CALCAREOUS NANNOPLANKTON RESPONSE TO THE LATEST CENOMANIAN OCEANIC ANOXIC EVENT 2 PERTURBATION

Morphometric analyses were performed on Biscutum constans, Zeugrhabdotus erectus, Discorhabdus rotatorius and Watznaueria barnesiae specimens from five sections spanning the Cenomanian-Turonian boundary interval including Oceanic Anoxic Event (OAE) 2 (~ 94 Ma). The study provides evidence for size fluctuations and dwarfism of B. constans during OAE 2, followed by a partial recovery at the end of the event: this taxon appears to be the most sensitive species, with similar and coeval size trends in all the analyzed sections. Conversely, morphometry shows negligible or unsystematic coccolith variations in Z. erectus, D. rotatorius and W. barnesiae. The comparison of OAE 2 data with those available for the early Aptian OAE 1a and latest Albian OAE 1d, indicates that B. constans repeatedly underwent size reduction and temporary dwarfism possibly implying that the same paleoenvironmental factors controlled calcification of B. constans during subsequent OAEs although the amplitude of B. constans coccolith reduction is significantly larger for OAE 1a than OAE 2. Paleoceanographic reconstructions suggest that ocean chemistry related to the amount of CO2 and toxic metal concentrations played a central role in B. constans coccolith secretion, while temperature and nutrient availability do not seem to have been crucial. Contrary to OAE 1a, Z. erectus, D. rotatorius and W. barnesiae appear to be substantially unrelated to OAE 2 paleoenvironmental stress, possibly because of different degrees of perturbation.  &nbsp

Osservatorio territoriale droga e tossicodipendenze. Il Fenomeno delle dipendenze sul territorio della ASL MI 1. Anno 2007.

Report on the state of legal and illegal substances use in the territory of the Local Healthcare Service-Mi 2, Province of Milan.Il report analizza il fenomeno delle dipendenze nel territorio della ASL Milano 2. La descrizione del fenomeno si sviluppa intorno all\u27analisi degli indicatori individuati dall\u27Osservatorio Europeo delle Dipendenze di Lisbona (OEDT): 1) uso di sostanze nella popolazione generale (questo indicatore va a rilevare i comportamenti nei confronti di alcol e sostanze psicoattive da parte della popolazione generale; 2) prevalenza d\u27uso problematico delle sostanze psicoattive; 3) domanda di trattamento degli utilizzatori di sostanze; 4) mortalit? degli utilizzatori di sostanze; 5) malattie infettive. Altri due importanti indicatori che si stanno sviluppando, e che vengono qui illustrati, sono l\u27analisi delle Schede di Dimissione Ospedaliera (SDO) e gli indicatori relativi alle conseguenza sociali dell\u27uso di droghe (criminalit? droga correlata). Inoltre sono state applicate diverse metodologie standard di stima sia per quantificare la quota parte sconosciuta di utilizzatori di sostanze che non afferiscono ai servizi, sia per identificarne alcune caratteristiche

The Cyclostratigraphy Intercomparison Project (CIP): consistency, merits and pitfalls

Cyclostratigraphy is an important tool for understanding astronomical climate forcing and reading geological time in sedimentary sequences, provided that an imprint of insolation variations caused by Earth’s orbital eccentricity, obliquity and/or precession is preserved (Milankovitch forcing). Numerous stratigraphic and paleoclimate studies have applied cyclostratigraphy, but the robustness of the methodology and its dependence on the investigator have not been systematically evaluated. We developed the Cyclostratigraphy Intercomparison Project (CIP) to assess the robustness of cyclostratigraphic methods using an experimental design of three artificial cyclostratigraphic case studies with known input parameters. Each case study is designed to address specific challenges that are relevant to cyclostratigraphy. Case 1 represents an offshore research vessel environment, as only a drill-core photo and the approximate position of a late Miocene stage boundary are available for analysis. In Case 2, the Pleistocene proxy record displays clear nonlinear cyclical patterns and the interpretation is complicated by the presence of a hiatus. Case 3 represents a Late Devonian proxy record with a low signal-to-noise ratio with no specific theoretical astronomical solution available for this age. Each case was analyzed by a test group of 17-20 participants, with varying experience levels, methodological preferences and dedicated analysis time. During the CIP 2018 meeting in Brussels, Belgium, the ensuing analyses and discussion demonstrated that most participants did not arrive at a perfect solution, which may be partly explained by the limited amount of time spent on the exercises (∼4.5 hours per case). However, in all three cases, the median solution of all submitted analyses accurately approached the correct result and several participants obtained the exact correct answers. Interestingly, systematically better performances were obtained for cases that represented the data type and stratigraphic age that were closest to the individual participants’ experience. This experiment demonstrates that cyclostratigraphy is a powerful tool for deciphering time in sedimentary successions and, importantly, that it is a trainable skill. Finally, we emphasize the importance of an integrated stratigraphic approach and provide flexible guidelines on what good practices in cyclostratigraphy should include. Our case studies provide valuable insight into current common practices in cyclostratigraphy, their potential merits and pitfalls. Our work does not provide a quantitative measure of reliability and uncertainty of cyclostratigraphy, but rather constitutes a starting point for further discussions on how to move the maturing field of cyclostratigraphy forward

"Delirium Day": A nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool

Background: To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number of participants in these studies has not exceeded a few hundred. To overcome these limitations, we have determined, in a multicenter study, the prevalence of delirium over a single day among a large population of patients admitted to acute and rehabilitation hospital wards in Italy. Methods: This is a point prevalence study (called "Delirium Day") including 1867 older patients (aged 65 years or more) across 108 acute and 12 rehabilitation wards in Italian hospitals. Delirium was assessed on the same day in all patients using the 4AT, a validated and briefly administered tool which does not require training. We also collected data regarding motoric subtypes of delirium, functional and nutritional status, dementia, comorbidity, medications, feeding tubes, peripheral venous and urinary catheters, and physical restraints. Results: The mean sample age was 82.0 \ub1 7.5 years (58 % female). Overall, 429 patients (22.9 %) had delirium. Hypoactive was the commonest subtype (132/344 patients, 38.5 %), followed by mixed, hyperactive, and nonmotoric delirium. The prevalence was highest in Neurology (28.5 %) and Geriatrics (24.7 %), lowest in Rehabilitation (14.0 %), and intermediate in Orthopedic (20.6 %) and Internal Medicine wards (21.4 %). In a multivariable logistic regression, age (odds ratio [OR] 1.03, 95 % confidence interval [CI] 1.01-1.05), Activities of Daily Living dependence (OR 1.19, 95 % CI 1.12-1.27), dementia (OR 3.25, 95 % CI 2.41-4.38), malnutrition (OR 2.01, 95 % CI 1.29-3.14), and use of antipsychotics (OR 2.03, 95 % CI 1.45-2.82), feeding tubes (OR 2.51, 95 % CI 1.11-5.66), peripheral venous catheters (OR 1.41, 95 % CI 1.06-1.87), urinary catheters (OR 1.73, 95 % CI 1.30-2.29), and physical restraints (OR 1.84, 95 % CI 1.40-2.40) were associated with delirium. Admission to Neurology wards was also associated with delirium (OR 2.00, 95 % CI 1.29-3.14), while admission to other settings was not. Conclusions: Delirium occurred in more than one out of five patients in acute and rehabilitation hospital wards. Prevalence was highest in Neurology and lowest in Rehabilitation divisions. The "Delirium Day" project might become a useful method to assess delirium across hospital settings and a benchmarking platform for future surveys

Carbon-and oxygen-isotope signature of the Toarcian Oceanic Anoxic Event:insights from two Tethyan pelagic sequences (Gajum and Sogno Cores – Lombardy Basin, northern Italy)

The early Toarcian Oceanic Anoxic Event (T-OAE) was associated with major climatic changes involving profound effects on the global carbon cycle. In this study, we present new carbon-and oxygen-isotope, CaCO3 and total organic carbon (TOC) records from two cores (Sogno and Gajum Cores) that recovered pelagic successions from north-western Tethys. A palaeobathymetry of about 1000 and 1500 m water depth is tentatively reconstructed for the Gajum and Sogno sites, respectively. The investigated sections thereby represent some of the deepest records of the T-OAE in the western Tethys. During the early Toarcian, sedimentation in the Lombardy Basin (Southern Alps, northern Italy) was characterized by the deposition of the Fish Level (Livello a Pesci), a dark grey to black marly claystone with low CaCO3 content and relatively high TOC content. In the two cores, the Fish Level (similar to 5 m and similar to 15 m-thick at Sogno and Gajum, respectively) is subdivided into three lithostratigraphic intervals: a lower part, with minimum CaCO3 (5-10 %) and TOC (similar to 0.2-0.3 %) values; a central part with a progressive increase in TOC up to similar to 1.4 %, and an upper part characterized by the highest TOC up to similar to 2.5 %. Within the Fish Level a lower grey interval and an upper black interval are defined based on lithological features. Carbon-isotope chemostratigraphy resolves a delta C-13(carb) negative excursion of similar to 3 parts per thousand at Sogno and similar to 6 parts per thousand at Gajum, and a delta C-13(org) negative excursion of similar to 7 parts per thousand at both locations. This global carbon cycle anomaly, named the 'Jenkyns Event', is here subdivided into a lower J1 and an upper J2 segment. As highlighted by lithostratigraphic evidence, nannofossil biostratigraphy and chemostratigraphic correlations, a hiatus elides part of the succession below the Fish Level in the Gajum Core, although without compromising the completeness of the Fish Level itself. High-resolution delta C-13 data indicate that the base of the Fish Level is synchronous, but the top diachronous at the two coring sites. The same synchroneity of the base and diachroneity of the top of the black shale interval is identified in the Umbria-Marche Basin, suggesting that the duration of anoxia was not identical over very modest to relatively long distances

Influence of prolonged maceration on phenolic compounds, volatile profile and sensory properties of wines from Minutolo and Verdeca, two Apulian white grape varieties

Prolonged maceration was applied to two Apulian white grape cultivars, Minutolo and Verdeca. The impact of prolonged maceration (up to six months) on the quality of the wines was evaluated through characterization of phenolic, volatile and sensory profiles. Macerated wines presented a peak of extraction after 4 months, followed by a decrease probably due to precipitation/reabsorption. Extraction of seed phenols occurred during longer maceration times. Volatile profile was also modified, showing a different behavior at different maceration times. Oxidation and aging compounds appeared during maceration, that are unusual for traditional white wines. Furthermore, maceration successfully enhanced varietal identity of Minutolo. The terpene profile of Minutolo wines changed during maceration, with a maximum of terpenols after 1 month of maceration, while longer maceration added a pattern of oxidized terpenes. Sensory analysis highlighted clearly distinct profiles of wines, according to both cultivar and maceration time. A good attitude was observed of both varieties to undergo maceration. In particular, Verdeca appeared suitable for longer maceration times, with flowery, citrus and apricot notes after 4 months, while enhanced apricot notes were perceived after 6 months. On the other hand, Minutolo wine after 6 months of maceration was characterized by a marked astringency and peach flavor