Computing genetic evaluations through application of generalized least squares to an animal model

International audienc

Aesthetic Wit(h)nessing in the Era of Trauma

Israeli/French artist and psychoanalytical theorist, Bracha Ettinger has declared: “In art today we are moving from phantasm to trauma. Contemporary aesthetics is moving from phallic structure to matrixial sphere.” In analysing the significance of this claim, this article will bring together the legacies of feminist, post-colonial cultural theories in relation to the current focus on trauma, memory and aesthetics in an international context. The understanding of the twentieth century as a century of catastrophe demands theoretical attention be given to concepts such as trauma, as artists with deep ethical commitments bring issues of traumatic legacies to the surface of cultural awareness and potentially provide through the aesthetic encounter a passage from the traces of trauma. This article introduces, explains and analyses the contribution of Bracha Ettinger as a major theoretician of trauma, aesthetics and above all sexual difference. In addition, it elaborates on her parallel concept of a matrixial aesthetic practice, enacted through a post-conceptual painting, that retunes the legacies of technologies of surveillance and documentation/archiving, as a means to effect the passage to a future that accepts the burden of sharing the trauma while processing and transforming it. The article demonstrates the dual functions of Ettingerian theories of a matrixial supplement to the phallocentric Imaginary and Symbolic in relation to the major challenges we face as we seek to understand, acknowledge and move on from the catastrophes that render our age post-traumatic

The long journey: maternal trauma, tears and kisses in a work by Chantal Akerman

Chantal Akerman is now one of the most highly regarded filmmakers in Europe with a long career reaching back into the 1970s when she was first hailed as part of a new feminist cinema. As independent cinema lost ground and its own locations, Akerman was invited to create installations for her films and thus to traverse the boundaries between cinema and new media art forms. While still making commercial cinema, Akerman elaborates its themes in other forms. One such installation, WALKING NEXT TO ONE'S SHOELACES INSIDE AN EMPTY FRIDGE (2004), created an occasion for her to film together with her own mother, the haunting presence of many of her films and much of the feminist analysis of Akermanian cinema. This time, Akerman led her mother back to her own mother through an object, the only remnant of a young woman murdered in Auschwitz. This paper is an analysis of what happened during this filming which leads to a retrospective reading of Akerman's films from 1968 in terms of traumatic inscriptions of the shared transgenerationally transmitted but unspoken trauma that finds its moment of formulation in this 'event' that was filmed and then made into an installation. Drawing on Ettingerian matrixial revisions to trauma theory and to psychoanalytical aesthetics, notably through the concept of fascinance as a durational non-visual gazing through which the feminine subject seeks knowledge of a feminine other, I argue that we can, in the light of this 'event' of the 2004 work, reconfigure Akerman's work in terms of a journey towards the traumatic kernel that, encrypted, leads to repetition, but formulated through the durational artwork facilitates passage of its remnants

Assessment of heavy metals bioavailability in dumpsites of Zaria Metropolis, Nigeria

The objectives of this study was to investigate the chemical fractionation, mobility and bioavailability of Cd, Cu, Mn, Pb and Zn in refuse waste soils of some dumpsites in Zaria metropolis. The heavy metals in the waste soils samples were sequentially extracted and measured using atomic absorption spectrometry. Mean of total extractable metals in the samples analysed for Cd, Cu, Mn, Pb and Zn ranged from 25.86 – 95.71, 1.70 – 446.43, 141.92 – 423.22, 39.9 – 739.10, and 122.45 – 511.57 mgKg-1 dry weight, respectively. Cd and Pb were mostly found to be in the mobile phase of the samples indicating that the metals are potentially more bioavailable to the environment than the other metals studied. Overall, the order of mobility and bioavailability of the metals is Cd > Pb > Zn > Mn > Cu

Cubic-spline interpolation to estimate effects of inbreeding on milk yield in first lactation Holstein cows

Milk yield records (305d, 2X, actual milk yield) of 123,639 registered first lactation Holstein cows were used to compare linear regression (y = β0 + β1X + e), quadratic regression, (y = β0 + β1X + β2X2 + e) cubic regression (y = β0 + β1X + β2X2 + β3X3 +e) and fixed factor models, with cubic-spline interpolation models, for estimating the effects of inbreeding on milk yield. Ten animal models, all with herd-year-season of calving as fixed effect, were compared using the Akaike corrected-Information Criterion (AICc). The cubic-spline interpolation model with seven knots had the lowest AICc, whereas for all those labeled as “traditional”, AICc was higher than the best model. Results from fitting inbreeding using a cubic-spline with seven knots were compared to results from fitting inbreeding as a linear covariate or as a fixed factor with seven levels. Estimates of inbreeding effects were not significantly different between the cubic-spline model and the fixed factor model, but were significantly different from the linear regression model. Milk yield decreased significantly at inbreeding levels greater than 9%. Variance component estimates were similar for the three models. Ranking of the top 100 sires with daughter records remained unaffected by the model used

Field evidence for the upwind velocity shift at the crest of low dunes

Wind topographically forced by hills and sand dunes accelerates on the upwind (stoss) slopes and reduces on the downwind (lee) slopes. This secondary wind regime, however, possesses a subtle effect, reported here for the first time from field measurements of near-surface wind velocity over a low dune: the wind velocity close to the surface reaches its maximum upwind of the crest. Our field-measured data show that this upwind phase shift of velocity with respect to topography is found to be in quantitative agreement with the prediction of hydrodynamical linear analysis for turbulent flows with first order closures. This effect, together with sand transport spatial relaxation, is at the origin of the mechanisms of dune initiation, instability and growth.Comment: 13 pages, 6 figures. Version accepted for publication in Boundary-Layer Meteorolog

Close Encounters of the Weak Kind: Investigations of Electron-Electron Interactions between Dissimilar Spins in Hybrid Rotaxanes.

We report a family of hybrid [2]rotaxanes based on inorganic [Cr7NiF8(O2C t Bu)16]- ("{Cr7Ni}") rings templated about organic threads that are terminated at one end with pyridyl groups. These rotaxanes can be coordinated to [Cu(hfac)2] (where Hhfac = 1,1,1,5,5,5-hexafluoroacetylacetone), to give 1:1 or 1:2 Cu:{Cr7Ni} adducts: {[Cu(hfac)2](py-CH2NH2CH2CH2Ph)[Cr7NiF8(O2C t Bu)16]}, {[Cu(hfac)2][py-CH2NH2CH2CH3][Cr7NiF8(O2C t Bu)16]}, {[Cu(hfac)2]([py-CH2CH2NH2CH2C6H4SCH3][Cr7NiF8(O2C t Bu)16])2}, {[Cu(hfac)2]([py-C6H4-CH2NH2(CH2)4Ph][Cr7NiF8(O2C t Bu)16])2}, and {[Cu(hfac)2]([3-py-CH2CH2NH2(CH2)3SCH3][Cr7NiF8(O2C t Bu)16])2}, the structures of which have been determined by X-ray diffraction. The {Cr7Ni} rings and CuII ions both have electronic spin S = 1/2, but with very different g-values. Continuous-wave EPR spectroscopy reveals the exchange interactions between these dissimilar spins, and hence the communication between the different molecular components that comprise these supramolecular systems. The interactions are weak such that we observe AX or AX2 type spectra. The connectivity between the {Cr7Ni} ring and thread terminus is varied such that the magnitude of the exchange interaction J can be tuned. The coupling is shown to be dominated by through-bond rather than through-space mechanisms

Synthesis and Anti-Mycobacterium tuberculosis Activity of Imidazo[2,1-b][1,3]oxazine Derivatives against Multidrug-Resistant Strains

The emergence of multidrug-resistant strains of M. tuberculosis has raised concerns due to the greater difficulties in patient treatment and higher mortality rates. Herein, we revisited the 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine scaffold and identified potent new carbamate derivatives having MIC90 values of 0.18–1.63 μM against Mtb H37Rv. Compounds 47–49, 51–53, and 55 exhibited remarkable activity against a panel of clinical isolates, displaying MIC90 values below 0.5 μM. In Mtb-infected macrophages, several compounds demonstrated a 1-log greater reduction in mycobacterial burden than rifampicin and pretomanid. The compounds tested did not exhibit significant cytotoxicity against three cell lines or any toxicity to Galleria mellonella. Furthermore, the imidazo[2,1-b][1,3]oxazine derivatives did not show substantial activity against other bacteria or fungi. Finally, molecular docking studies revealed that the new compounds could interact with the deazaflavin-dependent nitroreductase (Ddn) in a similar manner to pretomanid. Collectively, our findings highlight the chemical universe of imidazo[2,1-b][1,3]oxazines and their promising potential against MDR-TB