepreneurs who lack green value orientations are nevertheless performing green actions and thus perpetuating the green socio-political context. Another contribution of this research lies in its thesis that the increasing emphasis in the recycling industry is a social construction of reality, but one given an objective nature attached to the language of green. This is intensified by the entrepreneurs articulation of their reality. Thus, as well as its contribution to both entrepreneurship and recycling literatures, the study provides an informed platform for policy makers and practitioners

A review of research methods in entrepreneurship 1985-2013.

Purpose – The purpose of this paper is to address the research questions: which methodologies and data gathering methods are employed by researchers publishing in top entrepreneurship journals, and how has this changed over time? Design/methodology/approach – The data gathering methods of research published in five top entrepreneurship journals between 1985 and 2013, a period of nearly three decades, were recorded. Findings – The data demonstrate that entrepreneurship research is dominated by positivist approaches and data gathering methods, but that this picture is changing over time. The data also reveal differences in methods used in research published in North American and European journals. Research limitations/implications – It is argued that increased discussion of the limitations, benefits and implications of research methods is needed across the field as a whole. It is concluded that although there is some methodological reflexivity in the field of a macro, abstract nature, there is little at the micro level of individual research designs. Originality/value – There is a number of existing reviews of methods in the field but none over such a long time period that include such a large corpus of papers. Of particular value to scholars engaged in debates about the proportions and merits of different research methods is the identification of long-term trends away from primary data gathering in general and survey approaches in particular. Debates surrounding the existence of different regional “schools” of entrepreneurship will be informed by the differing patterns of methods found in the five outlets included in the study

Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants : a cross-sectional study

Introduction and aim: Patient quality of life (QOL) while on long-term oral anticoagulant therapy has been receiving greater attention in recent years due to the increase in life expectancy brought about by advances in medical care. This study aimed to compare the QOL, treatment satisfaction, hospitalization and bleeding rate in patients on long-term warfarin versus direct oral anticoagulants (DOAC). Methods: This was a cross-sectional study of patients with non-valvular atrial fibrillation (NVAF) or venous thromboembolism (VTE) on long-term anticoagulant therapy attending the cardiology clinic and anticoagulation clinic of the University Malaya Medical Centre from July 1, 2016, to June 30, 2018. Patient QOL was assessed by using the Short Form 12 Health Survey (SF12), while treatment satisfaction was assessed by using the Perception of Anticoagulation Treatment Questionnaire 2 (PACT-Q2). Results: A total of 208 patients were recruited; 52.4% received warfarin and 47.6% received DOAC. There was no significant difference in QOL between warfarin and DOAC based on SF12 (physical QOL, P=0.083; mental QOL, P=0.665). Nevertheless, patients in the DOAC group were significantly more satisfied with their treatment compared to the warfarin group based on PACT-Q2 (P=0.004). The hospitalisation rate was significantly higher in the warfarin group than the DOAC group (15.6% versus 3.0%, P=0.002). Clinically relevant minor bleeds and severe bleeding events were non-significantly higher in the warfarin group than the DOAC group (66.7% versus 40.0%, P=0.069). Conclusion: Compared to warfarin, treatment of NVAF and VTE with DOAC showed comparable QOL, higher treatment satisfaction, lesser hospitalization, and a non-significant trend toward fewer bleeding episodes

An entrepreneurial theorising of the recycling industry

The research interest for this study began with a general observation of the lack of theory-practice integration between the academic context of recycling and entrepreneurship set against the growth in the recycling industry. The research thus began by asking, ‘how well does entrepreneurship explain the recycling industry?’ This research focuses on the recycling entrepreneurs’ entrepreneurial experiences and their relationships with their social context. Twenty-five recycling entrepreneurs were interviewed in-depth using unstructured interviews as the primary data collection method. Inductive analysis has been applied to these data on multiple levels. Firstly, a context (structure) level analysis identified a green culture and structure arising from social demands pertaining to environmental concerns and the corresponding political responses that gave rise to socio-cultural and economic implications. Secondly, an entrepreneur (agent) level analysis revealed that the entrepreneurs’ motivation to start and continue recycling businesses was attached to a particular value perception of the recycling opportunity. This orientation underlies the different forms of opportunity constructions. Analysis at the process level drew upon the interactive processes between the preceding two levels to understand the dynamic relationship between structure and agency. The analysis demonstrated the entrepreneurs’ role in manifesting entrepreneurial events via value extraction processes realised through embeddedness. This included different ways of adaptation to the green structure, adoption of green values and the forging of ties. In doing so, they imbued the structure with an apparent overarching creation of green values. The novel analytical approach adopted for this study provides avenues of advancement in entrepreneurship research: firstly, in the adoption of value orientation as the unit of analysis; and secondly, in the dynamic nature of the analytical approach which explored the interrelatedness between structure, agent and agency. This analysis has identified a paradox whereby entrepreneurs who lack green value orientations are nevertheless performing green actions and thus perpetuating the green socio-political context. Another contribution of this research lies in its thesis that the increasing emphasis in the recycling industry is a social construction of reality, but one given an objective nature attached to the language of ‘green’. This is intensified by the entrepreneurs’ articulation of their reality. Thus, as well as its contribution to both entrepreneurship and recycling literatures, the study provides an informed platform for policy makers and practitioners.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Anxiety and depression in patients with haematological neoplasms in Malaysia

ABSTRACT Background: It is not uncommon that anxiety and depression occur in patients with cancers, and past researches have shown that the quality of life of patients is negatively affected. This study aims to determine the prevalence of anxiety and depression of patients with haematological cancers in Malaysia and to investigate the possible association of these psychological symptoms with their quality of life. Methods: This is a cross-sectional study where patients with haematological cancers attending two major hospitals were recruited. Anxiety and depression symptoms were assessed using the Hospital Anxiety and Depression scale (HADS). Quality of life (QoL) of these patients was measured using the European Organisation for Research and Treatment of Cancer quality of life questionnaire (E ORTC QLQ C30). An overall summary QoL score in combination with financial difficulty score and global health score were used for analysis. Results: A total of 319 patients were recruited. Thirty-three percent of patients had anxiety symptoms, 23.5% had depression symptoms. In summary the overall score of QoL is significantly lower in patients with higher scores for depression and anxiety, (p<0.05). Patients who exhibit anxiety symptoms were more frequently female, still undergoing treatment whereas patients who had higher depression scores were older and had acute leukemias or myeloproliferative neoplasms. Patients who have depression are significantly associated with a higher financial difficulty score, p<0.05. Conclusion: The poor quality of life in patients who have anxiety and depression should raise awareness amongst the health professions treating them so that additional support can be provided

Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19

Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes

Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry

Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings

Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19

Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world's largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60&nbsp;years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death.&nbsp;The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death

The value of open-source clinical science in pandemic response: lessons from ISARIC

International audienc