Uranus, Cronus and Zeus: Greek mythology and its differents conceptions about time

Reality of Time is an abstract and intuitive concept. Temporality can be experienced and understood, but cannot be felt. Even the experience of Time becomes ambiguous if we think in natural time (as eternal and unchanging) and human time (as changeable and finite) as two distinct instances of a common reality. Depending on this perception, Time is simultaneously, as defined by Mircea Eliade, “sacred” and “profane”: eternal and recoverable, historical and irreducible. In this article, we intend to examine briefly the figures of Uranus, Cronus and Zeus as symbolic representatives of these two different conceptions of Time in the ancient Hellenic imagination

Uranos, Cronos e Zeus : a mitologia grega e suas distintas percepções do tempo

A realidade do tempo é uma noção asbtrata e intuitiva. A temporalidade pode ser experienciada e compreendida, mas não sentida. Emesmo a experiência do tempo se torna ambígua, se pensarmos no tempo natural (eterno e imutável) e no tempo humano (mutável e finito) como duas instâncias distintas de uma realidade comum. Consoante tal percepção, o tempo é simultaneamente, como define Mircea Eliade, "sagrado" e "profano": eterno e recuperável, histórico e irredutível. É neste sentido que pretendemos analisar brevemente as figuras de Úranos, Cronos e Zeus como representantes simbólicos dessas duas diferentes concepções do tempo no antigo imaginário helênico.Reality of Time is an abstract and intuitive concept. Temporality can be experienced and understood, but cannot be felt. Even the experience of Time becomes ambiguous if we think in natural time (as eternal and unchanging) and human time (as changeable and finite) as two distinct instances of a common reality. Depending on this perception, Time is simultaneously, as defined by Mircea Eliade, "sacred" and "profane": eternal and recoverable, historical and irreducible. In this article, we intend to examine briefly the figures of Uranus, Cronus and Zeus as symbolic representatives of these two different conceptions of Time in the ancient Hellenic imagination

Using a nitrilase for the surface modification of acrylic fibres

The surface of an acrylic fibre was modified with a commercial nitrilase (EC 3.5.5.1). The effect of fibre solvents and polyols on nitrilase catalysis efficiency and stability was investigated. The nitrilase action on the acrylic fabric was improved by the combined addition of 1 M sorbitol and 4% N, N-dimethylacetamide. The colour levels for samples treated with nitrilase increased 156% comparing to the control samples. When the additives were introduced in the treatment media, the colour levels increased 199%. The enzymatic conversion of nitrile groups into the corresponding carboxylic groups, on the fibre surface, was followed by the release of ammonia and polyacrylic acid. A surface erosion phenomenon took place and determined the “oscillatory” behaviour of the amount of dye uptake with time of treatment. These results showed that the outcome of the application of the nitrilase for the acrylic treatment is intimately dependent on reaction media parameters, such as time, enzyme activity and formulation.(undefined

Unveiling biological activities of marine fungi: the effect of sea salt

There is an urgent need for new substances to overcome current challenges in the health sciences. Marine fungi are known producers of numerous compounds, but the manipulation of growth conditions for optimal compound production can be laborious and time-consuming. In Portugal, despite its very long coastline, there are only a few studies on marine fungi. From a collection of Portuguese marine fungi, we screened for antimicrobial, antioxidant, enzymatic, and cytotoxic activities. Mycelia aqueous extracts, obtained by high pressure-assisted extraction, and methanolic extracts of culture media showed high antioxidant, antimicrobial, and cytotoxic activities. The mycelium extracts of Cladosporium rubrum showed higher antioxidant potential compared to extracts from other fungi. Mycelia and culture media extracts of Aspergillus affinis and Penicillium lusitanum inhibited the growth of Staphylococcus aureus, Kocuria rhizophila, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa, including multiresistant strains. Penicillium lusitanum and Trichoderma aestuarinum inhibited the growth of clinical strains of Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis. All extracts from culture media were cytotoxic to Vero cells. Sea salt induced alterations in the mycelium's chemical composition, leading to different activity profiles.info:eu-repo/semantics/publishedVersio

Determination of ochratoxin A in bread: evaluation of microwave-assisted extraction using an orthogonal composite design coupled with response surface methodology

An analytical method using microwave-assisted extraction (MAE) and liquid chromatography (LC) with fluorescence detection (FD) for the determination of ochratoxin A (OTA) in bread samples is described. A 24 orthogonal composite design coupled with response surface methodology was used to study the influence of MAE parameters (extraction time, temperature, solvent volume, and stirring speed) in order to maximize OTA recovery. The optimized MAE conditions were the following: 25 mL of acetonitrile, 10 min of extraction, at 80 °C, and maximum stirring speed. Validation of the overall methodology was performed by spiking assays at five levels (0.1–3.00 ng/g). The quantification limit was 0.005 ng/g. The established method was then applied to 64 bread samples (wheat, maize, and wheat/maize bread) collected in Oporto region (Northern Portugal). OTAwas detected in 84 % of the samples with a maximum value of 2.87 ng/g below the European maximum limit established for OTA in cereal products of 3 ng/g

VII Workshop on Computational Data Analysis and Numerical Methods

Dear participants, colleagues and friends, it is a great honour and a privilege to give you all a warmest welcome to the VII Workshop on Computational Data Analysis and Numerical Methods (VII WCDANM), which is organized by the Polytechnic Institute of Tomar (located in the center of Portugal in the beautiful city of Tomar), with the support of some Portuguese research centers, hoping that the final result may exceed the expectations of the participants, sponsors and organizers. Due to the worldwide pandemic caused by the COVID-19 virus, for the first time, this meeting will be transmitted through videoconference (webminar). Nevertheless, the important contributions of Adélia Sequeira (University of Lisbon, Portugal), Sílvia Barbeiro (University of Coimbra, Portugal), Malay Banerjee (Indian Instituto of Techonology Kampur, India) and Indranhil Ghosh (University of North Carolina at Wilmington, USA) as Plenary Speakers, the high scientific level of oral and poster presentations and an active audience will certainly contribute to the success of the meeting. Part of the accepted papers (theoretical and applied) by the VII WCDANM involve big data, data mining, data science and machine learning, in different areas of research, some giving emphasis to coronavirus. A very special thanks to this small, yet important, scientific community, since this event could not be possible without any of these essential and complementary parts. This year, there is also the possibility to attend a course on ŞModeling Partial Least Squares Structural Equations (PLS-SEM) using SmartPLSŤ given by Christian M. Ringle ((TUHH) Hamburg University of Technology, Germany), who kindly and readily accepted our invitation and to whom we are very grateful. A special acknowledgment is also due to the Members of the Executive, Scientific and Organizing Committees. In particular, Anuj Mubayi (Arizona StateUniversity,USA),MilanStehlík(Johannes KeplerUniversity,Austria), AnaNata,IsabelPitacasandManuelaFernandes(hostsfromthePolytechnic Institute of Tomar, Portugal), A. Manuela Gonçalves (University of Minho, Portugal), Teresa Oliveira (Aberta University) and Fernando Carapau (University of Évora, Portugal) have been relentless in search for a balanced, broad and interesting program, having achieved an excellent result. For the third consecutive year, the Journal of Applied Statistics (Taylor & Francis) and Neural Computing and Applications (Springer) are also associated to the event, being extremely important in the dissemination of the scientific results achieved at the meeting. Given the above, it is a pleasure to be ”together” with all of you in this web conference, hoping it may provide an intellectual stimulus and an opportunity for the scientific community to jointly work and disseminate scientific research, namely presenting approaches that may contribute to the solution of the pandemic we are experiencing in the expectation that the present might be past in the near future

Still a Powerful Tool?

Background: New therapies with prognostic benefits have been recently introduced in heart failure with reduced ejection fraction (HFrEF) management. The aim of this study was to evaluate the prognostic power of current listing criteria for heart transplantation (HT) in an HFrEF cohort submitted to cardiopulmonary exercise testing (CPET) between 2009 and 2014 (group A) and between 2015 and 2018 (group B). Methods: Consecutive patients with HFrEF who underwent CPET were followed-up for cardiac death and urgent HT. Results: CPET was performed in 487 patients. The composite endpoint occurred in 19.4% of group A vs. 7.4% of group B in a 36-month follow-up. Peak VO2 (pVO2) and VE/VCO2 slope were the strongest independent predictors of mortality. International Society for Heart and Lung Transplantation (ISHLT) thresholds of pVO2 ≤ 12 mL/kg/min (≤14 if intolerant to β-blockers) and VE/VCO2 slope > 35 presented a similar and lower Youden index, respectively, in group B compared to group A, and a lower positive predictive value. pVO2 ≤ 10 mL/kg/min and VE/VCO2 slope > 40 outperformed the traditional cut-offs. An ischemic etiology subanalysis showed similar results. Conclusion: ISHLT thresholds showed a lower overall prognostic effectiveness in a contemporary HFrEF population. Novel parameters may be needed to improve risk stratification.publishersversionpublishe