409 research outputs found
Sawtooth period pacing and locking by EC power control on TCV
Abstract #TP9.127 submitted for the DPP11 Meeting of The American Physical Society
Complement Split Product C5a Mediates the LipopolysaccharideâInduced Mobilization of CfuâS and Haemopoietic Progenitor Cells, But Not the Mobilization Induced By Proteolytic Enzymes
Abstract. Intravenous (i.v.) injection of mice with lipopolysaccharide (LPS), and the proteolytic enzymes trypsin and proteinase, mobilizes pluripotent haemopoietic stem cells (CFUâs) as well as granulocyteâmacrophage progenitor cells (GMâCFU) and the early progenitors of the erythroid lineage (EâBFU) from the haemopoietic tissues into the peripheral blood. We investigated the involvement of the complement (C) system in this process. It appeared that the early mobilization induced by LPS and other activators of the alternative complement pathway, such as Listeria monocytogenes (Lm) and zymosan, but not that induced by the proteolytic enzymes, was absent in C5âdeficient mice. the mobilization by C activators in these mice could be restored by injection of C5âsufficient serum, suggesting a critical role for C5. The manner in which C5 was involved in the C activationâmediated stem cell mobilization was studied using a serum transfer system. C5âsufficient serum, activated in vitro by incubation with Lm and subsequently liberated from the bacteria, caused mobilization in both C5âsufficient and C5âdeficient mice. C5âdeficient serum was not able to do so. the resistance of the mobilizing principle to heat treatment (56°C, 30 min) strongly suggests that it is identical with the C5 split product C5a, or an in vivo derivative of C5a. This conclusion was reinforced by the observation that a single injection of purified rat C5a into C5âdeficient mice also induced mobilization of CFUâs. Copyrigh
Exact Cover with light
We suggest a new optical solution for solving the YES/NO version of the Exact
Cover problem by using the massive parallelism of light. The idea is to build
an optical device which can generate all possible solutions of the problem and
then to pick the correct one. In our case the device has a graph-like
representation and the light is traversing it by following the routes given by
the connections between nodes. The nodes are connected by arcs in a special way
which lets us to generate all possible covers (exact or not) of the given set.
For selecting the correct solution we assign to each item, from the set to be
covered, a special integer number. These numbers will actually represent delays
induced to light when it passes through arcs. The solution is represented as a
subray arriving at a certain moment in the destination node. This will tell us
if an exact cover does exist or not.Comment: 20 pages, 4 figures, New Generation Computing, accepted, 200
An Outcome Evaluation of the Implementation of the Triple P â Positive Parenting Program in Hong Kong
The present study evaluated the effectiveness of the Positive Parenting Program (Triple P) with a sample of Chinese parents of children with early onset conduct related problems in Hong Kong. The participants consisted of 91 parents whose children attended maternal and child health centers and child assessment centers for service, and were between three to seven years old. Participants were randomly assigned to the intervention (TP) and a waitlist control group (WL. There was no significant difference in pre-intervention measures between the two groups. However, at post intervention, participants in the TP group reported significantly lower levels of child behavior problems, lower dysfunctional parenting styles, and higher parent sense of competence, compared to the WL group. Implications of these findings for the use of Triple P with families of Chinese descent are discussed
An assessment of the resolution limitation due to radiation-damage in x-ray diffraction microscopy
X-ray diffraction microscopy (XDM) is a new form of x-ray imaging that is
being practiced at several third-generation synchrotron-radiation x-ray
facilities. Although only five years have elapsed since the technique was first
introduced, it has made rapid progress in demonstrating high-resolution
threedimensional imaging and promises few-nm resolution with much larger
samples than can be imaged in the transmission electron microscope. Both life-
and materials-science applications of XDM are intended, and it is expected that
the principal limitation to resolution will be radiation damage for life
science and the coherent power of available x-ray sources for material science.
In this paper we address the question of the role of radiation damage. We use a
statistical analysis based on the so-called "dose fractionation theorem" of
Hegerl and Hoppe to calculate the dose needed to make an image of a lifescience
sample by XDM with a given resolution. We conclude that the needed dose scales
with the inverse fourth power of the resolution and present experimental
evidence to support this finding. To determine the maximum tolerable dose we
have assembled a number of data taken from the literature plus some
measurements of our own which cover ranges of resolution that are not well
covered by reports in the literature. The tentative conclusion of this study is
that XDM should be able to image frozen-hydrated protein samples at a
resolution of about 10 nm with "Rose-criterion" image quality.Comment: 9 pages, 4 figure
Forced oscillations in a hydrodynamical accretion disk and QPOs
This is the second of a series of papers aimed to look for an explanation on
the generation of high frequency quasi-periodic oscillations (QPOs) in
accretion disks around neutron star, black hole, and white dwarf binaries. The
model is inspired by the general idea of a resonance mechanism in the accretion
disk oscillations as was already pointed out by Abramowicz & Klu{\'z}niak
(\cite{Abramowicz2001}). In a first paper (P\'etri \cite{Petri2005a}, paper I),
we showed that a rotating misaligned magnetic field of a neutron star gives
rise to some resonances close to the inner edge of the accretion disk. In this
second paper, we suggest that this process does also exist for an asymmetry in
the gravitational potential of the compact object. We prove that the same
physics applies, at least in the linear stage of the response to the
disturbance in the system. This kind of asymmetry is well suited for neutron
stars or white dwarfs possessing an inhomogeneous interior allowing for a
deviation from a perfectly spherically symmetric gravitational field. We show
by a linear analysis that the disk initially in a cylindrically symmetric
stationary state is subject to three kinds of resonances: a corotation
resonance, a Lindblad resonance due to a driven force and a parametric sonance.
The highest kHz QPOs are then interpreted as the orbital frequency of the disk
at locations where the response to the resonances are maximal. It is also found
that strong gravity is not required to excite the resonances.Comment: Accepte
Menus for Feeding Black Holes
Black holes are the ultimate prisons of the Universe, regions of spacetime
where the enormous gravity prohibits matter or even light to escape to
infinity. Yet, matter falling toward the black holes may shine spectacularly,
generating the strongest source of radiation. These sources provide us with
astrophysical laboratories of extreme physical conditions that cannot be
realized on Earth. This chapter offers a review of the basic menus for feeding
matter onto black holes and discusses their observational implications.Comment: 27 pages. Accepted for publication in Space Science Reviews. Also to
appear in hard cover in the Space Sciences Series of ISSI "The Physics of
Accretion onto Black Holes" (Springer Publisher
Shadowing in Inelastic Scattering of Muons on Carbon, Calcium and Lead at Low XBj
Nuclear shadowing is observed in the per-nucleon cross-sections of positive
muons on carbon, calcium and lead as compared to deuterium. The data were taken
by Fermilab experiment E665 using inelastically scattered muons of mean
incident momentum 470 GeV/c. Cross-section ratios are presented in the
kinematic region 0.0001 < XBj <0.56 and 0.1 < Q**2 < 80 GeVc. The data are
consistent with no significant nu or Q**2 dependence at fixed XBj. As XBj
decreases, the size of the shadowing effect, as well as its A dependence, are
found to approach the corresponding measurements in photoproduction.Comment: 22 pages, incl. 6 figures, to be published in Z. Phys.
Atmospheric Heating and Wind Acceleration: Results for Cool Evolved Stars based on Proposed Processes
A chromosphere is a universal attribute of stars of spectral type later than
~F5. Evolved (K and M) giants and supergiants (including the zeta Aurigae
binaries) show extended and highly turbulent chromospheres, which develop into
slow massive winds. The associated continuous mass loss has a significant
impact on stellar evolution, and thence on the chemical evolution of galaxies.
Yet despite the fundamental importance of those winds in astrophysics, the
question of their origin(s) remains unsolved. What sources heat a chromosphere?
What is the role of the chromosphere in the formation of stellar winds? This
chapter provides a review of the observational requirements and theoretical
approaches for modeling chromospheric heating and the acceleration of winds in
single cool, evolved stars and in eclipsing binary stars, including physical
models that have recently been proposed. It describes the successes that have
been achieved so far by invoking acoustic and MHD waves to provide a physical
description of plasma heating and wind acceleration, and discusses the
challenges that still remain.Comment: 46 pages, 9 figures, 1 table; modified and unedited manuscript;
accepted version to appear in: Giants of Eclipse, eds. E. Griffin and T. Ake
(Berlin: Springer
GONADOTROPHIN RESPONSES TO GnRH PULSES IN HYPOGONADOTROPHIC HYPOGONADISM: LH RESPONSIVENESS IS MAINTAINED IN THE PRESENCE OF LUTEAL PHASE CONCENTRATIONS OF OESTROGEN AND PROGESTERONE
LH pulse secretion changes during the menstrual cycle from a rapid regular pattern in the follicular phase to a slower and irregular pattern in the luteal phase. To determine whether the irregular LH pulse pattern in the luteal phase reflects altered GnRH secretion or altered pituitary responsiveness to GnRH, we gave low dose GnRH pulses (25 ng/kg i.v.) every 2 h or every hour for 10 or 12 d to three women with isolated GnRH deficiency. After 4 d of GnRH alone, oestradiol (E 2 ) was given and after 6 d progesterone (P) was added to mimic the hormonal milieu of the luteal phase. LH and FSH were measured every 4 h throughout and also every 20 min for 6 or 12 h, before and after GnRH alone (day 0 and day 4), after E 2 (day 6), and after E 2 + P (day 10 and day 12). Both GnRH pulse frequencies resulted in a rapid increase in plasma FSH to peaks on day 4 (every 2 h) and day 2 and 3 (every hour). FSH concentrations then declined as plasma E 2 rose to 50â80 pg/ml reflecting the selective inhibitory effect of E 2 on FSH release. Plasma LH was also increased after the hourly GnRH injections and this regimen was associated with a more rapid rise in E 2 reflecting follicular maturation. In contrast to the differences in mean hormone concentrations, administration of GnRH at both frequencies resulted in sustained one-on-one responsiveness of LH that was maintained in the presence of both oestrogen and progesterone at mid-luteal phase concentrations. We conclude that the slow frequency of LH pulses observed during the luteal phase reflects decreased GnRH pulse frequency rather than impaired pituitary responsiveness to GnRH.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74947/1/j.1365-2265.1987.tb00786.x.pd
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