Coupled neutronic/thermal-hydraulic hot channel analysis of high power density civil marine SMR cores

Core average power density of standard small modular reactors (SMR) are generally limited to 60–65 MW/m3, which is 40% lower than for a standard civil PWR in order to accommodate better thermal margins. While designing a SMR core for civil marine propulsion systems, it is required to increase its power density to make more attractive for future deployment. However, there are obvious thermal-hydraulic (TH) concerns regarding a high power density (HPD) core, which needs to be satisfied in order to ensure safe operation through accurate prediction of the TH parameters. This paper presents a coupled neutronic/thermal-hydraulic (TH) hot channel analysis of a HPD 375 MWth soluble-boron-free PWR core using 19.25% 235U enriched micro- heterogeneous ThO2-UO2 duplex fuel and 16% 235U enriched homogeneously mixed all-UO2 fuel with a 15 effective full-power-years (EFPY) core life. To perform this analysis the hybrid Monte Carlo reactor physics code MONK is coupled with sub-channel analysis TH code COBRA-EN. This approach is used to investigate the feasibility of different HPD marine PWR concepts and to identify the main TH challenges characterising these designs. To design HPD cores of between 82 and 111 MW/m3, three cases were chosen by optimizing the fuel pin diameter, pin pitch and pitch-to-diameter ratio. These cases have been studied to determine whether TH safety limits are satisfied by evaluating key parameters, such as minimum departure from nucleate boiling ratio, surface heat flux, critical heat flux, cladding inner surface and fuel centreline temperatures, and pressure drop. The results show that it is possible to achieve a core power density of 100 MW/m3 for both the candidate fuels, a ∼50% improvement on the reference design (63 MW/m3), while meeting the target core lifetime of 15 EFPY and remaining within TH limits. The size of the pressure vessel can therefore be reduced substantially and the economic competitiveness of the proposed civil marine PWR reactor core significantly improved

Brain MRI in a patient with classical galactosemia: acute event of unilateral hemispheric cerebral edema

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Holographic Superconductors with Power-Maxwell field

With the Sturm-Liouville analytical and numerical methods, we investigate the behaviors of the holographic superconductors by introducing a complex charged scalar field coupled with a Power-Maxwell field in the background of $d$-dimensional Schwarzschild AdS black hole. We note that the Power-Maxwell field takes the special asymptotical solution near boundary which is different from all known cases. We find that the larger power parameter $q$ for the Power-Maxwell field makes it harder for the scalar hair to be condensated. We also find that, for different $q$, the critical exponent of the system is still 1/2, which seems to be an universal property for various nonlinear electrodynamics if the scalar field takes the form of this paper.Comment: 14 pages, 1 figure, and 2 table

Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology.

Trypanosoma cruzi, the flagellate protozoan agent of Chagas disease or American trypanosomiasis, is unable to synthesize sialic acids de novo. Mucins and trans-sialidase (TS) are substrate and enzyme, respectively, of the glycobiological system that scavenges sialic acid from the host in a crucial interplay for T. cruzi life cycle. The acquisition of the sialyl residue allows the parasite to avoid lysis by serum factors and to interact with the host cell. A major drawback to studying the sialylation kinetics and turnover of the trypomastigote glycoconjugates is the difficulty to identify and follow the recently acquired sialyl residues. To tackle this issue, we followed an unnatural sugar approach as bioorthogonal chemical reporters, where the use of azidosialyl residues allowed identifying the acquired sugar. Advanced microscopy techniques, together with biochemical methods, were used to study the trypomastigote membrane from its glycobiological perspective. Main sialyl acceptors were identified as mucins by biochemical procedures and protein markers. Together with determining their shedding and turnover rates, we also report that several membrane proteins, including TS and its substrates, both glycosylphosphatidylinositol-anchored proteins, are separately distributed on parasite surface and contained in different and highly stable membrane microdomains. Notably, labeling for α(1,3)Galactosyl residues only partially colocalize with sialylated mucins, indicating that two species of glycosylated mucins do exist, which are segregated at the parasite surface. Moreover, sialylated mucins were included in lipid-raft-domains, whereas TS molecules are not. The location of the surface-anchored TS resulted too far off as to be capable to sialylate mucins, a role played by the shed TS instead. Phosphatidylinositol-phospholipase-C activity is actually not present in trypomastigotes. Therefore, shedding of TS occurs via microvesicles instead of as a fully soluble form

Conservation status of a recently described endemic land snail, Candidula coudensis, from the Iberian Peninsula

Research ArticleWe assessed the distribution, population size and conservation status of Candidula coudensis, a recently described endemic land snail from Portugal. From March 2013 to April 2014, surveys were carried out in the region where the species was described. We found an extent of occurrence larger than originally described, but still quite small (13.5 km2). The species was found mainly in olive groves, although it occurred in a variety of other habitats with limestone soils, including grasslands, scrublands and stone walls. Minimum population estimate ranged from 110,000–311,000 individuals. The main identified potential threats to the species include wildfires, pesticides and quarrying. Following the application of IUCN criteria, we advise a conservation status of either “Least Concern” or “Near-threatened” under criterion D (restricted population)info:eu-repo/semantics/publishedVersio

Acute ECG ST-segment elevation mimicking myocardial infarction in a patient with pulmonary embolism

Pulmonary embolism is a common cardiovascular emergency, but it is still often misdiagnosed due to its unspecific clinical symptoms. Elevated troponin concentrations are associated with greater morbidity and mortality in patients with pulmonary embolism. Right ventricular ischemia due to increased right ventricular afterload is believed to be underlying mechanism of elevated troponin values in acute pulmonary embolism, but a paradoxical coronary artery embolism through opened intra-artrial communication is another possible explanation as shown in our case report

O egresso de enfermagem da FENF/UERJ no mundo do trabalho

Estudo qualitativo da satisfação do egresso da Faculdade de Enfermagem da Universidade do Estado do Rio de Janeiro no mundo do trabalho. Identifica e analisa a percepção do egresso sobre sua atuação e vivência no mundo do trabalho. O estudo faz parte do processo avaliativo institucional subseqüente a reforma curricular e implantação do projeto político pedagógico, baseado na Teoria Crítica da Educação. Os doze sujeitos graduaram-se no período de 2000 a 2005. Aplicaram-se entrevistas, e através da análise de conteúdo temática emergiram duas categorias empíricas: o prazer advindo do trabalho e o sofrimento advindo do trabalho. Conclui-se que o novo currículo tem produzido os resultados esperados. Os egressos vêm desempenhando atribuições de competência do enfermeiro e mostraram-se críticos e reflexivos em suas auto-avaliações. Considerou-se que são necessárias avaliações contínuas, capazes de permitir a identificação das exigências evolutivas do mercado de trabalho e conseqüentes reajustes nas propostas curriculares