Is biopsy necessary? Role of DCE-MRI in BIRADS-3 lesions

PURPOSEWe aimed to evaluate BIRADS-3 breast lesions with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and compare with histopathology, and to investigate the effectiveness of breast MRI for follow-up and management.METHODSA total of 84 BIRADS-3 lesions reported by US or mammography and evaluated by DCE-MRI between September 2014 and October 2015 were included in this study. All patients underwent percutaneous or surgical biopsy for histopathologic diagnosis. Morphologic and kinematic features on MRI were compared with histopathologic results.RESULTSOf the 84 BIRADS-3 breast lesions, 9 (10.7%) had malignant features on DCE-MRI and all were verified with histopathologic results. DCE-MRI had 96.7% sensitivity, 72% specificity, 92% positive predictive value, and 82.5% negative predictive value. MRI and histopathology results were correlated for the diagnosis of malignant lesions. The sensitivity and negative predictive value of MRI for diagnosis of malignant lesions were both 100%.CONCLUSIONDifferentiation of benign versus malignant lesions was accomplished with 100% accuracy with DCE-MRI. We suggest that DCE-MRI should be an additional diagnostic tool and problem-solving modality for BIRADS-3 lesions, particularly in patients with relative risk factors

Evaluation of the Effects of Varicoceles and Fertility Status on Volumetry and Shear-wave Elastography

Aim: This study aims to compare the volumetry and shear-wave elastography findings in infertile and fertile patients and evaluate the effect of presence of varicoceles on the parameters. Materials-Methods: 40 infertile and 20 fertile patients (120 testes) (mean age 29,3±6,7) between January 2018-November 2018 were included in this prospective study. All patients underwent testicular B-mode and doppler ultrasonography (US) and shear-wave elastography (SWE). Patients were sub-grouped according to fertility status and presence or absence of varicoceles. Results: Testis stiffness was significantly higher in testes without varicoceles than those with varicoceles (p=0.021). It was also higher in fertile patients than infertile patients (p=0.015). Testes volumes were higher in fertile patients and patients with varicoceles (p=0.011 and p=0.028, respectively). Conclusion: SWE is a non-invasive, cheap and reproducible technique with promising results for diagnosis and follow-up in the evaluation of infertility

Phosphorus-nitrogen compounds. Part 48. syntheses of the phosphazenium salts containing 2-pyridyl pendant arm: structural characterizations, thermal analysis, antimicrobial and cytotoxic activity studies

533-550The phosphazenium salts (protic ionic liquids, PILs/protic molten salts, PMOSs) (6a-6d and 7a) of the free phosphazene bases (4a-4d and 5a) have been prepared by the reactions of the corresponding cyclotriphosphazenes with the bulky gentisic acid. The structures of the PMOS have been evaluated using the elemental analyses, FTIR, 1H, 13C{1H} and 31P{1H} NMR data. The molecular and crystal structures of 4a and 6c are established by X-ray crystallography. The thermal properties of the PMOS are determined using TG and DTA techniques. On the other hand, the antimicrobial activities of the free phosphazene bases (4a-4d and 5a-5d) and PMOSs (6a-6d and 7a) are screened against the selected bacteria and yeast strains. The antimicrobial activities of the free phosphazene bases and the PMOSs are compared. The interactions of the phosphazenes and their salts with plasmid DNA are elucidated by the agarose gel electrophoresis. The evaluations of the cytotoxic activities of these compounds are also studied against to L929 fibroblast and breast cancer cells (MDA-MB-231)

Phosphorus-nitrogen compounds. Part 48. Syntheses of the phosphazenium salts containing 2-pyridyl pendant arm: Structural characterizations, thermal analysis, antimicrobial and cytotoxic activity studies

The phosphazenium salts (protic ionic liquids, PILs/protic molten salts, PMOSs) (6a-6d and 7a) of the free phosphazene bases (4a-4d and 5a) were prepared by the reactions of the corresponding cyclotriphosphazenes with the bulky gentisic acid. The structures of the PMOS were evaluated using the elemental analyses, FTIR, 1H, 13C{1H} and 31P{1H} NMR data. The molecular and crystal structures of 4a and 6c were established by X-ray crystallography. The thermal properties of the PMOS were determined using TG and DTA techniques. On the other hand, the antimicrobial activities of the free phosphazene bases (4a-4d and 5a-5d) and PMOSs (6a-6d and 7a) were screened against the selected bacteria and yeast strains. The antimicrobial activities of the free phosphazene bases and the PMOSs were compared. The interactions of the phosphazenes and their salts with plasmid DNA were elucidated by the agarose gel electrophoresis. The evaluations of the cytotoxic activities of these compounds were also studied against to L929 fibroblast and breast cancer cells (MDA-MB-231).  

Kolorektal Kanser Karaciğer Metastazlarında Yttrıum 90 ile Radyoembolizasyonun Orta ve Uzun Dönem Etkinliğinin Değerlendirilmesi

Purpose: The aim of this study was to establish the efficacy of radioembolization with Yttrium 90 in chemotherapy resistant, inoperable hepatic metastatic colorectal carcinoma patients. Material-Methods: 48 hepatic-dominant metastatic colorectal patients who underwent radioembolization with Yttrium 90 between September 2008- May 2014 were included in this study. The patients were evaluated by CT, MRI or PET-CT before and after the procedure at regular intervals. Results: In all patients who had radioembolization post-procedural overall survival was 12.8 months, time to progression was 2.8 months. Since the patients had RE at advanced stage, 58% of patients could not have their chemotherapy after the procedure. Nevertheless, median survival after metastasis was 32.8 months. Conclusions: Radioembolization is a safe local-regional treatment option in patients with chemotherapy resistant, inoperable hepatic metastatic colorectal carcinoma patients. In our study, radioembolization had a survival of 12.8 months in salvage therapy of chemotherapy resistant, advanced stage hepatic dominant colorectal carcinoma patients with a very low toxicity. Radioembolization treatment at an earlier stage may lead to favourable results in the management of hepatic metastatic colorectal carcinoma. Nevertheless, in order to better establish the efficacy of radioembolization and its role in the management, extensive prospective studies are needed in the future.Amaç: Bu çalışmada kemoterapiye cevapsız ve cerrahiye uygun olmayan karaciğer metastazlı kolorektal kanser hastalarında Yttrium 90 ile radyoembolizasyonun etkinliğinin değerlendirilmesi amaçlandı. Gereç ve Yöntem: Çalışmaya Eylül 2008- Mayıs 2014 tarihleri arasında Hacettepe Üniversitesi Radyoloji Anabilim Dalı Vasküler Girişimsel Radyoloji Bölümünde Y-90 ile radyoembolizasyon yapılan 48 karaciğer-dominant kolorektal kanser hastası (hmKRK) dahil edildi. Tedavi öncesi ve sonrasında hastalar BT, MRG ya da PET-BT ile değerlendirildi. Bulgular: Radyoembolizasyon yapılan hastalarda işlem sonrası genel sağ kalım süresi 12,8 ay, progresyona kadar geçen süre 2,8 ay idi. RE'nin son dönemde yapılmış olması nedeniyle hastaların %58'i işlem sonrası kemoterapi alamamıştı. Metastaz sonrası ortanca sağ kalım süresi 32,8 ay idi. Sonuçlar: Karaciğer metastazı bulunan, kemoterapiye yanıtsız ve cerrahiye uygun olmayan kolorektal kanser olgularında radyoembolizasyon güvenle uygulanabilecek bir lokal-bölgesel tedavi yöntemidir. Çalışmamızda kemoterapi altında progresyon göstermiş, agresif, ileri evre hastalarda kurtarma tedavisi olarak uygulandığında bile düşük toksisite ile 12.8 ay'lık bir sağ kalım sağlanabildiği gösterilmiştir. Radyoembolizasyonun daha erken evre hastalıkta uygulanması kolorektal kanser tedavisinde daha olumlu sonuçlar sağlayabilmektedir. Y-90 ile radyoembolizasyonun sağ kalım üzerine etkinliğinin ve tedavi basamaklarındaki yerinin daha doğru bir şekilde ortaya konabilmesi için gelecekte yapılacak geniş prospektif çalışmalara ihtiyaç duyulmaktadır

Peter Behrens As An Industrial Designer

Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 1998Thesis (M.Sc. ) -- İstanbul Technical University, Institute of Science and Technology, 1998"Endüstriyel Tasarımcı Olarak Peter Behrens" adını taşıyan bu tez ile modern hareketin öncülerinden biri olan Alman ressam, grafik sanatçısı, mimar ve endüstriyel tasarımcı Peter Behrens' in tüm çalışmalarının ve döneminin incelenmesi doğrultusunda endüstriyel tasarım alanı faaliyeti incelenmiştir. Bu tez altı bölümden oluşmaktadır. Giriş bölümünün ardından ikinci bölümde Behrens' in yaşadığı dönemle paralel olarak 19.yüzyıl ve erken 20. yüzyıl Avrupa Ortamı ele alınmaktadır. Burada, tarih içindeki sanat akımları kronolojik olarak örneklerle irdelenmiş, Behrens'in yaşamı ile kesişmeleri incelenmiştir. Üçüncü bölümde Peter Behrens'in tüm yaşamı özet olarak anlatılmış, sanat ve endüstri ile ilgili olan görüşlerim açıkladığı kendi yazısına yer verilmiştir. Dördüncü bölümde Peter Behrens'in endüstriyel tasarım alam dışı faaliyetleri olan ressamlığı, grafik tasarımcılığı, mimarlığı ve eğitmenliği görüşleri ve eserleri ile açıklanmış, asistanlığım yapmış büyük mimarlar Gropius, Mies van der Rohe ve Le Corbusier'nin üzerindeki Behrens etkileri araştırılmıştır. Tezin ana konusunu oluşturan beşinci bölümde, Behrens'in endüstriyel tasarım alanı faaliyeti, erken dönem tasarımları, AEG tasarımları ve AEG sonrası tasarımları olarak üç alt başlıkta örneklerle incelenmiştir. Altıncı ve son bölümde çalışmanın ve incelemelerin sonuçları değerlendirilmiştir.Yüksek LisansM.Sc

An 88-year-old dyspneic woman: What Is Your Diagnosis?

Cite this article as: Türk M, Türk G, Yalçın KS, Yıldırım F. An 88-year-old dyspneic woman: What Is Your Diagnosis? Eurasian J Pulmonol 2017; 19: 176-8

Detection of Methicillin Resistance and Various Virulence Factors in Staphylococcus aureus Strains Isolated from Nasal Carriers

Background: Staphylococus aureus can be found as a commensal on skin and nasal flora or it may cause local and invasive infections. S. aureus has a large number of virulence factors. Aims: To investigate the methicillin resistance and frequency of various virulence factors in S. aureus nasal isolates. Study Design: Descriptive study. Methods: Nasal samples collected from university students were cultured in media. S. aureus was identified by conventional methods and the Staphyloslide latex test (Becton Dickinson, Sparks, USA). Antibiotic susceptibility tests were conducted, and the methicillin resistance was determined. The mecA, nuc, pvl and staphylococcal toxin genes were examined by polymerase chain reaction (PCR). Results: S. aureus was isolated in 104 of 600 (17.3%) nasal samples. In total, 101 (97.1%) S. aureus isolates were methicillin-sensitive and the remaining 3 (2.9%) were methicillin-resistant. Furthermore, all but five isolates carried at least one staphylococcal enterotoxin gene, with seg being predominant. The tst and eta genes were determined in 29 (27.9%), and 3 (2.9%) isolates, respectively. None of the S. aureus isolates harbored see, etb, and pvl genes. Conclusion: A moderate rate of S. aureus carriage and low frequency of MRSA were detected in healthy students. S. aureus isolates had a high prevalence of staphylococcal enterotoxin genes and the tst gene. In this study, a large number of virulence factors were examined in S. aureus nasal isolates, and the data obtained from this study can be used for monitoring the prevalence of virulence genes in S. aureus strains isolated from nasal carriers