The upswing of regional income inequality in Spain (1860-1930).

This paper studies the evolution of Spanish regional inequality from 1860 to 1930. The results point to the coexistence of two basic forces behind changes in regional economic inequality: industrial specialization and labor productivity differentials. The initial expansion of industrialization, in a context of growing economic integration of regions, promoted the spatial concentration of manufacturing in certain regions, which also benefited from the greatest advances in terms of labor productivity. Since 1900, the diffusion of manufacturing production to a greater number of locations generated the emulation of production structures and a process of catching-up in labor productivity and wages.Industrialization; Market Integration; Heckscher-Ohlin Model; New Economic Geography;

The upswing of regional income inequality in Spain (1860–1930).

This paper studies the evolution of Spanish regional inequality from 1860 to 1930. The results point to the coexistence of two basic forces behind changes in regional economic inequality: industrial specialization and labor productivity differentials. The initial expansion of industrialization, in a context of growing economic integration of regions, promoted the spatial concentration of manufacturing in certain regions, which also benefited from the greatest advances in terms of labor productivity. Since 1900, the diffusion of manufacturing production to a greater number of locations has generated the emulation of production structures and a process of catching-up in labor productivity and wagesIndustrialization; Market integration; Heckscher–Ohlin model; New economic geography; Regional convergence;

The long-term patterns of regional income inequality in Spain (1860-2000)

This paper studies the evolution of Spanish regional inequality from 1860 to 2000. The results point to the coexistence of two basic forces behind changes in regional economic inequality: differences in economic structure and labor productivity across regions. In the Spanish case, the initial expansion of industrialization during the period 1860-1900, in a context of growing economic integration of regions, promoted the spatial concentration of manufacturing in certain regions, which also benefited from the greatest advances in terms of labor productivity. Since 1900 and until 1985, the diffusion of manufacturing and services production to a greater number of locations generated the emulation of production structures and a process of catching-up in labor productivity and wages. So, in these first 125 years, national market integration and economic growth has been followed by a Ushaped evolution of regional incomes inequality. Nevertheless, some productivity differentials remained and, from 1985 on, the Spanish entry in the UE generated a new upsurge of divergence in productivity across Spanish regions that could be in the base of a new phase of regional income divergence

Historia de la filosofía

Ningun

Insights on the economic estimates of the climate costs of the aviation sector due to air management in 2018-19

Air navigation service providers ensure that aircrafts keep safely apart by prescribing vertical and horizontal distances to each other. In the European Union and its associated members, regulation is carried out via a performance scheme which measures and sets targets for the different key performance areas. For the environmental area, targets in terms of CO2 and other pollutants were set by assuming that there would be continuous improvements for the Key performance Environment indicator based on actual trajectory. However, although a higher Horizontal Flight Efficiency (HFE) measurement usually means a more direct flight trajectory, this does not necessarily translate into a climate optimal trajectory. Thus, vertical flight efficiency also needs to be considered. There is also an interdependency between airspace and Air Traffic Management Capacity and Environment: when the offered capacity falls short of the demand for flights, ground delays, holdings and traffic shifts to adjacent areas occur. This entails detours and a deterioration of the HFE-indicator. Results show that total climate costs for 2018 and 2019 may be as high as 1 bn EUR, of which about 34% is due to CO2 emissions. In particular, the climate costs of CO2 emissions due to capacity constraints range from 54 to 301 million EUR, depending on whether CO2 costs are measured in terms of avoidance costs or under the EU Emissions Trading System (EU ETS). Following the first criterion and the short to medium run up to 2030, the estimated costs would amount to 112 million EUR. In the long run, from 2040 to 2060, these costs would amount to 301 Million EUR. With the estimates of the EU ETS, the cost by 2030 would be close to 54 million EUR and 153.5 million EUR for the long run. Volatility of carbon pricing may play a very significant role, but fortunately can be hedged. Therefore, a shortfall of capacity leads to delay costs and considerable environmental costs. As capacity is planned in the medium to long-term, traffic forecasts are a crucial element. This means that further research is warranted into the interdependency of traffic forecasts, capacity and environmental costs. © 2021 Publicaciones Dyna Sl. All rights reserved.This research is supported by the Basque Government through the BERC 2018-2021 programme and by the Spanish Ministry of Economy and Competitiveness (MINECO) through BC3 María de Maeztu excellence accreditation MDM-2017-0714. Further support is provided by the project MINECO RTI 2018-093352-B-I00

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues

RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents acting through lethal mutagenesis. We have synthesized novel N-6-substituted purine analogues with ambiguous incorporation characteristics due to tautomerization of the nucleobase. The most potent of these analogues reduced the titer of poliovirus (PV) and coxsackievirus (CVB3) over 1,000-fold during a single passage in HeLa cell culture, with an increase in transition mutation frequency up to 65-fold. Kinetic analysis of incorporation by the PV polymerase indicated that these analogues were templated ambiguously with increased efficiency compared to the known mutagenic nucleoside ribavirin. Notably, these nucleosides were not efficient substrates for cellular ribonucleotide reductase in vitro, suggesting that conversion to the deoxyriboucleoside may be hindered, potentially limiting genetic damage to the host cell. Furthermore, a high-fidelity PV variant (G64S) displayed resistance to the antiviral effect and mutagenic potential of these analogues. These purine nucleoside analogues represent promising lead compounds in the development of clinically useful antiviral therapies based on the strategy of lethal mutagenesis

Transgénesis: una moderna biotecnología reproductiva en animales de interés zootécnico

Los continuos avances en el conocimiento de la biología molecular han permitido un gran progreso de la ciencia, mediante la modificación genética tanto de virus, bacterias como de organismos superiores. Estos procedimientos de alta complejidad que comprenden a la ingeniería genética permiten identificar, reproducir, modificar y transferir material genético en células, tejidos u organismos. A su vez, las modernas técnicas reproductivas que han logrado incrementar progresivamente su eficiencia en los últimos años (inseminación artificial, sincronización hormonal de estros, fecundación "in vitro", fertilización asistida, transferencia de embriones, clonación, etc.), constituyen herramientas indispensables para seguir avanzando en las nuevas investigaciones referidas a la modificación genética en los animales. Se describen brevemente las diversas metodologías empleadas para la realización de transgénesis en animales de interés zootécnico.Continuous advances in the understanding of molecular biology have allowed great progress of science, through genetic modification of viruses, bacteria and higher organisms. These highly complex procedures that include genetic engineering enable to identify, reproduce, modify and transfer genetic material into cells, tissues or organisms. In turn, modern reproductive techniques that have managed to gradually increase their efficiency in recent years (artificial insemination, hormonal synchronization of estrus, fertilization "in vitro", assisted fertilization, embryo transfer, cloning, etc.) are essential tools for continue advancing in new research concerning genetic modification in animals. The various methodologies used to carry out transgenesis in animals of zootechnical interest are briefly described.Fil: Gibbons, A.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Patagonia Norte. Estación Experimental Agropecuaria San Carlos de Bariloche; ArgentinaFil: Bevacqua, Romina Jimena. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Producción Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fernandez Martin, R.. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Producción Animal; ArgentinaFil: Pereyra Bonnet, Federico Alberto. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cueto, M.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Patagonia Norte. Estación Experimental Agropecuaria San Carlos de Bariloche; ArgentinaFil: Bruno Galarraga, María Macarena. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Patagonia Norte. Estación Experimental Agropecuaria San Carlos de Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Salamone, Daniel Felipe. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Producción Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin