486 research outputs found
Challenges of Profile Likelihood Evaluation in Multi-Dimensional SUSY Scans
Statistical inference of the fundamental parameters of supersymmetric
theories is a challenging and active endeavor. Several sophisticated algorithms
have been employed to this end. While Markov-Chain Monte Carlo (MCMC) and
nested sampling techniques are geared towards Bayesian inference, they have
also been used to estimate frequentist confidence intervals based on the
profile likelihood ratio. We investigate the performance and appropriate
configuration of MultiNest, a nested sampling based algorithm, when used for
profile likelihood-based analyses both on toy models and on the parameter space
of the Constrained MSSM. We find that while the standard configuration is
appropriate for an accurate reconstruction of the Bayesian posterior, the
profile likelihood is poorly approximated. We identify a more appropriate
MultiNest configuration for profile likelihood analyses, which gives an
excellent exploration of the profile likelihood (albeit at a larger
computational cost), including the identification of the global maximum
likelihood value. We conclude that with the appropriate configuration MultiNest
is a suitable tool for profile likelihood studies, indicating previous claims
to the contrary are not well founded.Comment: 21 pages, 9 figures, 1 table; minor changes following referee report.
Matches version accepted by JHE
Bottom-Up Assembly of Hydrogels from Bacteriophage and Au Nanoparticles: The Effect of Cis- and Trans-Acting Factors
Hydrogels have become a promising research focus because of their potential for biomedical application. Here we explore the long-range, electrostatic interactions by following the effect of trans-acting (pH) and cis-acting factors (peptide mutation) on the formation of Au-phage hydrogels. These bioinorganic hydrogels can be generated from the bottom-up assembly of Au nanoparticles (Au NP) with either native or mutant bacteriophage (phage) through electrostatic interaction of the phage pVIII major capsid proteins (pVIII). The cis-acting factor consists of a peptide extension displayed on the pVIII that mutates the phage. Our results show that pH can dictate the direct-assembly and stability of Au-phage hydrogels in spite of the differences between the native and the mutant pVIII. The first step in characterizing the interactions of Au NP with phage was to generate a molecular model that identified the charge distribution and structure of the native and mutant pVIII. This model indicated that the mutant peptide extension carried a higher positive charge relative to the native pVIII at all pHs. Next, by monitoring the Au-phage interaction by means of optical microscopy, elastic light scattering, fractal dimension analysis as well as Uv-vis and surface plasmon resonance spectroscopy, we show that the positive charge of the mutant peptide extension favors the opposite charge affinity between the phage and Au NP as the pH is decreased. These results show the versatility of this assembly method, where the stability of these hydrogels can be achieved by either adjusting the pH or by changing the composition of the phage pVIII without the need of phage display libraries
Rhizosheath-root system changes exopolysaccharide content but stabilizes bacterial community across contrasting seasons in a desert environment
Abstract
Background
In hot deserts daily/seasonal fluctuations pose great challenges to the resident organisms. However, these extreme ecosystems host unique microenvironments, such as the rhizosheathâroot system of desert speargrasses in which biological activities and interactions are facilitated by milder conditions and reduced fluctuations. Here, we examined the bacterial microbiota associated with this structure and its surrounding sand in the desert speargrass Stipagrostis pungens under the contrasting environmental conditions of summer and winter in the Sahara Desert.
Results
The belowground rhizosheathâroot system has higher nutrient and humidity contents, and cooler temperatures than the surrounding sand. The plant responds to the harsh environmental conditions of the summer by increasing the abundance and diversity of extracellular polymeric substances (EPS) compared to the winter. On the contrary, the bacterial community associated with the rhizosheathâroot system and its interactome remain stable and, unlike the bulk sand, are unaffected by the seasonal environmental variations. The rhizosheathâroot system bacterial communities are consistently dominated by Actinobacteria and Alphaproteobacteria and form distinct bacteria communities from those of bulk sand in the two seasons. The microbiome-stabilization mediated by the plant host acts to consistently retain beneficial bacteria with multiple plant growth promoting functions, including those capable to produce EPS, which increase the sand water holding capacity ameliorating the rhizosheath micro-environment.
Conclusions
Our results reveal the capability of plants in desert ecosystems to stabilize their below ground microbial community under seasonal contrasting environmental conditions, minimizing the heterogeneity of the surrounding bulk sand and contributing to the overall holobiont resilience under poly-extreme conditions
Numerical Studies on the Influence of Cavity Thermal Expansion on the Performance of a High-Power Gyrotron
An iterative procedure is described, which models the influence of the thermal expansion of the gyrotron cavity on the expected gyrotron performance. It is a multiphysics simulation method, which involves electrodynamic, thermal-hydraulic, and thermo-mechanical simulations. The method is applied to the first European 170-GHz, 1-MW continuous wave prototype gyrotron for the ITER. According to the simulations, a performance reduction of 15% is expected at nominal operating parameters, because of the thermal expansion of the cavity. Alternative operating points to mitigate this effect are proposed and numerically validated. The numerical results are discussed in light of experimental findings
Improving the sensitivity of Higgs boson searches in the golden channel
Leptonic decays of the Higgs boson in the ZZ* channel yield what is known as
the golden channel due to its clean signature and good total invariant mass
resolution. In addition, the full kinematic distribution of the decay products
can be reconstructed, which, nonetheless, is not taken into account in
traditional search strategy relying only on measurements of the total invariant
mass. In this work we implement a type of multivariate analysis known as the
matrix element method, which exploits differences in the full production and
decay matrix elements between the Higgs boson and the dominant irreducible
background from q bar{q} -> ZZ*. Analytic expressions of the differential
distributions for both the signal and the background are also presented. We
perform a study for the Large Hadron Collider at sqrt{s}=7 TeV for Higgs masses
between 175 and 350 GeV. We find that, with an integrated luminosity of 2.5
fb^-1 or higher, improvements in the order of 10 - 20 % could be obtained for
both discovery significance and exclusion limits in the high mass region, where
the differences in the angular correlations between signal and background are
most pronounced.Comment: 31 pages, 8 figures. v2: Minus signs in definitions of angles
corrected. Typos fixed. Reference added. Cosmetic changes to Figure 4.
Additional sentence added for clarificatio
Brane-world black holes and the scale of gravity
A particle in four dimensions should behave like a classical black hole if
the horizon radius is larger than the Compton wavelength or, equivalently, if
its degeneracy (measured by entropy in units of the Planck scale) is large. For
spherically symmetric black holes in 4 + d dimensions, both arguments again
lead to a mass threshold MC and degeneracy scale Mdeg of the order of the
fundamental scale of gravity MG. In the brane-world, deviations from the
Schwarzschild metric induced by bulk effects alter the horizon radius and
effective four-dimensional Euclidean action in such a way that MC \simeq Mdeg
might be either larger or smaller than MG. This opens up the possibility that
black holes exist with a mass smaller than MG and might be produced at the LHC
even if M>10 TeV, whereas effects due to bulk graviton exchanges remain
undetectable because suppressed by inverse powers of MG. Conversely, even if
black holes are not found at the LHC, it is still possible that MC>MG and MG
\simeq 1TeV.Comment: 4 pages, no figur
Enhancement of nematic order and global phase diagram of a lattice model for coupled nematic systems
We use an infinite-range Maier-Saupe model, with two sets of local
quadrupolar variables and restricted orientations, to investigate the global
phase diagram of a coupled system of two nematic subsystems. The free energy
and the equations of state are exactly calculated by standard techniques of
statistical mechanics. The nematic-isotropic transition temperature of system A
increases with both the interaction energy among mesogens of system B, and the
two-subsystem coupling . This enhancement of the nematic phase is manifested
in a global phase diagram in terms of the interaction parameters and the
temperature . We make some comments on the connections of these results with
experimental findings for a system of diluted ferroelectric nanoparticles
embedded in a nematic liquid-crystalline environment.Comment: 11 pages, 3 figures, to appear in Volume 42 of the Brazilian Journal
of Physic
Solving the mu problem with a heavy Higgs boson
We discuss the generation of the mu-term in a class of supersymmetric models
characterized by a low energy effective superpotential containing a term lambda
S H_1 H_2 with a large coupling lambda~2. These models generically predict a
lightest Higgs boson well above the LEP limit of 114 GeV and have been shown to
be compatible with the unification of gauge couplings. Here we discuss a
specific example where the superpotential has no dimensionful parameters and we
point out the relation between the generated mu-term and the mass of the
lightest Higgs boson. We discuss the fine-tuning of the model and we find that
the generation of a phenomenologically viable mu-term fits very well with a
heavy lightest Higgs boson and a low degree of fine-tuning. We discuss
experimental constraints from collider direct searches, precision data, thermal
relic dark matter abundance, and WIMP searches finding that the most natural
region of the parameter space is still allowed by current experiments. We
analyse bounds on the masses of the superpartners coming from Naturalness
arguments and discuss the main signatures of the model for the LHC and future
WIMP searches.Comment: Extended discussion of the LHC phenomenology, as published on JHEP
plus an addendum on the existence of further extremal points of the
potential. 47 pages, 16 figure
Inflammatory myoglandular polyp of the cecum: case report and review of literature
<p>Abstract</p> <p>Background</p> <p>Inflammatory myoglandular polyp (IMGP) is a rare non-neoplastic polyp of the large bowel, commonly with a distal localization (rectosigmoid), obscure in its pathogenesis. Up till now, 60 cases of IMGP have been described in the literature, but none located in the cecum.</p> <p>Case presentation</p> <p>We report a case of a 53-year-old man who was admitted to our hospital for further evaluation of positive fecal occult blood test associated to anemia. A colonoscopy identified a red, sessile, lobulated polyp of the cecum, 4.2 cm in diameter, partially ulcerated. The histological examination of the biopsy revealed the presence of inflammatory granulation tissue with lymphocytic and eosinophil infiltration associated to a fibrous stroma: it was diagnosed as inflammatory fibroid polyp. Considering the polyp's features (absence of a peduncle and size) that could increase the risk of a polypectomy, a surgical resection was performed. Histological examination of the specimen revealed inflammatory granulation tissue in the lamina propria, hyperplastic glands with cystic dilatations, proliferation of smooth muscle and multiple erosions on the polyp surface: this polyp was finally diagnosed as IMGP. There was also another little polyp next to the ileocecal valve, not revealed at the colonoscopy, 0.8 cm in diameter, diagnosed as tubulovillous adenoma with low grade dysplasia.</p> <p>Conclusions</p> <p>This is the first case of IMGP of the cecum. It is a benign lesion of unknown pathogenesis and must be considered different from other non-neoplastic polyps of the large bowel such as inflammatory cap polyps (ICP), inflammatory cloacogenic polyps, juvenile polyps (JP), inflammatory fibroid polyps (IFP), polyps secondary to mucosal prolapse syndrome (MPS), polypoid prolapsing mucosal folds of diverticular disease. When symptomatic, IMGP should be removed endoscopically, whereas surgical resection is reserved only in selected patients as in our case.</p
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