Detecting a stochastic gravitational wave background with the Laser Interferometer Space Antenna

The random superposition of many weak sources will produce a stochastic background of gravitational waves that may dominate the response of the LISA (Laser Interferometer Space Antenna) gravitational wave observatory. Unless something can be done to distinguish between a stochastic background and detector noise, the two will combine to form an effective noise floor for the detector. Two methods have been proposed to solve this problem. The first is to cross-correlate the output of two independent interferometers. The second is an ingenious scheme for monitoring the instrument noise by operating LISA as a Sagnac interferometer. Here we derive the optimal orbital alignment for cross-correlating a pair of LISA detectors, and provide the first analytic derivation of the Sagnac sensitivity curve.Comment: 9 pages, 11 figures. Significant changes to the noise estimate

Stress testing and non-invasive coronary angiography in patients with suspected coronary artery disease: time for a new paradigm

Diagnosis and management of coronary artery disease represents major challenges to our health care system, affecting millions of patients each year. Until recently, the diagnosis of coronary artery disease was possible only through cardiac catheterization and invasive coronary angiography. To avoid the risks of an invasive procedure, stress testing is often employed for an initial assessment of patients with suspected coronary artery disease, serving as a gatekeeper for cardiac catheterization. With the emergence of non-invasive coronary angiography, the question arises if such a strategy is still sensible, particularly, in view of only a modest agreement between stress testing results and the presence of coronary artery disease established by cardiac catheterization. Much data in support of the diagnostic accuracy and prognostic value of non-invasive coronary angiography by computed tomography have emerged within the last few years. These data challenge the role of stress testing as the initial imaging modality in patients with suspected coronary artery disease. This article reviews the clinical utility, limitations, as well as the hazards of stress testing compared with non-invasive coronary artery imaging by computed tomography. Finally, the implications of this review are discussed in relation to clinical practice

Diving into the vertical dimension of elasmobranch movement ecology

Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quantified the variance in liability to disease explained

Combination of searches for Higgs boson decays into a photon and a massless dark photon using pp collisions at √s = 13 TeV with the ATLAS detector

A combination of searches for Higgs boson decays into a visible photon and a massless dark photon (H → γγd) is presented using 139 fb−1 of proton-proton collision data at a centre-of-mass energy of √s = 13 TeV recorded by the ATLAS detector at the Large Hadron Collider. The observed (expected) 95% confidence level upper limit on the Standard Model Higgs boson decay branching ratio is determined to be B(H → γγd) < 1.3% (1.5)%. The search is also sensitive to higher-mass Higgs bosons decaying into the same final state. The observed (expected) 95% confidence level limit on the cross-section times branching ratio ranges from 16 fb (20 fb) for mH = 400 GeV to 1.0 fb (1.5 fb) for mH = 3 TeV. Results are also interpreted in the context of a minimal simplified model

Chandra Stacking Constraints on the Contribution of 24 μ\mum Spitzer Sources to the Unresolved Cosmic X-Ray Background

We employ X-ray stacking techniques to examine the contribution from X-ray undetected, mid-infrared-selected sources to the unresolved, hard (6-8 keV) cosmic X-ray background (CXB). We use the publicly available, 24 micron Spitzer Space Telescope MIPS catalogs from the Great Observatories Origins Deep Survey (GOODS) - North and South fields, which are centered on the 2 Ms Chandra Deep Field-North and the 1 Ms Chandra Deep Field-South, to identify bright (S_24 > 80 microJy) mid-infrared sources that may be powered by heavily obscured AGNs. We measure a significant stacked X-ray signal in all of the X-ray bands examined, including, for the first time, a significant (3.2 sigma) 6-8 keV stacked X-ray signal from an X-ray undetected source population. We find that the X-ray-undetected MIPS sources make up about 2% (or less) of the total CXB below 6 keV, but about 6% in the 6-8 keV band. The 0.5-8 keV stacked X-ray spectrum is consistent with a hard power-law (Gamma = 1.44 +/- 0.07), with the spectrum hardening at higher X-ray energies. Our findings show that these bright MIPS sources do contain obscured AGNs, but are not the primary source of the unresolved 50% of 6-8 keV CXB. Our study rules out obscured, luminous QSOs as a significant source of the remaining unresolved CXB and suggests that it most likely arises from a large population of obscured, high-redshift (z > 1), Seyfert-luminosity AGNs.Comment: 5 pages (emulateapj format), 4 figures; submitted to ApJ Letter

The self-pattern and Buddhist psychology

In this paper, we address core insights from Buddhist psychology about mind-body phenomena and the self, and we relate such insights to the notion of the self-pattern developed in the pattern theory of self. We emphasize the dynamic, temporal and enactive characteristics of the self-pattern, consistent with the core Buddhist notion of non-self. Although there is no one-to-one mapping of Buddhist psychological concepts onto the pattern theory of self, there are important similarities among such concepts and the various processes and dynamical relations that constitute a pragmatic self-pattern that can explain both experiences of self and non-self. Buddhist psychology and the notion of the self-pattern offer mutual insight into the processes, the dynamics, and the implications for questions about well-being and a flexibility that avoids anxiety and reduces attachment, craving, and suffering

Physiological consequences of varying large shark exposure on striped bass (Morone saxatilis)

Large marine predators often aggregate seasonally in discrete locations to take advantage of optimal foraging conditions, leading to spatial and temporal variation in their exposure on other species. However, our understanding of the impacts this exposure may have on the behavior and physiology of prey is poor, especially in marine systems. Here, we evaluated the non-consumptive effects of potential exposure to large sharks (white sharks, Carcharodon carcharias (Linnaeus, 1758)) on the stres