Assignment schemes for replicated services in Jini

This paper introduces and compares different schemes for assignment of replicated services in Jini - an object oriented middleware architecture for network-centric computing. Each client in Jini has to be assigned a service selected from the pool of available services, which have joined the Jini federation and registered with the lookup service. Both early and delayed assignments are considered as basic options in our evaluation. The information for the system load can be collected at four different levels of detail in order to be used in the process of assignment decisions. In our analysis, we concentrate on the scenario where the requests for service generated by the clients follow independent user-initiated or machine-initiated transactions. The performance evaluation of the assignment schemes follows the queuing systems methodology. The comparisons are done with regard to the mean residence time of the clients in the system as well as the control overhead imposed by the assignment schemes. A case study of the scheme using the lowest information level proves the effectiveness, applicability and limitations of the delayed assignment in comparison to the early one. These results are a first step towards developing a methodology for building large-scale applications for Jini-based distributed systems

Cognitive function in COPD

In order to characterise the overall clinical picture of chronic obstructive pulmonary disease (COPD) a better understanding of all relevant comorbidities is required. It is increasingly recognised that COPD is a multi-component disease, but little attention has been paid to its effects on cognitive function. Cognitive dysfunction is associated with increased mortality and disability; however, it remains poorly understood in COPD. This review examines mechanisms of injury and dysfunction to the brain and considers the methods used to evaluate cognition, and assembles evidence concerning the nature and level of cognitive impairment in COPD. Our main findings are: 1) there may be a pattern of cognitive dysfunction specific to COPD; 2) cognitive function is only mildly impaired in patients without hypoxaemia; 3) the incidence of cognitive dysfunction is higher in hypoxaemia; 4) hypoxaemia, hypercapnia, smoking and comorbidities (such as vascular disease) are unlikely to account for all of the cognitive dysfunction seen in COPD; 5) there is weak or no association between cognitive function and mood, fatigue or health status; 6) cognitive dysfunction may be associated with increased mortality and disability; and 7) there is limited evidence for a significant effect of treatment on cognitive function

Comparative Analysis Of The Structure And Content Of Faculties Of Pharmacy Curricula For Pharmacy Master Degree In Bulgaria

Фармацевтичната професия е регулирана, защото представлява дейност от обществена значимост и е от съществено значение за живота и здравето на хората. Правото за упражняването ѝ е определено чрез законови, подзаконови или административни разпоредби. Проучени и анализирани са актуалните учебни планове в петте факултета по фармация в България. Минималният хорариум по задължителните, общо 26 учебни дисциплини е 3015 часа, съгласно Единните държавни изисквания (ЕДИ). Всеки един от петте фармацевтични факултета в България се характеризира с различия в заложената в учебния план теоретична подготовка и брой учебни дисциплини.The pharmaceutical profession is regulated because it is an activity of social significance and is essential for the lifeand health of people. The right to practice it is determined by laws, regulations or administrative provisions. The current curricula at the five faculties of pharmacy in Bulgaria have been studied and analyzed. The minimum horarium of the compulsory, totally 26 subjects is 3015 hours, according to the Unified State Requirements. Each of the five faculties of pharmacy in Bulgaria is characterized by differences in the theoretical education set in the curriculum and the number of subjects

Environment, Ram Pressure, and Shell Formation in HoII

Neutral hydrogen VLA D-array observations of the dwarf irregular galaxy HoII, a prototype galaxy for studies of shell formation, are presented. HI is detected to radii over 16' or 4 R_25, and M_HI=6.44x10^8 M_sun. The total HI map has a comet-like appearance suggesting that HoII is affected by ram pressure from an intragroup medium (IGM). A rotation curve corrected for asymmetric drift was derived and an analysis of the mass distribution yields a total mass 6.3x10^9 M_sun, of which about 80% is dark. HoII lies northeast of the M81 group's core, along with Kar52 (M81dwA) and UGC4483. No signs of interaction are observed and it is argued that HoII is part of the NGC2403 subgroup, infalling towards M81. A case is made for ram pressure stripping and an IGM in the M81 group. Stripping of the disk outer parts would require an IGM density n_IGM>=4.0x10^-6 atoms/cm^3 at the location of HoII. This corresponds to 1% of the virial mass of the group uniformly distributed over a volume just enclosing HoII and is consistent with the X-ray properties of small groups. It is argued that existing observations of HoII do not support self-propagating star formation scenarios, whereby the HI holes and shells are created by supernova explosions and stellar winds. Many HI holes are located in low surface density regions of the disk, where no star formation is expected or observed. Ram pressure has the capacity to enlarge preexisting holes and lower their creation energies, helping to bridge the gap between the observed star formation rate and that required to create the holes. (abridged)Comment: 43 pages, including 7 figures. 4 figures available as JPEG only. Complete manuscript including full resolution figures available at http://www.strw.leidenuniv.nl/~bureau/pub_list.html . Accepted for publication in The Astronomical Journa

Mapping genetic variations to three- dimensional protein structures to enhance variant interpretation: a proposed framework

The translation of personal genomics to precision medicine depends on the accurate interpretation of the multitude of genetic variants observed for each individual. However, even when genetic variants are predicted to modify a protein, their functional implications may be unclear. Many diseases are caused by genetic variants affecting important protein features, such as enzyme active sites or interaction interfaces. The scientific community has catalogued millions of genetic variants in genomic databases and thousands of protein structures in the Protein Data Bank. Mapping mutations onto three-dimensional (3D) structures enables atomic-level analyses of protein positions that may be important for the stability or formation of interactions; these may explain the effect of mutations and in some cases even open a path for targeted drug development. To accelerate progress in the integration of these data types, we held a two-day Gene Variation to 3D (GVto3D) workshop to report on the latest advances and to discuss unmet needs. The overarching goal of the workshop was to address the question: what can be done together as a community to advance the integration of genetic variants and 3D protein structures that could not be done by a single investigator or laboratory? Here we describe the workshop outcomes, review the state of the field, and propose the development of a framework with which to promote progress in this arena. The framework will include a set of standard formats, common ontologies, a common application programming interface to enable interoperation of the resources, and a Tool Registry to make it easy to find and apply the tools to specific analysis problems. Interoperability will enable integration of diverse data sources and tools and collaborative development of variant effect prediction methods