Caracterización Taxonómica y Filogenómica de Salinivibrio Socompensis SP. NOV.

Se conocencomo bacteriashalófilasaquellas que requieren condiciones salinas para crecer y que presentan un óptimo decrecimiento al 5-15% de sales, pudiendo además existir otros factores extremos. Entre estosmicroorganismos encontramos al género Salinivibrio, caracterizado por ser bacilos curvados Gram-negativos, anaerobios facultativos, móviles, concrecimiento enun rango de salinidad de 1-20%, un rango de pH de 5-10 y un rango de temperaturade5-45ºC. El contenido en G+C del ADN es de49,4-50,5moles%.Actualmente, cuenta con cinco especies y dos subespecies.El trabajo de Gorriti et al.(2014) describeuna cepa que podría constituiruna posible nueva especie aislada dellago alcalino Socompa (Argentina). En el presente estudio sehallevadoa cabo una completa caracterización polifásicade dicha cepa. Para ello, sehacomparado el gen ARNr 16S con las secuencias presentesen las bases de datos y posteriormente se realizó un estudio del core-genomade dichomicroorganismo que sugiere que constituye una nueva especie del género Salinivibrio.Dicho estudio se completó mediante el cálculo de los índicesANIb, ANIm e hibridación ADN-ADN in silico. Simultáneamente, se realizóuna caracterización fenotípica que hapermitido determinarque presentaun óptimo de NaCl del7-7,5%, un óptimo de pH de 7,5-8, y que coincide con las otras especies del género en su capacidadpara producircatalasa y oxidasa yotras características bioquímicas, pero presenta diferencias con respecto a dichas especies. Por último, cuenta con un perfil de ácidos grasosdondeC16:0 y C18:1 son mayoritarios,al igual que otras especies del géneroSalinivibrio. Los resultados obtenidos indican que la cepa S35 constituye una nueva especie para la que proponemos la denominación de Salinivibrio socompensis sp. nov.Universidad de Sevilla. Doble grado en Farmacia y Óptica y Optometrí

Validación del proceso de producción de la solución de NaOH 32% p/p según la normativa EU GMP Parte II

Treballs Finals de Grau d'Enginyeria Química, Facultat de Química, Universitat de Barcelona, Curs: 2017-2018, Tutors: Esther Chamarro Aguilera, Manel Vicente Buil, David Carreras i ViñasOne of the main quality requirements for GMP regulations is the process validation in order to guarantee the consumer satisfaction. Therefore, the manufacturers have to control the critical points of the manufacturing process through the qualification and validation during the product’s life cycle. The intention is to show what is the process validation and all the factors that are involved in it as well as the importance of the process validation to demonstrate that a manufacturing process is consistent and produces a product which complies with predefined specifications. For that purpose, participation on the process validation of the manufacturing of NaOH 32% w/w solution GMP has been performed. The process validation of NaOH 32% w/w GMP started in December 2017 and its ending is scheduled at the end of the 2018. Firstly, the performance of a risk assessment with the establishment of the possible risks of the process through the detailed study of the manufacturing process of NaOH 32% GMP. The identified risks have allowed the creation of cleaning and operating procedures, and the development of corrective actions to reduce the possibilities of having quality or safety issues. Secondly, the engagement in the equipment qualification of vessel. The tasks involved in it have been consisted in create and complete the documentation of Design Qualification, Installation Qualification, Operational Qualification and Performance Qualification. Thirdly, due to the fact that NaOH 32% GMP is manufactured in multiproduct plant, the determination of Barium Hydroxide 8-Hydrate as the “worst case” through the performance of the risk analysis based on the solubility, toxicity and the hardest to clean of whole the products manufactured in the equipment in order to validate the cleaning procedure suggested. Fourthly, some improvements and recommendations has been suggested during this project as a result of the current process study performed to elaborate the Product Quality Review suchas the approach of water system qualification, the reconsideration of the products specifications and the application of a tool to collect the information obtained from the product and the process. To achieve these tasks, it has been necessary to gaining knowledge and understanding about Good Manufacturing Practices (cGMP) and the concepts of validation. This knowledge has been based on guidelines and regulations of ICH (International Council for Harmonisation), EMEA (European Medicines Agency) and FDA (Food and Drug Administration)

An Eligible Bachelor: Austen, Love, and Marriage in Pride and Prejudice and Eligible by Curtis Sittenfeld.

Jane Austen’s six novels have been the starting point of many sequels, continuations, and adaptations. One of such is Eligible by Curtis Sittenfeld, a rewriting of Pride and Prejudice set in 21st-century U.S.A., where the search for an eligible bachelor becomes a TV reality show. This essay analyzes how Sittenfeld modifies Austen’s characterization of the main characters and their matrimonial quest taking into account how marriage has changed since the 19th century, exploring what elements persist and what adjustments need to be made in order to bring the spirit of the original to our current days and if such an attempt is ultimately successful.post-print524 K

Cálculo hidráulico de puentes históricos

En la presente tesina se ha realizado un estudio del comportamiento de los cursos fluviales al ser atravesados por puentes antiguos en forma de arco. Estos puentes se caracterizan por presentar áreas de obstrucción elevadas que provocan la dificultad del flujo para pasar por debajo del puente. Esta dificultad se refleja en importantes sobreelevaciones de la lámina de agua que pueden provocar inundaciones donde, sin la presencia de estos puentes, quizás no se hubieran producido. Por otro lado, las pilas de estos puentes son muy robustas y amplias, por lo que provocan erosiones locales importantes en los cauces de ríos de lechos granulares. A esta erosión local se le suma el efecto de la erosión por la contracción producida por el puente. Esta erosión por contracción, además, afecta a la sobrerelevación de la lámina de agua

Mission: Vol. 2, No. 3

Mission: Vol. 2, No. 3. The articles in this issue include: Editorials, The Lamp and the Mirror by William J. Cook, Jr., The Dilemma of Christian Youth by James Wilson, The Dream Lives On by Thomas A. Langford, The Visitor Unaware by E. E. Rice, Song Of The Innocent by Neva Goodwin, Pilate\u27s Washbowl by Lewis Randolph, Conference On Race Relations, Meditation on the Lord\u27s Supper by Elton D. Higgs, Mission Reviews by William N. Fryer and Everett Ferguson, Mission Forum, and Missing The Mark by J. W. Roberts

La verdad está dentro de estas páginas: las novelas de Expediente X y los usos de la literatura de ciencia ficción

Conferencias y Comunicaciones del primer Congreso Internacional de literatura fantástica y ciencia ficción, celebrado del 6 al 9 de mayo de 2008 en la Universidad Carlos III de Madri

Engineering disorder in three-dimensional photonic crystals

We demonstrate the effect of introducing controlled disorder in self-assembled three-dimensional photonic crystals. Disorders are induced through controlling the self-assembling process using an electrolyte of specific concentrations. Structural characterization reveals increase in disorder with increase in concentrations of the electrolyte. Reflectivity and transmittance spectra are measured to probe the photonic stop gap at different levels of disorder. With increase in disorder the stop gap is vanished and that results in a fully random photonic nanostructure where the diffuse scattered intensity reaches up to 100%. Our random photonic nanostructure is unique in which all scatters have the same size and shape. We also observe the resonant characteristics in the multiple scattering of light.Comment: 13 pages, 3 figure

CVA with wrong-way risk and correlation between defaults: An application to an interest rate swap

This paper presents a counterparty credit risk adjustment model to value overthe-counter financial derivatives. To do so, a bilateral credit valuation adjustment with wrong-way risk (WWR) and dependency between the defaults of both contract parties is developed in line with the Hull-White model (2012), which calculates default probabilities using a hazard rate modelled as an exponential function dependent on the value of the derivative. The model proposed incorporates a modified hazard rate for each entity, which includes the company’s own exposure to credit risk attributable to the other entity’s default. By so doing, a correlation between the respective defaults of the entities party to the financial derivative is added. The model developed is also applied to obtain the fair value of an interest rate swap and the results obtained, using Monte Carlo simulation, demonstrate that the value of this swap adjusted to the credit risk falls when the dependency between the entities’ defaults is considered