Mapping Atomic Motions with Electrons: Toward the Quantum Limit to Imaging Chemistry

Recent advances in ultrafast electron and X-ray diffraction have pushed imaging of structural dynamics into the femtosecond time domain, that is, the fundamental time scale of atomic motion. New physics can be reached beyond the scope of traditional diffraction or reciprocal space imaging. By exploiting the high time resolution, it has been possible to directly observe the collapse of nearly innumerable possible nuclear motions to a few key reaction modes that direct chemistry. It is this reduction in dimensionality in the transition state region that makes chemistry a transferable concept, with the same class of reactions being applicable to synthetic strategies to nearly arbitrary levels of complexity. The ability to image the underlying key reaction modes has been achieved with resolution to relative changes in atomic positions to better than 0.01 Å, that is, comparable to thermal motions. We have effectively reached the fundamental space-time limit with respect to the reaction energetics and imaging the acting forces. In the process of ensemble measured structural changes, we have missed the quantum aspects of chemistry. This perspective reviews the current state of the art in imaging chemistry in action and poses the challenge to access quantum information on the dynamics. There is the possibility with the present ultrabright electron and X-ray sources, at least in principle, to do tomographic reconstruction of quantum states in the form of a Wigner function and density matrix for the vibrational, rotational, and electronic degrees of freedom. Accessing this quantum information constitutes the ultimate demand on the spatial and temporal resolution of reciprocal space imaging of chemistry. Given the much shorter wavelength and corresponding intrinsically higher spatial resolution of current electron sources over X-rays, this Perspective will focus on electrons to provide an overview of the challenge on both the theory and the experimental fronts to extract the quantum aspects of molecular dynamics

Farmers' management of rice varietal diversity in the mid-hills of Nepal: implications for on-farm conservation and crop improvement

Season-long monitoring of on-farm rice (Oryza sativa, L.) plots in Nepal explored farmers' decision-making process on the deployment of varieties to agroecosystems, application of production inputs to varieties, agronomic practices and relationship between economic return and area planted per variety. Farmers deploy varieties [landraces (LRs) and modern varieties (MVs)] to agroecosystems based on their understanding of characteristics of varieties and agroecosystems, and the interaction between them. In marginal growing conditions, LRs can compete with MVs. Within an agroecosystem, economic return and area planted to varieties have positive relationship, but this is not so between agroecosystems. LRs are very diverse on agronomic and economic traits; therefore, they cannot be rejected a priori as inferior materials without proper evaluation. LRs have to be evaluated for useful traits and utilized in breeding programmes to generate farmer-preferred materials for marginal environments and for their conservation on-farm

ASSESSING THE IMPACTS OF CLIMATE CHANGE ON THE HYDROLOGY OF THE INDRAWATI RIVER BASIN, NEPAL

Abstract. This study details climate change assessment of the hydrological regime of Indrawati basin of Nepal. The study uses Soil and Water Assessment Tool (SWAT) model to delineate, discretize and parameterize the Indrawati basin to compute model's input parameters. The model was then run for 1990–2014 to simulate the discharge at the outlet (Dholalghat). The coefficient of determination R2 and Nash-Sutcliffe (ENS) were used to evaluate model calibration and validation. The results found were satisfactory for the gauging station R2 = 0.951 and ENS = 0.901 for calibration and R2 = 0.937 and. ENS = 0.906 for validation. The calibrated hydrological model was run for the future climate change scenario using the RegCM4-LMDZ4 data and the relative changes with the baseline scenarios were analyzed. The comparison suggests that the historical trend of flow is decreasing at the rate of 0.55 m3/s per year. According to RegCM4-LMDZ4 simulations, the trend is going to continue but at a flatter rate. The decreasing trend is observed to be very less. The characteristic peak flow month in the historical scenario is August but the RegCM4-LMDZ4 led simulated flows suggest a shift in monthly peak to October suggesting decrease in monsoon flows and a subsequent significant increase in flows from October to January

Cervical cancer screening in Nepal: Ethical considerations

© 2015 Gyawali et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.phpCervical cancer is the leading cause of cancer deaths for women worldwide. Cervical screening and early treatment can help to prevent cervical cancers. Cervical screening programs in Nepal are often associated with a number of socioeconomic, cultural, and ethical challenges. This paper discusses some central ethical challenges in providing cervical cancer screening in the Nepalese context and culture. It is necessary to address these challenges for successful implementation of such screening programs

Optical Proximity Sensing for Pose Estimation During In-Hand Manipulation

During in-hand manipulation, robots must be able to continuously estimate the pose of the object in order to generate appropriate control actions. The performance of algorithms for pose estimation hinges on the robot's sensors being able to detect discriminative geometric object features, but previous sensing modalities are unable to make such measurements robustly. The robot's fingers can occlude the view of environment- or robot-mounted image sensors, and tactile sensors can only measure at the local areas of contact. Motivated by fingertip-embedded proximity sensors' robustness to occlusion and ability to measure beyond the local areas of contact, we present the first evaluation of proximity sensor based pose estimation for in-hand manipulation. We develop a novel two-fingered hand with fingertip-embedded optical time-of-flight proximity sensors as a testbed for pose estimation during planar in-hand manipulation. Here, the in-hand manipulation task consists of the robot moving a cylindrical object from one end of its workspace to the other. We demonstrate, with statistical significance, that proximity-sensor based pose estimation via particle filtering during in-hand manipulation: a) exhibits 50% lower average pose error than a tactile-sensor based baseline; b) empowers a model predictive controller to achieve 30% lower final positioning error compared to when using tactile-sensor based pose estimates.Comment: 8 pages, 6 figure

Plant breeding can be made more efficient by having fewer, better crosses

BACKGROUND: Crop yields have to increase to provide food security for the world’s growing population. To achieve these yield increases there will have to be a significant contribution from genetic gains made by conventional plant breeding. However, the breeding process is not efficient because crosses made between parental combinations that fail to produce useful varieties consume over 99% of the resources. RESULTS: We tested in a rice-breeding programme if its efficiency could be improved by using many fewer, but more judiciously chosen crosses than usual. In a 15-year programme in Nepal, with varietal testing also in India and Bangladesh, we made only six crosses that were stringently chosen on complementary parental performance. We evaluated their success by the adoption and official release of the varieties they produced. We then modelled optimum cross number using assumptions based on our experimental results. Four of the six crosses succeeded. This was a fifty-fold improvement over breeding programmes that employ many crosses where only about one, or fewer, crosses in 200 succeed. Based on these results, we modelled the optimum number of crosses by assuming there would be a decline in the reliability of the breeder’s prediction of the value of each cross as more crosses were made (because there is progressively less information on the traits of the parents). Fewer-cross programmes were more likely to succeed and did so using fewer resources. Making more crosses reduced the overall probability of success of the breeding programme. CONCLUSIONS: The efficiency of national and international breeding programmes would be increased by making fewer crosses among more carefully chosen parents. This would increase the number of higher yielding varieties that are delivered to farmers and hence help to improve food security

Simulation-based flood fragility and vulnerability analysis for expanding cities

Accurately quantifying flood-induced impacts on buildings and other infrastructure systems is essential for risk-sensitive planning and decision-making in expanding urban regions. Flood-induced impacts are directly related to the physical components of assets damaged due to contact with water. Such components include building contents (e.g., appliances, furniture) and other non-structural components whose damage/unavailability can severely impact the buildingsﾒ functionality. Conventional fragility analysis approaches for flooding do not account for the physical damage to the individual components, mostly relying on empirical methods based on historical data. However, recent studies proposed simulation-based, assembly-based fragility models that account for the damage to the building components. Such fragility models require developing detailed inventories of vulnerable components of households and identifying building archetypes to be considered in a building portfolio for the region of interest. Content inventories and building portfolios have so far been obtained for specific socio-economic contexts such as the United States of America. However, building types and their content can significantly differ between countries, making the available fragility models and computational frameworks unsuitable for flood vulnerability analysis in rapidly expanding cities characterised by extensive informal settlements, such as low- and middle-income countries. This paper details how to adapt the available methodologies for flood vulnerability assessment to the context of formal and informal settlements of expanding cities in the global south. It also details the development of content inventories for households in these cities using field surveys. The proposed survey is deployed in various areas vulnerable to floods in Kathmandu, Nepal. Based on the survey results, each component within the household is associated with a corresponding flood capacity (resistance) distribution (in terms of water height and flood duration). These distributions are then employed in a simulation-based probabilistic framework to obtain fragility relationship and consequence models. The relevant differences between the results obtained in this study and those from previous studies are then investigated for a case-study building type. In addition, the influence of socio-economic factors (e.g., household income) and past flood experience (possibly resulting in various flood-risk mitigation strategies at a household level) on the resulting flood impacts is also included in the model

Preservation of geochemical characteristics in Permo-Triassic mudstones by metagenesis and low-grade metamorphism in the Tethys Himalaya, Central Nepal

Abstract HKT-ISTP 2013 A

Virulence of Moroccan f. Revealed by International Differential Barley Genotypes

Pyrenophora teres f. teres (Ptt), causing net blotch in barley, is an important and frequently isolated leaf pathogen across the globe. The virulence spectrum of Ptt from North Africa including Morocco is poorly understood. Sixteen barley genotypes were challenged, at seedling stage, with 15 Ptt isolates that were collected from different agroecological zones of Morocco. The experiment was conducted in a factorial arrangement of treatments in a randomized complete block design with three replicates. The ANOVA revealed highly significant (P < 0.001) effects of genotype (G), isolate (I) and G×I interaction explaining 23.2, 62.5, and 13.9% of the variation, respectively. Therefore, the current study revealed highly diverse virulence pattern of Moroccan isolates. Furthermore, the results indicated that minor virulence of Ptt isolates dominated over virulence interaction. In addition, Taffa (6-rowed) and Aglou (2 rowed), had the highest level of resistance to Ptt, while Coast and Rabat071 were the most susceptible genotypes. Pt2, Pt7, Pt8 and Pt4 were being the most virulent isolates, while Pt10 and Pt11 were the least virulent isolates. The emergence of the new Ptt pathotypes, which were highly virulent to durable resistance in Rabat071 posed a risk of breaking down the currently deployed resistance to net blotch in Morocco. A careful evaluation and selection of Ptt isolates based on minor virulence pattern to barley genotypes is essential for successful barley breeding program for resistance to net blotch in Morocco