Y-stent-assisted coil embolization of anterior circulation aneurysms using two solitaire AB devices: a single enter experience

Wide-neck intracranial aneurysms remain a challenge to endovascular treatment. We describe our experience in repairing wide-neck aneurysms of the anterior circulation located at arterial branch points using coil embolization assisted by Y-stenting using two Solitaire® stents. Six wide-neck intracranial aneurysms located on the middle cerebral artery bifurcation 3, pericallosal artery 1, and anterior communicating artery 2 were repaired by Y-stent-assisted coil embolization using two Solitaire® stents. Four cases were incidental findings of aneurysm and two cases were previously treated ruptured aneurysms that had undergone recanalization. All the cases were successfully treated without complications. Follow-up by digital subtraction angiography and magnetic resonance angiography at six months showed the stents to be patent with no recanalization of the aneurysm sacs. Repairing wide-neck aneurysms of the anterior circulation by Y-stent-assisted coil embolization using two Solitaire® stents is a simple and safe method of treating complex aneurysms. While the results are promising, larger series with longer term follow-ups are needed to corroborate that this treatment method is superior to other technique

Photocatalytic hydrogen production performance of 1-D ZnO nanostructures : role of structural properties

Synthesis of zinc oxide (ZnO) nanowires (NWs) grown via vapor-liquid-solid (VLS) process using Gold (Au) as a catalyst metal on aluminum-doped zinc oxide (AZO) seed layer is reported in the present work. During the growth procedure, the nucleation process helps us to obtain ZnO nanowires with Au on the tip, confirming the VLS growth mechanism. Different morphologies were obtained after the variation in the growth parameters in the VLS process, and further, their role in the photocatalytic performance was studied. Changes in the structural properties of nanowires allowed us to modify the aspect ratio and surface area of the nanostructures. X-ray diffraction (XRD) showed that the principal orientation of the nanowires was (002) in the present case. Scanning electron microscopy (SEM) showed the structural properties of 1-D nanostructures (nanowires), and statistical analysis revealed that the average diameter in the present case was found to be varied from 57 to 85 nm. Scanning transmission electron microscopy (STEM) technique revealed the different elements present on the surface of ZnO NWs. Further, the compositional profile of nanostructures was cross-verified using Energy dispersive Spectroscopy (EDS). Photoluminescence (PL) and UV Visible studies were employed to study the optical properties of nanowires. UV–Vis measurements showed the role of different structural properties of nanowires on the absorption spectra, especially in the visible region. The ZnO nanowires were tested as photocatalysts for hydrogen production from water splitting reaction, and it was found in particular nanowires with random orientation with optimal diameter distribution show the stable and highest photocatalytic performance

Zinc associated nanomaterials and their intervention in emerging respiratory viruses: Journey to the field of biomedicine and biomaterials.

Respiratory viruses represent a severe public health risk worldwide, and the research contribution to tackle the current pandemic caused by the SARS-CoV-2 is one of the main targets among the scientific community. In this regard, experts from different fields have gathered to confront this catastrophic pandemic. This review illustrates how nanotechnology intervention could be valuable in solving this difficult situation, and the state of the art of Zn-based nanostructures are discussed in detail. For virus detection, learning from the experience of other respiratory viruses such as influenza, the potential use of Zn nanomaterials as suitable sensing platforms to recognize the S1 spike protein in SARS-CoV-2 are shown. Furthermore, a discussion about the antiviral mechanisms reported for ZnO nanostructures is included, which can help develop surface disinfectants and protective coatings. At the same time, the properties of Zn-based materials as supplements for reducing viral activity and the recovery of infected patients are illustrated. Within the scope of noble adjuvants to improve the immune response, the ZnO NPs properties as immunomodulators are explained, and potential prototypes of nanoengineered particles with metallic cations (like Zn2+) are suggested. Therefore, using Zn-associated nanomaterials from detection to disinfection, supplementation, and immunomodulation opens a wide area of opportunities to combat these emerging respiratory viruses. Finally, the attractive properties of these nanomaterials can be extrapolated to new clinical challenges

Zinc associated nanomaterials and their intervention in emerging respiratory viruses:Journey to the field of biomedicine and biomaterials

Respiratory viruses represent a severe public health risk worldwide, and the research contribution to tackle the current pandemic caused by the SARS-CoV-2 is one of the main targets among the scientific community. In this regard, experts from different fields have gathered to confront this catastrophic pandemic. This review illustrates how nanotechnology intervention could be valuable in solving this difficult situation, and the state of the art of Zn-based nanostructures are discussed in detail. For virus detection, learning from the experience of other respiratory viruses such as influenza, the potential use of Zn nanomaterials as suitable sensing platforms to recognize the S1 spike protein in SARS-CoV-2 are shown. Furthermore, a discussion about the antiviral mechanisms reported for ZnO nanostructures is included, which can help develop surface disinfectants and protective coatings. At the same time, the properties of Zn-based materials as supplements for reducing viral activity and the recovery of infected patients are illustrated. Within the scope of noble adjuvants to improve the immune response, the ZnO NPs properties as immunomodulators are explained, and potential prototypes of nanoengineered particles with metallic cations (like Zn(2+)) are suggested. Therefore, using Zn-associated nanomaterials from detection to disinfection, supplementation, and immunomodulation opens a wide area of opportunities to combat these emerging respiratory viruses. Finally, the attractive properties of these nanomaterials can be extrapolated to new clinical challenges

Anticipating Challenges in Optical Nanobiosensors for Global Detection of Respiratory Viruses and Emerging Threats

The unprecedented SARS-CoV-2 pandemic has opened huge opportunities for nanomaterial-based biosensors focused on timely detection of emerging respiratory viruses, where challenges must address actions for fast response and massive application. Accordingly, we provide a comprehensive perspective on critical aspects, including nanomaterials, biofunctionalization strategies, and bioreceptors engineering to increase accuracy, emphasizing optical nanobiosensors. The first biosensing prototype performance reveals the need to consider crucial factors for improvement, such as handling detection in complex matrices, standardization for commercial purposes, portability, integration with artificial intelligence, sustainability, and economic feasibility. By achieving these goals, biosensors would foster a prepared global healthcare landscape

Interaction Study of Anti‐E. coli Immobilization on 1DZnO at Nanoscale for Optical Biosensing Application

Abstract Developing low‐cost biosensing platforms for robust detection response and sensitivity at low concentrations is of great interest. This work reports synthesizing 1D ZnO nanostructured materials (1DZnO) with controllable properties utilizing a metal catalyst‐assisted vapor phase growth technique (VLS). The obtained materials are functionalized with (3‐aminopropyl) trimetoxysilane (APTMS) and immobilized with anti‐Escherichia coli enteropathogenic (EPEC) antibodies. Characterization results show changes in the optical and structural properties of 1DZnO that are correlated with the biofunctionalization methodologies. Further, the biofunctionalization process is assessed on 1DZnO surface platforms to obtain acceptable antibody immobilization efficiencies (52%, 96%, and 100%) using a low‐concentration antibody solution (30 µg ml−1). Special techniques such as focused ion beam micromachining and scanning tunneling electron microscopy are proposed to appreciate the semiconductor biofunctionalization layer around 1DZnO and explain the physics of the interaction process. It is found that morphology obtained from distinct synthesis methods, solvents, and functionalization agents can generate functional groups for biomolecule attachment. Remarkably, it is demonstrated that biofunctionalization on 1DZnO takes place all over a single nanostructure. This work presents a proof‐of‐concept focused on generating pathogen sensing platforms using 1DznO semiconducting materials, providing new insights into bio‐analytes interaction with structures at the nanoscale

N-methyl-1H-indole-2-carboxamide from the marine fungus Cladosporium cladosporioides

The crystal structure of N-methyl-1H-indole-2-carboxamide C10H10N2O was determined by single crystal X-ray diffraction. The structure can be described as consisting of an indole group and as substituent, linked at C2, the N-methylcarboxamide group. The molecular structure is essentially planar. The crystal packing results in N-H-------O hydrogen bonds which join the molecules into centrosymmetric dimeric rings. The knowledge of the crystal structure allows a complete assignment of the 1H and 13C-NMR spectra. The N-methyl-1H-indole-2-carboxamide is the first indole derivative isolated from marine fungus