LA ADMINISTRACIÓN ELECTRÓNICA EN ESPAÑA: DE LA “ADMINISTRACIÓN EN PAPEL” A LA “E-ADMINISTRACIÓN”

Since the early 90s, our society is undergoing different changes associated to the massive use of technologies of information and communication (ICT). In the context of this new social model – called Information Society- public administrations have to adapt by introducing new technologies in their everyday activities. However, the transformation of public administrations goes beyond the use of ICT. The change that has occurred is a transformation from a paper-and-pencil administration to a real e-Government. This requires changes in the law and in the relations between administration and citizens. This paper analyses the development of this process in the public administrations of Spain.Desde principios de los 90, nuestra sociedad está sufriendo una serie de cambios, asociados al uso masivo de las nuevas tecnologías de la información y la comunicación (TIC). En este nuevo modelo social, conocido bajo el nombre de Sociedad de la Información, las Administraciones Públicas han tenido que adaptarse, introduciendo las nuevas tecnologías en su actividad cotidiana. No obstante, la transformación de las Administraciones Públicas va más allá del uso de las TIC, pues supone una auténtica transformación des de una Administración en papel a una verdadera Administración electrónica. Todo ello conlleva modificaciones en el ordenamiento jurídico, así como en las relaciones entre la Administración con los ciudadanos. En este trabajo, analizamos el desarrollo de este proceso en las Administraciones públicas españolas.

Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction

Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer. Virtual screening identified certain 3,4,5-trisubstituted 4H-1,2,4-triazoles as moderately potent inhibitors of this interaction. A series of analogues were synthesized based on the 1,2,4-triazole scaffold and were evaluated for inhibition of the annexin A2–S100A10 protein interaction in competitive binding assays. 2-[(5-{[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]methyl}-4-(furan-2-ylmethyl)-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[4-(propan-2-yl)phenyl]acetamide (36) showed improved potency and was shown to disrupt the native complex between annexin A2 and S100A10

Role of CD45 Signaling Pathway in Galactoxylomannan-Induced T Cell Damage

Previously, we reported that Galactoxylomannan (GalXM) activates the extrinsic and intrinsic apoptotic pathways through an interaction with the glycoreceptors on T cells. In this study we establish the role of the glycoreceptor CD45 in GalXM-induced T cell apoptosis, using CD45+/+ and CD45−/− cell lines, derived from BW5147 murine T cell lymphoma. Our results show that whereas CD45 expression is not required for GalXM association by the cells, it is essential for apoptosis induction. In CD45+/+ cells, CD45 triggering by GalXM reduces the activation of Lck, ZAP70 and Erk1/2. Conversely, in CD45−/− cells, Lck was hyperphosphorylated and did not show any modulation after GalXM stimulation. On the whole, our findings provide evidence that the negative regulation of Lck activation occurs via CD45 engagement. This appears to be related to the capacity of GalXM to antagonize T cell activation and induce T cell death. Overall this mechanism may be responsible for the immune paralysis that follows GalXM administration and could explain the powerful immunosuppression that accompanies cryptococcosis

Synthese et caracterisation de copolymeres thermotropes lineaires de type poly (fumarate d'arylene)-bloc-poly (fumarate d'alkylene)

Available from INIST (FR), Document Supply Service, under shelf-number : T 78185 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

Evaluation of serials collection of the library of Communication Sciences UAB

Es descriu el procés emprat per a l'avaluació del fons i s'especifica el tipus d'avaluació realitzada. Es presenten les conclusions i les recomanacions d'accions futures. Finalment es completa amb la descripció de les decisions preses a partir de les recomanacions.Description of the process used to evaluate the collection specifying of the type of evaluation carried out. The conclusions and recommendations for  future actions are presented. The decisions taken based on the recommendations are described

Islamofòbia, humor i llibertat d'expressió : anàlisi del tractament de l'islam en tres revistes satíriques: 'El Jueves', 'Charlie Hebdo' i 'Mongolia'

Anàlisi de portades i caricatures sobre l'islam en tres revistes satíriques ('El Jueves', 'Charlie Hebdo' i 'Mongolia') a través de conceptes com l'humor, la sàtira, l'ofensa, el discurs de l'odi o la llibertat d'expressió, per tal d'estudiar si hi ha islamofobia o no. Completen aquest anàlisi les reflexions de dibuixants i musulmans, amb l'objectiu d'aclarir els aspectes més controvertits. El període d'anàlisi va des del setembre del 2005, quan va esclatar l'anomenada "crisi de les caricatures de Mahoma", fins a l'actualitat.Análisis de portadas y caricaturas sobre el islam en tres revistas satíricas ('El Jueves', 'Charlie Hebdo' y 'Mongolia'). El trabajo analiza los mensajes de cada portada a través de factores como el humor, la sátira, la ofensa, el discurso del odio o la libertad de expresión con tal de estudiar si hay islamofobia o no. Completan este análisis las reflexiones de los propios dibujantes y musulmanes, con el objetivo de esclarecer algunos aspectos más controvertidos. El análisis va desde septiembre de 2005 -cuando estalló "crisis de las caricaturas de Mahoma- hasta la actualidad.This dissertation is a discourse analysis of front covers and caricatures in three satirical magazines ('El Jueves', 'Charlie Hebdo' and 'Mongolia'). Every cover is analysed taking into account factors such as humour, satire, offense, hate speech and freedom of speech, with the final objective of studying whether there is Islamophobia or not. There is also a part where both cartoonists and Muslims speak their minds in order to clarify the most controversial aspects. The analysis starts in September 2005 with the so-called Muhammad cartoons controversy and ends in the present