Linking the Web of Things: LDP-CoAP Mapping

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Linked Data (in Low-Resource) Platforms: A Mapping for Constrained Application Protocol

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Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

Alcune considerazioni su codificazione e decodificazione

La recentissima approvazione della legge 103/2017 (cd. Riforma del processo penale) è solo l’ultimo dei tentativi, alcuni di successo, altri abortiti, di riforma di parti del codice di procedura penale. Le riforme dei grandi codici, però, quando riuscite, vanno di pari passo con la presenza di una pletora di leggi speciali ad essi esterne che rendono sempre più difficoltoso per l’operatore del diritto riuscire a districarsi nella giungla di norme allo stato esistenti. Semplificazioni normative anche numericamente imponenti possono porsi solo quale palliativo per il passato e non quale modus operandi per il futuro. L’articolo si propone una veloce panoramica sulla problematica e alcuni spunti di riflessione per soluzioni future

An Integrated System for Large Scale Scanning of Nuclear Emulsions

The European Scanning System, developed to analyse nuclear emulsions at high speed, has been completed with the development of a high level software infrastructure to automate and support large- scale emulsion scanning. In one year, an average installation is capable of performing data-taking and online analysis on a total surface ranging from few m2 to tens of m2, acquiring many billions of tracks, corresponding to several TB. This paper focuses on the procedures that have been implemented and on their impact on physics measurements. The system proved robust, reliable, fault-tolerant and user- friendly, and seldom needs assistance. A dedicated relational Data Base system is the backbone of the whole infrastructure, storing data themselves and not only catalogues of data files, as in common practice, being a unique case in high-energy physics DAQ systems. The logical organisation of the system is described and a summary is given of the physics measurement that are readily available by automated processing