Scanning tunnelling miscroscopy/spectroscopy and X-ray absorption spectroscopy studies of Co adatoms and anoislands on highly oriented pyrolytic graphite

In this paper, the scanning tunneling microscopy, scanning tunneling spectroscopy and X-ray absorption spectroscopy of cobalt adatoms and nanoislands were studied on a highly oriented pyrolytic graphite. Local electronic structure were observed by STS.\ud \u

Journalism expands in spite of the crisis: digital-native news media in Spain

Digital-native news organizations have grown steadily in Spain since the mid-1990s and they have become established as a major force in the media market. Paradoxically, their biggest expansion coincided with the Great Recession (2008–2014). In fact, their numbers increased most during 2012–2013, when traditional media were cutting staff in response to the economic crisis, and unemployment rates in the media sector as a whole hit their peak. However, these digital-native news startups have yet to prove their sustainability and stability. This study uses our own database of 3,862 native and non-native digital news outlets in Spain and the Reuters Institute Digital News Report to analyze a number of characteristics of these media, such as the percentage that have gone inactive, the relative popularity of legacy brands vs. digital natives, multi-platform synergies, content subject matter, geographical location, ownership, and funding sources. Based on these quantitative parameters, this study reviews the structural strengths and weaknesses of digital-native media in the Spanish news market. Taking into account these findings, we conclude that the surge in digital-native news media observed in Spain during the Great Recession followed the pattern of creative destruction described by several economists

El ecosistema que viene

En 2011, Iñaki Gabilondo publicaba un libro de título cre- puscular: El fin de una época. Uno de los periodistas más presti- giosos de España entonaba en aquellas páginas una despedida si no a la profesión —en 2018 continúa analizando la actualidad en un videoblog de El País—, sí al menos a cierta forma de ejercerla. «El periodismo —escribía— está viviendo una verda- dera transición de una época a otra, la muerte de un ciclo y el nacimiento de otro. Estamos en pleno proceso de despedida del mundo que habíamos conocido para dirigirnos, aún de manera imprecisa, hacia ese nuevo universo complejísimo de lo digital y las nuevas conectividades» (Gabilondo, 2011: 149-150). En efecto, para cuando se escribían esas líneas, las tecnologías di- gitales no solo habían modificado las herramientas con las que nos informamos, sino que, apenas en un cuarto de siglo, habían transformado el periodismo en su integridad. Con ello, se han abierto tantas incógnitas como oportunidades. Al compás de los cambios tecnológicos, han evolucionado los lenguajes informativos, los procesos de trabajo en las redaccio- nes, los perfiles profesionales de los periodistas, las formas en las que estos se relacionan con la audiencia y, en definitiva, todos y cada uno de los ámbitos en los que se concreta la actividad periodística. Como resultado de esos cambios, tal y como reve- lan los capítulos anteriores, en España ha emergido un nuevo mercado periodístico

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ~60 000 individuals in the discovery stage and ~90 000 samples in the replication stage. Results Our study resu

Age does matter in adolescents and young adults versus older adults with advanced melanoma; a national cohort study comparing tumor characteristics, treatment pattern, toxicity and response

Cutaneous melanoma is a common type of cancer in Adolescents and Young Adults (AYAs, 15–39 years of age). However, AYAs are underrepresented in clinical trials investigating new therapies and the outcomes from these therapies for AYAs are therefore unclear. Using prospectively collected nation-wide data from the Dutch Melanoma Treatment Registry (DMTR), we compared baseline characteristics, mutational profiles, treatment strategies, grade 3–4 adverse events (AEs), responses and outcomes in AYAs (n = 210) and older adults (n = 3775) who were diagnosed with advanced melanoma between July 2013 and July 2018. Compared to older adults, AYAs were more frequently female (51% versus 40%, p = 0.001), and had a better Eastern Cooperative Oncology Group performance status (ECOG 0 in 54% versus 45%, p = 0.004). BRAF and NRAS mutations were age dependent, with more BRAF V600 mutations in AYAs (68% versus 46%) and more NRAS mutations in older adults (13% versus 21%), p < 0.001. This finding translated in distinct first-line treatment patterns, where AYAs received more initial targeted therapy. Overall, grade 3–4 AE percentages following first-line systemic treatment were similar for AYAs and older adults; anti-PD-1 (7% versus 14%, p = 0.25), anti-CTLA-4 (16% versus 33%, p = 0.12), anti-PD-1 + anti-CTLA-4 (67% versus 56%, p = 0.34) and BRAF/MEK-inhibition (14% versus 23%, p = 0.06). Following anti-CTLA-4 treatment, no AYAs experienced a grade 3–4 colitis, while 17% of the older adults did (p = 0.046). There was no difference in response to treatment between AYAs and older adults. The longer overall survival observed in AYAs (hazard ratio (HR) 0.7; 95% CI 0.6–0.8) was explained by the increased cumulative incidence of non-melanoma related deaths in older adults (sub-distribution HR 2.8; 95% CI 1.5–4.9), calculated by competing risk analysis. The results of our national cohort study show that baseline characteristics and mutational profiles differ between AYAs and older adults with advanced melanoma, leading to different treatment choices made in daily practice. Once treatment is initiated, AYAs and older adults show similar tumor responses and melanoma-specific survival

GPI Spectra of HR 8799 c, d, and e from 1.5 to 2.4 μm with KLIP Forward Modeling

Stars and planetary system