From the Characterization of Ranging Error to the Enhancement of Nodes Localization for Group of Wireless Body Area Networks

International audienceTime-based localization in Wireless Body Area Networks (WBANs), has attracted growing research interest for the last past years. Nodes positions can be estimated based on peer-to-peer radio transactions between devices. Indeed, the accuracy of the localization process could be highly affected by different factors , such as the WBAN channels where the signal is propagating through, as well as the nodes mobility that bias the peer-to-peer range estimation, and thus, the final achieved localization accuracy. The goal of this paper consists in characterizing the impact of mobility and WBAN channel on the ranging and localization estimation, based on real mobility traces acquired through a motion capture system. More specifically, the ranging error is evaluated over all the WBANs links (i.e. on-body, off-body and body-to-body links), while an impulse Radio Ultra-Wideband (IR-UWB) physical layer, as well as a TDMA-based Medium Access Control (MAC) are playing on. The simulation results show that the range measurement error can be modeled as a Gaussian distribution. To deal with the gaus-sianity observation of ranging error and to provide high positioning accuracy, an adjustable extended Kalman Filter (EKF) is proposed

Quantifying the impact of scheduling and mobility on IR-UWB localization in body area networks

International audience—In the context of radiolocation in Wireless Body Area Networks (WBANs), nodes positions can be estimated through time-based ranging algorithms. For instance, the distance separating a couple of nodes can be estimated accurately by measuring the Round Trip Time of Flight of an Impulse Radio Ultra Wideband (IR-UWB) link. This measure usually relies on two or three messages transactions. Such exchanges take time and a rapid mobility of the nodes can reduce the ranging accuracy and consequently impact nodes localization process. In this paper, we quantify this localization error by confronting two broadcast-based optimized implementations of the three-way ranging algorithm with real mobility traces, acquired through a motion capture system. We then evaluate, in the same scenarios, the impact of the MAC-level scheduling of the packets within a TDMA frame localization accuracy. The results, obtained with the WSNet simulator, show that MAC scheduling can be utilized to mitigate the effect of nodes mobility

Annulation d'interférence dans les systèmes optiques à accès multiple par répartition de codes (O-CDMA)

- Dans cet article, nous présentons l'étude d'un récepteur à annulation parallèle d'interférence précédé d'un limiteur optique, pour un système DS-CDMA optique. Le but de ce récepteur est de réduire l'Interférence d'Accès Multiple (IAM) due aux codes optiques unipolaires. Nous montrons que l'utilisation du récepteur présenté permet d'améliorer le système, au niveau de la longueur des codes utilisés, ou au niveau de la gestion des séquences allouées aux utilisateurs actifs

Atmospheric Sciences Perspectives on Integrated, Coordinated, Open, Networked (ICON) Science

Abstract: This collaborative article discusses the opportunities and challenges of adopting integrated, coordinated, open, and networked (ICON) principles in atmospheric sciences. From the global nature of the atmosphere, there has always been a need for atmospheric science to be an ICON science. With the help of evolving technology, it is possible to go further in implementing and spreading the ICON principles for productive global collaboration. In particular, technology transfer and applications could be approached with reproducibility in mind, and data‐sharing infrastructure could enable easier and better international collaboration. There are, however, various challenges in following the ICON principles in the acquisition, quality control, and maintenance of data, and the publication of results in a systematic way. Moreover, the extent of such issues varies geographically and hence poses different challenges to implementing ICON principles. In this commentary article, we briefly state our perspectives on the state of ICON, challenges we have met, and future opportunities. Furthermore, we describe how atmospheric science researchers have benefited from these collaborative multi‐dimensional approaches that fulfill the core goal of ICON

Neonatal Handling Affects Durably Bonding and Social Development

The neonatal period in humans and in most mammals is characterized by intense mother-young interactions favoring pair bonding and the adaptation of neonates to their new environment. However, in many post-delivery procedures, human babies commonly experience combined maternal separation and intense handling for about one hour post-birth. Currently, the effects of such disturbances on later attachment and on the development of newborns are still debated: clearly, further investigations are required. As animals present good models for controlled experimentation, we chose domestic horses to investigate this issue. Horses, like humans, are characterized by single births, long lactating periods and selective mother-infant bonds. Routine postnatal procedures for foals, as for human babies, also involve intense handling and maternal separation. In the present study, we monitored the behavior of foals from early stages of development to “adolescence”, in a normal ecological context (social groups with adults and peers). Experimental foals, separated from their mothers and handled for only 1 hour post-birth, were compared to control foals, left undisturbed after birth. Our results revealed short- and long-term effects of this unique neonatal experience on attachment and subsequent social competences. Thus, experimental foals presented patterns of insecure attachment to their mothers (strong dependence on their mothers, little play) and impaired social competences (social withdrawal, aggressiveness) at all ages. We discuss these results in terms of mother-young interactions, timing of interactions and relationships between bonding and subsequent social competences. Our results indicate that this ungulate species could become an interesting animal model. To our knowledge, this is the first clear demonstration that intervention just after birth affects bonding and subsequent social competences (at least until “adolescence”). It opens new research directions for studies on both humans and other animals

Differential regulation of C-terminal splice variants of the glutamate transporter GLT-1 by tumor necrosis factor-alpha in primary cultures of astrocytes

The high-affinity glutamate transporter GLT-1 plays a key role in the control of the glutamate homeostasis in the central nervous system and protects neurons against excitotoxicity. Splice variants of the original transcript have been identified and their involvement in neurodegenerative disorders has been proposed. However, the functions and the regulations of these isoforms remain unclear. In this study, we focused our interest on the expression of two C-terminal splice variants of GLT-1 (GLT-1a and b) in primary astrocyte cultures exposed to distinct chemical environments. While GLT-1a and GLT-1b mRNAs were both increased in response to treatment with N(6),2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dBcAMP), the culture supplement G5 or tumor necrosis factor-alpha (TNF-α), the regulation of GLT-1b appeared quicker and was more pronounced. Besides, using validated antibodies, we evidenced a differential regulation of the two proteins in cells exposed to TNF-α. Thus, while dBcAMP and the G5 supplement stimulated the expression of both isoforms at 3 and 7 days, a transient upregulation of GLT-1a was induced by TNF-α, which contrasts with the sustained induction of the GLT-1b isoform. These results shed light on the complex influence of the pro-inflammatory cytokine TNF-α on GLT-1a mRNA and protein expression and on the necessity to distinctly consider the GLT-1 isoforms with appropriate tools in studies addressing the regulation of glutamate transporters

PICK1 expression in reactive astrocytes within the spinal cord of amyotrophic lateral sclerosis (ALS) rats.

M. C. Focant, S. Goursaud, C. Boucherie, A. O. Dumont and E. Hermans (2013) Neuropathology and Applied Neurobiology39, 231-242 PICK1 expression in reactive astrocytes within the spinal cord of amyotrophic lateral sclerosis (ALS) rats Aims: The protein interacting with C kinase 1 (PICK1), a PDZ domain-containing protein mainly expressed in the central nervous system, interacts with the glutamate receptor subunit GluR2, with the glutamate transporter GLT-1b and with the enzyme serine racemase. These three proteins appear as key actors in the glutamate-mediated excitotoxicity associated with amyotrophic lateral sclerosis (ALS), in both patients and animal models of the disease. In this study, we examined the expression of PICK1 in the spinal cord of transgenic rats expressing a mutated form of the human superoxide dismutase 1 (hSOD1 ) during the progression of the disease. Methods: Expression of PICK1 was examined by real-time qPCR at presymptomatic and symptomatic stages as well as at end-stage. The expression of PICK1 in the different cell types of the spinal cord was examined by immunohistochemistry. Results: The overall expression of PICK1 is not modified in cervical and lumbar spinal cord of transgenic (hSOD1 ) rats during the progression of the disease. Nonetheless, immunohistochemical studies of lumbar ventral horns revealed a shift of PICK1 expression from motor neurones in healthy rats to activated astrocytes in end-stage hSOD1 animals. Conclusions: Considering the documented influence of PICK1 expression on d-serine release and glutamate transport in astrocytes, these findings point to a potential implication of PICK1 in the progression of ALS