An agent-based simulator for quantifying the cost of uncertainty in production systems

Product-mix problems, where a range of products that generate different incomes compete for a limited set of production resources, are key to the success of many organisations. In their deterministic forms, these are simple optimisation problems; however, the consideration of stochasticity may turn them into analytically and/or computationally intractable problems. Thus, simulation becomes a powerful approach for providing efficient solutions to real-world productmix problems. In this paper, we develop a simulator for exploring the cost of uncertainty in these production systems using Petri nets and agent-based techniques. Specifically, we implement a stochastic version of Goldratt’s PQ problem that incorporates uncertainty in the volume and mix of customer demand. Through statistics, we derive regression models that link the net profit to the level of variability in the volume and mix. While the net profit decreases as uncertainty grows, we find that the system is able to effectively accommodate a certain level of variability when using a Drum-Buffer-Rope mechanism. In this regard, we reveal that the system is more robust to mix than to volume uncertainty. Later, we analyse the cost-benefit trade-off of uncertainty reduction, which has important implications for professionals. This analysis may help them optimise the profitability of investments. In this regard, we observe that mitigating volume uncertainty should be given higher consideration when the costs of reducing variability are low, while the efforts are best concentrated on alleviating mix uncertainty under high costs.This article was financially supported by the State Research Agency of the Spanish Ministry of Science and Innovation (MCIN/AEI/ 10.13039/50110 0 011033), via the project SPUR, with grant ref. PID2020–117021GB-I00. In addition, the authors greatly appreciate the valuable and constructive feedback received from the Editorial team of this journal and two anonymous reviewers in the different stages of the review process

Performance Analysis of Direct N-Body Algorithms on Special-Purpose Supercomputers

Direct-summation N-body algorithms compute the gravitational interaction between stars in an exact way and have a computational complexity of O(N^2). Performance can be greatly enhanced via the use of special-purpose accelerator boards like the GRAPE-6A. However the memory of the GRAPE boards is limited. Here, we present a performance analysis of direct N-body codes on two parallel supercomputers that incorporate special-purpose boards, allowing as many as four million particles to be integrated. Both computers employ high-speed, Infiniband interconnects to minimize communication overhead, which can otherwise become significant due to the small number of "active" particles at each time step. We find that the computation time scales well with processor number; for 2*10^6 particles, efficiencies greater than 50% and speeds in excess of 2 TFlops are reached.Comment: 34 pages, 15 figures, submitted to New Astronom

Acidification and solar drying of manure-based digestate to produce improved fertilizing products

The increase in energy and fertilizer consumption makes it necessary to develop sustainable alternatives for agriculture. Anaerobic digestion and digestates appeared to be suitable options. However, untreated digestates still have high water content and can increase greenhouse gas emissions during storage and land application. In this study, manure-derived digestate and solid fraction of digestate after separation were treated with a novel solar drying technology to reduce their water content, combined with acidification to reduce the gaseous emissions. The acidified digestate and acidified solid fraction of digestate recovered more nitrogen and ammonia nitrogen than their respective non-acidified products (1.5–1.3 times for TN; 14 times for TAN). Ammonia and methane emissions were reduced up to 94% and 72% respectively, compared to the non-acidified ones, while N2O increased more than 3 times. Dried digestate and dried acidified digestate can be labeled as NPK organic fertilizer regarding the European regulation, and the dried solid fraction and the improved dried acidified solid fraction can be labeled as N or P organic fertilizer. Moreover, plant tests showed that N concentrations in fresh lettuce leaves were within the EU limit with all products in all the cases. However, zinc concentration appeared to be a limitation in some of the products as their concentration exceeded the European legal limits.This work was funded by the European Union under the Circular Agronomics project (H2020 research and innovation project Nº.773649) and Nutry2Cycle project (H2020 research and innovation project Nº.773682). IRTA thanks the support of the CERCA Program and the Consolidated Research Group TERRA (ref.2017SGR1292), both from the Generalitat de Catalunya. L. Morey thanks the financial support of AGAUR, of the Generalitat de Catalunya (grant reference number 2019FI_B00694). We would like to thank the help of Celia Segura Godoy and Pau Berenguer i Planas during the sampling campaigns.Peer ReviewedPostprint (published version

Spontaneous scalarization of charged Black Holes

Extended scalar-tensor Gauss-Bonnet (ESTGB) gravity has been recently argued to exhibit spontaneous scalarization of vacuum black holes (BAs). A similar phenomenon can be expected in a larger class of models, which includes, e.g., Einstein-Maxwell scalar (EMS) models, where spontaneous scalarization of electrovacuum BHs should occur. EMS models have no higher curvature corrections, a technical simplification over ESTGB models that allows us to investigate, fully nonlinearly, BH scalarization in two novel directions. First, numerical simulations in spherical symmetry show, dynamically, that Reissner-Nordstrom (RN) BHs evolve into a perturbatively stable scalarized BH. Second, we compute the nonspherical sector of static scalarized BH solutions bifurcating from the RN BH trunk. Scalarized BHs form an infinite (countable) number of branches and possess a large freedom in their multipole structure. Unlike the case of electrovacuum, the EMS model admits static, asymptotically flat, regular on and outside the horizon BHs without spherical symmetry and even without any spatial isometrics, which are thermodynamically preferred over the electrovacuum state. We speculate on a possible dynamical role of these nonspherical scalarized BHs.publishe

Effect of Dexamethasone in Neospora Caninum Seropositive Calves

The aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups as follow: group A: 4 sero- positive calves treated with DXM; group B: 4 seropositive calves without DXM; group C: 3 seronegative calves treated with DXM, and group D: 4 seronegative calves without DXM treatment. The absolute leukocyte count was higher in both groups A and C in the 3rd day after the first dose of DXM mainly due to a significant neutrophilia (p0.05). Similarly, IFN-γ levels did not change among experimental groups (p>0.05). DNA was de- tected in calves from groups A and B at 7 Days Post Administra- tion (dpa) and from group A at 14 dpa. Even when DXM adminis- tration induced hemotological parameter changes, no reactivation of Neospora-infection was observed according to specific IgG titers and presence of the parasite on leukocytes in naturally seropositive beef male calves.Fil: Idarraga Bedoya, S.. Universidad Nacional de Mar del Plata; ArgentinaFil: Armendano, Joaquín Ignacio. Universidad Nacional de Mar del Plata; ArgentinaFil: Gual, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata; ArgentinaFil: Hecker, Yanina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Leunda, M. R.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Pereyra, S.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Verna, Andrea Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Campero, C. M.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Odeón, Anselmo Carlos. Universidad Nacional de Mar del Plata; ArgentinaFil: Moore, Dadin Prando. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin