Chitinase and Fizz family members are a generalized feature of nematode infection with selective Upregulation of Ym1 and F10.1 by antigen-presenting cells

Ym1 and Fizz1 are secreted proteins that have been identified in a variety of Th2-mediated inflammatory settings. We originally found Ym1 and Fizz1 as highly expressed macrophage genes in a Brugia malayi infection model. Here, we show that their expression is a generalized feature of nematode infection and that they are induced at the site of infection with both the tissue nematode Litomosoides sigmodontis and the gastrointestinal nematode Nippostrongylus brasiliensis. At the sites of infection with N. brasiliensis, we also observed induction of other chitinase and Fizz family members (ChaFFs): acidic mammalian chitinase (AMCase) and Fizz2. The high expression of both Ym1 and AMCase in the lungs of infected mice suggests that abundant chitinase production is an important feature of Th2 immune responses in the lung. In addition to expression of ChaFFs in the tissues, Ym1 and Fizz1 expression was observed in the lymph nodes. Expression both in vitro and in vivo was restricted to antigen-presenting cells, with the highest expression in B cells and macrophages. ChaFFs may therefore be important effector or wound-repair molecules at the site of nematode infection, with potential regulatory roles for Ym1 and Fizz1 in the draining lymph nodes

Public Health Service Project Py 71-1, National Institutes of Health Projects HE 11829 and HE 12536

SUMMARY Entrance block of an atrial premature beat (APB) into the atrioventricular node is demonstrated by its lack of effect on the A-V nodal conduction of a subsequent beat which is introduced before the full recovery time of the A-V node. This phenomenon was demonstrated in five patients by using programmed atrial stimulation and His bundle recordings. Entrance block into the A-V node occurred in a narrow range (28-33%) of the basic cycle length and concealed conduction occurred at coupling intervals longer than this range. It appears that entrance block of these early APBs is due to a "functional block" between the atrium and the A-V node

Automated Coronal Hole Detection using Local Intensity Thresholding Techniques

We identify coronal holes using a histogram-based intensity thresholding technique and compare their properties to fast solar wind streams at three different points in the heliosphere. The thresholding technique was tested on EUV and X-ray images obtained using instruments onboard STEREO, SOHO and Hinode. The full-disk images were transformed into Lambert equal-area projection maps and partitioned into a series of overlapping sub-images from which local histograms were extracted. The histograms were used to determine the threshold for the low intensity regions, which were then classified as coronal holes or filaments using magnetograms from the SOHO/MDI. For all three instruments, the local thresholding algorithm was found to successfully determine coronal hole boundaries in a consistent manner. Coronal hole properties extracted using the segmentation algorithm were then compared with in situ measurements of the solar wind at 1 AU from ACE and STEREO. Our results indicate that flux tubes rooted in coronal holes expand super-radially within 1 AU and that larger (smaller) coronal holes result in longer (shorter) duration high-speed solar wind streams

Inhibition of electromagnetically induced absorption due to excited state decoherence in Rb vapor

The explanation presented in [Taichenachev et al, Phys. Rev. A {\bf 61}, 011802 (2000)] according to which the electromagnetically induced absorption (EIA) resonances observed in degenerate two level systems are due to coherence transfer from the excited to the ground state is experimentally tested in a Hanle type experiment observing the parametric resonance on the $$ line of $^{87}$Rb. While EIA occurs in the $F=1\to F^{\prime}=2$ transition in a cell containing only $Rb$ vapor, collisions with a buffer gas ($30 torr$ of $Ne$) cause the sign reversal of this resonance as a consequence of collisional decoherence of the excited state. A theoretical model in good qualitative agreement with the experimental results is presented.Comment: 8 pages, 7 figures, submitted to Physical Review

The stellar mass ratio of GK Persei

We study the absorption lines present in the spectra of the long-period cataclysmic variable GK Per during its quiescent state, which are associated with the secondary star. By comparing quiescent data with outburst spectra we infer that the donor star appears identical during the two states and the inner face of the secondary star is not noticeably irradiated by flux from the accreting regions. We obtain new values for the radial velocity semi-amplitude of the secondary star, Kk = 120.5 +- 0.7 km/s, a projected rotational velocity, Vksin i = 61.5 +- 11.8 km/s and consequently a measurement of the stellar mass ratio of GK Per, q = Mk/Mwd = 0.55 +- 0.21. The inferred white dwarf radial velocities are greater than those measured traditionally using the wings of Doppler-broadened emission lines suspected to originate in an accretion disk, highlighting the unsuitability of emission lines for mass determinations in cataclysmic variables. We determine mass limits for both components in the binary, Mk >= 0.48 +- 0.32 Msolar and Mwd >= 0.87 +- 0.24 Msolar.Comment: 8 pages, 8 figures, accepted by MNRA

Star cluster formation and star formation: the role of environment and star-formation efficiencies

“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s10509-009-0088-5By analyzing global starburst properties in various kinds of starburst and post-starburst galaxies and relating them to the properties of the star cluster populations they form, I explore the conditions for the formation of massive, compact, long-lived star clusters. The aim is to determine whether the relative amount of star formation that goes into star cluster formation as opposed to field star formation, and into the formation of massive long-lived clusters in particular, is universal or scales with star-formation rate, burst strength, star-formation efficiency, galaxy or gas mass, and whether or not there are special conditions or some threshold for the formation of star clusters that merit to be called globular clusters a few billion years later.Peer reviewe

Extreme Ultra-Violet Spectroscopy of the Lower Solar Atmosphere During Solar Flares

The extreme ultraviolet portion of the solar spectrum contains a wealth of diagnostic tools for probing the lower solar atmosphere in response to an injection of energy, particularly during the impulsive phase of solar flares. These include temperature and density sensitive line ratios, Doppler shifted emission lines and nonthermal broadening, abundance measurements, differential emission measure profiles, and continuum temperatures and energetics, among others. In this paper I shall review some of the advances made in recent years using these techniques, focusing primarily on studies that have utilized data from Hinode/EIS and SDO/EVE, while also providing some historical background and a summary of future spectroscopic instrumentation.Comment: 34 pages, 8 figures. Submitted to Solar Physics as part of the Topical Issue on Solar and Stellar Flare

Delivery of hepato-pancreato-biliary surgery during the COVID-19 pandemic: an European-African Hepato-Pancreato-Biliary Association (E-AHPBA) cross-sectional survey

Background: The extent of the COVID-19 pandemic and the resulting response has varied globally. The European and African Hepato-Pancreato-Biliary Association (E-AHPBA), the premier representative body for practicing HPB surgeons in Europe and Africa, conducted this survey to assess the impact of COVID-19 on HPB surgery. Methods: An online survey was disseminated to all E-AHPBA members to assess the effects of the pandemic on unit capacity, management of HPB cancers, use of COVID-19 screening and other aspects of service delivery. Results: Overall, 145 (25%) members responded. Most units, particularly in COVID-high countries (>100,000 cases) reported insufficient critical care capacity and reduced HPB operating sessions compared to COVID-low countries. Delayed access to cancer surgery necessitated alternatives including increased neoadjuvant chemotherapy for pancreatic cancer and colorectal liver metastases, and locoregional treatments for hepatocellular carcinoma. Other aspects of service delivery including COVID-19 screening and personal protective equipment varied between units and countries. Conclusion: This study demonstrates that the COVID-19 pandemic has had a profound adverse impact on the delivery of HPB cancer care across the continents of Europe and Africa. The findings illustrate the need for safe resumption of cancer surgery in a “new” normal world with screening of patients and staff for COVID-19

Active Galactic Nuclei at the Crossroads of Astrophysics

Over the last five decades, AGN studies have produced a number of spectacular examples of synergies and multifaceted approaches in astrophysics. The field of AGN research now spans the entire spectral range and covers more than twelve orders of magnitude in the spatial and temporal domains. The next generation of astrophysical facilities will open up new possibilities for AGN studies, especially in the areas of high-resolution and high-fidelity imaging and spectroscopy of nuclear regions in the X-ray, optical, and radio bands. These studies will address in detail a number of critical issues in AGN research such as processes in the immediate vicinity of supermassive black holes, physical conditions of broad-line and narrow-line regions, formation and evolution of accretion disks and relativistic outflows, and the connection between nuclear activity and galaxy evolution.Comment: 16 pages, 5 figures; review contribution; "Exploring the Cosmic Frontier: Astrophysical Instruments for the 21st Century", ESO Astrophysical Symposia Serie